A5017918502- Mechanical Circulatory Support Devices
- Cardiac Structural Anomalies and Repair
- Transplantation: Methods and Outcomes
- Mitochondrial Function and Pathology
- Amyotrophic Lateral Sclerosis Research
- Pancreatic and Hepatic Oncology Research
- Neurogenetic and Muscular Disorders Research
- Cancer Genomics and Diagnostics
- Natural product bioactivities and synthesis
- Nanoparticle-Based Drug Delivery
- Wound Healing and Treatments
- Parkinson's Disease Mechanisms and Treatments
- Pharmacological Effects of Natural Compounds
- Advanced Drug Delivery Systems
- Chemokine receptors and signaling
- Immunotherapy and Immune Responses
- Endoplasmic Reticulum Stress and Disease
- Gastric Cancer Management and Outcomes
- Drug Solubulity and Delivery Systems
- Radiomics and Machine Learning in Medical Imaging
- Viral Infections and Immunology Research
- Galectins and Cancer Biology
- Cardiac Valve Diseases and Treatments
- Ion channel regulation and function
- T-cell and B-cell Immunology
Massachusetts General Hospital
2023-2025
Harvard University
2023-2025
Ho Chi Minh City University of Education
2025
Shriners Hospitals for Children - Boston
2024
Boston Children's Hospital
2013-2024
National Hospital of Pediatrics
2024
San Francisco State University
2024
Pendar Technologies (United States)
2024
University of Alabama at Birmingham
2020-2023
University of North Carolina at Charlotte
2019-2022
Heart failure is a common, lethal condition whose pathogenesis poorly understood. Recent studies have identified low levels of myocyte apoptosis (80–250 myocytes per 105 nuclei) in failing human hearts. It remains unclear, however, whether this cell death coincidental finding, protective process, or causal component pathogenesis. Using transgenic mice that express conditionally active caspase exclusively the myocardium, we demonstrate very (23 nuclei, compared with 1.5 nuclei controls) are...
Recent data suggest that the Berlin Heart EXCOR Pediatric ventricular assist device is superior to extracorporeal membrane oxygenation for bridge heart transplantation. Published are limited 1 in 4 children who received as part of US clinical trial. We analyzed outcomes all characterize an unselected cohort and identify risk factors mortality facilitate patient selection.This multicenter, prospective study involved implanted with at 47 centers from May 2007 through December 2010. Multiphase...
Pancreatic ductal adenocarcinoma (PDAC) is one of the most lethal cancers, with a 5-year survival 8%. Current therapeutic regimens are largely ineffective and underscore need for novel treatment strategies. Chromosomal rearrangements involving anaplastic lymphoma kinase (ALK) gene have been identified in several neoplasms. In addition, ALK protein inhibitors proven efficacy patients ALK-rearranged tumors. However, translocations PDAC not described. Through comprehensive genomic profiling...
Standard cancer treatments involve surgery, radiotherapy, chemotherapy, and immunotherapy. In clinical practice, the respective drugs are applied orally or intravenously leading to their systemic circulation in whole organism. For chemotherapeutics immune modulatory agents, severe side effects such as depression autoimmunity can occur. At same time intratumoral drug doses often too low for effective therapy. Since monotherapies frequently cannot cure cancer, due synergistic multimodal...
Endoplasmic reticulum (ER) stress and its consequent unfolded protein response (UPR) are believed to be associated with progression, survival chemoresistance of a variety tumor cells through multiple cellular processes, including autophagy. Therefore, the ER stress-autophagy pathway presents potential molecular target for therapeutic intervention. The objective this study was evaluate efficacy autophagy modulators in context pancreatic ductal adenocarcinoma (PDAC).We first targeted IRE1α, an...
Alterations in cardiac energy metabolism after a myocardial infarction contribute to the severity of heart failure (HF). Although fatty acid oxidation can be impaired HF, it is unclear if stimulating desirable approach treat HF. Both immediate and chronic malonyl coenzyme A decarboxylase inhibition, which decreases oxidation, improved function through enhancing efficiency post-myocardial rat that underwent permanent left anterior descending coronary artery ligation. The beneficial effects...
Abstract The aim of the present study is to recover a waste titania catalyst from α‐pinene isomerization, recycle it and use in production inorganic pigments. acid‐contaminated (ACT), prepared ilmenite ore by sulphation, has potential function as solid acid due presence both Brønsted Lewis sites, with specific surface area 163 m 2 g −1 . catalytic efficiency was evaluated isomerization turpentine (83.8 wt.% α‐pinene) at reaction temperature 120°C, using turpentine:catalyst mass ratio 4:1....
