A5101781151- Pancreatic and Hepatic Oncology Research
- Pancreatitis Pathology and Treatment
- Neuroendocrine Tumor Research Advances
- Cancer Genomics and Diagnostics
- Lung Cancer Research Studies
- Neuroblastoma Research and Treatments
- Gallbladder and Bile Duct Disorders
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Pediatric Hepatobiliary Diseases and Treatments
- Autophagy in Disease and Therapy
- Surgical Simulation and Training
- Gastrointestinal disorders and treatments
- Colorectal Cancer Screening and Detection
- Gastric Cancer Management and Outcomes
- Colorectal Cancer Treatments and Studies
- Anatomy and Medical Technology
- Colorectal and Anal Carcinomas
- Cardiac, Anesthesia and Surgical Outcomes
- Abdominal Surgery and Complications
- Renal cell carcinoma treatment
- Patient Safety and Medication Errors
- Trauma and Emergency Care Studies
- Delphi Technique in Research
- Injury Epidemiology and Prevention
- Hepatitis B Virus Studies
University of Pittsburgh Medical Center
2014-2024
Yahoo (United Kingdom)
2024
UPMC Health System
2024
University of Pittsburgh
2008-2024
Johns Hopkins Medicine
2023
Johns Hopkins University
2023
Cancer Research Center
2023
UPMC Presbyterian
2018
Presbyterian Hospital
2018
National Pancreas Foundation
2014
To review the epidemiology and characteristics of patients who died or underwent colectomy secondary to fulminant Clostridium difficile colitis.In with C. colitis, a progressive, systemic inflammatory state may develop that is unresponsive medical therapy; it progress death.The authors reviewed 2,334 hospitalized colitis from January 1989 December 2000. Sixty-four for pathologically proven 2000, incidence in increased baseline 0.68% 1.2%, whom life-threatening symptoms developed 1.6% 3.2%....
Pancreatic neuroendocrine tumors (PanNET) are a heterogeneous group of neoplasms with increasing incidence and unpredictable behavior. Whole-exome sequencing has identified recurrent mutations in the genes DAXX ATRX, which correlate loss protein expression alternative lengthening telomeres (ALT). Both ALT DAXX/ATRX were initially reported to be associated favorable prognosis; however, recent studies suggest contrary. Our aims assess prevalence prognostic significance both primary metastatic...
We hypothesized that autophagy inhibition would increase response to chemotherapy in the preoperative setting for patients with pancreatic adenocarcinoma. performed a randomized controlled trial assess inhibitor hydroxychloroquine combination gemcitabine and nab-paclitaxel.Participants potentially resectable tumors were two cycles of nab-paclitaxel (PG) alone or (PGH), followed by resection. The primary endpoint was histopathologic resected specimen. Secondary clinical endpoints included...
Background & AimsNext-generation sequencing (NGS) of pancreatic cyst fluid is a useful adjunct in the assessment patients with cyst. However, previous studies have been retrospective or single institutional experiences. The aim this study was to prospectively evaluate NGS on multi-institutional cohort real time.MethodsThe performance 22-gene panel (PancreaSeq) first retrospectively confirmed and then within 2-year timeframe, PancreaSeq testing used endoscopic ultrasound–guided fine-needle...
Management guidelines for pancreatic intraductal papillary mucinous neoplasms (IPMN) and cystic (MCN) are based on the assumption that cysts can be accurately distinguished from other lesions. Previous studies using surgical material have identified recurrent mutations in GNAS KRAS neoplasms. Yet, diagnostic utility of testing both genes cyst fluid obtained by endoscopic ultrasound-fine-needle aspiration (EUS-FNA) remains unclear.GNAS was performed EUS-FNA 91 cysts: 41 IPMNs, 9 IPMNs with...
EARLY in the morning on December 20, 1977, high-velocity winds centered around Arvin, a town at southern extreme of San Joaquin Valley near Bakersfield, Kern County, California, bore aloft soil containing arthroconidia Coccidioides immitis. Dispersion this by peculiar wind conditions resulted an epidemic coccidioidomycosis area encompassing approximately 87,000 km2, larger than state Maine. We report morbidity, mortality and cost Sacramento 2797 km2 northern limit Valley, which is normally .
Objective: To determine the impact of enhanced recovery after surgery (ERAS) pathway implementation on outcomes, and cost robotic open pancreatoduodenectomy. Background: ERAS pathways have shown benefit in pancreatoduodenectomy (OPD). The (RPD) is unknown. Methods: Retrospective review consecutive RPD OPDs pre-ERAS (July, 2014–July, 2015) 2015–July, 2016) period. Univariate multivariate logistic regression was used to operative approach alone, or combination (pre-ERAS + OPD, RPD, RPD) length...
Robotic pancreatectomy is gaining momentum; however, limited data exist on the long-term survival of this approach for pancreatic ductal adenocarcinoma (PDAC). The objective study to compare oncologic outcomes robotic pancreaticoduodenectomy (RPD) and distal (RDP) open surgery in patients with PDAC.Robotic stages I-III PDAC were obtained from 2010 2016 National Cancer Database.We identified 17 831 pancreaticoduodenectomies 2718 pancreatectomies which 626 (4%) 332 (12%) robotic, respectively....
We report the development and validation of a combined DNA/RNA next-generation sequencing (NGS) platform to improve evaluation pancreatic cysts.
Hereditary pancreatitis is an autosomal dominant disorder with 80% penetrance and variable expressivity. The vast majority of cases have been linked to mutations within the cationic trypsinogen gene, also referred as serine protease 1 (PRSS1). Other than inheritance, PRSS1 has considered clinically pathologically indistinguishable from other etiologies chronic pancreatitis. However, date, histologic findings not well described. We, therefore, collected pancreatic specimens 10 patients...
Neoadjuvant therapy (NAT) is rarely associated with a complete histopathologic response in patients pancreatic ductal adenocarcinoma (PDAC) but results downstaging of regional nodal disease. Such after NAT may have implications for the use additional adjuvant (AT).
To explore the diagnostic challenges, management, and clinical outcomes of patients with isolated peripancreatic necrosis (PPN), emphasis on extent involvement, compare them to pancreatic (PN).PPN, a relatively new term, has been included as separate entity in Revised Atlanta Classification.Clinical data recruited acute pancreatitis were recorded prospectively. Contrast-enhanced computed tomographic scans reviewed by expert radiologists blinded outcomes.In total, 271 400 underwent...