A5050580729- Colorectal Cancer Treatments and Studies
- Colorectal Cancer Surgical Treatments
- Colorectal and Anal Carcinomas
- Cancer, Lipids, and Metabolism
- Hepatocellular Carcinoma Treatment and Prognosis
- Cancer, Hypoxia, and Metabolism
- Pancreatic and Hepatic Oncology Research
- Genetic factors in colorectal cancer
- Colorectal Cancer Screening and Detection
- Gastric Cancer Management and Outcomes
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Cancer Research and Treatments
- Intraperitoneal and Appendiceal Malignancies
- Ovarian cancer diagnosis and treatment
- Appendicitis Diagnosis and Management
- Lung Cancer Diagnosis and Treatment
- Radiomics and Machine Learning in Medical Imaging
- Gastrointestinal Tumor Research and Treatment
- Diverticular Disease and Complications
- Advanced X-ray and CT Imaging
- RNA Interference and Gene Delivery
- Advances in Oncology and Radiotherapy
- Cardiac, Anesthesia and Surgical Outcomes
- RNA modifications and cancer
- Neuroendocrine Tumor Research Advances
Memorial Sloan Kettering Cancer Center
2023-2025
Kettering University
2025
The University of Texas Southwestern Medical Center
2022-2024
Southwestern Medical Center
2022-2023
Harold C. Simmons Comprehensive Cancer Center
2023
Cleveland Clinic
2013-2020
Cleveland Clinic Lerner College of Medicine
2016-2019
The University of Texas MD Anderson Cancer Center
2018
American Society of Colon and Rectal Surgeons
2018
New York University
2017
BACKGROUND Molecular biomarkers offer the potential for refining prognostic determinants in patients undergoing cancer surgery. Among with colorectal cancer, KRAS and BRAF are important biomarkers, but their role surgical therapy liver metastases is unknown. In this study, incidence significance of mutations were determined (CRLM). METHODS analysis was performed on 202 surgery CRLM between 2003 2008. Tumor samples analyzed somatic using sequencing (KRAS, codon12/13, BRAF, V600E). The...
Currently, one of the most commonly available biomarkers in treatment patients with colorectal liver metastases (CRLM) is Kirsten rat sarcoma viral oncogene homolog (KRAS); however, prognostic implications specific mutations KRAS gene are still not well defined.To investigate impact on undergoing resection for CRLM.This retrospective single-center study was conducted from January 1, 2003, to December 31, 2013. Data about 331 who underwent hepatic CRLM at Johns Hopkins Hospital between 2003...
Robotic colorectal surgery is becoming the preferred surgical approach for cancer (CRC). It offers several technical advantages over conventional laparoscopy that could improve patient outcomes. In this retrospective cohort study, we compared robotic and laparoscopic CRC using a national of patients.Using colectomy-targeted ACS-NSQIP database (2015-2020), procedures malignant etiologies were identified by CPT codes right colectomy (RC), left (LC), low anterior resection (LAR). Optimal pair...
Importance Patients treated with radiotherapy (RT) for prostate cancer (PC) have increased risk of secondary rectal (SRC) and more limited treatment options. Objective To assess the tumor molecular profile, clinical characteristics, oncologic outcomes SRC after PC compare them those primary (PRC). Design, Setting, Participants This case-control study included patients diagnosed 5 or years RT PRC who were at Memorial Sloan Kettering Cancer Center in New York between February 1, 1994,...
Objective: The aim of this study was to evaluate trends over time in perioperative outcomes for patients undergoing hepatectomy. Background: As care and surgical technique hepatectomy have improved, the indications complexity liver resections evolved. However, resulting effect on short-term has not been well described. Methods: Consecutive during 1998 2015 at 1 institution were analyzed. Perioperative outcomes, including comprehensive complication index (CCI), compared between who underwent...
To evaluate the independent prognostic ability of American Joint Committee on Cancer (AJCC) tumor regression scores within pathologic stage II and III rectal cancers.Response to neoadjuvant chemoradiation (nCRT) has been debated as a biologic surrogate for biology prognosis in cancer. AJCC have shown correlate with prognosis.Patient demographics, characteristics, (0 = complete response; 1 isolated cells remaining; 2 residual cancer outgrown by fibrosis; 3 extensive cancer) were assessed from...
