A5027737835- Hepatocellular Carcinoma Treatment and Prognosis
- Colorectal Cancer Treatments and Studies
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Pancreatic and Hepatic Oncology Research
- Gallbladder and Bile Duct Disorders
- Genetic factors in colorectal cancer
- Lung Cancer Treatments and Mutations
- Gastric Cancer Management and Outcomes
- Cancer Genomics and Diagnostics
- Neuroendocrine Tumor Research Advances
- Liver Disease Diagnosis and Treatment
- Renal cell carcinoma treatment
- Radiomics and Machine Learning in Medical Imaging
- Frailty in Older Adults
- Nutrition and Health in Aging
- Adrenal and Paraganglionic Tumors
- Pituitary Gland Disorders and Treatments
- Colorectal Cancer Surgical Treatments
- Inflammatory Bowel Disease
- Cancer, Hypoxia, and Metabolism
- Cardiac, Anesthesia and Surgical Outcomes
- Viral-associated cancers and disorders
- Organ Transplantation Techniques and Outcomes
- Colorectal and Anal Carcinomas
- Inflammatory Biomarkers in Disease Prognosis
Memorial Sloan Kettering Cancer Center
2020-2025
Massachusetts Institute of Technology
2024
Charité - Universitätsmedizin Berlin
2018-2023
Johns Hopkins University
2014-2021
Johns Hopkins Medicine
2014-2021
Johns Hopkins Hospital
2014-2021
Cleveland Clinic
2018-2021
University of California, San Francisco
2021
Bodossaki Foundation
2021
University of Verona
2021
To apply the principles of Metro-ticket paradigm to develop a prognostic model for patients undergoing hepatic resection colorectal liver metastasis (CRLM).Whereas hepatocellular "Metro-ticket" tool utilizes continuum tumor size and number, similar concept CRLM has not been investigated.Tumor Burden Score (TBS) was defined using distance from origin on Cartesian plane incorporating maximum (x-axis) number lesions (y-axis). The discriminatory power [area under curve (AUC)] goodness-of-fit...
BRAF mutations are reportedly associated with aggressive tumor biology. However, in contrast primary colorectal cancer, the association of V600E and non-V600E survival recurrence after resection liver metastases (CRLM) has not been well studied.To investigate prognostic independently compared other determinants, such as KRAS mutations.In this cohort study, all patients who underwent for CRLM curative intent from January 1, 2000, through December 31, 2016, at institutions participating...
Abstract Background This study sought to develop a clinical risk score for resectable colorectal liver metastasis (CRLM) by combining clinicopathological and clinically available biological indicators, including KRAS. Methods A cohort of patients who underwent resection CRLM at the Johns Hopkins Hospital (JHH) was analysed identify independent predictors overall survival (OS) that can be assessed before operation; these factors were combined into Genetic And Morphological Evaluation (GAME)...
Currently, one of the most commonly available biomarkers in treatment patients with colorectal liver metastases (CRLM) is Kirsten rat sarcoma viral oncogene homolog (KRAS); however, prognostic implications specific mutations KRAS gene are still not well defined.To investigate impact on undergoing resection for CRLM.This retrospective single-center study was conducted from January 1, 2003, to December 31, 2013. Data about 331 who underwent hepatic CRLM at Johns Hopkins Hospital between 2003...
Adrenocortical carcinoma (ACC) is a rare but aggressive endocrine tumor, and the prognostic factors associated with long-term outcomes after surgical resection remain poorly defined.To define clinicopathological variables recurrence-free survival (RFS) overall (OS) curative of ACC to propose nomograms for individual risk prediction.Nomograms predict RFS OS were proposed using multi-institutional cohort patients who underwent curative-intent surgery at 13 major institutions in United States...
To investigate the potential clinical advantage of anatomical resection versus nonanatomical for colorectal liver metastases, according to KRAS mutational status.KRAS-mutated metastases (CRLM) are known be more aggressive than wild-type tumors. Although resections have been demonstrated as a viable approach CRLM patients with similar oncologic outcomes resections, this may not case subset KRAS-mutated CRLM.389 who underwent hepatic status were identified. Survival estimates calculated using...
Background hepatocarcinogenesis is considered a major cause of postoperative recurrence de novo hepatocellular carcinoma (HCC) in patients with liver cirrhosis (LC). The degree underlying injury has reportedly correlated surgical outcomes HCC. However, the pattern and annual rate HCC are still unclear.To clarify LC.Data from 799 who underwent curative hepatectomy for at Toranomon Hospital Johns Hopkins between January 1, 1995, December 31, 2014, were retrospectively collected analyzed. Of...
Objective: To evaluate the changing impact of genetic and clinicopathologic factors on conditional overall survival (CS) over time in patients with resectable colorectal liver metastasis. Background: CS estimates account for likelihood may reveal prognostic as accrues from date surgery. Methods: analysis was performed 1099 an international, multi-institutional cohort. Three-year (CS3) at “xth” year after surgery were calculated follows: CS3 = ( x + 3)/CS ). The standardized difference d )...
Intrahepatic cholangiocarcinoma (iCCA) is often multifocal (ie, satellites or intrahepatic metastases) at presentation.
The prognostic impact of primary colorectal cancer (CRC) location following resection liver metastasis (CRLM) remains largely unknown. We sought to characterize the implications tumor among patients who underwent curative-intent hepatectomy for CRLM.Tumors cecum, ascending, and transverse colon were defined as right-sided; tumors sigmoid flexure, descending, left-sided. Clinicopathologic long-term survival data collected assessed using univariable multivariable analyses.About 475 CRLM at a...
Although frailty is a known determinant of poor postoperative outcomes, it can be difficult to identify in patients before surgery. The authors sought develop preoperative risk model predict mortality among aged 65 years or more.Clinical and morphometric data including total psoas area (TPA), volume (TPV) density (Hounsfield unit average calculation, HUAC) were collected for undergoing hepatopancreaticobiliary (HPB) surgery between 2012 2014. Multivariable Cox proportional hazards regression...
Objective: The purpose of this study is to determine preoperative factors that are predictive malignancy in patients undergoing pancreatic resection for intraductal papillary mucinous neoplasms (IPMN). Summary Background Data: IPMN the pancreas may be precursor lesions cancer (PC) and represent a target early diagnosis or prevention. While there has been much effort define risk malignant pathology, guidelines ever-changing controversy remains surrounding which would benefit most from...
We sought to determine whether Neutrophil-lymphocyte ratio (NLR) or platelet-lymphocyte (PLR) were associated with outcomes of patients undergoing surgery for a hepatopancreatico-biliary (HPB) malignancy.Between 2000 and 2013, 452 who underwent an HPB procedure malignant indication identified. Clinicopathological characteristics, NLR, PLR, as well short- long-term analyzed. High NLR PLR classified using cut-off value 5 190, respectively, based on ROC curve analysis.Patients low versus high...