Christof Sohn
A5084545133- Breast Cancer Treatment Studies
- HER2/EGFR in Cancer Research
- Cancer Cells and Metastasis
- BRCA gene mutations in cancer
- Breast Lesions and Carcinomas
- Estrogen and related hormone effects
- Cancer Immunotherapy and Biomarkers
- Breast Implant and Reconstruction
- Cancer Genomics and Diagnostics
- Ovarian cancer diagnosis and treatment
- Cancer Treatment and Pharmacology
- Endometrial and Cervical Cancer Treatments
- Immunotherapy and Immune Responses
- Pelvic floor disorders treatments
- Reproductive System and Pregnancy
- Pregnancy and preeclampsia studies
- Cancer, Stress, Anesthesia, and Immune Response
- MicroRNA in disease regulation
- Inflammatory mediators and NSAID effects
- Genetic Associations and Epidemiology
- Computational Drug Discovery Methods
- Genetic factors in colorectal cancer
- Epigenetics and DNA Methylation
- Pelvic and Acetabular Injuries
- Preterm Birth and Chorioamnionitis
Heidelberg University
2013-2022
University Hospital Heidelberg
2013-2022
Breast Center
2010-2021
Cancer Research Center
2012-2021
Frauenklinik Heidelberg
2010-2021
German Cancer Research Center
2005-2021
National Center for Tumor Diseases
2012-2021
University of Manchester
2021
St Mary's Hospital
2021
Edinburgh Cancer Research
2021
Genetic variations, such as single nucleotide polymorphisms (SNPs) in microRNAs (miRNA) or the miRNA binding sites may affect dependent gene expression regulation, which has been implicated various cancers, including breast cancer, and alter individual susceptibility to cancer. We investigated associations between related SNPs cancer risk. First we evaluated 2,196 a case-control study combining nine genome wide association studies (GWAS). Second, further 42 with suggestive evidence for using...
Data for multiple common susceptibility alleles breast cancer may be combined to identify women at different levels of risk. Such stratification could guide preventive and screening strategies. However, empirical evidence genetic risk is lacking. We investigated the value using 77 cancer-associated single nucleotide polymorphisms (SNPs) stratification, in a study 33 673 cases 381 control European origin. tested all possible pair-wise multiplicative interactions constructed 77-SNP polygenic...
In recent years, circulating miRNAs have attracted a great deal of attention as promising novel markers for various diseases. Here, we investigated their potential to serve minimally invasive, early detection breast cancer in blood plasma. We profiled extracted from the plasma stage patients (taken at time-point diagnosis) and healthy control individuals using TaqMan low-density arrays (TLDA). Selected candidates identified initial screen were further validated an extended study cohort 207...
The use of circulating tumor cells (CTC) as a prognostic marker in metastatic breast cancer (MBC) has been well established. However, their efficacy and accuracy are still under scrutiny mainly because methods enrichment identification. We hypothesized that miRNAs can predict the CTC status patients with MBC, tested for same. Furthermore, we aimed at establishing panel capable differentiating MBC cases from healthy controls.Circulating plasma CTC-positive CTC-negative controls, were profiled...
In Germany, most breast cancer patients are treated in specialized units (BCU), which certified, and routinely monitored. Herein, we evaluate up-to-date oncological outcome of (BC) molecular subtypes routine clinical care a BCU.The study was prospectively single-center cohort 4102 female cases with primary, unilateral, non-metastatic between 01 January 2003 31 December 2012. The five used (Luminal A-like, Luminal B/HER2 negative-like, positive-like, HER2-type, Triple negative) were analyzed....
The study presents data on the 3-month prevalences of postpartum anxiety disorders (PAD) and depressive (PDD) their comorbidity in a German community sample. Associations with sociodemographic variables previous history psychopathology were analysed.Data gathered longitudinal over first 3 months postpartum. In two-stage screening procedure, population-based representative sample 1024 women was assessed for symptoms depression using DSM-IV-based instruments.The estimated rates DSM-IV 11.1%...
We tested the hypotheses that CHEK2*1100delC heterozygosity is associated with increased risk of early death, breast cancer-specific and a second cancer in women first cancer.From 22 studies participating Breast Cancer Association Consortium, 25,571 white invasive were genotyped for observed up to 20 years (median, 6.6 years). examined death by estrogen receptor status after prospective studies.CHEK2*1100delC was found 459 patients (1.8%). In receptor-positive cancer, multifactorially...
Breast cancers demonstrate substantial biological, clinical and etiological heterogeneity. We investigated breast cancer risk associations of eight susceptibility loci identified in GWAS two putative candidate genes relation to specific tumor subtypes. Subtypes were defined by five markers (ER, PR, HER2, CK5/6, EGFR) other pathological features. Analyses included up 30 040 invasive cases 53 692 controls from 31 studies within the Cancer Association Consortium. confirmed previous reports...
Purpose Primary systemic therapy (PST) with gemcitabine (G), epirubicin (E), and docetaxel (Doc) has resulted in a pathologic complete response (pCR) 26% of primary breast cancer patients. This study was aimed at the identification gene expression signature diagnostic core biopsy tissue samples that predicts pCR. Patients Methods Core from patients operable cancer, T2-4N0-2M0, enrolled onto two phase I II trials evaluating GEDoc (n = 48) GE sequentially followed by Doc (GEsDoc; n 52) as PST...
Metastasis is the principal cause of high morbidity and mortality among breast cancer (BC) patients. Identification markers that can be routinely monitored to predict onset metastasis in BC patients prognosis metastatic (MBC) would increase their median survival. In this study, plasma miRNAs 40 MBC were profiled by TaqMan low density arrays with prognostic capacity identified. The candidates validated initially samples 237 subsequently 335 from an independent study cohort Sixteen established...
Over the last few years, circulating microRNAs (miRNAs) have emerged as promising novel and minimally invasive markers for various diseases, including cancer. We already showed that certain miRNAs are deregulated in plasma of breast cancer patients when compared to healthy women. Herein we further explored their potential serve early detection blood plasma. Circulating miR-127-3p, miR-376a miR-652, selected candidates from a miRNA array-based screening, were found be associated with first...
Dysregulations concerning the composition and function of regulatory T cells (T(regs)) are assumed to be involved in pathophysiology complicated pregnancies. We used six-colour flow cytometric analysis demonstrate that total CD4(+) CD127(low+/-) CD25(+) forkhead box protein 3 (FoxP3)(+) T(reg) cell pool contains four distinct subsets: DR(high+) CD45RA(-), DR(low+) DR(-) CD45RA(-) T(regs) naive CD45RA(+) T(regs). During normal course pregnancy, most prominent changes were observed between...
Regulatory T cells (Tregs) exert a key role in tolerance induction to the semi‐allogeneic fetus. Currently, it is not known whether immunological rejection processes are involved of normal term or irresistible preterm labor. In this study, we examined there were differences percentage total CD4 + CD127 low+/− CD25 FoxP3 ‐Treg‐cell pool, its suppressive activity and composition with distinct Treg subsets (HLA‐DR low+ ‐, HLA‐DR high+ − ‐ naive CD45RA ‐Tregs) between laboring women. We found...