Barbara Burwinkel

ORCID: 0000-0002-6752-2589
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Research Areas
  • BRCA gene mutations in cancer
  • Genetic Associations and Epidemiology
  • MicroRNA in disease regulation
  • Cancer-related molecular mechanisms research
  • Epigenetics and DNA Methylation
  • Genetic factors in colorectal cancer
  • Estrogen and related hormone effects
  • Circular RNAs in diseases
  • Cancer Genomics and Diagnostics
  • Cancer Cells and Metastasis
  • Genomics and Chromatin Dynamics
  • Nutrition, Genetics, and Disease
  • Genomic variations and chromosomal abnormalities
  • RNA modifications and cancer
  • DNA Repair Mechanisms
  • Gene expression and cancer classification
  • HER2/EGFR in Cancer Research
  • RNA Research and Splicing
  • Bioinformatics and Genomic Networks
  • Cancer-related gene regulation
  • Breast Cancer Treatment Studies
  • Molecular Biology Techniques and Applications
  • Glycogen Storage Diseases and Myoclonus
  • Cytokine Signaling Pathways and Interactions
  • Cancer Risks and Factors

German Cancer Research Center
2014-2023

Heidelberg University
2014-2023

University of Washington
2023

Seattle Children's Hospital
2023

DKFZ-ZMBH Alliance
2009-2022

Cancer Research Center
2012-2021

University of Manchester
2021

Edinburgh Cancer Research
2021

St Mary's Hospital
2021

University Hospital Heidelberg
2011-2020

MicroRNAs (miRNAs), a class of post-transcriptional gene expression regulators, have recently been detected in human body fluids, including peripheral blood plasma as extracellular nuclease resistant entities. However, the origin and function circulating miRNA remain essentially unknown. Here, we confirmed that mature contrast to mRNA or snRNA is strikingly stable cell culture media. Furthermore, found most media completely passed through 0.22 µm filters but remained supernatant after...

10.1093/nar/gkr254 article EN cc-by-nc Nucleic Acids Research 2011-05-24
Kyriaki Michailidou Sara Lindström Joe Dennis Jonathan Beesley Shirley Hui and 95 more Siddhartha Kar Audrey Lemaçon Penny Soucy Dylan M. Glubb Asha Rostamianfar Manjeet K. Bolla Qin Wang Jonathan P. Tyrer Ed Dicks Andrew Lee Zhaoming Wang Jamie Allen Renske Keeman Ursula Eilber Juliet D. French Xiaohong Chen Laura Fachal Karen McCue Amy E. McCart Reed Maya Ghoussaini Jason S. Carroll Xia Jiang Hilary K. Finucane Marcia Adams Muriel A. Adank Habibul Ahsan Kristiina Aittomäki Hoda Anton‐Culver Natalia Antonenkova Volker Arndt Kristan J. Aronson Banu K. Arun Paul L. Auer François Bacot Myrto Barrdahl Caroline Baynes Matthias W. Beckmann Sabine Behrens Javier Benı́tez Marina Bermisheva Leslie Bernstein Carl Blomqvist Natalia Bogdanova Stig E. Bojesen Bernardo Bonanni Anne‐Lise Børresen‐Dale Judith S. Brand Hiltrud Brauch Paul Brennan Hermann Brenner Louise A. Brinton Per Broberg Ian W. Brock Annegien Broeks Angela Brooks‐Wilson Sara Y. Brucker Thomas Brüning Barbara Burwinkel Katja Butterbach Qiuyin Cai Hui Cai Trinidad Caldés Federico Canzian Ángel Carracedo Brian D. Carter Jose E. Castelao Tsun Leung Chan Ting‐Yuan David Cheng Kee Seng Chia Ji‐Yeob Choi Hans Christiansen Christine L. Clarke Margriet Collée Don Conroy Emilie Cordina‐Duverger Sten Cornelissen David G. Cox Angela Cox Simon S. Cross Julie M. Cunningham Kamila Czene Mary B. Daly Peter Devilee Kimberly F. Doheny Thilo Dörk Isabel dos‐Santos‐Silva Martine Dumont Lorraine Durcan Miriam Dwek Diana Eccles Arif B. Ekici A. Heather Eliassen Carolina Ellberg Mingajeva Elvira Christoph Engel

