A5078198832- Pancreatic and Hepatic Oncology Research
- Cancer Genomics and Diagnostics
- Neuroendocrine Tumor Research Advances
- Pancreatitis Pathology and Treatment
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Renal cell carcinoma treatment
- Radiomics and Machine Learning in Medical Imaging
- Cancer Cells and Metastasis
- Lung Cancer Research Studies
- Gastric Cancer Management and Outcomes
- Hepatocellular Carcinoma Treatment and Prognosis
- Gallbladder and Bile Duct Disorders
- Neuroblastoma Research and Treatments
- Cancer Research and Treatments
- Cancer Immunotherapy and Biomarkers
- Colorectal Cancer Treatments and Studies
- Genetic factors in colorectal cancer
- Colorectal Cancer Screening and Detection
- Gastrointestinal Tumor Research and Treatment
- Epigenetics and DNA Methylation
- Bone and Dental Protein Studies
- TGF-β signaling in diseases
- Colorectal Cancer Surgical Treatments
- Caveolin-1 and cellular processes
- RNA modifications and cancer
Johns Hopkins Medicine
2016-2025
Johns Hopkins University
2016-2025
Johns Hopkins Hospital
2016-2025
Cancer Research Center
2016-2025
Sidney Kimmel Comprehensive Cancer Center
2017-2024
Tianjin University of Technology and Education
2024
The University of Melbourne
2023
Peking Union Medical College Hospital
2023
Chinese Academy of Medical Sciences & Peking Union Medical College
2023
Bloomberg (United States)
2021-2023
Objective: To describe accurately the pattern, timing, and predictors of disease recurrence after a potentially curative resection for pancreatic ductal adenocarcinoma (PDAC). Summary Background Data: After surgery PDAC, most patients will develop recurrence. Understanding patterns timing failure can help guide improvements in therapy. Methods: Patients who underwent pancreatectomy PDAC at Johns Hopkins Hospital between 2000 2010 were included. Exclusion criteria incomplete follow-up...
Significance Few patients with pancreatic cancer survive longer than 5 y, in part because most are identified only after their disease has progressed to an advanced stage. In this study, we show how combining mutations circulating tumor DNA (ctDNA) protein markers can result a screening test improved sensitivity while retaining specificity. The combination of the ctDNA and was superior any single marker. Moreover, detected nearly two-thirds cancers that had no evidence distant metastasis at...
Objective: The aim of this study was to evaluate and validate the proposed 8th edition American Joint Committee on Cancer (AJCC) system for T N staging pancreatic adenocarcinoma. Summary Background Data: Investigators have questioned clinical relevance reproducibility previous AJCC Methods: Prospective databases at Memorial Sloan Kettering (MSK), Massachusetts General Hospital (MGH), Johns Hopkins (JHH) were queried patients who had undergone resection Patients underwent a margin-negative...
The NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines) for Neuroendocrine and Adrenal Gland Tumors focus on the diagnosis, treatment, management of patients with neuroendocrine tumors (NETs), adrenal tumors, pheochromocytomas, paragangliomas, multiple endocrine neoplasia. NETs are generally subclassified by site origin, stage, histologic characteristics. Appropriate diagnosis treatment often involves collaboration between specialists disciplines, using specific biochemical,...
Purpose Deleterious germline mutations contribute to pancreatic cancer susceptibility and are well documented in families which multiple members have had cancer. Methods To define the prevalence of these patients with apparently sporadic cancer, we sequenced 32 genes, including known DNA prepared from normal tissue obtained 854 ductal adenocarcinoma, 288 other periampullary neoplasms, 51 non-neoplastic diseases who underwent resection at Johns Hopkins Hospital between 2000 2015. Results...
The NCCN Guidelines for Neuroendocrine and Adrenal Tumors provide recommendations the management of adult patients with neuroendocrine tumors (NETs), adrenal gland tumors, pheochromocytomas, paragangliomas. Management NETs relies heavily on site primary NET. These Insights summarize options 2018 updates to guidelines locoregional advanced disease, and/or distant metastasis originating from gastrointestinal tract, bronchopulmonary, thymus NETs.
The aim of the study was to identify survival patients with locally advanced pancreatic cancer (LAPC) and assess effect surgical resection after neoadjuvant therapy on patient outcomes.An increasing number LAPC who respond favorably undergo resection. impact surgery is largely unknown.All presented institutional multidisciplinary clinic (PMDC) from January 2013 September 2017 were included in study. Demographics clinical data treatment documented. Primary tumor rates overall (OS) primary...
