A5101830008- Lymphoma Diagnosis and Treatment
- CAR-T cell therapy research
- Bladder and Urothelial Cancer Treatments
- Urinary and Genital Oncology Studies
- Urological Disorders and Treatments
- Endometriosis Research and Treatment
- Genital Health and Disease
- Uterine Myomas and Treatments
- Immune Cell Function and Interaction
- Cancer, Lipids, and Metabolism
- Gynecological conditions and treatments
- Signaling Pathways in Disease
- Acute Myeloid Leukemia Research
- Esophageal Cancer Research and Treatment
- Apelin-related biomedical research
- Cardiovascular Health and Disease Prevention
- Sarcoma Diagnosis and Treatment
- Cardiovascular Disease and Adiposity
- Cancer Mechanisms and Therapy
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Pancreatitis Pathology and Treatment
- Blood Pressure and Hypertension Studies
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Hematopoietic Stem Cell Transplantation
- Cancer Genomics and Diagnostics
Sun Yat-sen University
2023-2025
Eighth Affiliated Hospital of Sun Yat-sen University
2023-2025
Jilin University
2025
Lanzhou University
2020-2024
Lanzhou University Second Hospital
2020-2024
Ningbo University
2014-2024
Xiangya Hospital Central South University
2024
Central South University
2024
Henan Cancer Hospital
2009-2023
Ningbo First Hospital
2017-2023
Abstract Severe acute pancreatitis (SAP) is often associated with pulmonary inflammation leading to lung injury. Daphnetin, a natural coumarin derivative, has been reported exert anti-inflammatory effects. Here, we explored the effect and possible mechanism of daphnetin in mouse model SAP-associated injury induced by an intraperitoneal injection l -arginine. The severity pancreatic determined histology its score. Immunostaining inflammatory apoptotic cells was used demonstrate tissue...
Thrombocytopenia is a hematologic disorder characterized by an abnormally low platelet count in peripheral blood. Recent studies have identified mutations DUT as the primary cause of bone marrow failure and diabetes mellitus syndrome (BMFDMS), condition commonly associated with thrombocytopenia. In this study, novel rabbit model thrombocytopenia carrying c.3020A>G (p.Y116C) mutation was established using SpRY-ABEmax-mediated base editing. This accurately recapitulates clinical manifestations...
Acute pancreatitis (AP) is a common serious acute condition of the digestive system that remains clinical challenge. Severe (SAP) in particular characterized by high morbidity and mortality. The present study was designed to investigate protective effect Galangin (Gal), natural flavonol obtained from lesser galangal, on L-arginine-induced SAP mice AR42J cells. Amylase lipase activities were measured histopathology pancreas, lung, kidney evaluated. Inflammation oxidative stress assessed using...
Background Xenograft kidney transplantation has been receiving increasing attention. The purpose of this study is to use bibliometric analysis identify papers in research field and explore their current status development trends.
Background Bone marrow mesenchymal stem cells (BMSCs) hold promise for repairing myocardial injury following acute infarction (AMI), but their clinical application is hindered by poor migration, homing efficiency, and survival rates. Previously, we demonstrated that ELABELA (ELA), a small peptide, enhances the of rat BMSCs under hypoxia-reoxygenation (H/R) conditions activating ERK1/2. However, role ELA in promoting migration to injured cardiomyocytes remains unclear. Methods Primary...
Diabetic foot ulcer (DFU) is a serious complication of diabetes. Elabela (ELA), ligand apelin receptor (APJ), was shown to promote angiogenesis and suppress inflammation. This study aimed illustrate the role ELA in DFU wound healing. A whole-skin defect model constructed using db/m db/db mice observe effects on The function endothelial cells cultured high glucose medium investigated. Administration peri-wound area accelerated closure reduced inflammatory infiltration. Indicators DNA damage,...
4036 Background: Esophageal squamous cell carcinoma (ESCC) is the predominant histological subtype of esophageal cancer in South America and East Asian countries remains an unmet medical need worldwide. Previous studies have shown efficacy programmed death 1 (PD-1) targeted therapy a subset patients with metastatic ESCC. However, robust predictive biomarkers to PD-1 antibody-based immunotherapy remain undefined. Methods: Patients included this analysis were part multi-center, phase Ib/II...
Abstract Objective To compare perioperative and oncologic outcomes of open modified ureterosigmoidostomy urinary diversion (OMUUD) intracorporeal (IMUUD) following laparoscopic radical cystectomy (LRC). Patients methods We retrospectively reviewed our single institutional collected database patients undergoing LRC from October 2011 to 2019. The characteristics were compared between OMUUD IMUUD, overall survival (OS) progression-free (PFS) evaluated by the Kaplan-Meier method. Results...
