A5048485512- Civil and Structural Engineering Research
- Structural Load-Bearing Analysis
- Structural Engineering and Materials Analysis
- Engineering Structural Analysis Methods
- Structural Engineering and Vibration Analysis
- Railway Engineering and Dynamics
- Engineering and Materials Science Studies
- Structural Behavior of Reinforced Concrete
- Nanoparticle-Based Drug Delivery
- Fatigue and fracture mechanics
- Molecular Communication and Nanonetworks
- Mechanical stress and fatigue analysis
- Geotechnical Engineering and Underground Structures
- Concrete Corrosion and Durability
- Characterization and Applications of Magnetic Nanoparticles
- Structural Analysis of Composite Materials
- Infrastructure Maintenance and Monitoring
- Wireless Body Area Networks
- Energy Harvesting in Wireless Networks
- Advanced biosensing and bioanalysis techniques
- Hydraulic and Pneumatic Systems
- Nanoplatforms for cancer theranostics
- Mechanical and Thermal Properties Analysis
- Immunotherapy and Immune Responses
- Fire effects on concrete materials
Graz University of Technology
2016-2025
Universitätsklinikum Erlangen
2015-2024
Friedrich-Alexander-Universität Erlangen-Nürnberg
2017-2024
Else Kröner-Fresenius-Stiftung
2014-2024
German Institute for Adult Education – Leibniz Centre for Lifelong Learning
2022
Fraunhofer Research Institution for Materials Recycling and Resource Strategies IWKS
2021
Institut für Stahlbau Leipzig (Germany)
2009-2018
Monomeric serum immunoglobulin A (IgA) can contribute to the development of various autoimmune diseases, but regulation IgA effector functions is not well defined. Here, we show that two subclasses (IgA1 and IgA2) differ in their effect on immune cells due distinct binding signaling properties. Whereas IgA2 acts pro-inflammatory neutrophils macrophages, IgA1 does have pronounced effects. Moreover, different glycosylation profiles, with possessing more sialic acid than IgA2. Removal increases...
Background: Rising criticism of currently available contrast agents for magnetic resonance imaging, either due to their side effects or limited possibilities in terms functional evoked the need safer and more versatile agents. We previously demonstrated suitability novel dextran-coated superparamagnetic iron oxide nanoparticles (SPION Dex ) biomedical applications safety biocompatibility. Methods: In present study, we investigated size-dependent cross-linking process these particles as well...
Abstract: The promising potential of superparamagnetic iron oxide nanoparticles (SPIONs) in various nanomedical applications has been frequently reported. However, although many different synthesis methods, coatings, and functionalization techniques have described, not core-shell SPION drug delivery systems are available for clinicians at the moment. Here, bovine serum albumin was adsorbed onto lauric acid-stabilized SPIONs. agglomeration behavior, zeta potential, their dependence on...
Abstract: A highly selective and efficient cancer therapy can be achieved using magnetically directed superparamagnetic iron oxide nanoparticles (SPIONs) bearing a sufficient amount of the therapeutic agent. In this project, SPIONs with dextran cisplatin-bearing hyaluronic acid coating were successfully synthesized as novel cisplatin drug delivery system. Transmission electron microscopy images well X-ray diffraction analysis showed that individual magnetite particles around 4.5 nm in size...
Simple and easy to implement testbeds are needed further advance molecular communication research. To this end, paper presents an in-vessel testbed using magnetic nanoparticles dispersed in aqueous suspension as they also used for drug targeting biotechnology. The transmitter is realized by electronic pump injection via a Y-connector. A second provides background flow signal propagation. For reception, we employ susceptometer, device including coil, where the particles move through generate...
Abstract: Iron oxide-based contrast agents have been in clinical use for magnetic resonance imaging (MRI) of lymph nodes, liver, intestines, and the cardiovascular system. Superparamagnetic iron oxide nanoparticles (SPIONs) high potential as a agent MRI, but no intravenous oxide-containing are currently approved imaging. The aim our work was to analyze hemocompatibility immuno-safety new type dextran-coated SPIONs (SPIONdex) characterize these with ultra-high-field MRI. Key parameters...
Abstract: Superparamagnetic iron oxide nanoparticles (SPIONs) are promising tools for the treatment of different diseases. Their magnetic properties enable therapies involving drug targeting (MDT), hyperthermia or imaging. Depending on intended treatment, specific characteristics SPIONs required. While particles used imaging should circulate extended periods time in vascular system, MDT be accumulated target area to come into close proximity of, incorporated into, tumor cells. In this study,...
Immune activation with T cell tumor infiltration is beneficial for the prognosis of patients suffering from solid cancer. Depending on their immune status, tumors can be immunologically classified into three groups: "hot" are infiltrated lymphocytes, "cold" not and "immune excluded" only in peripheral tissue. Checkpoint inhibitors provide new therapeutic options by triggering response cells. In order to enable this cold as well, cells must enriched tumor. Therefore, we use principle magnetic...
In this second part of our survey on experimental research in Synthetic Molecular Communication (SMC), we review works long-range SMC systems, i.e., systems with communication ranges more than a few millimeters. Despite the importance for evolution towards mature paradigm that will eventually support revolutionary applications beyond reach today's prevalent paradigms, existing body literature is still comparatively sparse. Long-range have been proposed information transmission two types...
Abstract: Combining the concept of magnetic drug targeting and photodynamic therapy is a promising approach for treatment cancer. A high selectivity as well significant fewer side effects can be achieved by this method, since therapeutic only takes place in area where accumulation particles an external electromagnet radiation laser system overlap. In article, novel hypericin-bearing delivery has been developed synthesis superparamagnetic iron oxide nanoparticles (SPIONs) with...
