Vascular endothelial cell growth factor (VEGF) is strongly induced by oxidative stress in retinal pigment epithelial (RPE) cells, and VEGF-A a survival for various types. This study was conducted to determine whether the autocrine VEGF signaling pathway RPE cells involved mechanism of adaptive response stress.ARPE-19 were treated with hydrogen peroxide, death measured flow cytometry annexin V-fluorescein isothiocyanate. Survival analysis performed pretreatment VEGF-A-neutralizing antibodies,...

To evaluate the effects of macular ischemia on visual outcomes in patients with diabetic edema (DME), after intravitreal bevacizumab injections.Data 59 eyes 53 consecutive treated for DME were retrospectively reviewed. Data from preoperative fluorescein angiography (FA) tests examined. Patients an enlarged foveal avascular zone (FAZ), >or=1000 microm, or a broken perifoveal capillary ring at border FAZ, distinct area nonperfusion within one disk diameter center transit phase angiography,...

The purpose of this study was to evaluate the effectiveness intravitreal injection bevacizumab for treatment central serous chorioretinopathy.In retrospective case series, six patients (six eyes) with chorioretinopathy were treated an bevacizumab. outcome measures included visual acuity Early Treatment Diabetic Retinopathy Study letters, macular thickness measurement optical coherence tomography, changes in fluorescein angiography, and indocyanine green angiography.The mean age 42.3 years...

In Brief Purpose: To evaluate the concentration of various cytokines in aqueous humor patients with naive, recurrent, and regressed choroidal neovascularization (CNV) age-related macular degeneration after bevacizumab treatment. Methods: Aqueous samples were collected from 36 eyes 10 controls during cataract surgery. Of degeneration, 5 naïve to injection, 14 had recurrent CNV treatment, 17 Cytokines measured by an immunoassay using multianalyte biochip array technology (Evidence investigator...

<i>Objective:</i> To report the initial experiences with 25-gauge transconjunctival sutureless vitrectomy (TSV) system, including intraoperative and postoperative problems. <i>Methods:</i> We retrospectively reviewed medical records surgical videotapes of 50 consecutive patients who underwent performed by one surgeon using TSV system. <i>Results:</i> Intraoperatively, we encountered such problems as difficulty in inserting microcannula, which led to...

To describe the pathoanatomy of diabetic macular edema in optical coherence tomography and its correlation with fluorescein angiography patterns.Sixty eyes 56 patients were analyzed. Diabetic was classified into typical focal leakage (from microaneurysm), diffuse (the capillary plexus), or combined/questionable using retinal thickness profiles. The pooling patterns matched to corresponding images analyzed.Focal shows swelling predominantly outer plexiform layer (OPL). Deeply located...

In Brief Purpose: To describe characteristic findings of acute retinal ischemic damage in optical coherence tomography. Methods: Eighteen cases arterial occlusion with available fundus photography, tomography, and/or fluorescein angiography the early phase (<1 month) more than 2 months follow-up were reviewed. A site-to-site analysis between tomography morphology and correlating images done on each visit. Results: Retinal opacities at first presentation vague to mild opacity four eyes,...

&lt;i&gt;Purpose:&lt;/i&gt; Indications for photodynamic therapy (PDT) have increased from age-related macular degeneration with choroidal neovascularization (CNV), containing more than 50% of the classic component, to occult CNV, myopic CNV and due ocular histoplasmosis syndrome. In present study, effect PDT verteporfin was examined in polypoidal vasculopathy (PCV) macula. &lt;i&gt;Methods:&lt;/i&gt; performed 9 eyes PCV Fundus examination, fluorescein angiography, indocyanine green...

PURPOSE. This study was undertaken to investigate the association between complement factor H (CFH) gene and exudative age-related macular degeneration (AMD) in Korean patients. METHODS. Genomic DNA isolated from peripheral leukocytes of patients with AMD (n 114) control subjects 187). The sole criterion for presence choroidal neovascularization. Four single-nucleotide polymorphisms (SNPs: 275CT, I62V, Y402H, IVS15) located promoter, exon 2, 9, intron 15 CFH were genotyped by PCR-based...

Retinal pigment epithelium (RPE) cells of the proliferative vitreoretinopathy (PVR) membrane take on shape fibroblasts and participate in fibrosis, thus deviating from character epithelial cells. This study was undertaken to evaluate RPE cell transdifferentiation vitro. During culture porcine cells, primary 10th-passaged were investigated for growth response transforming factor (TGF) β&lt;sub&gt;2&lt;/sub&gt;, change phenotype amount collagen synthesis as well expression α-smooth-muscle...

&lt;div class="ftSection"&gt;&lt;span class="ftInlineSubsectionTitle"&gt;Background and Objective:&lt;/span&gt;&lt;p&gt;To investigate the factors related to postoperative hypotony after 25-gauge sutureless vitrectomy.&lt;/p&gt;&lt;/div&gt;&lt;div class="ftInlineSubsectionTitle"&gt;Patients Methods:&lt;/span&gt;&lt;p&gt;Of 109 consecutive eyes undergoing vitrectomy, 95 fluid-filled were randomly assigned three groups according order of infusion cannula removal. In group 1 (30 eyes), was...

This pilot study aimed to evaluate the efficacy and safety of subthreshold micropulse yellow (577-nm) laser photocoagulation (SMYLP) in treatment diabetic macular edema (DME).We reviewed 14 eyes 12 patients with DME who underwent SMYLP a 15% duty cycle at an energy level immediately below that test burn. The exposure time was 20 ms spot diameter 100 µm. Laser pulses were administered confluent, repetitive manner 3 × pattern mode.The mean follow-up 7.9 ± 1.6 months. baseline-corrected visual...

To investigate the clinical features of central retinal vein occlusion (CRVO) in relation to presence a prominent middle limiting membrane (p-MLM) sign on presenting optical coherence tomography, which may suggest macular ischemia and poor visual outcome.Fifty consecutive eyes with acute CRVO <1 month symptom duration before presentation were retrospectively reviewed. A hyperreflective line located outer plexiform layer tomography was used as ischemia. Cases p-MLM grouped compared group no...

&lt;i&gt;Aims:&lt;/i&gt; To evaluate the short-term safety and efficacy of a single intravitreal bevacizumab injection in patients with polypoidal choroidal vasculopathy (PCV). &lt;i&gt;Methods:&lt;/i&gt; The records treated for PCV were retrospectively reviewed. All evaluated by complete ophthalmic examination, optical coherence tomography fluorescein indocyanine green angiography. Changes visual acuity central retinal thickness (CRT) over 3 months main outcome measures....

To identify optical coherence tomography (OCT) patterns of diabetic macular edema (DME) predictive visual outcomes after intravitreal bevacizumab (IVB; Avastin®) injection.We retrospectively examined 56 consecutive eyes that were given IVB injections for DME alongside the preoperative OCT data. Using this information, we categorized into 2 groups: group 1 showing diffuse patterns; demonstrating cystoid (CME).The mean follow-up period was 11.66 ± 3.98 months. Group gained 0.04 9.27 ETDRS...

A retrospective case report of a retinitis pigmentosa patient who underwent vitrectomy for epiretinal membrane after intravitreal autologous stem cell implantation.A 71-year-old female RP came to our clinic ophthalmic evaluation injection. Four months ago, she injection both eyes at another hospital. New thick (ERM) with extensive macular pucker was found on her left eye. She pars plana and membranectomy. After biopsy, many CD34-positive cells were detected in ERM specimen.This is the first...