10.1038/nature24284 article EN Nature 2017-10-20
Kyriaki Michailidou Per Hall Anna González‐Neira Maya Ghoussaini Joe Dennis and 95 more Roger L. Milne Marjanka K. Schmidt Jenny Chang‐Claude Stig E. Bojesen Manjeet K. Bolla Qin Wang Ed Dicks Andrew Lee Clare Turnbull Nazneen Rahman Olivia Fletcher Julian Peto Lorna J. Gibson Isabel dos‐Santos‐Silva Heli Nevanlinna Taru Muranen Kristiina Aittomäki Carl Blomqvist Kamila Czene Astrid Irwanto Jianjun Liu Quinten Waisfisz Hanne Meijers‐Heijboer Muriel A. Adank Rob B. van der Luijt Rebecca Hein Norbert Dahmen L. Beckman Alfons Meindl Rita K. Schmutzler Bertram Müller‐Myhsok Peter Lichtner John L. Hopper Melissa C. Southey Enes Makalic Daniel F. Schmidt André G. Uitterlinden Albert Hofman David J. Hunter Stephen J. Chanock Daniel Vincent François Bacot Daniel C. Tessier Sander Canisius Lodewyk F.A. Wessels Christopher A. Haiman Mitul Shah Robert Luben Judith Brown Craig Luccarini Nils Schoof Keith Humphreys Jingmei Li Børge G. Nordestgaard Sune F. Nielsen Henrik Flyger Fergus J. Couch Xianshu Wang Celine M. Vachon Kristen N. Stevens Diether Lambrechts Matthieu Moisse Robert Paridaens Marie‐Rose Christiaens Anja Rudolph Stefan Nickels Dieter Flesch‐Janys Nichola Johnson Zoe Aitken Kirsimari Aaltonen Tuomas Heikkinen Annegien Broeks Laura J. van’t Veer C. Ellen van der Schoot Pascal Guénel Thérèse Truong Pierre Laurent–Puig F. Ménégaux Frederik Marmé Andreas Schneeweiß Christof Sohn Barbara Burwinkel M. Pilar Zamora José Ignacio Arias Pérez Guillermo Pita M. Rosario Alonso Angela Cox Ian W. Brock Simon S. Cross Malcolm Reed Elinor J. Sawyer Ian Tomlinson Michael J. Kerin Nicola Miller Brian E. Henderson

10.1038/ng.2563 article EN Nature Genetics 2013-03-27
Nasim Mavaddat Kyriaki Michailidou Joe Dennis Michael Lush Laura Fachal and 95 more Andrew Lee Jonathan P. Tyrer Ting‐Huei Chen Qin Wang Manjeet K. Bolla Xin Yang Muriel A. Adank Thomas U. Ahearn Kristiina Aittomäki Jamie Allen Irene L. Andrulis Hoda Anton‐Culver Natalia Antonenkova Volker Arndt Kristan J. Aronson Paul L. Auer Päivi Auvinen Myrto Barrdahl Laura E. Beane Freeman Matthias W. Beckmann Sabine Behrens Javier Benı́tez Marina Bermisheva Leslie Bernstein Carl Blomqvist Natalia Bogdanova Stig E. Bojesen Bernardo Bonanni Anne‐Lise Børresen‐Dale Hiltrud Brauch Michael Bremer Hermann Brenner Adam R. Brentnall Ian W. Brock Angela Brooks‐Wilson Sara Y. Brucker Thomas Brüning Barbara Burwinkel Daniele Campa Brian D. Carter Jose E. Castelao Stephen J. Chanock Rowan T. Chlebowski Hans Christiansen Christine L. Clarke J. Margriet Collée Emilie Cordina‐Duverger Sten Cornelissen Fergus J. Couch Angela Cox Simon S. Cross Kamila Czene Mary B. Daly Peter Devilee Thilo Dörk Isabel dos‐Santos‐Silva Martine Dumont Lorraine Durcan Miriam Dwek Diana Eccles Arif B. Ekici A. Heather Eliassen Carolina Ellberg Christoph Engel Mikael Eriksson D. Gareth Evans Peter A. Fasching Jonine D. Figueroa Olivia Fletcher Henrik Flyger Asta Försti Lin Fritschi Marike Gabrielson Manuela Gago‐Dominguez Susan M. Gapstur José A. García‐Sáenz Mia M. Gaudet V. Georgoulias Graham G. Giles I. R. Gilyazova Gord Glendon Mark S. Goldberg David E. Goldgar Anna González‐Neira Grethe I.G. Alnæs Mervi Grip Jacek Gronwald Anne Grundy Pascal Guénel Lothar Haeberle Eric Hahnen Christopher A. Haiman Niclas Håkansson Ute Hamann Susan E. Hankinson

Stratification of women according to their risk breast cancer based on polygenic scores (PRSs) could improve screening and prevention strategies. Our aim was develop PRSs, optimized for prediction estrogen receptor (ER)-specific disease, from the largest available genome-wide association dataset empirically validate PRSs in prospective studies. The development comprised 94,075 case subjects 75,017 control European ancestry 69 studies, divided into training validation sets. Samples were...