116 Background: Patients with Esophageal squamous cell carcinoma (EC) often present advanced and metastatic stage disease, which has poor prognosis limited treatment options, represent an important unmet medical need especially in China/Asia. JS001, a humanized recombinant IgG4 antibody against PD-1, selectively blocks the interactions of PD-1 its ligands PD-L1 PD-L2, promotes antigen specific T-cell activation. A phase I study JS001 Chinese patients heavily pretreated solid tumors...
Abstract Background Graft-versus-host disease (GVHD) is one of the most complex complications after allogeneic stem cell transplantation. Current standard grading system based on clinical symptoms in skin, liver and intestinal. However, it’s difficult to differ GVHD its extent just by manifestation. Here we retrospectively analyzed immune function patients implemented transplantation Ningbo first Hospital from Jan 2013 2018. Results data are collected 51 (mean age was 42; 45.1% women). The...
The phosphatase and tensin homolog deleted on chromosome 10 (PTEN) P53 tumor suppressors are among the most commonly inactivated or mutated genes in human cancers, whose pathways cross-talk interact a complementary mode. In order to understand their roles relationship diffuse large B-cell lymphoma (DLBCL), we examined expression evaluated prognostic significance 62 patients with DLBCL treated standard chemotherapy. Results showed that PTEN protein was lost 23 (37.1%) cases, loss associated...
Myocardial infarction (MI) leads to enhanced activity of cardiac fibroblasts (CFs) and abnormal deposition extracellular matrix proteins, resulting in fibrosis. Tartrate-resistant acid phosphatase 5 (ACP5) has been shown promote cell proliferation phenotypic transition. However, it remains unclear whether ACP5 is involved the development fibrosis after MI. The present study aimed investigate role post-MI its potential underlying mechanisms.
Summary Acute myeloid leukaemia (AML) is a heterogeneous disease characterized by complex molecular and cytogenetic abnormalities. Pro‐oxidant cellular redox status common hallmark of AML cells, providing rationale for redox‐based anticancer strategy. We previously discovered that auranofin (AUF), initially used the treatment rheumatoid arthritis repositioned its activity, can synergize with pharmacological concentration vitamin C (VC) against breast cancer cell line models. In this study,...
Pre‑eclampsia is an important cause of maternal and fetal morbidity mortality that associated with decreased placental perfusion. In the present study, vascular corrosion casting was used to investigate differences in structural changes fetoplacental vasculature between normal pre‑eclamptic placentas. An improved epoxy resin technique study. Casting media were infused into 40 placentas through umbilical arteries veins order construct three dimensional vasculatures. The number branches,...
The long‑term survival rate in paediatric acute lymphoblastic leukaemia (ALL) exceeds 80%; however, the outcome of adult ALL remains to be poor. Glucocorticoids (GCs) are preferred drugs traditional treatment patients. In anti‑leukaemia molecular mechanisms GCs, c‑Myc inhibition serves a critical role. present study, inhibitor that increased sensitivity GCs NALM6 cells B‑cell‑ALL cell line and CEM T‑cell‑ALL was investigated. data demonstrated 10058‑F4, inhibitor, growth inhibition, G0/G1...
The purpose of the research is to study histopathology and expression survivin, estrogen progesterone receptors (ER/PR) in endometrium patients with dysfunctional uterine bleeding (DUB) treated radiofrequency endometrial ablation (REA). A total 98 DUB were enrolled this case–control study. Among them, 66 underwent REA treatment 32 optioned for hormone therapy as control group. Immunohistochemical analysis ER PR was carried out on tissue samples collected before 6 7 months after both groups....
The aim of this study was to compare psoas compartment block (PCB) and supra-inguinal fascia iliaca (SFIB) in terms pain management the need for additional systemic analgesia perioperative phase developmental dysplasia hip (DDH).Sixty pediatric patients were randomized into PCB group SFIB group. Numeric Rating Scale (NRS) scores used assess postoperative during initial 24 h after extubation. Sufentanil consumption, patient-controlled (PCA) demands, complications also recorded.The NRS...
Abstract Background Myelodysplastic syndromes (MDS) is a group of heterogeneous myeloid clonal diseases originating from hematopoietic stem cells. It has been demonstrated that apolipoproteins A1(ApoA1) are associated with disease risk in many cancer types. However, there still lacks evidence regarding the link between ApoA1 and MDS. This study was designed to investigate prognostic value pretreatment levels MDS patients. Methods We retrospectively analyzed cohort 228 patients explore serum...
Workflow computing has become an essential part of many scientific and engineering fields, while workflow scheduling long been a well-known NP-complete research problem. Major previous works can be classified into two categories: heuristic-based guided random-search-based methods. Monte Carlo Tree Search (MCTS) is recently proposed search methodology with great success in AI on game playing, such as Computer Go. However, researchers found that MCTS also potential application other domains,...