A5028104786- Pancreatic and Hepatic Oncology Research
- Pancreatitis Pathology and Treatment
- Gallbladder and Bile Duct Disorders
- Pediatric Hepatobiliary Diseases and Treatments
- Neuroendocrine Tumor Research Advances
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Liver Disease Diagnosis and Treatment
- Organ Transplantation Techniques and Outcomes
- Gastrointestinal disorders and treatments
- Cancer Genomics and Diagnostics
- Genetic and Kidney Cyst Diseases
- Liver Disease and Transplantation
- Parathyroid Disorders and Treatments
- Transplantation: Methods and Outcomes
- Renal cell carcinoma treatment
- Organ and Tissue Transplantation Research
- Clinical Nutrition and Gastroenterology
- Congenital Anomalies and Fetal Surgery
- Vascular Procedures and Complications
- Genetic factors in colorectal cancer
- Appendicitis Diagnosis and Management
- Abdominal vascular conditions and treatments
- Aortic aneurysm repair treatments
- Colorectal Cancer Screening and Detection
- COVID-19 Clinical Research Studies
University of Pittsburgh
2015-2025
University of Pittsburgh Medical Center
2016-2025
The University of Texas Health Science Center at San Antonio
2020-2024
Le Bonheur Children's Hospital
2024
UPMC Presbyterian
2016-2021
The University of Texas Health Science Center at Houston
2020
The University of Texas MD Anderson Cancer Center
2020
The University of Texas at Austin
2020
Cleveland Clinic
2018
Creative Commons
2018
Objective DNA-based testing of pancreatic cyst fluid (PCF) is a useful adjunct to the evaluation cysts (PCs). Mutations in KRAS / GNAS are highly specific for intraductal papillary mucinous neoplasms (IPMNs) and cystic (MCNs), while TP53 PIK3CA PTEN alterations associated with advanced neoplasia. A prospective study was performed evaluate preoperative PCF DNA testing. Design Over 43-months, 626 specimens from 595 patients were obtained by endoscopic ultrasound (EUS)-fine needle aspiration...
RAS mutations are common in thyroid tumors and confer a high risk of cancer when detected fine-needle aspiration (FNA) specimens. Specific characteristics RAS-positive cancers not well described. From April 2007 to 2009, 921 consecutive patients undergoing FNA were evaluated prospectively with panel molecular markers. Ultrasonographic, cytological, histological, surgical outcomes retrospectively assessed. Sixty-eight aspirates from 66 positive for including 63 cytologically indeterminate...
Objective Despite improvements in imaging, serum CA19-9 and pathological evaluation, differentiating between benign malignant bile duct strictures remains a diagnostic conundrum. Recent developments next-generation sequencing (NGS) have opened new opportunities for early detection management of cancers but, to date, not been rigorously applied biliary specimens. Design We prospectively evaluated 28-gene NGS panel (BiliSeq) using endoscopic retrograde cholangiopancreatography-obtained...
Background & AimsIntraductal oncocytic papillary neoplasms (IOPNs) of the pancreas and bile duct contain epithelial cells with numerous, large mitochondria are cystic precursors to pancreatic ductal adenocarcinoma (PDAC) cholangiocarcinoma (CCA), respectively. However, IOPNs do not have genomic alterations found in other pancreatobiliary neoplasms. In fact, no recurrent been described IOPNs. PDACs without activating mutations KRAS gene rearrangements, so we investigated whether fusions...
Chronic pancreatitis is an inflammatory condition of the pancreas with clinical manifestations ranging from abdominal pain, acute pancreatitis, exocrine and/or endocrine dysfunction, and pancreatic cancer. There a need for longitudinal studies in well-phenotyped patients to ascertain utility cross-sectional imaging findings chronic diagnosis assessment disease severity. CT MR cholangiopancreatography are most common performed evaluation pancreatitis. Currently, there no universal reporting...
Pancreatic ductal adenocarcinoma (PDAC) is one of the most lethal cancers, with a 5-year survival 8%. Current therapeutic regimens are largely ineffective and underscore need for novel treatment strategies. Chromosomal rearrangements involving anaplastic lymphoma kinase (ALK) gene have been identified in several neoplasms. In addition, ALK protein inhibitors proven efficacy patients ALK-rearranged tumors. However, translocations PDAC not described. Through comprehensive genomic profiling...
Standardization of MRI Screening and Reporting in Individuals With Elevated Risk Pancreatic Ductal Adenocarcinoma: Consensus Statement the PRECEDE ConsortiumChenchan Huang, MD1, Diane M. Simeone, MD2, Lyndon Luk, MD3, Elizabeth Hecht, MD4, Gaurav Khatri, MD5, Avinash Kambadakone, MBBS, MD, DNB6, Hersh Chandarana, Justin Ream, MD7, Jessica N. Everett, MS2, Alexander Guimaraes, PhD8, Joy Liau, PhD9, Anil K. Dasyam, MD10, Carla Harmath, MD11, Alec J. Megibow, MPH1 for ConsortiumAudio Available...
Abstract Background While alcohol is known to sensitize the pancreas acute injury, role of short‐term episodic drinking in regular drinkers unknown. Methods We conducted a case‐crossover study (1) determine hazardous period prior first episode pancreatitis (FAP) or recurrent (RAP) and (2) evaluate dose–response association between FAP/RAP. Patients hospitalized for FAP/RAP with an AUDIT‐C score ≥3 were enrolled. Recent lifetime history collected through interviews. Drinking index attack was...
Background Ductal features alone may not offer high diagnostic sensitivity or most accurate disease severity of chronic pancreatitis (CP). Purpose Diagnose CP based on multiparametric MRI and MRCP features. Study Type Prospective. Population Between February 2019 May 2021, 46 control (23 males, 49.3 ± 14.1 years), 45 suspected (20 48.7 12.5 definite 53.7 14.6 years) patients were enrolled at seven hospitals in the MINIMAP study. classification was imaging findings clinical presentation....
To explore the diagnostic challenges, management, and clinical outcomes of patients with isolated peripancreatic necrosis (PPN), emphasis on extent involvement, compare them to pancreatic (PN).PPN, a relatively new term, has been included as separate entity in Revised Atlanta Classification.Clinical data recruited acute pancreatitis were recorded prospectively. Contrast-enhanced computed tomographic scans reviewed by expert radiologists blinded outcomes.In total, 271 400 underwent...