10.1016/j.ajhg.2018.11.002 article EN cc-by-nc-nd The American Journal of Human Genetics 2018-12-13
Leila Dorling Sara Carvalho Jamie Allen Anna González‐Neira Craig Luccarini and 95 more Cecilia Wahlström Karen A. Pooley Michael T. Parsons Cristina Fortuño Qin Wang Manjeet K. Bolla Joe Dennis Renske Keeman M. Rosario Alonso Núria Álvarez Belén Herráez María Victoria Fernández Rocío Núñez‐Torres Ana Osório Jeanette Valcich Minerva Li Therese Törngren Patricia Harrington Caroline Baynes Don Conroy Brennan Decker Laura Fachal Nasim Mavaddat Thomas U. Ahearn Kristiina Aittomäki Natalia Antonenkova Norbert Arnold Patrick Arveux Margreet G.E.M. Ausems Päivi Auvinen Heiko Becher Matthias W. Beckmann Sabine Behrens Marina Bermisheva Katarzyna Białkowska Carl Blomqvist Natalia Bogdanova Nadja Bogdanova-Markov Stig E. Bojesen Bernardo Bonanni Anne‐Lise Børresen‐Dale Hiltrud Brauch Michael Bremer Ignacio Briceño Thomas Brüning Barbara Burwinkel David Cameron Nicola J. Camp Archie Campbell Ángel Carracedo Jose E. Castelao Melissa H. Cessna Stephen J. Chanock Hans Christiansen J. Margriet Collée Emilie Cordina‐Duverger Sten Cornelissen Kamila Czene Thilo Dörk Arif B. Ekici Christoph Engel Mikael Eriksson Peter A. Fasching Jonine D. Figueroa Henrik Flyger Asta Försti Marike Gabrielson Manuela Gago‐Dominguez V. Georgoulias Fabián Gil Graham G. Giles Gord Glendon E. Gómez Grethe I.G. Alnæs Pascal Guénel Andreas Hadjisavvas Lothar Haeberle Eric Hahnen Per Hall Ute Hamann Elaine F. Harkness Jaana M. Hartikainen Mikael Hartman Wei He Bernadette A. M. Heemskerk‐Gerritsen Peter Hillemanns Frans B.L. Hogervorst Antoinette Hollestelle Weang-Kee Ho Maartje J. Hooning Anthony Howell Keith Humphreys Faiza Idris Anna Jakubowska Audrey Jung

Genetic testing for breast cancer susceptibility is widely used, but many genes, evidence of an association with weak, underlying risk estimates are imprecise, and reliable subtype-specific lacking.

10.1056/nejmoa1913948 article EN New England Journal of Medicine 2021-01-20
Liisa M. Pelttari Sofia Khan Mikko Vuorela Johanna I. Kiiski Sara Vilske and 92 more Viivi Nevanlinna Salla Ranta Johanna Schleutker Robert Winqvist Anne Kallioniemi Thilo Dörk Natalia Bogdanova Jonine D. Figueroa Paul D.P. Pharoah Marjanka K. Schmidt Alison M. Dunning Montserrat García‐Closas Manjeet K. Bolla Joe Dennis Kyriaki Michailidou Sophia Wang John L. Hopper Melissa C. Southey Efraim H. Rosenberg Peter A. Fasching Matthias W. Beckmann Julian Peto Isabel dos‐Santos‐Silva Elinor J. Sawyer Ian Tomlinson Barbara Burwinkel Harald Surowy Pascal Guénel Thérèse Truong Stig E. Bojesen Børge G. Nordestgaard Javier Benı́tez Anna González‐Neira Susan L. Neuhausen Hoda Anton‐Culver Hermann Brenner Volker Arndt Alfons Meindl Rita K. Schmutzler Hiltrud Brauch Thomas Brüning Annika Lindblom Sara Margolin Graham J. Mann Jaana M. Hartikainen Georgia Chenevix‐Trench Laurien Van Dyck Hilde Janssen Jenny Chang-Claude Anja Rudolph Paolo Radice Paolo Peterlongo Emily Hallberg Janet E. Olson Graham G. Giles Roger L. Milne Christopher A. Haiman Fredrick R. Schumacher Jacques Simard Martine Dumont Vessela Kristensen Anne‐Lise Børresen‐Dale Wei Zheng Alicia Beeghly‐Fadiel Mervi Grip Irene L. Andrulis Gord Glendon Peter Devilee Caroline Seynaeve Maartje J. Hooning Margriet Collée Angela Cox Simon S. Cross Mitul Shah Robert Luben Ute Hamann Diana Torres Anna Jakubowska Jan Lubiński Fergus J. Couch Drakoulis Yannoukakos Nick Orr Anthony J. Swerdlow Hatef Darabi Jingmei Li Kamila Czene Per Hall Douglas F. Easton Johanna Mattson Carl Blomqvist Kristiina Aittomäki Heli Nevanlinna

Common variation on 14q24.1, close to RAD51B, has been associated with breast cancer: rs999737 and rs2588809 the risk of female cancer rs1314913 male cancer. The aim this study was investigate role RAD51B variants in predisposition, particularly context familial Finland. We sequenced coding region 168 Finnish patients from Helsinki for identification possible recurrent founder mutations. In addition, we studied known rs999737, rs2588809, SNPs haplotypes 44,791 cases 43,583 controls 40...