Heart failure, a leading global health challenge, affects over 23 million people worldwide, with heart transplantation being the gold standard for end-stage disease. However, scarcity of viable donor hearts presents significant barrier, only one-third available grafts used due to stringent selection criteria. Machine perfusion technologies, particularly normothermic machine (NMP), offer promise in improving graft preservation and assessment, yet their full potential predicting...
Background Character strengths–based intervention (CSI) has the potential to enhance self-esteem and reduce depression, leading improved quality of life (QoL) for breast cancer patients. Objective To explore effects an evidence-based culturally appropriate CSI among Chinese female patients with their perceptions CSI. Methods This study was a multisite assessor-blinded randomized controlled trial. The underwent multiple stages modeling as cultural tailoring, supported by self-produced booklet...
The electrical gradient across the mitochondrial inner membrane (Psi(m)) is established by electron transport chain (ETC) activity and permits Ca(2+) sequestration. Using rhodamine-123, we determined how repetitive nerve stimulation (100 Hz) affects Psi(m) in motor terminals innervating mouse levator auris muscles. Stimulation-induced depolarizations wild-type (WT) were small (<5 mV at 30 degrees C) reversible. These depended on influx into terminals, as they inhibited when P/Q-type channels...
Given the tolerability of nPG in first-line therapy, we desired to evaluate response and toxicity profiles second-line gemcitabine with nab-paclitaxel (nPG) following FOLFIRINOX. Methods: We retrospectively identified 30 patients who received FOLFIRINOX for unresectable or metastatic pancreatic adenocarcinoma followed by nPG. Response was evaluated RECIST criteria carbohydrate antigen 19-9 (CA19-9) change.Median age 63 years 77% percent having disease. Nineteen (63%) achieved PR based on...
Mitochondria sequester much of the Ca 2+ that enters motor nerve terminals during repetitive stimulation at frequencies exceeding 10–20 Hz. We studied post‐stimulation extrusion from mitochondria by measuring changes in matrix [Ca ] with fluorescent indicators loaded into terminal mouse levator auris longus muscle. Trains action potentials 50 Hz produced a rapid increase mitochondrial followed plateau, which was usually maintained after end stimulus train and then slowly decayed back to...
Cysteine-rich intestinal protein (CRIP), which contains a double zinc finger motif, is member of the Group 2 LIM family. Our results showed that developmental regulation CRIP in neonates was not influenced by conventional vs. specific pathogen-free housing conditions. Thymic and splenic expression developmentally regulated. A line transgenic (Tg) mice overexpress rat gene created. When challenged with lipopolysaccharide, Tg lost more weight, exhibited increased mortality, experienced greater...
Nanoparticles for a specific delivery are likely to be designed cancer therapeutic effectiveness and improvement. In this study, fucoidan-oleic acid conjugate was prepared investigated in terms of loading capacity poorly water-soluble anti-cancer drugs maximize the treatment. Fucoidan used as hydrophilic portion an amphiphilic structure improving effects. Paclitaxel curcumin were chosen other model loaded conjugates. The results showed that self-assembled nanoparticles with different sizes...
Cytotoxic and cytostatic chemotherapeutics act by attacking rapidly dividing tumor cells, predominantly affecting malignant tissue to a certain degree preserving healthy cells. Nonetheless, severe side effects are caused as quickly proliferating cells such hematopoietic precursors mucous membranes impaired well. This limits the administered dose eventually allows escape treatment. In order increase intratumoral drug concentration simultaneously reduce systemic effects, nanoparticles have...
Salinity is one of the major abiotic stresses affecting plant productivity. Soybean [ Glycine max (L.) Merr.] moderately sensitive to salt‐affected soils. In this study, Arabidopsis vacuolar H + ‐pyrophosphatase gene ( AtAVP1 ) and a Na /H antiporter AtNHX1 were co‐expressed determine if compartmentation in vacuole feasible improve salt tolerance soybean. The transgenic plants co‐expressing enhanced compared with those expressing individual or , which more tolerant than nontransgenic control...
Lifelog can provide useful insights of our daily activities. It is essential to a flexible way for users retrieve certain events or moments interest, corresponding wide variation query types. This motivates us develop FIRST, Flexible Interactive Retrieval SysTem, help combine integrate various components in manner handle different scenarios, such as visual clustering data based on color histogram, similarity, GPS location, scene attributes. We also employ personalized concept detection and...
Patients with continuous flow ventricular assist devices (CF-VADs) are at high risk for non-surgical bleeding, speculated to associate the loss of pulsatility following CF-VAD placement. It has been hypothesized that shear stress causes elongation and increased enzymatic degradation von Willebrand Factor (vWF), a key player in thrombus formation sites vascular damage. However, role on unravelling behavior vWF not widely explored.