A5045128636- Endometrial and Cervical Cancer Treatments
- Ovarian cancer diagnosis and treatment
- Radiomics and Machine Learning in Medical Imaging
- Pancreatitis Pathology and Treatment
- Pancreatic and Hepatic Oncology Research
- MRI in cancer diagnosis
- Uterine Myomas and Treatments
- Pancreatic function and diabetes
- Cervical Cancer and HPV Research
- Angiogenesis and VEGF in Cancer
- Endometriosis Research and Treatment
- AI in cancer detection
- Diabetes and associated disorders
- Cancer Cells and Metastasis
- CNS Lymphoma Diagnosis and Treatment
- Cancer Risks and Factors
- Gastrointestinal disorders and treatments
- Estrogen and related hormone effects
- Lymphoma Diagnosis and Treatment
- Cancer, Hypoxia, and Metabolism
- Sarcoma Diagnosis and Treatment
- Digital Radiography and Breast Imaging
- Liver Disease Diagnosis and Treatment
- Cancer-related molecular mechanisms research
- Cardiovascular Disease and Adiposity
University of Bergen
2016-2025
Haukeland University Hospital
2016-2025
Hospital Universitario Insular de Gran Canaria
2021
Norwegian University of Science and Technology
2015
Engineering Service Center und Handel (Germany)
2009
Oslo University Hospital
2009
Background Improved methods for preoperative risk stratification in endometrial cancer are highly requested by gynecologists. Texture analysis is a method quantification of heterogeneity images, increasingly reported as promising diagnostic tool various types, but largely unexplored cancer. Purpose To explore whether tumor texture parameters from MRI related to known prognostic features (deep myometrial invasion, cervical stroma lymph node metastases, and high‐risk histological subtype)...
Following the European Society of Gynaecological Oncology (ESGO), for Radiotherapy and (ESTRO), Pathology (ESP) joint guidelines (2018) management patients with cervical cancer, treatment decisions should be guided by modern imaging techniques. After five years (2023), an update ESGO-ESTRO-ESP recommendations was performed, further confirming this statement. Transvaginal/transrectal ultrasound (TRS/TVS) or pelvic magnetic resonance (MRI) enables tumor delineation precise assessment its local...
<b>BACKGROUND AND PURPOSE:</b> Studying imaging findings of non–acquired immunodeficiency syndrome (AIDS) primary central nervous system lymphoma (PCNSL), we hypothesized that the presentation has changed with increasing incidence PCNSL and is related to clinical factors (eg, time diagnosis patient9s being diagnosed alive or at postmortem examination). <b>MATERIALS METHODS:</b> Chart histologic reviews patients recorded as having during 1989–2003 in Norwegian Cancer Registry identified 98...
Abstract Aims Hepatocyte nuclear factor 1B ( HNF1B ) gene mutation carriers have a systemic disease characterized by congenital malformations in the urogenital tract, diabetes mellitus of maturity‐onset young type and dysfunction liver exocrine pancreas. We aimed to investigate pancreatic structure function mutations. Methods studied five subjects from two families with previously reported R137_K161del novel F148L . All patients underwent computed tomography (CT) magnetic resonance...
Both pancreatic volume reduction and lipomatosis have been observed in subjects with diabetes. The underlying molecular pathological mechanisms are, however, poorly known, it has speculated that both features are secondary to We recently described atrophy diabetic of two Norwegian families a novel syndrome diabetes exocrine dysfunction caused by heterozygous carboxyl-ester lipase (CEL) mutations. To explore the early events this syndrome, we performed radiological examinations pancreas...
Our objective was to prospectively explore the diagnostic value of <sup>18</sup>F-FDG PET/CT for preoperative staging in endometrial carcinomas and investigate whether PET–specific quantitative tumor parameters reflect clinical histologic characteristics. <b>Methods:</b> Preoperative performed on 129 consecutive carcinoma patients. Two physicians who did not know findings or results independently reviewed images, assessing primary tumor, cervical stroma involvement metastatic spread,...
Despite successful implementation of drugs targeting the human epidermal growth factor receptor 2 (HER2) in breast and gastric cancers, potential HER2 as a therapeutic target other cancers has been less studied, including endometrial cancer. We investigated expression levels (ERBB2) large cohort cancer lesions, also complex atypical hyperplasia metastatic lesions. 67 precursor 790 primary 383 lesions were for relation to clinicopathologic features outcome. Protein assessed by...
Abstract Preoperative MR imaging in endometrial cancer patients provides valuable information on local tumor extent, which routinely guides choice of surgical procedure and adjuvant therapy. Furthermore, whole-volume analyses images may provide radiomic signatures potentially relevant for better individualization optimization treatment. We apply a convolutional neural network automatic segmentation patients, enabling automated extraction texture parameters volume. The was trained, validated...
The incidence of primary central nervous system lymphoma (PCNSL) appears to be increasing in some countries, whereas it is stable others. Many reports the last decades have suggested that there been improvements treatment PCNSL. objective this study was analyze time trends incidence, clinical features, histologic diagnosis, treatment, and outcome nonacquired immunodeficiency syndrome (non-AIDS) PCNSL Norway from 1989 2003.Patients were identified by a chart review all patients who had...
The aim of this study was to explore the relation between preoperative tumor size based on magnetic resonance imaging (MRI) and surgical pathologic staging parameters (deep myometrial invasion, cervical stroma metastatic lymph nodes) assess prognostic impact in endometrial carcinomas. Interobserver variability for different measurements also assessed.Preoperative pelvic MRI 212 patients with histologically confirmed carcinomas read independently by 3 radiologists. Maximum diameters were...
PD-L1 and PD-1 are predictive markers for immunotherapy increasingly relevant in endometrial cancer. The reported fraction of positive primary tumors has been inconsistent. We investigated the expression tumors, also stratified by MSI. As is foremost metastatic disease, was assessed corresponding lesions.PD-L1 a prospective, population based cancer cohort 700 patients with lesions from 68 74 respectively. Fresh tissue used gene analysis.In expressed 59% 63%, respectively, but no impact on...