Argonaute protein is associated with post-transcriptional control of cytoplasmic gene expression through miRNA-induced silencing complexes (miRISC). Specific cellular and environmental conditions can trigger AGO to accumulate in the nucleus. Localization central understanding miRNA action, yet consequences being nucleus are undefined. We show nuclear enrichment AGO2 HCT116 cells grown two-dimensional culture high density, three-dimensional tumor spheroid culture, human colon tumors. The...
Objective: Analyze conditional recurrence-free survival (cRFS) for rectal cancer patients with complete clinical response (cCR) after neoadjuvant chemoradiation (nCRT) managed nonoperatively each year without recurrence. Summary Background Data: Select cCR nCRT have been nonoperatively. Risk factors local recurrence, the need prolonged follow-up, and risk of recurrence over time are not well defined. Methods: Retrospective review cT2-4N0-2M0 treated nCRT. Mean follow-up was 64 months....
Abstract Neoadjuvant radiation is standard of care for locally advanced rectal cancer. Response to highly variable and directly linked with survival. However, there currently are no validated biomarkers or molecular targets predict improve response, which would help develop personalized treatment ideally targeted therapies. Here, we identified a novel biomarker, coenzyme A synthase (COASY), whose mRNA expression was consistently elevated in radioresistant human cancers. This observation...
136 Background: National guidelines recommend surgery when pathology analysis of a colorectal polyp reveals high-risk features: positive margin/piecemeal resection (PM/PR), lymphovascular/perineural invasion (LVI/PNI), poor differentiation (PD), or tumor budding (TB). However, some patients choose to avoid surgery, with its morbidity and quality-of-life implications, despite the risk residual disease. Methods: This single-center cohort study determined rates luminal lymph node disease...
Summary Peritoneal carcinomatosis is a common yet deadly manifestation of gastrointestinal cancers, with few effective treatments. To identify targetable determinants peritoneal metastasis, we focused on appendiceal adenocarcinoma (AC), cancer that metastasizes almost exclusively to the peritoneum. Current treatments are extrapolated from colorectal (CRC), AC has distinct genomic alterations, mucinous morphology and peritoneum restricted metastatic pattern. Further, no stable preclinical...
Abstract Malignant appendiceal epithelial tumors (AC) present a rare and diverse group of neoplasms.1 Treatment options are limited especially with peritoneal recurrence. Alpha beta particle therapy using radioisotopes, when delivered by pre-targeted radioimmunotherapy (PRIT) approach, can be effective wide therapeutic window. SADA-PRIT exploits an initial long plasma half-life SADA tetramers for increased tumor uptake unbound, their disassembly to monomer rapid renal clearance, thereby...
Disease-free survival estimated from the time of surgery does not account for changing likelihood based on already accrued. Conditional disease-free is defined as probability remaining disease free after reaching a specific point without recurrence.The purpose this study was to evaluate conditional patients with rectal cancer who were treated by proctectomy neoadjuvant chemoradiation.Demographics, tumor characteristics, and regression scores assessed. Three-year at x year formula cDFS3 =...
While the incidence of cholangiocarcinoma is rising, little known about young-onset disease. We compared clinical characteristics and outcomes between patients with cholangiocarcinoma, diagnosed ages 18 <50 years, typical-onset at age 50 years or greater.We used National Cancer Database to identify (n = 2520) 23,826). frequency demographic two groups. overall survival groups using multivariable Cox regression analysis after adjusting for age, gender, race/ethnicity, comorbidity, facility...
Abstract Colorectal cancer (CRC) remains a leading killer in the U.S. with resistance to treatment as largest hurdle cure. cancer-initiating cells (CICs) are self-renewing tumor population that contribute relapse. Here, we report patient-derived CICs display relative chemoresistance compared differentiated progeny. In contrast, conventional cell lines failed model therapeutic resistance. preferentially repaired chemotherapy-induced DNA breaks, prompting us interrogate damage pathways against...
BACKGROUND: The incidence of colorectal cancer in the young (under age 40) is increasing, and this population has worse oncologic outcomes. Mucinous histology a potential prognostic factor cancer, but not been evaluated specifically patients. OBJECTIVE: objective study was to determine factors associated with poor outcome patients (≤40 years) relationships between mucinous outcomes population. DESIGN: This retrospective study. SETTING: Patients from single-institution tertiary care center...