A5046533177- Endometrial and Cervical Cancer Treatments
- Ovarian cancer diagnosis and treatment
- Cancer Genomics and Diagnostics
- Cancer-related molecular mechanisms research
- Estrogen and related hormone effects
- RNA Research and Splicing
- Cancer Cells and Metastasis
- Cancer, Lipids, and Metabolism
- Radiomics and Machine Learning in Medical Imaging
- MicroRNA in disease regulation
- Cytokine Signaling Pathways and Interactions
- Epigenetics and DNA Methylation
- Angiogenesis and VEGF in Cancer
- Lung Cancer Treatments and Mutations
- Cancer-related gene regulation
- Endometriosis Research and Treatment
- PI3K/AKT/mTOR signaling in cancer
- Genetic factors in colorectal cancer
- Sarcoma Diagnosis and Treatment
- Breast Cancer Treatment Studies
- Cervical Cancer and HPV Research
- Microtubule and mitosis dynamics
- Kruppel-like factors research
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Cancer, Hypoxia, and Metabolism
University of Bergen
2016-2025
Haukeland University Hospital
2016-2025
Uni Research (Norway)
2013
University Medical Center Hamburg-Eppendorf
2013
Universität Hamburg
2013
Endometrial cancer is the most commonly diagnosed of female reproductive tract in developed countries. Through genome-wide association studies (GWAS), we have previously identified eight risk loci for endometrial cancer. Here, present an expanded meta-analysis 12,906 cases and 108,979 controls (including new genotype data 5624 cases) identify nine novel significant loci, including a locus on 12q24.12 by meta-GWAS colorectal At five expression quantitative trait (eQTL) analyses candidate...
We hypothesized that estrogen receptor-α (ER-α) status in endometrial carcinomas, associated with poor prognosis, is reflected transcriptional signatures suggesting targets for new therapy.Endometrial carcinoma samples a primary investigation cohort (n = 76) and three independent validation cohorts 155/286/111) were analyzed through integrated molecular profiling. Biomarkers assessed by immunohistochemistry (IHC), DNA oligonucleotide microarray, quantitative PCR (qPCR), single-nucleotide...
Abstract The Protocadherin 10 (PCDH10) is inactivated often by promoter hypermethylation in various human tumors, but its possible functional role as a tumor suppressor gene not established. In this study, we identify PCDH10 novel Wnt pathway regulatory element endometrioid endometrial carcinoma (EEC). was downregulated EEC cells aberrant methylation of promoter. Restoring levels suppressed cell growth and triggered apoptosis xenografts. Gene expression profiling revealed part the...
Background Improved methods for preoperative risk stratification in endometrial cancer are highly requested by gynecologists. Texture analysis is a method quantification of heterogeneity images, increasingly reported as promising diagnostic tool various types, but largely unexplored cancer. Purpose To explore whether tumor texture parameters from MRI related to known prognostic features (deep myometrial invasion, cervical stroma lymph node metastases, and high‐risk histological subtype)...
Murine retroviral vectors carrying an enhancer detection cassette were used to generate 95 transgenic lines of fish in which reporter expression is observed distinct patterns during embryonic development. We mapped 65 insertion sites the as yet unfinished zebrafish genome sequence. Many integrations map close previously known developmental genes, including transcription factors Pax, Hox, Sox, Pou, Otx, Emx, zinc-finger and bHLH gene families. In most cases, activated provirus located in, or...
Three quarter of endometrial carcinomas are treated at early stage. Still, 15 to 20% these patients experience recurrence, with little effect from systemic therapies. Homo sapiens v-Ki-ras2 Kirsten rat sarcoma viral oncogenes homologue (KRAS) mutations have been reported an important role in tumorigenesis for human cancers, but there is limited knowledge regarding clinical relevance KRAS status carcinomas. We performed a comprehensive and integrated characterisation genome-wide expression...
Despite successful implementation of drugs targeting the human epidermal growth factor receptor 2 (HER2) in breast and gastric cancers, potential HER2 as a therapeutic target other cancers has been less studied, including endometrial cancer. We investigated expression levels (ERBB2) large cohort cancer lesions, also complex atypical hyperplasia metastatic lesions. 67 precursor 790 primary 383 lesions were for relation to clinicopathologic features outcome. Protein assessed by...
