Stig E. Bojesen

ORCID: 0000-0002-4061-4133
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Research Areas
  • BRCA gene mutations in cancer
  • Genetic Associations and Epidemiology
  • Nutrition, Genetics, and Disease
  • Cancer Genomics and Diagnostics
  • Epigenetics and DNA Methylation
  • Nutritional Studies and Diet
  • Genetic factors in colorectal cancer
  • Pancreatic and Hepatic Oncology Research
  • RNA modifications and cancer
  • Inflammatory Biomarkers in Disease Prognosis
  • Cancer Risks and Factors
  • Chronic Obstructive Pulmonary Disease (COPD) Research
  • Bioinformatics and Genomic Networks
  • Genomics and Chromatin Dynamics
  • Telomeres, Telomerase, and Senescence
  • Radiomics and Machine Learning in Medical Imaging
  • Estrogen and related hormone effects
  • Cancer-related molecular mechanisms research
  • Genomic variations and chromosomal abnormalities
  • Global Cancer Incidence and Screening
  • Breast Cancer Treatment Studies
  • Studies on Chitinases and Chitosanases
  • Gene expression and cancer classification
  • Adipokines, Inflammation, and Metabolic Diseases
  • Molecular Biology Techniques and Applications

University of Copenhagen
2016-2025

Gentofte Hospital
2016-2025

Weatherford College
2025

Copenhagen University Hospital
2015-2024

Frederiksberg Hospital
2014-2024

Rigshospitalet
2001-2024

Capital Region of Denmark
2009-2024

Bispebjerg Hospital
2005-2023

Herlev Hospital
2013-2022

Cancer Research Center
2010-2021

Douglas F. Easton Karen A. Pooley Alison M. Dunning Paul D.P. Pharoah Deborah J. Thompson and 95 more Dennis G. Ballinger Jeffery P. Struewing Jonathan J. Morrison Helen I. Field Robert Luben Nicholas J. Wareham Shahana Ahmed Catherine S. Healey Richard Bowman Craig Luccarini Don Conroy Mitul Shah Hannah Munday Clare Jordan Barbara Perkins Judy West Karen Redman Kristy Driver Kerstin B. Meyer Christopher A. Haiman Laurence Kolonel Brian E. Henderson Loı̈c Le Marchand Paul Brennan Suleeporn Sangrajrang Valérie Gaborieau Fabrice Odefrey Chen‐Yang Shen Pei‐Ei Wu Hui‐Chun Wang Diana Eccles D. Gareth Evans Julian Peto Olivia Fletcher Nichola Johnson Sheila Seal Michael R. Stratton Nazneen Rahman Georgia Chenevix‐Trench Stig E. Bojesen Børge G. Nordestgaard C. K. Axelsson Montserrat García‐Closas Louise A. Brinton Stephen J. Chanock Jolanta Lissowska Beata Pepłońska Heli Nevanlinna Rainer Fagerholm Hannaleena Eerola Daehee Kang Keun-Young Yoo Dong‐Young Noh Sei Hyun Ahn David J. Hunter Susan E. Hankinson David G. Cox Per Hall Sara Wedrén Jianjun Liu Yen-Ling Low Natalia Bogdanova Peter Schürmann Thilo Dörk Rob A.�E.�M. Tollenaar Catharina E. Jacobi Peter Devilee Jan G.M. Klijn Alice J. Sigurdson Michele M. Doody Bruce H. Alexander Jinghui Zhang Angela Cox Ian W. Brock Gordon R. Macpherson Malcolm Reed Fergus J. Couch Ellen L. Goode Janet E. Olson Hanne Meijers‐Heijboer Ans van den Ouweland André G. Uitterlinden Fernando Rivadeneira Roger L. Milne Glòria Ribas Anna González‐Neira Javier Benı́tez John L. Hopper Margaret McCredie Melissa C. Southey Graham G. Giles Chris Schroen Christina Justenhoven Hiltrud Brauch Ute Hamann

10.1038/nature05887 article EN Nature 2007-05-27
Kyriaki Michailidou Sara Lindström Joe Dennis Jonathan Beesley Shirley Hui and 95 more Siddhartha Kar Audrey Lemaçon Penny Soucy Dylan M. Glubb Asha Rostamianfar Manjeet K. Bolla Qin Wang Jonathan P. Tyrer Ed Dicks Andrew Lee Zhaoming Wang Jamie Allen Renske Keeman Ursula Eilber Juliet D. French Xiaohong Chen Laura Fachal Karen McCue Amy E. McCart Reed Maya Ghoussaini Jason S. Carroll Xia Jiang Hilary K. Finucane Marcia Adams Muriel A. Adank Habibul Ahsan Kristiina Aittomäki Hoda Anton‐Culver Natalia Antonenkova Volker Arndt Kristan J. Aronson Banu K. Arun Paul L. Auer François Bacot Myrto Barrdahl Caroline Baynes Matthias W. Beckmann Sabine Behrens Javier Benı́tez Marina Bermisheva Leslie Bernstein Carl Blomqvist Natalia Bogdanova Stig E. Bojesen Bernardo Bonanni Anne‐Lise Børresen‐Dale Judith S. Brand Hiltrud Brauch Paul Brennan Hermann Brenner Louise A. Brinton Per Broberg Ian W. Brock Annegien Broeks Angela Brooks‐Wilson Sara Y. Brucker Thomas Brüning Barbara Burwinkel Katja Butterbach Qiuyin Cai Hui Cai Trinidad Caldés Federico Canzian Ángel Carracedo Brian D. Carter Jose E. Castelao Tsun Leung Chan Ting‐Yuan David Cheng Kee Seng Chia Ji‐Yeob Choi Hans Christiansen Christine L. Clarke Margriet Collée Don Conroy Emilie Cordina‐Duverger Sten Cornelissen David G. Cox Angela Cox Simon S. Cross Julie M. Cunningham Kamila Czene Mary B. Daly Peter Devilee Kimberly F. Doheny Thilo Dörk Isabel dos‐Santos‐Silva Martine Dumont Lorraine Durcan Miriam Dwek Diana Eccles Arif B. Ekici A. Heather Eliassen Carolina Ellberg Mingajeva Elvira Christoph Engel

