A5010062331- Pancreatic and Hepatic Oncology Research
- Cancer Genomics and Diagnostics
- Cancer Treatment and Pharmacology
- Cancer Immunotherapy and Biomarkers
- Prostate Cancer Treatment and Research
- Renal cell carcinoma treatment
- Genetic factors in colorectal cancer
- Immunotherapy and Immune Responses
- Retinal Diseases and Treatments
- Prostate Cancer Diagnosis and Treatment
- Radiopharmaceutical Chemistry and Applications
- Obstructive Sleep Apnea Research
- Hematopoietic Stem Cell Transplantation
- Neuroscience of respiration and sleep
- Radiomics and Machine Learning in Medical Imaging
- Ocular Diseases and Behçet’s Syndrome
- Mesenchymal stem cell research
- Toxoplasma gondii Research Studies
- Medical Imaging Techniques and Applications
- MRI in cancer diagnosis
- Glaucoma and retinal disorders
- Retinal Imaging and Analysis
- Respiratory Support and Mechanisms
- Histone Deacetylase Inhibitors Research
- Lung Cancer Research Studies
Sidney Kimmel Comprehensive Cancer Center
2020-2024
Johns Hopkins University
2019-2024
CHA Bundang Medical Center
2024
CHA University
2024
Bloomberg (United States)
2020-2023
Sidney Kimmel Cancer Center
2023
Kim's Eye Hospital
2023
Johns Hopkins Medicine
2019-2023
University of Baltimore
2023
Catholic University of Korea
2007-2020
Complete metastatic ablation of oligometastatic prostate cancer may provide an alternative to early initiation androgen deprivation therapy (ADT).To determine if stereotactic ablative radiotherapy (SABR) improves oncologic outcomes in men with cancer.The Observation vs Stereotactic Ablative Radiation for Oligometastatic Prostate Cancer (ORIOLE) phase 2 randomized study accrued participants from 3 US radiation treatment facilities affiliated a university hospital May 2016 March 2018 data...
Successful pancreatic ductal adenocarcinoma (PDAC) immunotherapy necessitates optimization and maintenance of activated effector T cells (Teff). We prospectively collected applied multi-omic analyses to paired pre- post-treatment PDAC specimens in a platform neoadjuvant study granulocyte-macrophage colony-stimulating factor-secreting allogeneic vaccine (GVAX) ± nivolumab (anti-programmed cell death protein 1 [PD-1]) uncover sensitivity resistance mechanisms. show that GVAX-induced tertiary...
Prostate cancer (PCa) becomes resistant to androgen ablation through adaptive upregulation of the receptor in response low-testosterone microenvironment. Bipolar therapy (BAT), defined as rapid cycling between high and low serum testosterone, disrupts this regulation castration-resistant PCa (CRPC).
Abstract A neoadjuvant immunotherapy platform clinical trial allows for rapid evaluation of treatment-related changes in tumors and identifying targets to optimize treatment responses. We enrolled patients with resectable pancreatic adenocarcinoma into such a (NCT02451982) receive cancer GVAX vaccine low-dose cyclophosphamide alone (Arm A; n = 16), anti-PD-1 antibody nivolumab B; 14), both anti-CD137 agonist urelumab C; 10), respectively. The primary endpoint Arms A/B - change IL17A...
The purpose of this study was to evaluate the effectiveness intravitreal injection bevacizumab for treatment central serous chorioretinopathy.In retrospective case series, six patients (six eyes) with chorioretinopathy were treated an bevacizumab. outcome measures included visual acuity Early Treatment Diabetic Retinopathy Study letters, macular thickness measurement optical coherence tomography, changes in fluorescein angiography, and indocyanine green angiography.The mean age 42.3 years...
Animal models show that systemically administered bone marrow-derived mesenchymal stem cells (MSCs) home to sites of primary and metastatic prostate cancer (PC)-making them candidates selectively deliver cytotoxic agents. To further assess this potential as a cell-based therapeutic vehicle, phase I study testing homing infused allogeneic MSCs preprostatectomy was conducted. The objective safety feasibility determine if accumulate within PC tissue. were quantified using beads, emulsion,...
Genomic biomarkers that predict response to anti-PD1 therapy in prostate cancer are needed. Frameshift mutations predicted generate more neoantigens than missense mutations; therefore, we hypothesized the number or proportion of tumor frameshift would correlate with cancer.