10.1371/journal.pone.0153788 article EN public-domain PLoS ONE 2016-05-05
Sofia Khan Dario Greco Kyriaki Michailidou Roger L. Milne Taru Muranen and 95 more Tuomas Heikkinen Kirsimari Aaltonen Joe Dennis Manjeet K. Bolla Jianjun Liu Per Hall Astrid Irwanto Keith Humphreys Jingmei Li Kamila Czene Jenny Chang‐Claude Rebecca Hein Anja Rudolph Petra Seibold Dieter Flesch‐Janys Olivia Fletcher Julian Peto Isabel dos‐Santos‐Silva Nichola Johnson Lorna J. Gibson Zoe Aitken John L. Hopper Helen Tsimiklis Minh Bui Enes Makalic Daniel F. Schmidt Melissa C. Southey Carmel Apicella Jennifer Stone Quinten Waisfisz Hanne Meijers‐Heijboer Muriel A. Adank Rob B. van der Luijt Alfons Meindl Rita K. Schmutzler Bertram Müller‐Myhsok Peter Lichtner Clare Turnbull Nazneen Rahman Stephen J. Chanock David J. Hunter Angela Cox Simon S. Cross Malcolm Reed Marjanka K. Schmidt Annegien Broeks Laura J. V. a. n't. Veer Frans B.L. Hogervorst Peter A. Fasching Michael Schrauder Arif B. Ekici Matthias W. Beckmann Stig E. Bojesen Børge G. Nordestgaard Sune F. Nielsen Henrik Flyger Javier Benı́tez Pilar Zamora José Ignacio Arias Pérez Christopher A. Haiman Brian E. Henderson Fredrick R. Schumacher Loı̈c Le Marchand Paul D.P. Pharoah Alison M. Dunning Mitul Shah Robert Luben Judith Brown Fergus J. Couch Xianshu Wang Celine M. Vachon Janet E. Olson Diether Lambrechts Matthieu Moisse Robert Paridaens Marie-Rose Christiaens Pascal Guénel Thérèse Truong Pierre Laurent–Puig Claire Mulot F. Marmé Barbara Burwinkel Andreas Schneeweiß Christof Sohn Elinor J. Sawyer Ian Tomlinson Michael J. Kerin Nicola Miller Irene L. Andrulis Julia A. Knight Sandrine Tchatchou Anna Marie Mulligan Thilo Dörk Natalia Bogdanova Natalia Antonenkova

Genetic variations, such as single nucleotide polymorphisms (SNPs) in microRNAs (miRNA) or the miRNA binding sites may affect dependent gene expression regulation, which has been implicated various cancers, including breast cancer, and alter individual susceptibility to cancer. We investigated associations between related SNPs cancer risk. First we evaluated 2,196 a case-control study combining nine genome wide association studies (GWAS). Second, further 42 with suggestive evidence for using...

10.1371/journal.pone.0109973 article EN cc-by PLoS ONE 2014-11-12
Nasim Mavaddat Paul D.P. Pharoah Kyriaki Michailidou Jonathan P. Tyrer Mark N. Brook and 95 more Manjeet K. Bolla Qin Wang Joe Dennis Alison M. Dunning Mitul Shah Robert Luben Judith Brown Stig E. Bojesen Børge G. Nordestgaard Sune F. Nielsen Henrik Flyger Kamila Czene Hatef Darabi Mikael Eriksson Julian Peto Isabel dos‐Santos‐Silva Frank Dudbridge Nichola Johnson Marjanka K. Schmidt Annegien Broeks Senno Verhoef Emiel J. Rutgers Anthony J. Swerdlow Alan Ashworth Nick Orr Minouk J. Schoemaker Jonine D. Figueroa Stephen J. Chanock Louise A. Brinton Jolanta Lissowska Fergus J. Couch Janet E. Olson Celine M. Vachon V. Shane Pankratz Diether Lambrechts Hans Wildiers Chantal Van Ongeval Erik Van Limbergen Vessela Kristensen Grethe Grenaker Alnæs Silje Nord Anne‐Lise Børresen‐Dale Heli Nevanlinna Taru Muranen Kristiina Aittomäki Carl Blomqvist Jenny Chang‐Claude Anja Rudolph Petra Seibold Dieter Flesch‐Janys Peter A. Fasching Lothar Haeberle Arif B. Ekici Matthias W. Beckmann Barbara Burwinkel Frederik Marmé Andreas Schneeweiß Christof Sohn Amy Trentham‐Dietz Polly A. Newcomb Linda Titus Kathleen M. Egan David J. Hunter Sara Lindström Rulla M. Tamimi Peter Kraft Nazneen Rahman Clare Turnbull Anthony Renwick Sheila Seal Jingmei Li Jianjun Liu Keith Humphreys Javier Benı́tez M. Pilar Zamora José Ignacio Arias Pérez Primitiva Menéndez Anna Jakubowska Jan Lubiński Katarzyna Jaworska–Bieniek Katarzyna Durda Natalia Bogdanova Natalia Antonenkova Thilo Dörk Hoda Anton‐Culver Susan L. Neuhausen Argyrios Ziogas Leslie Bernstein Peter Devilee Robert A.E.M. Tollenaar Caroline Seynaeve Christi J. van Asperen Angela Cox Simon S. Cross Malcolm Reed