Abstract Blood lipids have been associated with the development of a range cancers, including breast, lung and colorectal cancer. For endometrial cancer, observational studies reported inconsistent associations between blood cancer risk. To reduce biases from unmeasured confounding, we performed bidirectional, two‐sample Mendelian randomization analysis to investigate relationship levels three (low‐density lipoprotein [LDL] high‐density [HDL] cholesterol, triglycerides) Genetic variants each...
// Anna Berg 1,2 , Erling A. Hoivik Siv Mjøs Frederik Holst Henrica M. J. Werner Ingvild L. Tangen Amaro Taylor-Weiner 7,8,9 William Gibson Kanthida Kusonmano 1,2,3 Elisabeth Wik 4,5 Jone Trovik Mari K. Halle Anne Øyan 1,6 Karl-Henning Kalland Andrew D. Cherniack 7 Rameen Beroukhim Ingunn Stefansson Gordon B. Mills 10 Camilla Krakstad and Helga Salvesen 1,2* 1 Department of Clinical Science, Center for Cancer Biomarkers, University Bergen, Norway 2 Gynecology Obstetrics,...
PD-L1 and PD-1 are predictive markers for immunotherapy increasingly relevant in endometrial cancer. The reported fraction of positive primary tumors has been inconsistent. We investigated the expression tumors, also stratified by MSI. As is foremost metastatic disease, was assessed corresponding lesions.PD-L1 a prospective, population based cancer cohort 700 patients with lesions from 68 74 respectively. Fresh tissue used gene analysis.In expressed 59% 63%, respectively, but no impact on...
A major hurdle in translational endometrial cancer (EC) research is the lack of robust preclinical models that capture both inter- and intra-tumor heterogeneity. This has hampered development new treatment strategies for people with EC.EC organoids were derived from resected patient tumor tissue expanded a chemically defined medium. Established EC orthotopically implanted into female NSG mice. Patient corresponding characterized by morphological evaluation, biomarker gene expression whole...
The incidence of breast cancer in young women (aged under 40) is on the rise and associated with more aggressive tumor characteristics lower survival rates. Breast most frequently diagnosed sixth decade, research presents results based data from older patients. By using large-scale clinico-pathologic transcriptomic Molecular Taxonomy Cancer International Consortium (METABRIC) (n = 1932), we aimed to explore age-related differences treatment, characteristics, gene expression signatures. Young...
Epithelial-to-mesenchymal-transition (EMT) and upregulation of chemokine receptors are linked to lymphatic metastasis in various types cancer including breast cancer. However, the underlying molecular mechanisms not fully understood. Using a triple-negative mammary carcinoma model, conditioned for through expression C-C receptor 7 (CCR7), we identified intrinsic tumor plasticity associated with EMT as critical determinant effective metastasis. Specifically, cells upregulate Podoplanin (PDPN)...
The nuclear receptor steroidogenic factor 1/adrenal 4 binding protein (SF-1/Ad4BP) is an essential regulator of endocrine development and function, the expression corresponding gene (sf-1/ad4bp) precisely regulated in a time- tissue-dependent manner. We previously demonstrated that basal promoter sf-1/ad4bp controlled by DNA methylation its status reflects pattern SF-1/Ad4BP. Recently, three intronic enhancers were identified target SF-1/Ad4BP to fetal adrenal (FAdE; adrenal-specific...
Epac 1 and 2 (Epac1/2; exchange factors directly activated by cAMP) are multidomain proteins that mediate cellular responses upon activation the signaling molecule cAMP. Epac1 is ubiquitously expressed, whereas Epac2 exhibits a restricted expression pattern. The gene encoding gives rise to at least three protein isoforms (Epac2A, Epac2B Epac2C) exhibit confined tissue cell specific profiles. Here, we describe alternative promoter usage for different of Epac2, demonstrate activity these...
// Camilla Krakstad 1,2 , Ingvild L. Tangen Erling A. Hoivik Mari K. Halle Anna Berg Henrica M. Werner Maria B. Ræder Kanthida Kusonmano 1,2,3 June X. Zou 4 Anne Øyan 5,6 Ingunn Stefansson 5,7 Jone Trovik Karl-Henning Kalland Hong-Wu Chen and Helga Salvesen 1 Centre for Cancer Biomarkers, Department of Clinical Science, University Bergen, Bergen, Norway 2 Gynecology Obstetrics, Haukeland Hospital, 3 Computational Biology Unit, Internal Medicine Biochemistry Molecular...