10.1038/nature24284 article EN Nature 2017-10-20
Kyriaki Michailidou Per Hall Anna González‐Neira Maya Ghoussaini Joe Dennis and 95 more Roger L. Milne Marjanka K. Schmidt Jenny Chang‐Claude Stig E. Bojesen Manjeet K. Bolla Qin Wang Ed Dicks Andrew Lee Clare Turnbull Nazneen Rahman Olivia Fletcher Julian Peto Lorna J. Gibson Isabel dos‐Santos‐Silva Heli Nevanlinna Taru Muranen Kristiina Aittomäki Carl Blomqvist Kamila Czene Astrid Irwanto Jianjun Liu Quinten Waisfisz Hanne Meijers‐Heijboer Muriel A. Adank Rob B. van der Luijt Rebecca Hein Norbert Dahmen L. Beckman Alfons Meindl Rita K. Schmutzler Bertram Müller‐Myhsok Peter Lichtner John L. Hopper Melissa C. Southey Enes Makalic Daniel F. Schmidt André G. Uitterlinden Albert Hofman David J. Hunter Stephen J. Chanock Daniel Vincent François Bacot Daniel C. Tessier Sander Canisius Lodewyk F.A. Wessels Christopher A. Haiman Mitul Shah Robert Luben Judith Brown Craig Luccarini Nils Schoof Keith Humphreys Jingmei Li Børge G. Nordestgaard Sune F. Nielsen Henrik Flyger Fergus J. Couch Xianshu Wang Celine M. Vachon Kristen N. Stevens Diether Lambrechts Matthieu Moisse Robert Paridaens Marie‐Rose Christiaens Anja Rudolph Stefan Nickels Dieter Flesch‐Janys Nichola Johnson Zoe Aitken Kirsimari Aaltonen Tuomas Heikkinen Annegien Broeks Laura J. van’t Veer C. Ellen van der Schoot Pascal Guénel Thérèse Truong Pierre Laurent–Puig F. Ménégaux Frederik Marmé Andreas Schneeweiß Christof Sohn Barbara Burwinkel M. Pilar Zamora José Ignacio Arias Pérez Guillermo Pita M. Rosario Alonso Angela Cox Ian W. Brock Simon S. Cross Malcolm Reed Elinor J. Sawyer Ian Tomlinson Michael J. Kerin Nicola Miller Brian E. Henderson

10.1038/ng.2563 article EN Nature Genetics 2013-03-27
Nasim Mavaddat Kyriaki Michailidou Joe Dennis Michael Lush Laura Fachal and 95 more Andrew Lee Jonathan P. Tyrer Ting‐Huei Chen Qin Wang Manjeet K. Bolla Xin Yang Muriel A. Adank Thomas U. Ahearn Kristiina Aittomäki Jamie Allen Irene L. Andrulis Hoda Anton‐Culver Natalia Antonenkova Volker Arndt Kristan J. Aronson Paul L. Auer Päivi Auvinen Myrto Barrdahl Laura E. Beane Freeman Matthias W. Beckmann Sabine Behrens Javier Benı́tez Marina Bermisheva Leslie Bernstein Carl Blomqvist Natalia Bogdanova Stig E. Bojesen Bernardo Bonanni Anne‐Lise Børresen‐Dale Hiltrud Brauch Michael Bremer Hermann Brenner Adam R. Brentnall Ian W. Brock Angela Brooks‐Wilson Sara Y. Brucker Thomas Brüning Barbara Burwinkel Daniele Campa Brian D. Carter Jose E. Castelao Stephen J. Chanock Rowan T. Chlebowski Hans Christiansen Christine L. Clarke J. Margriet Collée Emilie Cordina‐Duverger Sten Cornelissen Fergus J. Couch Angela Cox Simon S. Cross Kamila Czene Mary B. Daly Peter Devilee Thilo Dörk Isabel dos‐Santos‐Silva Martine Dumont Lorraine Durcan Miriam Dwek Diana Eccles Arif B. Ekici A. Heather Eliassen Carolina Ellberg Christoph Engel Mikael Eriksson D. Gareth Evans Peter A. Fasching Jonine D. Figueroa Olivia Fletcher Henrik Flyger Asta Försti Lin Fritschi Marike Gabrielson Manuela Gago‐Dominguez Susan M. Gapstur José A. García‐Sáenz Mia M. Gaudet V. Georgoulias Graham G. Giles I. R. Gilyazova Gord Glendon Mark S. Goldberg David E. Goldgar Anna González‐Neira Grethe I.G. Alnæs Mervi Grip Jacek Gronwald Anne Grundy Pascal Guénel Lothar Haeberle Eric Hahnen Christopher A. Haiman Niclas Håkansson Ute Hamann Susan E. Hankinson

Stratification of women according to their risk breast cancer based on polygenic scores (PRSs) could improve screening and prevention strategies. Our aim was develop PRSs, optimized for prediction estrogen receptor (ER)-specific disease, from the largest available genome-wide association dataset empirically validate PRSs in prospective studies. The development comprised 94,075 case subjects 75,017 control European ancestry 69 studies, divided into training validation sets. Samples were...