Data for multiple common susceptibility alleles breast cancer may be combined to identify women at different levels of risk. Such stratification could guide preventive and screening strategies. However, empirical evidence genetic risk is lacking. We investigated the value using 77 cancer-associated single nucleotide polymorphisms (SNPs) stratification, in a study 33 673 cases 381 control European origin. tested all possible pair-wise multiplicative interactions constructed 77-SNP polygenic...

10.1093/jnci/djv036 article EN cc-by JNCI Journal of the National Cancer Institute 2015-04-02
Stig E. Bojesen Karen A. Pooley Sharon E. Johnatty Jonathan Beesley Kyriaki Michailidou and 95 more Jonathan P. Tyrer Stacey L. Edwards Hilda A. Pickett Howard C. Shen Chanel E. Smart Kristine M. Hillman L. Phuong Kate Lawrenson Michael D. Stutz Yi Lu Rod Karevan Nicholas T. Woods Rebecca L. Johnston Juliet D. French Xiaohong Chen Maren Weischer Sune F. Nielsen Melanie Maranian Maya Ghoussaini Shahana Ahmed Caroline Baynes Manjeet K. Bolla Qin Wang Joe Dennis Lesley McGuffog Daniel Barrowdale Andrew Lee Sue Healey Michael Lush Daniel C. Tessier Daniel Vincent Françis Bacot Ignace Vergote Sandrina Lambrechts Evelyn Despierre Harvey A. Risch Anna González‐Neira Mary Anne Rossing Guillermo Pita Jennifer A. Doherty Núria Álvarez Melissa C. Larson Brooke L. Fridley Nils Schoof Jenny Chang‐Claude Mine Cicek Julian Peto Kimberly R. Kalli Annegien Broeks Sebastian M. Armasu Marjanka K. Schmidt Linde M. Braaf Boris Winterhoff Heli Nevanlinna Gottfried E. Konecny Diether Lambrechts Lisa Rogmann Pascal Guénel Attila Teoman Roger L. Milne Joaquín J. García Angela Cox Vijayalakshmi Shridhar Barbara Burwinkel Frederik Marmé Rebecca Hein Elinor J. Sawyer Christopher A. Haiman Shan Wang‐Gohrke Irene L. Andrulis Kirsten B. Moysich John L. Hopper Kunle Odunsi Annika Lindblom Graham G. Giles Hermann Brenner Jacques Simard Galina Lurie Peter A. Fasching Michael E. Carney Paolo Radice Lynne R. Wilkens Anthony J. Swerdlow Marc T. Goodman Hiltrud Brauch Montserrat García‐Closas Peter Hillemanns Robert Winqvist Matthias Dürst Peter Devilee Ingo B. Runnebaum Anna Jakubowska Jan Lubiński Graham J. Mann Ralf Bützow

10.1038/ng.2566 article EN Nature Genetics 2013-03-27
Shahana Ahmed Gilles Thomas Maya Ghoussaini Catherine S. Healey Manjeet K. Humphreys and 95 more Radka Platte Jonathan J. Morrison Melanie Maranian Karen A. Pooley Robert Luben Diana Eccles D. Gareth Evans Olivia Fletcher Nichola Johnson Isabel dos‐Santos‐Silva Julian Peto Michael R. Stratton Nazneen Rahman Kevin B. Jacobs Ross L. Prentice Garnet L. Anderson Aleksandar Rajkovic J. David Curb Regina G. Ziegler Christine D. Berg Saundra S. Buys Catherine A. McCarty Heather Spencer Feigelson Eugenia E. Calle Michael J. Thun W. Ryan Diver Stig E. Bojesen Børge G. Nordestgaard Henrik Flyger Thilo Dörk Peter Schürmann Peter Hillemanns Johann H. Karstens Natalia Bogdanova Natalia Antonenkova Iosif V. Zalutsky Marina Bermisheva С.А. Федорова Э. К. Хуснутдинова Daehee Kang Keun-Young Yoo Dong‐Young Noh Sei-Hyun Ahn Peter Devilee Christi J. van Asperen Robert A.E.M. Tollenaar Caroline Seynaeve Montserrat García‐Closas Jolanta Lissowska Louise A. Brinton Beata Pepłońska Heli Nevanlinna Tuomas Heikkinen Kristiina Aittomäki Carl Blomqvist John L. Hopper Melissa C. Southey Letitia Smith Amanda B. Spurdle Marjanka K. Schmidt Annegien Broeks Richard R van Hien Sten Cornelissen Roger L. Milne Glòria Ribas Anna González‐Neira Javier Benı́tez Rita K. Schmutzler Barbara Burwinkel Claus R. Bartram Alfons Meindl Hiltrud Brauch Christina Justenhoven Ute Hamann Jenny Chang‐Claude Rebecca Hein Shan Wang‐Gohrke Annika Lindblom Sara Margolin Graham J. Mann Veli-Matti Kosma Vesa Kataja Janet E. Olson Xianshu Wang Zachary Fredericksen Graham G. Giles Gianluca Severi Laura Baglietto Dallas R. English Susan E. Hankinson David G. Cox Peter Kraft Lars J. Vatten Kristian Hveem Merethe Kumle