To establish an evidence-based cut-off to differentiate between early and late recurrence compare clinicopathologic risk factors the two groups.A clear definition of "early recurrence" after pancreatic ductal adenocarcinoma resection is currently lacking.Patients undergoing pancreatectomy for 2000 2013 were included. Exclusion criteria neoadjuvant therapy incomplete follow-up. A minimum P-value approach was used evaluate optimal value recurrence-free survival divide patients into cohorts...
The robotic surgical system has been applied in liver surgery. However, controversies concerns exist regarding a variety of factors including the safety, feasibility, efficacy, and cost-effectiveness To promote development hepatectomy, this study aimed to evaluate current status hepatectomy provide sixty experts' consensus recommendations its development. Based on World Health Organization Handbook for Guideline Development, Consensus Steering Group Development were established determine...
Liver cancer is the fourth leading cause of cancer-related mortality and distinguished by a relative paucity chemotherapy options. It has been hypothesized that intratumor genetic heterogeneity may contribute to high failure rate chemotherapy. Here, we evaluated functional in cohort primary human liver organoid lines. Each surgical specimen was used generate multiple lines, obtained from distinct regions tumor. A total 27 lines were established tested with 129 drugs, generating 3,483 cell...
BRAF mutations are reportedly associated with aggressive tumor biology. However, in contrast primary colorectal cancer, the association of V600E and non-V600E survival recurrence after resection liver metastases (CRLM) has not been well studied.To investigate prognostic independently compared other determinants, such as KRAS mutations.In this cohort study, all patients who underwent for CRLM curative intent from January 1, 2000, through December 31, 2016, at institutions participating...
Pancreatic cysts are common and often pose a management dilemma, because some precancerous, whereas others have little risk of developing into invasive cancers. We used supervised machine learning techniques to develop comprehensive test, CompCyst, guide the patients with pancreatic cysts. The test is based on selected clinical features, imaging characteristics, cyst fluid genetic biochemical markers. Using data from 436 cysts, we trained CompCyst classify as those who required surgery,...
To describe the survival outcome of patients with borderline resectable or locally advanced pancreatic ductal adenocarcinoma (BR/LA-PDAC) who have a pathologic complete response (pCR) following neoadjuvant chemoradiation.Patients BR/LA-PDAC are often treated chemoradiation in an attempt to downstage tumor. Uncommonly, pCR may result.A retrospective review prospectively maintained database was performed at single institution. defined as no viable tumor identified pancreas lymph nodes by...
In research settings, circulating tumor DNA (ctDNA) shows promise as a tumor-specific biomarker for pancreatic ductal adenocarcinoma (PDAC). This study aims to perform analytical and clinical validation of KRAS ctDNA assay in Clinical Laboratory Improvement Amendments (CLIA) College American Pathology-certified laboratory.Digital-droplet PCR was used detect the major PDAC-associated somatic mutations (G12D, G12V, G12R, Q61H) liquid biopsies. For validation, 290 preoperative longitudinal...
To report pancreas surveillance outcomes of high-risk individuals within the multicenter Cancer Pancreas Screening-5 (CAPS5) study and to update patients enrolled in prior CAPS studies.
Background & AimsNext-generation sequencing (NGS) of pancreatic cyst fluid is a useful adjunct in the assessment patients with cyst. However, previous studies have been retrospective or single institutional experiences. The aim this study was to prospectively evaluate NGS on multi-institutional cohort real time.MethodsThe performance 22-gene panel (PancreaSeq) first retrospectively confirmed and then within 2-year timeframe, PancreaSeq testing used endoscopic ultrasound–guided fine-needle...
Successful pancreatic ductal adenocarcinoma (PDAC) immunotherapy necessitates optimization and maintenance of activated effector T cells (Teff). We prospectively collected applied multi-omic analyses to paired pre- post-treatment PDAC specimens in a platform neoadjuvant study granulocyte-macrophage colony-stimulating factor-secreting allogeneic vaccine (GVAX) ± nivolumab (anti-programmed cell death protein 1 [PD-1]) uncover sensitivity resistance mechanisms. show that GVAX-induced tertiary...
Importance Pancreatic ductal adenocarcinoma (PDAC) is a deadly disease with increasing incidence. The majority of PDACs are incurable at presentation, but population-based screening not recommended. Surveillance high-risk individuals for PDAC may lead to early detection, the survival benefit unproven. Objective To compare patients surveillance-detected US national data. Design, Setting, and Participants This comparative cohort study was conducted in multiple academic medical centers...
Abstract Background This study sought to develop a clinical risk score for resectable colorectal liver metastasis (CRLM) by combining clinicopathological and clinically available biological indicators, including KRAS. Methods A cohort of patients who underwent resection CRLM at the Johns Hopkins Hospital (JHH) was analysed identify independent predictors overall survival (OS) that can be assessed before operation; these factors were combined into Genetic And Morphological Evaluation (GAME)...