Background: Magnetic drug targeting (MDT) is an effective alternative for common applications, which reduces the systemic load and maximizes effect of, eg, chemotherapeutics at site of interest. After conjugation a magnetic carrier to chemotherapeutic agent, intra-arterial injection into tumor-afferent artery in presence external field ensures accumulation within tumor tissue. Materials methods: In this study, we used superparamagnetic iron oxide nanoparticles (SPIONs) coated with lauric...
Neutrophil extracellular trap (NET) formation is a powerful instrument to fight pathogens, but may induce collateral damage in the affected tissues. Besides pathogen-derived factors, immune complexes are potent inducers of NET formation. Neutrophils express IgA and IgG specific Fc receptors (FcRs) therefore respond complexed IgG. Especially context autoimmune diseases, have been shown trigger formation, process that putatively contributes disease severity. However, it question if both...
Since its emergence from the communication engineering community around one and a half decades ago, field of Synthetic Molecular Communication (SMC) has experienced continued growth, both in number technical contributions vibrant terms research funding. Throughout this process, vision SMC as novel, revolutionary paradigm constantly evolved, driven by feedback theoretical experimental studies, respectively. It is believed that especially latter ones will be crucial for transition towards...
Introduction: One of the major challenges in clinical translation nanoparticles is development formulations combining favorable efficacy and optimal safety. In past, iron oxide have been introduced as an alternative for gadolinium-containing contrast agents; however, candidates available at time were not free from adverse effects. Methods: Following a potent oxide-based agent SPION Dex , we now performed systematic comparison this formulation with conventional ferucarbotran ferumoxytol,...
Abstract The composites based on polylactide (PLA) and poly (3‐hydroxybutyrate‐ co ‐3‐hydroxyvalerate) (PHBV) with the addition of antibacterial particles: silver (Ag) copper oxide (CuO) are characterized. Basic mechanical properties biodegradation processes, as well biocompatibility materials human cells determined. Ag or CuO to polymers do not significantly affect their properties, flammability, rate. However, several differences between base observed. PLA‐based have higher tensile impact...
Surface-functionalized gold-coated superparamagnetic iron oxide nanoparticles (Au-SPIONs) may be a useful tool in various biomedical applications. To obtain Au-SPIONs, gold salt was precipitated onto citrate-stabilized SPIONs (Cit-SPIONs) using simple, aqueous one-pot technique inspired by the Turkevich method of nanoparticle synthesis. By further stabilization Au-SPION surface with additional citrate (Cit-Au-SPIONs), controllable and reproducible Z-averages enhanced long-term dispersion...
Superparamagnetic iron oxide nanoparticles (SPIONs) have attracted great attention in many biomedical fields and are used preclinical/experimental drug delivery, hyperthermia medical imaging. In this study, biocompatible magnetite carriers, stabilized by a dextran shell, were developed to carry tissue plasminogen activator (tPA) for targeted thrombolysis under an external magnetic field. Different concentrations of active tPA immobilized on carboxylated through carbodiimide-mediated amide...
If foreign particles enter the human body, immune system offers several mechanisms of response. Neutrophils forming first line defense either remove pathogens by phagocytosis, inactivate them degranulation or release reactive oxygen species immobilize chromatin decorated with granular proteins from cytoplasm as neutrophil extracellular traps (NETs). Besides viable microbes like fungi, bacteria viruses, also sterile inorganic including nanoparticles reportedly activate NET formation. The...
Abstract Surface modification of superparamagnetic iron oxide nanoparticles (SPIONs) has been introduced with lauric acid and oleic via co-precipitation thermal decomposition methods, respectively. This is required to increase the stability SPIONs when incorporated in hydrophobic, biodegradable biocompatible polymers such as poly (3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBV). In this work, solid-in-oil-in-water (S/O/W) emulsion-solvent extraction/evaporation method was utilized fabricate...
In the emerging field of molecular communication (MC), testbeds are needed to validate theoretical concepts, motivate applications, and guide further modeling efforts. To this end, paper presents a flexible extendable in-vessel testbed for flow-based macroscopic MC, abstractly modeling, e.g., part chemical reactor or blood vessel. Signaling is based on injecting non-reactive superparamagnetic iron oxide nanoparticles (SPIONs) dispersed in an aqueous suspension into tube with background flow....
Background Immunotherapy of cancer is an emerging field with the potential to improve long-term survival. Thus far, adoptive transfer tumor-specific T cells represents effective treatment option for tumors hematological system such as lymphoma, leukemia or myeloma. However, in solid tumors, efficacy low owing immunosuppressive microenvironment, on-target/off-tumor toxicity, limited extravasation out blood vessel, ineffective trafficking into tumor region. Superparamagnetic iron oxide...
Nanomedicine offers tremendous opportunities for the development of novel therapeutic and diagnostic tools. During last decades, extensive knowledge was gained about stabilizing coating nanoparticles, their functionalization drug binding release possible strategies therapies diagnostics different diseases. Most recently, more emphasis has been placed on nanotoxicology nanosafety aspects. The section experimental oncology nanomedicine developed a concept translating this into clinical...
The phototoxic effect of hypericin can be utilized for Photodynamic Therapy (PDT) cancer. After intravenous application and systemic distribution the drug in patient's body, tumor site is exposed to light. Subsequently, toxic reactive oxygen species (ROS) are generated, inducing cell death. To prevent unwanted activation other regions patients have avoid light during after treatment cycles, consequently impairing quality life. Here, we characterize toxicity hypericin-mediated effects on...