A5058342704- Alkaline Phosphatase Research Studies
- Carcinogens and Genotoxicity Assessment
- Prostate Cancer Diagnosis and Treatment
- Prostate Cancer Treatment and Research
- Parathyroid Disorders and Treatments
- Blood groups and transfusion
- Forensic and Genetic Research
- Hemoglobin structure and function
- Folate and B Vitamins Research
- Metabolism and Genetic Disorders
- Complement system in diseases
- Genetic Associations and Epidemiology
- Genetic and phenotypic traits in livestock
- Genetic diversity and population structure
- Arsenic contamination and mitigation
- Selenium in Biological Systems
- Erythrocyte Function and Pathophysiology
- Botanical Research and Chemistry
- Peptidase Inhibition and Analysis
- Hepatocellular Carcinoma Treatment and Prognosis
- Iron Metabolism and Disorders
- Pancreatitis Pathology and Treatment
- Biochemical and Molecular Research
- Neonatal Health and Biochemistry
- Aluminum toxicity and tolerance in plants and animals
Umeå University
2001-2024
Sundsvall Municipality
2003-2024
Länssjukhuset Sundsvall-Härnösand
2018-2023
Institute for Quality and Efficiency in Health Care
2013
Institute of Human Genetics
1959-2010
Institute of Genetics
1960-2009
University of Hawaii System
1964-2009
Lund University
1980-2009
Coriell Institute For Medical Research
2009
Institute for Medical Research
2009
A genetic perspective of human history in Europe was derived from 22 binary markers the nonrecombining Y chromosome (NRY). Ten lineages account for >95% 1007 European chromosomes studied. Geographic distribution and age estimates alleles are compatible with two Paleolithic one Neolithic migratory episode that have contributed to modern gene pool. significant correlation between NRY haplotype data principal components based on 95 protein observed, indicating effectiveness polymorphisms...
We present here a new interesting feature of the human tumor suppressor gene p53: very pronounced ethnic and clinal variation polymorphic codon 72 alleles. The frequency A1 (Pro) allele showed north-south cline from 17% in Swedish Saamis to 63% African Blacks (Nigerians), there was significant (p < 0.001) correlation (r = 0.95) between A2 latitude. In Finnish populations no differences were found with respect genotype distributions spontaneously aborted fetuses liveborn children, which makes...
When mitochondrial DNA sequence variation is analyzed from a sample of 637 individuals in 14 European populations, most populations show little differentiation with respect to each other. However, the Saami distinguish themselves by comparatively large amount difference when compared other different distribution diversity within population, and occurrence particular motifs. Thus, seem have long history distinct populations. Linguistic affiliations are not reflected patterns relationships...
The Rönnskär smelter in northern Sweden emits a number of potentially toxic substances, which arsenic, lead and sulphur dioxide have caused most public concern. Birth weight was studied the offspring women working at four populations (A–D) different distances from smelter. In employees two small industrial (A B) close to significantly decreased birth found. This decrease showed consistent parity dependence, affecting mainly later pregnancies.
Three polymorphisms in the human tumor suppressor gene p53 (BstUI and MspI RFLPs exon 4 intron 6 respectively a 16 bp duplication 3) their haplotype combinations were studied patients with breast cancer controls. A significant increase codon 72 BstUI A1 (pro) allele frequency (p= 0.016) of individuals carrying pro (pro/pro pro/arg) (OR,1.47; p = 0.014; 95% CI, 1.08–2.00) was observed cancer. This wasmost pronounced highly differentiated Significant associations found only BstUIand haplotypes...
A significantly increased frequency of chromosomal aberrations was found among lead-exposed workers at the Rönnskär smelter in northern Sweden. The showed a correlation with lead exposure as measured by blood levels lead. Strong individual variations were found. No synergistic effect smoking observed. Correlations between (chromosome and chromatid) breaks gaps, which lends further support to notion that gaps may be useful indicators genotoxic agents.
This paper reports the results of a study spontaneous abortion among female employees at RÖnnskär smelter and birth weight in their offspring. An increased frequency was found pregnancies where mother employed during pregnancy or had been before still living close to smelter. Women occupied connection with smelting processes significantly higher than other employees. When also father if only employed. In offspring mothers working decreased mainly later pregnancies. The lowest weights were...
Previous investigations have shown that trivalent arsenic is inducing chromosomal aberrations and sister chromatid exchanges (SCEs). In a search for the genotoxic mechanism we studied effects of oxygen-radical-scavenging enzymes superoxide dismutase (SOD) catalase (CAT) on arsenic-induced SCEs in cultured human lymphocytes. The results indicate SOD possibly also CAT protective effect against DNA damage. Arsenic, which emitted environmental pollutions e.g. from smelters coal-fired power...
A significantly increased frequency of chromosomal aberrations was found among arsenic-exposed workers at the Rönnskär smelter in northern Sweden. The correlation between and arsenic exposure rather poor. This may be due to individual variations susceptibility damage supposed cocarcinogenic action arsenic. results suggested an interaction smoking exposure. breaks gaps found, which suggests that used as indicators genotoxic agents.
Frequencies of spontaneous abortion were studied in populations located at different distances from the Rönnskår smelter northern Sweden. The emits a number potentially genotoxic substances like lead, arsenic and sulphur dioxide to environment. In population close significant increase frequency was found, compared more distantly populations.
Three p53 DNA polymorphisms (BstU I and Msp restriction fragment length (RFLPs) in exon 4 intron 6 respectively, a 16 bp duplication 3) their haplotype combinations were studied patients with colorectal cancer compared ulcerative colitis healthy controls. There only minor differences between controls, the significant difference was observed distribution of BstU I-Msp haplotypes. When single studied, significantly lower frequency found cancer. The protective effect more pronounced A1 alleles,...
Research Articles| August 26 2008 Genetic Variations of Human Serum Phosphatases Subject Area: Genetics K.-E. Arfors; Arfors From the Institute for Medical Genetics, Uppsala (Sweden) Search other works by this author on: This Site PubMed Google Scholar L. Beckman; Beckman L.-G. Lundin Acta Genetica et Statistica Medica (1963) 13 (2): 89–94. https://doi.org/10.1159/000151789 Article history Published Online: Content Tools Views Icon contents Figures & tables Video Audio Supplementary Data...
a combination of starch gel electrophoresis and various enzyme staining BLhniques multiple molecular forms enzymes have been demonstrated in large variety organisms. MARKERT MBLLER (1959) introduced the concept an isozyme, defined as one enzyme. In maize some highly interesting results found concerning esterase (SCHWARTZ 1960a, 1962~1, b, 1964) alkaline phosphatase ( SCHWARTZ 1960b). This report deals with genetic control leucine aminopeptidase (LAP) isozymes maize. The genetics this system...