10.1038/ng.354 article EN Nature Genetics 2009-03-29
Montserrat García‐Closas Fergus J. Couch Sara Lindström Kyriaki Michailidou Marjanka K. Schmidt and 95 more Mark N. Brook Nick Orr Suhn K. Rhie Elio Ríboli Heather Spencer Feigelson Loı̈c Le Marchand Julie E. Buring Diana Eccles Penelope Miron Peter A. Fasching Hiltrud Brauch Jenny Chang‐Claude Jane Carpenter Andrew K. Godwin Heli Nevanlinna Graham G. Giles Angela Cox John L. Hopper Manjeet K. Bolla Qin Wang Joe Dennis Ed Dicks Will J Howat Nils Schoof Stig E. Bojesen Diether Lambrechts Annegien Broeks Irene L. Andrulis Pascal Guénel Barbara Burwinkel Elinor J. Sawyer Antoinette Hollestelle Olivia Fletcher Robert Winqvist Hermann Brenner Graham J. Mann Ute Hamann Alfons Meindl Annika Lindblom Wei Zheng Peter Devillee Mark S. Goldberg Jan Lubiński Vessela N. Kristensen Anthony J. Swerdlow Hoda Anton‐Culver Thilo Dörk Kenneth Muir Keitaro Matsuo Anna H. Wu Paolo Radice Soo‐Hwang Teo Xiao‐Ou Shu William J. Blot Daehee Kang Mikael Hartman Suleeporn Sangrajrang Chen‐Yang Shen Melissa C. Southey Daniel J. Park Fleur Hammet Jennifer Stone Laura J. van’t Veer Emiel J. Rutgers Artitaya Lophatananon Sarah Stewart‐Brown Pornthep Siriwanarangsan Julian Peto Michael Schrauder Arif B. Ekici Matthias W. Beckmann Isabel dos‐Santos‐Silva Nichola Johnson Helen R. Warren Ian Tomlinson Michael J. Kerin Nicola Miller F Marmé Andreas Schneeweiß Christof Sohn Thérèse Truong Pierre Laurent–Puig Pierre Kerbrat Børge G. Nordestgaard Sune F. Nielsen Henrik Flyger Roger L. Milne José Ignacio Arias Pérez Primitiva Menéndez Heiko Müller Volker Arndt Christa Stegmaier Peter Lichtner Magdalena Lochmann Christina Justenhoven

10.1038/ng.2561 article EN Nature Genetics 2013-03-27
Felix R. Day Katherine S. Ruth Deborah J. Thompson Kathryn L. Lunetta Natalia Pervjakova and 95 more Daniel I. Chasman Lisette Stolk Hilary K. Finucane Patrick Sulem Brendan Bulik‐Sullivan Tõnu Esko Andrew D. Johnson Cathy E. Elks Nora Franceschini Chunyan He Elisabeth Altmaier Jennifer A. Brody Lude Franke Jennifer E. Huffman Margaux F. Keller Patrick F. McArdle Teresa Nutile Eleonora Porcu Antonietta Robino Lynda M. Rose Ursula M. Schick Jennifer A. Smith Alexander Teumer Michela Traglia Dragana Vuckovic Jie Yao Wei Zhao Eva Albrecht Najaf Amin Tanguy Corre Jouke‐Jan Hottenga Massimo Mangino Albert V. Smith Toshiko Tanaka Gonçalo R. Abecasis Irene L. Andrulis Hoda Anton‐Culver Antonis C. Antoniou Volker Arndt Alice M. Arnold Caterina Barbieri Matthias W. Beckmann Alicia Beeghly‐Fadiel Javier Benı́tez Leslie Bernstein Suzette J. Bielinski Carl Blomqvist Eric Boerwinkle Natalia Bogdanova Stig E. Bojesen Manjeet K. Bolla Anne‐Lise Børresen‐Dale Thibaud Boutin Hiltrud Brauch Hermann Brenner Thomas Brüning Barbara Burwinkel Archie Campbell Harry Campbell Stephen J. Chanock J. Ross Chapman Yii-Der Ida Chen Georgia Chenevix‐Trench Fergus J. Couch Andrea D. Coviello Angela Cox Kamila Czene Hatef Darabi Immaculata De Vivo Ellen W. Demerath Joe Dennis Peter Devilee Thilo Dörk Isabel dos‐Santos‐Silva Alison M. Dunning John D. Eicher Peter A. Fasching Jessica D. Faul Jonine D. Figueroa Dieter Flesch‐Janys Ilaria Gandin Melissa E. Garcia Montserrat García‐Closas Graham G. Giles Giorgia Girotto Mark S. Goldberg Anna González‐Neira Mark O. Goodarzi Megan L. Grove Daníel F. Guðbjartsson Pascal Guénel Xiuqing Guo Christopher A. Haiman Per Hall Ute Hamann