10.1016/j.ajhg.2018.11.002 article EN cc-by-nc-nd The American Journal of Human Genetics 2018-12-13
Leila Dorling Sara Carvalho Jamie Allen Anna González‐Neira Craig Luccarini and 95 more Cecilia Wahlström Karen A. Pooley Michael T. Parsons Cristina Fortuño Qin Wang Manjeet K. Bolla Joe Dennis Renske Keeman M. Rosario Alonso Núria Álvarez Belén Herráez María Victoria Fernández Rocío Núñez‐Torres Ana Osório Jeanette Valcich Minerva Li Therese Törngren Patricia Harrington Caroline Baynes Don Conroy Brennan Decker Laura Fachal Nasim Mavaddat Thomas U. Ahearn Kristiina Aittomäki Natalia Antonenkova Norbert Arnold Patrick Arveux Margreet G.E.M. Ausems Päivi Auvinen Heiko Becher Matthias W. Beckmann Sabine Behrens Marina Bermisheva Katarzyna Białkowska Carl Blomqvist Natalia Bogdanova Nadja Bogdanova-Markov Stig E. Bojesen Bernardo Bonanni Anne‐Lise Børresen‐Dale Hiltrud Brauch Michael Bremer Ignacio Briceño Thomas Brüning Barbara Burwinkel David Cameron Nicola J. Camp Archie Campbell Ángel Carracedo Jose E. Castelao Melissa H. Cessna Stephen J. Chanock Hans Christiansen J. Margriet Collée Emilie Cordina‐Duverger Sten Cornelissen Kamila Czene Thilo Dörk Arif B. Ekici Christoph Engel Mikael Eriksson Peter A. Fasching Jonine D. Figueroa Henrik Flyger Asta Försti Marike Gabrielson Manuela Gago‐Dominguez V. Georgoulias Fabián Gil Graham G. Giles Gord Glendon E. Gómez Grethe I.G. Alnæs Pascal Guénel Andreas Hadjisavvas Lothar Haeberle Eric Hahnen Per Hall Ute Hamann Elaine F. Harkness Jaana M. Hartikainen Mikael Hartman Wei He Bernadette A. M. Heemskerk‐Gerritsen Peter Hillemanns Frans B.L. Hogervorst Antoinette Hollestelle Weang-Kee Ho Maartje J. Hooning Anthony Howell Keith Humphreys Faiza Idris Anna Jakubowska Audrey Jung

Genetic testing for breast cancer susceptibility is widely used, but many genes, evidence of an association with weak, underlying risk estimates are imprecise, and reliable subtype-specific lacking.

10.1056/nejmoa1913948 article EN New England Journal of Medicine 2021-01-20
Liisa M. Pelttari Sofia Khan Mikko Vuorela Johanna I. Kiiski Sara Vilske and 92 more Viivi Nevanlinna Salla Ranta Johanna Schleutker Robert Winqvist Anne Kallioniemi Thilo Dörk Natalia Bogdanova Jonine D. Figueroa Paul D.P. Pharoah Marjanka K. Schmidt Alison M. Dunning Montserrat García‐Closas Manjeet K. Bolla Joe Dennis Kyriaki Michailidou Sophia Wang John L. Hopper Melissa C. Southey Efraim H. Rosenberg Peter A. Fasching Matthias W. Beckmann Julian Peto Isabel dos‐Santos‐Silva Elinor J. Sawyer Ian Tomlinson Barbara Burwinkel Harald Surowy Pascal Guénel Thérèse Truong Stig E. Bojesen Børge G. Nordestgaard Javier Benı́tez Anna González‐Neira Susan L. Neuhausen Hoda Anton‐Culver Hermann Brenner Volker Arndt Alfons Meindl Rita K. Schmutzler Hiltrud Brauch Thomas Brüning Annika Lindblom Sara Margolin Graham J. Mann Jaana M. Hartikainen Georgia Chenevix‐Trench Laurien Van Dyck Hilde Janssen Jenny Chang-Claude Anja Rudolph Paolo Radice Paolo Peterlongo Emily Hallberg Janet E. Olson Graham G. Giles Roger L. Milne Christopher A. Haiman Fredrick R. Schumacher Jacques Simard Martine Dumont Vessela Kristensen Anne‐Lise Børresen‐Dale Wei Zheng Alicia Beeghly‐Fadiel Mervi Grip Irene L. Andrulis Gord Glendon Peter Devilee Caroline Seynaeve Maartje J. Hooning Margriet Collée Angela Cox Simon S. Cross Mitul Shah Robert Luben Ute Hamann Diana Torres Anna Jakubowska Jan Lubiński Fergus J. Couch Drakoulis Yannoukakos Nick Orr Anthony J. Swerdlow Hatef Darabi Jingmei Li Kamila Czene Per Hall Douglas F. Easton Johanna Mattson Carl Blomqvist Kristiina Aittomäki Heli Nevanlinna

Common variation on 14q24.1, close to RAD51B, has been associated with breast cancer: rs999737 and rs2588809 the risk of female cancer rs1314913 male cancer. The aim this study was investigate role RAD51B variants in predisposition, particularly context familial Finland. We sequenced coding region 168 Finnish patients from Helsinki for identification possible recurrent founder mutations. In addition, we studied known rs999737, rs2588809, SNPs haplotypes 44,791 cases 43,583 controls 40...

