A5100365034- Mosquito-borne diseases and control
- Insect symbiosis and bacterial influences
- Malaria Research and Control
- Mathematical and Theoretical Epidemiology and Ecology Models
- Blood properties and coagulation
- Insect Pest Control Strategies
- Monoclonal and Polyclonal Antibodies Research
- Protein purification and stability
- Platelet Disorders and Treatments
- Ecosystem dynamics and resilience
- Microfluidic and Bio-sensing Technologies
- Viral Infectious Diseases and Gene Expression in Insects
- Mechanical Circulatory Support Devices
- Pregnancy-related medical research
- Photopolymerization techniques and applications
- Microfluidic and Capillary Electrophoresis Applications
- Nanopore and Nanochannel Transport Studies
- RNA regulation and disease
- Viral Infections and Vectors
- Viral Infections and Outbreaks Research
- Evolution and Genetic Dynamics
- Pigment Synthesis and Properties
- Polymer Science and Applications
- Problem and Project Based Learning
- Mathematical Biology Tumor Growth
Lehigh University
2019-2024
Merck & Co., Inc., Rahway, NJ, USA (United States)
2017-2024
Soochow University
2024
Wenzhou University
2015-2023
Wuhan Polytechnic University
2023
Zhongnan Hospital of Wuhan University
2022
Guangzhou University of Chinese Medicine
2022
Wuhan University
2022
Tsinghua University
2022
Rutgers, The State University of New Jersey
2013-2021
The disulfides in three monoclonal antibodies (mAb), the anti-HER2, anti-CD11a, and GLP-1 with IgG4-Fc fusion protein, were completely mapped by LC-MS combination of electron-transfer dissociation (ETD) collision induced (CID) fragmentation. In addition to mapping 4 inter- 12 intrachain (total 16), identification scrambled degraded samples (heat-stress) was achieved. scrambling likely attributed an initial breakage between light (Cys 214) heavy 223) chains same observation found a similar...
Developing a thorough understanding of experimental methods hepatic differentiation in progenitor cells (HPCs) should expand the knowledge hepatocyte induction vitro and may help to develop cell transplantation therapies for clinical usage HPCs liver diseases. A previous method effectively induced metabolic abilities HPCs. Periodic acid‑Schiff (PAS) staining is used identify glycogen synthesis function; however, this failed detect hepatocytes. The present study aimed investigate possible...
The Asian tiger mosquito, Aedes albopictus (Skuse), transmits important arboviral diseases and displaces native species. This peridomestic mosquito deposits eggs in natural artificial containers. Container larval habitats tend to be cryptic and, therefore, difficult reach by conventional insecticide treatments. We have developed an autodissemination station that transfers the insect growth regulator, pyriproxyfen, from oviposition sites. Mosquitoes visiting become contaminated with oil...
Abstract BACKGROUND Control of the container‐inhabiting mosquito, Aedes albopictus, is difficult using conventional methods due to its selection cryptic peri‐domestic habitats. We evaluated whether autodissemination stations can deliver sufficient pyriproxyfen sentinel containers produce significant pupal mortality in different habitats such as competing oviposition sites, habitats, junkyards and tire piles. also tested how far pesticide could be transferred over a 200‐m range. RESULTS...
Abstract Effective suppression of container-inhabiting Asian Tiger [Aedes albopictus (Skuse)] (Diptera: Culicidae) and yellow fever aegypti (L.)] mosquitoes presents one the most intractable problems for modern mosquito control. Traditional tools often fail to control populations these species, are prohibitively expensive or have negative environmental impacts. Novel approaches urgently needed integrated management programs. One promising techniques is autodissemination. We present results a...
(A). Optical tweezers characterized the mechanical properties of Single-MOlecule-based material REsponsive to Shear (SMORES). (B) Flow experiments demonstrated release therapeutic cargo at a threshold flow rate.
Ectopic pregnancy is commonly located in the fallopian tube. Nevertheless, two unusual types of ectopic pregnancy, intramural and rudimentary horn seriously threaten maternal life. The diagnosis treatment these implantation sites present a clinical challenge. In this study, we illustrated summarized current data regarding optimal from our experience.
Dengue virus (DENV) utilizes host factors throughout its life cycle. In this study, we identified RNA helicase A (RHA), a member of the DEAD/H family, as an important factor DENV. response to DENV2 infection, nuclear RHA protein was partially redistributed into cytoplasm. The short interfering RNA-mediated knockdown significantly reduced amounts infectious viral particles in various cells. multistep growth and Japanese encephalitis but not Zika virus. Further study showed that absence...
Patients with continuous flow ventricular assist devices (CF-VADs) are at high risk for non-surgical bleeding, speculated to associate the loss of pulsatility following CF-VAD placement. It has been hypothesized that shear stress causes elongation and increased enzymatic degradation von Willebrand Factor (vWF), a key player in thrombus formation sites vascular damage. However, role on unravelling behavior vWF not widely explored.
Microfluidic devices that allow biological particle separation and concentration have found wide applications in medical diagnosis. Here we present a viral polydimethylsiloxane (PDMS) device combines tangential flow microfiltration affinity capture to enrich HIV virus single flow-through fashion. The set-up contains filtration tandem resistance channel. consists of two parallel channels separated by polycarbonate nanoporous membrane. channel, with dimensions design-guided COMSOL simulation,...
In this paper, we investigate a stochastic nutrient-plankton model with impulsive control of the nutrient concentration and zooplankton population. Analytically, find that population size is nonnegative for sufficiently long time. We derive some sufficient conditions existence stable periodic oscillations, which indicate plankton populations will behave periodically. The numerical results show system experiences transition from extinction to coexistence species due emergence control....
The long‑term survival rate in paediatric acute lymphoblastic leukaemia (ALL) exceeds 80%; however, the outcome of adult ALL remains to be poor. Glucocorticoids (GCs) are preferred drugs traditional treatment patients. In anti‑leukaemia molecular mechanisms GCs, c‑Myc inhibition serves a critical role. present study, inhibitor that increased sensitivity GCs NALM6 cells B‑cell‑ALL cell line and CEM T‑cell‑ALL was investigated. data demonstrated 10058‑F4, inhibitor, growth inhibition, G0/G1...