A5079069884- Epigenetics and DNA Methylation
- Cancer Cells and Metastasis
- Cancer-related gene regulation
- RNA modifications and cancer
- MicroRNA in disease regulation
- Cancer Genomics and Diagnostics
- Cancer-related molecular mechanisms research
- BRCA gene mutations in cancer
- Thyroid Cancer Diagnosis and Treatment
- Genetic factors in colorectal cancer
- Lung Cancer Treatments and Mutations
- Genomics and Chromatin Dynamics
- Genetic Associations and Epidemiology
- Receptor Mechanisms and Signaling
- Genomic variations and chromosomal abnormalities
- Nutrition, Genetics, and Disease
- RNA Research and Splicing
- Neonatal Respiratory Health Research
- Telomeres, Telomerase, and Senescence
- S100 Proteins and Annexins
- Genetic Syndromes and Imprinting
- Nutritional Studies and Diet
- Cerebrovascular and genetic disorders
- Heart Failure Treatment and Management
- Cardiovascular Health and Risk Factors
Nanjing Medical University
2020-2025
Xijing University
2023
Chinese PLA General Hospital
2022
Beijing Friendship Hospital
2022
Capital Medical University
2022
Heidelberg University
2008-2017
German Cancer Research Center
2008-2017
University Hospital Heidelberg
2012-2017
University Medical Center Hamburg-Eppendorf
2012-2015
University of Copenhagen
2015
The use of circulating tumor cells (CTC) as a prognostic marker in metastatic breast cancer (MBC) has been well established. However, their efficacy and accuracy are still under scrutiny mainly because methods enrichment identification. We hypothesized that miRNAs can predict the CTC status patients with MBC, tested for same. Furthermore, we aimed at establishing panel capable differentiating MBC cases from healthy controls.Circulating plasma CTC-positive CTC-negative controls, were profiled...
The rarity of mutations in PALB2, CHEK2 and ATM make it difficult to estimate precisely associated cancer risks. Population-based family studies have provided evidence that at least some these are with breast risk as high those rare BRCA2 mutations. We aimed the relative risks specific variants via a multicentre case-control study.
Recently, the SNPs rs11614913 in hsa-mir-196a2 and rs3746444 hsa-mir-499 were reported to be associated with increased breast cancer risk, SNP rs2910164 hsa-mir-146a was shown have an effect on age of diagnosis. In order further investigate these SNPs, we genotyped a total 1894 cases negative for disease-causing mutations or unclassified variants BRCA1 BRCA2, 2760 controls from Germany Italy. We compared genotype allele frequencies rs2910164, versus German Italian series, two series...
Mean telomere length (TL) in blood cells is heritable and has been reported to be associated with risks of several diseases, including cancer. We conducted a meta-analysis three GWAS for TL (total n=2240) selected 1629 variants replication via the "iCOGS" custom genotyping array. All ∼200 000 iCOGS were analysed TL, those displaying associations healthy controls (n = 15 065) further tested breast cancer cases 11 024). found novel association (Ptrend < 4 × 10−10) at 3p14.4 close PXK evidence...
In the recent years, circulating microRNAs (miRNAs) have garnered a lot of attention and interest in field disease biomarkers. With characteristics such as high stability, low cost, possibility repeated sampling minimal invasiveness, miRNAs are ideal for development into diagnostic tests. There been many studies reported on potential early detection, prognostic, predictive biomarkers cancer. Here, we reviewed application plasma serum cancer focusing epithelial carcinomas [prostate, breast,...
Background: Recent genome-wide DNA methylation studies have found a pronounced difference in of the F2RL3 gene (also known as PAR-4) blood according to smoking exposure. Knowledge on variation by various degrees exposure is still very sparse.Objectives: We aimed assess dose–response relationships current and lifetime active with methylation.Methods: In large population-based study, we quantified at for 3,588 participants using matrix-assisted laser desorption ionization time-of-flight mass...
Smoking is a major cause of morbidity and mortality. Smoking-related epigenetic biomarkers may open new avenues to better quantify the adverse health effects smoking, understanding underlying mechanisms. We aimed evaluate clinical implications F2RL3 methylation, novel biomarker smoking exposure disclosed by recent genome-wide methylation studies.Blood DNA at (also known as PAR-4) was quantified in baseline samples 3588 participants aged 50-75 years large population-based prospective cohort...
Genome-wide association studies (GWASs) have revealed SNP rs889312 on 5q11.2 to be associated with breast cancer risk in women of European ancestry. In an attempt identify the biologically relevant variants, we analyzed 909 genetic variants across 103,991 individuals and control from 52 Breast Cancer Association Consortium. Multiple logistic regression analyses identified three independent signals: strongest associations were 15 correlated (iCHAV1), where minor allele best candidate,...