10.1371/journal.pone.0153788 article EN public-domain PLoS ONE 2016-05-05

Background Assessing the relationship between lung cancer and metabolic conditions is challenging because of confounding effect tobacco. Mendelian randomization (MR), or use genetic instrumental variables to assess causality, may help identify drivers cancer. Methods findings We identified instruments for potential risk factors evaluated these in relation using 29,266 cases (including 11,273 adenocarcinomas, 7,426 squamous cell 2,664 small cases) 56,450 controls. The MR analysis suggested a...

10.1371/journal.pone.0177875 article EN public-domain PLoS ONE 2017-06-08
Sofia Khan Dario Greco Kyriaki Michailidou Roger L. Milne Taru Muranen and 95 more Tuomas Heikkinen Kirsimari Aaltonen Joe Dennis Manjeet K. Bolla Jianjun Liu Per Hall Astrid Irwanto Keith Humphreys Jingmei Li Kamila Czene Jenny Chang‐Claude Rebecca Hein Anja Rudolph Petra Seibold Dieter Flesch‐Janys Olivia Fletcher Julian Peto Isabel dos‐Santos‐Silva Nichola Johnson Lorna J. Gibson Zoe Aitken John L. Hopper Helen Tsimiklis Minh Bui Enes Makalic Daniel F. Schmidt Melissa C. Southey Carmel Apicella Jennifer Stone Quinten Waisfisz Hanne Meijers‐Heijboer Muriel A. Adank Rob B. van der Luijt Alfons Meindl Rita K. Schmutzler Bertram Müller‐Myhsok Peter Lichtner Clare Turnbull Nazneen Rahman Stephen J. Chanock David J. Hunter Angela Cox Simon S. Cross Malcolm Reed Marjanka K. Schmidt Annegien Broeks Laura J. V. a. n't. Veer Frans B.L. Hogervorst Peter A. Fasching Michael Schrauder Arif B. Ekici Matthias W. Beckmann Stig E. Bojesen Børge G. Nordestgaard Sune F. Nielsen Henrik Flyger Javier Benı́tez Pilar Zamora José Ignacio Arias Pérez Christopher A. Haiman Brian E. Henderson Fredrick R. Schumacher Loı̈c Le Marchand Paul D.P. Pharoah Alison M. Dunning Mitul Shah Robert Luben Judith Brown Fergus J. Couch Xianshu Wang Celine M. Vachon Janet E. Olson Diether Lambrechts Matthieu Moisse Robert Paridaens Marie-Rose Christiaens Pascal Guénel Thérèse Truong Pierre Laurent–Puig Claire Mulot F. Marmé Barbara Burwinkel Andreas Schneeweiß Christof Sohn Elinor J. Sawyer Ian Tomlinson Michael J. Kerin Nicola Miller Irene L. Andrulis Julia A. Knight Sandrine Tchatchou Anna Marie Mulligan Thilo Dörk Natalia Bogdanova Natalia Antonenkova

Genetic variations, such as single nucleotide polymorphisms (SNPs) in microRNAs (miRNA) or the miRNA binding sites may affect dependent gene expression regulation, which has been implicated various cancers, including breast cancer, and alter individual susceptibility to cancer. We investigated associations between related SNPs cancer risk. First we evaluated 2,196 a case-control study combining nine genome wide association studies (GWAS). Second, further 42 with suggestive evidence for using...

10.1371/journal.pone.0109973 article EN cc-by PLoS ONE 2014-11-12

10.1038/ng1981 article EN Nature Genetics 2007-02-11
John R. B. Perry Felix R. Day Cathy E. Elks Patrick Sulem Deborah J. Thompson and 95 more Teresa Ferreira Chunyan He Daniel I. Chasman Tõnu Esko Guðmar Þorleifsson Eva Albrecht Wei Ang Tanguy Corre Diana L. Cousminer Bjarke Feenstra Nora Franceschini Andrea Ganna Andrew D. Johnson Sanela Kjellqvist Kathryn L. Lunetta George McMahon Ilja M. Nolte Lavinia Paternoster Eleonora Porcu Albert V. Smith Lisette Stolk Alexander Teumer Natalia Tšernikova Emmi Tikkanen Sheila Ulivi Erin K. Wagner Najaf Amin Laura J. Bierut Enda M. Byrne Jouke‐Jan Hottenga Daniel L. Koller Massimo Mangino Tune H. Pers Laura M. Yerges-Armstrong Jing Hua Zhao Irene L. Andrulis Hoda Anton‐Culver Femke Atsma Stefania Bandinelli Matthias W. Beckmann Javier Benı́tez Carl Blomqvist Stig E. Bojesen Manjeet K. Bolla Bernardo Bonanni Hiltrud Brauch Hermann Brenner Julie E. Buring Jenny Chang‐Claude Stephen J. Chanock Jinhui Chen Georgia Chenevix‐Trench J. Margriet Collée Fergus J. Couch David Couper Andrea D. Coviello Angela Cox Kamila Czene Pio D’Adamo George Davey Smith Immaculata De Vivo Ellen W. Demerath Joe Dennis Peter Devilee Aida Karina Dieffenbach Alison M. Dunning Guðný Eiríksdóttir Johan G. Eriksson Peter A. Fasching Luigi Ferrucci Dieter Flesch‐Janys Henrik Flyger Tatiana Foroud Lude Franke Melissa E. Garcia Montserrat García‐Closas Frank Geller Eco J. C. de Geus Graham G. Giles Daníel F. Guðbjartsson Vilmundur Guðnason Pascal Guénel Suiqun Guo Per Hall Ute Hamann Robin Haring Catharina A. Hartman Andrew C. Heath Albert Hofman Maartje J. Hooning John L. Hopper Frank B. Hu David J. Hunter David Karasik Douglas P. Kiel

