Barbara Burwinkel
- BRCA gene mutations in cancer
- Genetic Associations and Epidemiology
- MicroRNA in disease regulation
- Cancer-related molecular mechanisms research
- Epigenetics and DNA Methylation
- Genetic factors in colorectal cancer
- Estrogen and related hormone effects
- Circular RNAs in diseases
- Cancer Genomics and Diagnostics
- Cancer Cells and Metastasis
- Genomics and Chromatin Dynamics
- Nutrition, Genetics, and Disease
- Genomic variations and chromosomal abnormalities
- RNA modifications and cancer
- DNA Repair Mechanisms
- Gene expression and cancer classification
- HER2/EGFR in Cancer Research
- RNA Research and Splicing
- Bioinformatics and Genomic Networks
- Cancer-related gene regulation
- Breast Cancer Treatment Studies
- Molecular Biology Techniques and Applications
- Glycogen Storage Diseases and Myoclonus
- Cytokine Signaling Pathways and Interactions
- Cancer Risks and Factors
German Cancer Research Center
2014-2023
Heidelberg University
2014-2023
University of Washington
2023
Seattle Children's Hospital
2023
DKFZ-ZMBH Alliance
2009-2022
Cancer Research Center
2012-2021
University of Manchester
2021
Edinburgh Cancer Research
2021
St Mary's Hospital
2021
University Hospital Heidelberg
2011-2020
MicroRNAs (miRNAs), a class of post-transcriptional gene expression regulators, have recently been detected in human body fluids, including peripheral blood plasma as extracellular nuclease resistant entities. However, the origin and function circulating miRNA remain essentially unknown. Here, we confirmed that mature contrast to mRNA or snRNA is strikingly stable cell culture media. Furthermore, found most media completely passed through 0.22 µm filters but remained supernatant after...
Stratification of women according to their risk breast cancer based on polygenic scores (PRSs) could improve screening and prevention strategies. Our aim was develop PRSs, optimized for prediction estrogen receptor (ER)-specific disease, from the largest available genome-wide association dataset empirically validate PRSs in prospective studies. The development comprised 94,075 case subjects 75,017 control European ancestry 69 studies, divided into training validation sets. Samples were...
Genetic testing for breast cancer susceptibility is widely used, but many genes, evidence of an association with weak, underlying risk estimates are imprecise, and reliable subtype-specific lacking.
Common variation on 14q24.1, close to RAD51B, has been associated with breast cancer: rs999737 and rs2588809 the risk of female cancer rs1314913 male cancer. The aim this study was investigate role RAD51B variants in predisposition, particularly context familial Finland. We sequenced coding region 168 Finnish patients from Helsinki for identification possible recurrent founder mutations. In addition, we studied known rs999737, rs2588809, SNPs haplotypes 44,791 cases 43,583 controls 40...
Genetic variations, such as single nucleotide polymorphisms (SNPs) in microRNAs (miRNA) or the miRNA binding sites may affect dependent gene expression regulation, which has been implicated various cancers, including breast cancer, and alter individual susceptibility to cancer. We investigated associations between related SNPs cancer risk. First we evaluated 2,196 a case-control study combining nine genome wide association studies (GWAS). Second, further 42 with suggestive evidence for using...
Data for multiple common susceptibility alleles breast cancer may be combined to identify women at different levels of risk. Such stratification could guide preventive and screening strategies. However, empirical evidence genetic risk is lacking. We investigated the value using 77 cancer-associated single nucleotide polymorphisms (SNPs) stratification, in a study 33 673 cases 381 control European origin. tested all possible pair-wise multiplicative interactions constructed 77-SNP polygenic...
Nuclease resistant extracellular miRNAs have been found in all known biological fluids. The function of remains questionable; however, strong evidence suggests that these can be more than just byproducts cellular activity. Some miRNA species might carry cell-cell signaling during various physiological and pathological processes. In this review, we discuss the state-of-the-art field intercellular transport highlight current theories regarding origin miRNAs.
In recent years, circulating miRNAs have attracted a great deal of attention as promising novel markers for various diseases. Here, we investigated their potential to serve minimally invasive, early detection breast cancer in blood plasma. We profiled extracted from the plasma stage patients (taken at time-point diagnosis) and healthy control individuals using TaqMan low-density arrays (TLDA). Selected candidates identified initial screen were further validated an extended study cohort 207...
Observational epidemiological studies have shown that high body mass index (BMI) is associated with a reduced risk of breast cancer in premenopausal women but an increased postmenopausal women. It unclear whether this association mediated through shared genetic or environmental factors.
Endometrial cancer is the most commonly diagnosed of female reproductive tract in developed countries. Through genome-wide association studies (GWAS), we have previously identified eight risk loci for endometrial cancer. Here, present an expanded meta-analysis 12,906 cases and 108,979 controls (including new genotype data 5624 cases) identify nine novel significant loci, including a locus on 12q24.12 by meta-GWAS colorectal At five expression quantitative trait (eQTL) analyses candidate...
The use of circulating tumor cells (CTC) as a prognostic marker in metastatic breast cancer (MBC) has been well established. However, their efficacy and accuracy are still under scrutiny mainly because methods enrichment identification. We hypothesized that miRNAs can predict the CTC status patients with MBC, tested for same. Furthermore, we aimed at establishing panel capable differentiating MBC cases from healthy controls.Circulating plasma CTC-positive CTC-negative controls, were profiled...