This study aimed to evaluate the hypothesis that relief of nasal obstruction in subjects with obstructive sleep apnea (OSA) would lead reduce OSA severity and discuss available evidence on clinical efficacy surgery as a treatment modality for OSA.Twenty-five who had reduced patency cavity narrowing retroglossal or retropalatal airways were diagnosed underwent surgery, such septoplasty turbinoplasty correct pathologies. The effect was quantified by measuring minimal cross-sectional area (MCA)...
730 Background: Surgical resection is the only potentially curative treatment for pancreatic adenocarcinoma (PDAC) but involvement of adjacent vital structures in locally advanced (LAPC) precludes upfront resection. Neoadjuvant chemotherapy and/or radiation allows some LAPC patients to undergo outcomes remain dismal. In this trial, we investigate benefit combining chemotherapy, radiation, and immunotherapy improve by enhancing antitumor immunity. The use GVAX, Nivolumab, BMS-813160...
Background:Complications following lumbar transforaminal epidural injection are frequently related to inadvertent vascular of corticosteroids.Several methods have been proposed reduce the risk injection.The generally accepted technique during steroid is intermittent fluoroscopy.In fact, this may miss uptake due rapid washout.Because fleeting appearance contrast patterns, live fluoroscopy recommended injection.However, when patterns overlapped by expected it hard distinguish them even on...
The main mechanism of pathogenesis which causes systemic complications in obstructive sleep apnea (OSA) patients is believed to be intermittent hypoxia-induced intermediary effect and it depends on the burden oxidative stress during sleep. We aimed search predictive markers reflect with OSA whether excessive telomere length shortening a characteristic feature that can assess levels. used quantitative PCR measure using peripheral blood genomic DNA. Telomere lengths were compared an age- body...
We studied the relative roles of Duox2-derived reactive oxygen species (ROS) in host defense against influenza A virus (IAV) infection normal human nasal epithelial cells and mouse mucosa. found that Duox2 primarily generated ROS rapidly after IAV knockdown aggravated infection. In addition, enhancement significantly suppressed epithelium. particular, were required for induction retinoic acid-inducible gene (RIG)-I melanoma differentiation-associated protein 5 (MDA5) transcription. After...
TPS814 Background: Novel strategies are needed to improve immune responses in “cold” tumors such as pancreatic ductal adenocarcinoma (PDAC) and mismatch repair-proficient colorectal cancer (MMRp CRC). As a frequent oncogenic driver, mutant KRAS (mKRAS) neoantigens attractive targets augment anti-tumor immunity both diseases. Recently, adoptive transfer of mKRAS G12D-specific T cells has shown durable tumor regressions patients with metastatic CRC PDAC (Tran et. al., 2020; Leidner 2022)....
Clinical outcomes may differ among patients presenting with primary (de novo) metastatic hormone-sensitive prostate cancer (mHSPC) versus secondary (metachronous) mHSPC occurring after local therapy. It is unknown what molecular features distinguish these potentially distinct presentations.A single-center retrospective study of classified as (n = 121) or 106). A targeted set genes was analyzed: BRCA2, PTEN, RB1, TP53, SPOP, CDK12, any two out PTEN/RB1/TP53 alterations, and homologous...
TPS758 Background: KRAS mutations are identified in the majority of premalignant lesions that precede pancreatic ductal adenocarcinoma (PDAC). Arising during tumorigenesis, mutant (mKRAS) neoantigens less susceptible to central tolerance mechanisms and serve as ideal vaccine targets. Indeed, targeting mKRAS with vaccines has shown promising anti-tumor activity preclinical setting. For instance, our group previously demonstrated a Listeria-based G12D combined Treg-depleting agents can prevent...
To evaluate the effectiveness of sulodexide for treatment hard exudates (HE) in non-proliferative diabetic retinopathy (NPDR). This was a randomized, placebo-controlled, multicenter trial involving 130 patients (65 each group) who had mild-to-moderate NPDR with macular HE. Participants were given daily dose either 50 mg or matching placebo orally 12 months. Main outcome measure an improvement HE defined as decrease severity by at least two grades on 10-grade scale. evaluated fundus...
Purpose: To investigate the prevalence of Toxoplasma gondii and Toxocara canis in patients with uveitis.Method: Patients uveitis were examined. Serum antibodies to T. tested by using enzyme-linked immunosorbent assay (ELISA). Polymerase chain reaction (PCR) was done blood aqueous humor (AH).Results: 98 enrolled. Mean age 43.5 ± 13.2 years. Six seropositive for following pattern—anterior uveitis: 1; posterior retinitis: 2; pan 2. One patient had a positive result PCR T.gondii AH, who showed...