10.1038/nature13545 article EN Nature 2014-07-23
Felix R. Day Deborah J. Thompson Hannes Helgason Daniel I. Chasman Hilary K. Finucane and 95 more Patrick Sulem Katherine S. Ruth Sean Whalen Abhishek Sarkar Eva Albrecht Elisabeth Altmaier Marzyeh Amini Caterina Barbieri Thibaud Boutin Archie Campbell Ellen W. Demerath Ayush Giri Chunyan He Jouke‐Jan Hottenga Robert Karlsson Ivana Kolčić Po−Ru Loh Kathryn L. Lunetta Massimo Mangino Marco Brumat George McMahon Sarah E. Medland Ilja M. Nolte Raymond Noordam Teresa Nutile Lavinia Paternoster Natalia Perjakova Eleonora Porcu Lynda M. Rose Katharina E. Schraut Ayellet V. Segrè Albert V. Smith Lisette Stolk Alexander Teumer Irene L. Andrulis Stefania Bandinelli Matthias W. Beckmann Javier Benı́tez Sven Bergmann Murielle Bochud Eric Boerwinkle Stig E. Bojesen Manjeet K. Bolla Judith S. Brand Hiltrud Brauch Hermann Brenner Linda Broer Thomas Brüning Julie E. Buring Harry Campbell Eulalia Catamo Stephen J. Chanock Georgia Chenevix‐Trench Tanguy Corre Fergus J. Couch Diana L. Cousminer Angela Cox Laura Crisponi Kamila Czene George Davey Smith Eco J. C. de Geus Renée de Mutsert Immaculata De Vivo Joe Dennis Peter Devilee Isabel dos‐Santos‐Silva Alison M. Dunning Johan G. Eriksson Peter A. Fasching Lindsay Fernández‐Rhodes Luigi Ferrucci Dieter Flesch‐Janys Lude Franke Marike Gabrielson Ilaria Gandin Graham G. Giles Harald Grallert Daníel F. Guðbjartsson Pascal Guénel Per Hall Emily Hallberg Ute Hamann Tamara B. Harris Catharina A. Hartman Gerardo Heiss Maartje J. Hooning John L. Hopper Frank B. Hu David J. Hunter M. Arfan Ikram Hae Kyung Im Marjo‐Riitta Järvelin Peter K. Joshi David Karasik Manolis Kellis

10.1038/ng.3841 article EN Nature Genetics 2017-04-24
Nasim Mavaddat Paul D.P. Pharoah Kyriaki Michailidou Jonathan P. Tyrer Mark N. Brook and 95 more Manjeet K. Bolla Qin Wang Joe Dennis Alison M. Dunning Mitul Shah Robert Luben Judith Brown Stig E. Bojesen Børge G. Nordestgaard Sune F. Nielsen Henrik Flyger Kamila Czene Hatef Darabi Mikael Eriksson Julian Peto Isabel dos‐Santos‐Silva Frank Dudbridge Nichola Johnson Marjanka K. Schmidt Annegien Broeks Senno Verhoef Emiel J. Rutgers Anthony J. Swerdlow Alan Ashworth Nick Orr Minouk J. Schoemaker Jonine D. Figueroa Stephen J. Chanock Louise A. Brinton Jolanta Lissowska Fergus J. Couch Janet E. Olson Celine M. Vachon V. Shane Pankratz Diether Lambrechts Hans Wildiers Chantal Van Ongeval Erik Van Limbergen Vessela Kristensen Grethe Grenaker Alnæs Silje Nord Anne‐Lise Børresen‐Dale Heli Nevanlinna Taru Muranen Kristiina Aittomäki Carl Blomqvist Jenny Chang‐Claude Anja Rudolph Petra Seibold Dieter Flesch‐Janys Peter A. Fasching Lothar Haeberle Arif B. Ekici Matthias W. Beckmann Barbara Burwinkel Frederik Marmé Andreas Schneeweiß Christof Sohn Amy Trentham‐Dietz Polly A. Newcomb Linda Titus Kathleen M. Egan David J. Hunter Sara Lindström Rulla M. Tamimi Peter Kraft Nazneen Rahman Clare Turnbull Anthony Renwick Sheila Seal Jingmei Li Jianjun Liu Keith Humphreys Javier Benı́tez M. Pilar Zamora José Ignacio Arias Pérez Primitiva Menéndez Anna Jakubowska Jan Lubiński Katarzyna Jaworska–Bieniek Katarzyna Durda Natalia Bogdanova Natalia Antonenkova Thilo Dörk Hoda Anton‐Culver Susan L. Neuhausen Argyrios Ziogas Leslie Bernstein Peter Devilee Robert A.E.M. Tollenaar Caroline Seynaeve Christi J. van Asperen Angela Cox Simon S. Cross Malcolm Reed

Data for multiple common susceptibility alleles breast cancer may be combined to identify women at different levels of risk. Such stratification could guide preventive and screening strategies. However, empirical evidence genetic risk is lacking. We investigated the value using 77 cancer-associated single nucleotide polymorphisms (SNPs) stratification, in a study 33 673 cases 381 control European origin. tested all possible pair-wise multiplicative interactions constructed 77-SNP polygenic...