10.1038/ng.3412 article EN Nature Genetics 2015-09-28
Roger L. Milne Karoline Kuchenbaecker Kyriaki Michailidou Jonathan Beesley Siddhartha Kar and 95 more Sara Lindström Shirley Hui Audrey Lemaçon Penny Soucy Joe Dennis Xia Jiang Asha Rostamianfar Hilary K. Finucane Manjeet K. Bolla Lesley McGuffog Qin Wang Cora M. Aalfs Marcia Adams Julian Adlard Simona Agata Shahana Ahmed Habibul Ahsan Kristiina Aittomäki Fares Al‐Ejeh Jamie Allen Christine B. Ambrosone Christopher I. Amos Irene L. Andrulis Hoda Anton‐Culver Natalia Antonenkova Volker Arndt Norbert Arnold Kristan J. Aronson Bernd Auber Paul L. Auer Margreet G.E.M. Ausems Jacopo Azzollini François Bacot Judith Balmañà Monica Barile Laure Barjhoux Rósa B. Barkardóttir Myrto Barrdahl Daniel R. Barnes Daniel Barrowdale Caroline Baynes Matthias W. Beckmann Javier Benı́tez Marina Bermisheva Leslie Bernstein Yves‐Jean Bignon Kathleen R. Blazer Marinus J. Blok Carl Blomqvist William J. Blot Kristie Bobolis Bram Boeckx Natalia Bogdanova Anders Bojesen Stig E. Bojesen Bernardo Bonanni Anne‐Lise Børresen‐Dale Anikó Bozsik Angela R. Bradbury Judith S. Brand Hiltrud Brauch Hermann Brenner Brigitte Bressac–de Paillerets Carole Brewer Louise A. Brinton Per Broberg Angela Brooks‐Wilson Joan Brunet Thomas Brüning Barbara Burwinkel Saundra S. Buys Jinyoung Byun Qiuyin Cai Trinidad Caldés Maria A. Caligo Ian Campbell Federico Canzian Olivier Caron Ángel Carracedo Brian D. Carter Jose E. Castelao Laurent Castéra Virginie Caux‐Moncoutier Salina Chan Jenny Chang‐Claude Stephen J. Chanock Xiaohong Chen Ting‐Yuan David Cheng Jocelyne Chiquette Hans Christiansen Kathleen Claes Christine L. Clarke Thomas Conner Don Conroy Jackie Cook

10.1038/ng.3785 article EN Nature Genetics 2017-10-23

Nuclease resistant extracellular miRNAs have been found in all known biological fluids. The function of remains questionable; however, strong evidence suggests that these can be more than just byproducts cellular activity. Some miRNA species might carry cell-cell signaling during various physiological and pathological processes. In this review, we discuss the state-of-the-art field intercellular transport highlight current theories regarding origin miRNAs.

10.3389/fgene.2013.00119 article EN cc-by Frontiers in Genetics 2013-01-01

In recent years, circulating miRNAs have attracted a great deal of attention as promising novel markers for various diseases. Here, we investigated their potential to serve minimally invasive, early detection breast cancer in blood plasma. We profiled extracted from the plasma stage patients (taken at time-point diagnosis) and healthy control individuals using TaqMan low-density arrays (TLDA). Selected candidates identified initial screen were further validated an extended study cohort 207...