Breast cancer (BC) is the leading cause of cancer‐related mortality in women worldwide. Changes DNA methylation peripheral blood could be associated with malignancy at early stage. However, BC‐associated signatures were largely unknown. Here, we performed a genome‐wide screening and identified differentially methylated CpG site cg27091787 hyaluronoglucosaminidase 2 gene ( HYAL2 ) (discovery round 72 BC case 24 controls: p = 2.61 × 10 −9 adjusted for cell‐type proportions). The substantially...
Smoking accounts for a large share of lung cancer. F2RL3 methylation was recently identified as biomarker closely reflecting both current and past smoking exposure. We aimed to assess the associations with cancer incidence mortality. In population-based cohort study, measured in baseline blood samples 4,987 participants by MassARRAY. Associations incidence/mortality during median follow-up 10.9 years were assessed Cox regression, controlling potential confounders. The ability predict...
Candidate variant association studies have been largely unsuccessful in identifying common breast cancer susceptibility variants, although most underpowered to detect associations of a realistic magnitude. We assessed 41 non-synonymous single-nucleotide polymorphisms (nsSNPs) for which evidence with risk had previously reported. Case-control data were combined from 38 white European women (46 450 cases and 42 600 controls) analyzed using unconditional logistic regression. Strong was observed...
<title>Abstract</title> <bold>Background: </bold>Differentiation between benign and malignant thyroid nodules has been a challenge in clinical practice. We aim to explore novel biomarker determine the malignancy of nodules. <bold>Materials methods: </bold>In discovery study, 32 tissue samples from nodule (BTN) cancer (TC) patients were analyzed by Methylation 850K array RNA-Sequencing. TC associated FABP3 methylation was further verified mass spectrometry two independent studies (221 BTN vs....
Breast cancer (BC) is the leading in women worldwide. Changes DNA methylation peripheral blood could be associated with malignant diseases. Making use of screening results by llumina 27K Methylation Assay, we validated demethylation five CpG sites S100P gene cell BC patients three independent retrospective studies subjects from different centers (Validation I: 235 familial case and 206 controls, odds ratio per −1% > 1.03, P < 6.00 × 10–8 for all sites; Validation II: 189 sporadic 8.0 10–5...
Ultraconserved elements (UCEs) are segments of >200 bp length showing absolute sequence identity between orthologous regions human, rat and mouse genomes. The selection factors acting on these UCEs still unknown. Recent studies have shown that function as long-range enhancers flanking genes or involved in splicing when overlapping with exons. depletion among copy number variation well the significant under-representation single-nucleotide polymorphisms (SNPs) within also revealed their...
Conventional tumor markers have limited value for prognostication and treatment monitoring in metastatic breast cancer (MBC) patients novel circulating therefore need to be explored. Hyaluronic acid (HA) is a major macropolysaccharide the extracellular matrix reported associated with progression. In our study, we investigated plasma HA level respect progression free survival (PFS) overall (OS), as well MBC patients. The prognostic of was discovery cohort 212 2.5-year follow-up validated an...
// Qiuqiong Tang 1, 2 , Tim Holland-Letz 3 Alla Slynko Katarina Cuk Frederik Marme 1 Sarah Schott Jörg Heil 4 Bin Qu 5 Michael Golatta Melanie Bewerunge-Hudler 6 Christian Sutter 7 Harald Surowy Barbara Wappenschmidt 8 Rita Schmutzler Markus Hoth Peter Bugert 9 Claus R. Bartram Christof Sohn Andreas Schneeweiss 10 Rongxi Yang Burwinkel Molecular Biology of Breast Cancer, Department Gynecology and Obstetrics, University Heidelberg, Germany Division Epidemiology (C080), German Cancer...
Coronary heart disease (CHD) brings a heavy burden to society worldwide. Novel and minimally invasive biomarkers for the risk evaluation of CHD are urgently needed. Previous study has revealed that blood-based hypomethylation β-actin (ACTB) was associated with increased stroke, but not reported in yet.We aimed explore association between ACTB methylation case-control Chinese population.The level quantitatively determined by mass spectrometry 281 patients 272 controls. The estimated logistic...
beta-arrestins (beta-Arrs) are known to be associated with tumor signaling pathways such as transforming growth factor-beta1 (TGF-beta1), P53/Murine double minute (MDM2) and NF-kappaB. To investigate the role of beta-Arr in progression vivo, we generated transgenic mice by subcutaneously inoculating cells them. We found that xenograft initiated earlier grew more rapidly beta-Arr1 than both beta-Arr2 wild-type after murine liver cancer Hepa1-6 or lymphoma EL4 cells. Moreover, matrix...