10.1093/jnci/djv036 article EN cc-by JNCI Journal of the National Cancer Institute 2015-04-02
Stig E. Bojesen Karen A. Pooley Sharon E. Johnatty Jonathan Beesley Kyriaki Michailidou and 95 more Jonathan P. Tyrer Stacey L. Edwards Hilda A. Pickett Howard C. Shen Chanel E. Smart Kristine M. Hillman L. Phuong Kate Lawrenson Michael D. Stutz Yi Lu Rod Karevan Nicholas T. Woods Rebecca L. Johnston Juliet D. French Xiaohong Chen Maren Weischer Sune F. Nielsen Melanie Maranian Maya Ghoussaini Shahana Ahmed Caroline Baynes Manjeet K. Bolla Qin Wang Joe Dennis Lesley McGuffog Daniel Barrowdale Andrew Lee Sue Healey Michael Lush Daniel C. Tessier Daniel Vincent Françis Bacot Ignace Vergote Sandrina Lambrechts Evelyn Despierre Harvey A. Risch Anna González‐Neira Mary Anne Rossing Guillermo Pita Jennifer A. Doherty Núria Álvarez Melissa C. Larson Brooke L. Fridley Nils Schoof Jenny Chang‐Claude Mine Cicek Julian Peto Kimberly R. Kalli Annegien Broeks Sebastian M. Armasu Marjanka K. Schmidt Linde M. Braaf Boris Winterhoff Heli Nevanlinna Gottfried E. Konecny Diether Lambrechts Lisa Rogmann Pascal Guénel Attila Teoman Roger L. Milne Joaquín J. García Angela Cox Vijayalakshmi Shridhar Barbara Burwinkel Frederik Marmé Rebecca Hein Elinor J. Sawyer Christopher A. Haiman Shan Wang‐Gohrke Irene L. Andrulis Kirsten B. Moysich John L. Hopper Kunle Odunsi Annika Lindblom Graham G. Giles Hermann Brenner Jacques Simard Galina Lurie Peter A. Fasching Michael E. Carney Paolo Radice Lynne R. Wilkens Anthony J. Swerdlow Marc T. Goodman Hiltrud Brauch Montserrat García‐Closas Peter Hillemanns Robert Winqvist Matthias Dürst Peter Devilee Ingo B. Runnebaum Anna Jakubowska Jan Lubiński Graham J. Mann Ralf Bützow

10.1038/ng.2566 article EN Nature Genetics 2013-03-27

Rationale: Patients with chronic obstructive pulmonary disease (COPD) have an ongoing systemic inflammation, which can be assessed by measuring serum C-reactive protein (CRP).Objective: To determine whether increased CRP in individuals airway obstruction predicts future hospitalization and death from COPD.Methods: We performed a cohort study median of 8-yr follow-up 1,302 selected the Copenhagen City Heart Study.Measurements Main Results: measured at baseline, recorded COPD admissions deaths...

10.1164/rccm.200605-713oc article EN American Journal of Respiratory and Critical Care Medicine 2006-10-20
Shahana Ahmed Gilles Thomas Maya Ghoussaini Catherine S. Healey Manjeet K. Humphreys and 95 more Radka Platte Jonathan J. Morrison Melanie Maranian Karen A. Pooley Robert Luben Diana Eccles D. Gareth Evans Olivia Fletcher Nichola Johnson Isabel dos‐Santos‐Silva Julian Peto Michael R. Stratton Nazneen Rahman Kevin B. Jacobs Ross L. Prentice Garnet L. Anderson Aleksandar Rajkovic J. David Curb Regina G. Ziegler Christine D. Berg Saundra S. Buys Catherine A. McCarty Heather Spencer Feigelson Eugenia E. Calle Michael J. Thun W. Ryan Diver Stig E. Bojesen Børge G. Nordestgaard Henrik Flyger Thilo Dörk Peter Schürmann Peter Hillemanns Johann H. Karstens Natalia Bogdanova Natalia Antonenkova Iosif V. Zalutsky Marina Bermisheva С.А. Федорова Э. К. Хуснутдинова Daehee Kang Keun-Young Yoo Dong‐Young Noh Sei-Hyun Ahn Peter Devilee Christi J. van Asperen Robert A.E.M. Tollenaar Caroline Seynaeve Montserrat García‐Closas Jolanta Lissowska Louise A. Brinton Beata Pepłońska Heli Nevanlinna Tuomas Heikkinen Kristiina Aittomäki Carl Blomqvist John L. Hopper Melissa C. Southey Letitia Smith Amanda B. Spurdle Marjanka K. Schmidt Annegien Broeks Richard R van Hien Sten Cornelissen Roger L. Milne Glòria Ribas Anna González‐Neira Javier Benı́tez Rita K. Schmutzler Barbara Burwinkel Claus R. Bartram Alfons Meindl Hiltrud Brauch Christina Justenhoven Ute Hamann Jenny Chang‐Claude Rebecca Hein Shan Wang‐Gohrke Annika Lindblom Sara Margolin Graham J. Mann Veli-Matti Kosma Vesa Kataja Janet E. Olson Xianshu Wang Zachary Fredericksen Graham G. Giles Gianluca Severi Laura Baglietto Dallas R. English Susan E. Hankinson David G. Cox Peter Kraft Lars J. Vatten Kristian Hveem Merethe Kumle