10.1002/ijc.27799 article EN International Journal of Cancer 2012-08-28
Yan Guo Shaneda Warren Andersen Xiao‐Ou Shu Kyriaki Michailidou Manjeet K. Bolla and 95 more Qin Wang Montserrat García‐Closas Roger L. Milne Marjanka K. Schmidt Jenny Chang‐Claude Alison M. Dunning Stig E. Bojesen Habibul Ahsan Kristiina Aittomäki Irene L. Andrulis Hoda Anton‐Culver Volker Arndt Matthias W. Beckmann Alicia Beeghly‐Fadiel Javier Benı́tez Natalia Bogdanova Bernardo Bonanni Anne‐Lise Børresen‐Dale Judith S. Brand Hiltrud Brauch Hermann Brenner Thomas Brüning Barbara Burwinkel Graham Casey Georgia Chenevix‐Trench Fergus J. Couch Angela Cox Simon S. Cross Kamila Czene Peter Devilee Thilo Dörk Martine Dumont Peter A. Fasching Jonine D. Figueroa Dieter Flesch‐Janys Olivia Fletcher Henrik Flyger Florentia Fostira Marilie D. Gammon Graham G. Giles Pascal Guénel Christopher A. Haiman Ute Hamann Maartje J. Hooning John L. Hopper Anna Jakubowska Farzana Jasmine Mark A. Jenkins Esther M. John Nichola Johnson Michael E. Jones Maria Kabisch Muhammad G. Kibriya Julia A. Knight Linetta B. Koppert Veli‐Matti Kosma Vessela N. Kristensen Loı̈c Le Marchand Eunjung Lee Jingmei Li Annika Lindblom Robert Luben Jan Lubiński Kathi Malone Graham J. Mann Sara Margolin Frederik Marmé Catriona McLean Hanne Meijers‐Heijboer Alfons Meindl Susan L. Neuhausen Heli Nevanlinna Patrick Neven Janet E. Olson José Ignacio Arias Pérez Barbara Perkins Paolo Peterlongo Kelly‐Anne Phillips Katri Pylkäs Anja Rudolph Regina M. Santella Elinor J. Sawyer Rita K. Schmutzler Caroline Seynaeve Mitul Shah Martha J. Shrubsole Melissa C. Southey Anthony J. Swerdlow Amanda E. Toland Ian Tomlinson Diana Torres Thérèse Truong Giske Ursin Rob B. van der Luijt Senno Verhoef

Observational epidemiological studies have shown that high body mass index (BMI) is associated with a reduced risk of breast cancer in premenopausal women but an increased postmenopausal women. It unclear whether this association mediated through shared genetic or environmental factors.

10.1371/journal.pmed.1002105 article EN cc-by PLoS Medicine 2016-08-23
Tracy A. O’Mara Dylan M. Glubb Frédéric Amant Daniela Annibali Katie A. Ashton and 95 more John Attia Paul L. Auer Matthias W. Beckmann Amanda Black Manjeet K. Bolla Hiltrud Brauch Hermann Brenner Louise A. Brinton Daniel D. Buchanan Barbara Burwinkel Jenny Chang‐Claude Stephen J. Chanock Chu Chen Maxine M. Chen Timothy Cheng Christine L. Clarke Mark Clendenning Linda S. Cook Fergus J. Couch Angela Cox Marta Crous‐Bou Kamila Czene Felix R. Day Joe Dennis Jeroen Depreeuw Jennifer A. Doherty Thilo Dörk Sean C. Dowdy Matthias Dürst Arif B. Ekici Peter A. Fasching Brooke L. Fridley Christine M. Friedenreich Lin Fritschi Jenny N. Fung Montserrat García‐Closas Mia M. Gaudet Graham G. Giles Ellen L. Goode Maggie Gorman Christopher A. Haiman Per Hall Susan E. Hankison Catherine S. Healey Alexander Hein Peter Hillemanns Shirley Hodgson Erling A. Høivik Elizabeth Holliday John L. Hopper David J. Hunter Angela Jones Camilla Krakstad Vessela N. Kristensen Diether Lambrechts Loı̈c Le Marchand Xiaolin Liang Annika Lindblom Jolanta Lissowska Jirong Long Lingeng Lu Anthony M. Magliocco Lynn Martin Mark McEvoy Alfons Meindl Kyriaki Michailidou Roger L. Milne Miriam Mints Grant W. Montgomery Rami Nassir Håkan Olsson Irene Orlow Geoffrey Otton Claire Palles John R. B. Perry Julian Peto Loreall Pooler Jennifer Prescott Tony Proietto Timothy R. Rebbeck Harvey A. Risch Peter A. W. Rogers Matthias Rübner Ingo B. Runnebaum Carlotta Sacerdote Gloria E. Sarto Fredrick R. Schumacher Rodney J. Scott Veronica Wendy Setiawan Mitul Shah Xin Sheng Xiao‐Ou Shu Melissa C. Southey Anthony J. Swerdlow Emma Tham

Endometrial cancer is the most commonly diagnosed of female reproductive tract in developed countries. Through genome-wide association studies (GWAS), we have previously identified eight risk loci for endometrial cancer. Here, present an expanded meta-analysis 12,906 cases and 108,979 controls (including new genotype data 5624 cases) identify nine novel significant loci, including a locus on 12q24.12 by meta-GWAS colorectal At five expression quantitative trait (eQTL) analyses candidate...

10.1038/s41467-018-05427-7 article EN cc-by Nature Communications 2018-08-03

The use of circulating tumor cells (CTC) as a prognostic marker in metastatic breast cancer (MBC) has been well established. However, their efficacy and accuracy are still under scrutiny mainly because methods enrichment identification. We hypothesized that miRNAs can predict the CTC status patients with MBC, tested for same. Furthermore, we aimed at establishing panel capable differentiating MBC cases from healthy controls.Circulating plasma CTC-positive CTC-negative controls, were profiled...

10.1158/1078-0432.ccr-12-1407 article EN Clinical Cancer Research 2012-09-05
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