10.1038/ng.354 article EN Nature Genetics 2009-03-29

Biomarkers for the early diagnosis of patients with pancreatic cancer are needed to improve prognosis.To describe differences in microRNA expression whole blood between cancer, chronic pancreatitis, and healthy participants identify panels microRNAs use compared antigen 19-9 (CA19-9).A case-control study that included 409 25 pancreatitis who had been prospectively Danish BIOPAC (Biomarkers Patients Pancreatic Cancer) (July 2008-October 2012) plus 312 donors as participants. The expressions...

10.1001/jama.2013.284664 article EN JAMA 2014-01-21

We tested the hypothesis that baseline plasma levels of C-reactive protein (CRP) are associated with risk incident cancer in general population and early death patients cancer.A total 10,408 individuals from Danish who had CRP measured at were observed for up to 16 years; 1,624 developed cancer, these, 998 died during follow-up. Follow-up was 100% complete. excluded a diagnosis baseline.Baseline more than 3 versus less 1 mg/L multifactorially adjusted hazard ratios 1.3 (95% CI, 1.0 1.6) any...

10.1200/jco.2008.19.8440 article EN Journal of Clinical Oncology 2009-03-17
Montserrat García‐Closas Fergus J. Couch Sara Lindström Kyriaki Michailidou Marjanka K. Schmidt and 95 more Mark N. Brook Nick Orr Suhn K. Rhie Elio Ríboli Heather Spencer Feigelson Loı̈c Le Marchand Julie E. Buring Diana Eccles Penelope Miron Peter A. Fasching Hiltrud Brauch Jenny Chang‐Claude Jane Carpenter Andrew K. Godwin Heli Nevanlinna Graham G. Giles Angela Cox John L. Hopper Manjeet K. Bolla Qin Wang Joe Dennis Ed Dicks Will J Howat Nils Schoof Stig E. Bojesen Diether Lambrechts Annegien Broeks Irene L. Andrulis Pascal Guénel Barbara Burwinkel Elinor J. Sawyer Antoinette Hollestelle Olivia Fletcher Robert Winqvist Hermann Brenner Graham J. Mann Ute Hamann Alfons Meindl Annika Lindblom Wei Zheng Peter Devillee Mark S. Goldberg Jan Lubiński Vessela N. Kristensen Anthony J. Swerdlow Hoda Anton‐Culver Thilo Dörk Kenneth Muir Keitaro Matsuo Anna H. Wu Paolo Radice Soo‐Hwang Teo Xiao‐Ou Shu William J. Blot Daehee Kang Mikael Hartman Suleeporn Sangrajrang Chen‐Yang Shen Melissa C. Southey Daniel J. Park Fleur Hammet Jennifer Stone Laura J. van’t Veer Emiel J. Rutgers Artitaya Lophatananon Sarah Stewart‐Brown Pornthep Siriwanarangsan Julian Peto Michael Schrauder Arif B. Ekici Matthias W. Beckmann Isabel dos‐Santos‐Silva Nichola Johnson Helen R. Warren Ian Tomlinson Michael J. Kerin Nicola Miller F Marmé Andreas Schneeweiß Christof Sohn Thérèse Truong Pierre Laurent–Puig Pierre Kerbrat Børge G. Nordestgaard Sune F. Nielsen Henrik Flyger Roger L. Milne José Ignacio Arias Pérez Primitiva Menéndez Heiko Müller Volker Arndt Christa Stegmaier Peter Lichtner Magdalena Lochmann Christina Justenhoven

10.1038/ng.2561 article EN Nature Genetics 2013-03-27
Felix R. Day Katherine S. Ruth Deborah J. Thompson Kathryn L. Lunetta Natalia Pervjakova and 95 more Daniel I. Chasman Lisette Stolk Hilary K. Finucane Patrick Sulem Brendan Bulik‐Sullivan Tõnu Esko Andrew D. Johnson Cathy E. Elks Nora Franceschini Chunyan He Elisabeth Altmaier Jennifer A. Brody Lude Franke Jennifer E. Huffman Margaux F. Keller Patrick F. McArdle Teresa Nutile Eleonora Porcu Antonietta Robino Lynda M. Rose Ursula M. Schick Jennifer A. Smith Alexander Teumer Michela Traglia Dragana Vuckovic Jie Yao Wei Zhao Eva Albrecht Najaf Amin Tanguy Corre Jouke‐Jan Hottenga Massimo Mangino Albert V. Smith Toshiko Tanaka Gonçalo R. Abecasis Irene L. Andrulis Hoda Anton‐Culver Antonis C. Antoniou Volker Arndt Alice M. Arnold Caterina Barbieri Matthias W. Beckmann Alicia Beeghly‐Fadiel Javier Benı́tez Leslie Bernstein Suzette J. Bielinski Carl Blomqvist Eric Boerwinkle Natalia Bogdanova Stig E. Bojesen Manjeet K. Bolla Anne‐Lise Børresen‐Dale Thibaud Boutin Hiltrud Brauch Hermann Brenner Thomas Brüning Barbara Burwinkel Archie Campbell Harry Campbell Stephen J. Chanock J. Ross Chapman Yii-Der Ida Chen Georgia Chenevix‐Trench Fergus J. Couch Andrea D. Coviello Angela Cox Kamila Czene Hatef Darabi Immaculata De Vivo Ellen W. Demerath Joe Dennis Peter Devilee Thilo Dörk Isabel dos‐Santos‐Silva Alison M. Dunning John D. Eicher Peter A. Fasching Jessica D. Faul Jonine D. Figueroa Dieter Flesch‐Janys Ilaria Gandin Melissa E. Garcia Montserrat García‐Closas Graham G. Giles Giorgia Girotto Mark S. Goldberg Anna González‐Neira Mark O. Goodarzi Megan L. Grove Daníel F. Guðbjartsson Pascal Guénel Xiuqing Guo Christopher A. Haiman Per Hall Ute Hamann

10.1038/ng.3412 article EN Nature Genetics 2015-09-28
Montserrat García‐Closas Per Hall Heli Nevanlinna Karen A. Pooley Jonathan J. Morrison and 95 more Douglas Richesson Stig E. Bojesen Børge G. Nordestgaard C. K. Axelsson José Ignacio Arias Roger L. Milne Glòria Ribas Anna González‐Neira Javier Benı́tez Pilar Zamora Hiltrud Brauch Christina Justenhoven Ute Hamann Yon‐Dschun Ko Thomas Bruening Susanne Haas Thilo Dörk Peter Schürmann Peter Hillemanns Natalia Bogdanova Michael Bremer Johann H. Karstens Rainer Fagerholm Kirsimari Aaltonen Kristiina Aittomäki Karl von Smitten Carl Blomqvist Graham J. Mann Matti Uusitupa Matti Eskelinen Maria Tengström Veli‐Matti Kosma Vesa Kataja Georgia Chenevix‐Trench Amanda B. Spurdle Jonathan Beesley Xiaohong Chen Peter Devilee Christi J. van Asperen Catharina E. Jacobi Rob A.�E.�M. Tollenaar Petra E.A. Huijts Jan G.M. Klijn Jenny Chang‐Claude Silke Kropp Tracy Slanger Dieter Flesch‐Janys Elke Mutschelknauss Ramona Salazar Shan Wang‐Gohrke Fergus J. Couch Ellen L. Goode Janet E. Olson Celine M. Vachon Zachary S. Fredericksen Graham G. Giles Laura Baglietto Gianluca Severi John L. Hopper Dallas R. English Melissa C. Southey Christopher A. Haiman Brian E. Henderson Laurence N. Kolonel Loı̈c Le Marchand Daniel O. Stram David J. Hunter Susan E. Hankinson David G. Cox Rulla M. Tamimi Peter Kraft Mark E. Sherman Stephen J. Chanock Jolanta Lissowska Louise A. Brinton Beata Pepłońska Jan G.M. Klijn Maartje J. Hooning Han Meijers-Heijboer J. Margriet Collée Ans van den Ouweland André G. Uitterlinden Jianjun Liu Low Yen Lin Yuqing Li Keith Humphreys Kamila Czene Angela Cox Sabapathy P. Balasubramanian Simon S. Cross Malcolm Reed Fiona M. Blows Kristy Driver Alison M. Dunning Jonathan P. Tyrer

A three-stage genome-wide association study recently identified single nucleotide polymorphisms (SNPs) in five loci (fibroblast growth receptor 2 (FGFR2), trinucleotide repeat containing 9 (TNRC9), mitogen-activated protein kinase 3 K1 (MAP3K1), 8q24, and lymphocyte-specific 1 (LSP1)) associated with breast cancer risk. We investigated whether the associations between these SNPs risk varied by clinically important tumor characteristics up to 23,039 invasive cases 26,273 controls from 20...

10.1371/journal.pgen.1000054 article EN cc-by PLoS Genetics 2008-04-25
Roger L. Milne Karoline Kuchenbaecker Kyriaki Michailidou Jonathan Beesley Siddhartha Kar and 95 more Sara Lindström Shirley Hui Audrey Lemaçon Penny Soucy Joe Dennis Xia Jiang Asha Rostamianfar Hilary K. Finucane Manjeet K. Bolla Lesley McGuffog Qin Wang Cora M. Aalfs Marcia Adams Julian Adlard Simona Agata Shahana Ahmed Habibul Ahsan Kristiina Aittomäki Fares Al‐Ejeh Jamie Allen Christine B. Ambrosone Christopher I. Amos Irene L. Andrulis Hoda Anton‐Culver Natalia Antonenkova Volker Arndt Norbert Arnold Kristan J. Aronson Bernd Auber Paul L. Auer Margreet G.E.M. Ausems Jacopo Azzollini François Bacot Judith Balmañà Monica Barile Laure Barjhoux Rósa B. Barkardóttir Myrto Barrdahl Daniel R. Barnes Daniel Barrowdale Caroline Baynes Matthias W. Beckmann Javier Benı́tez Marina Bermisheva Leslie Bernstein Yves‐Jean Bignon Kathleen R. Blazer Marinus J. Blok Carl Blomqvist William J. Blot Kristie Bobolis Bram Boeckx Natalia Bogdanova Anders Bojesen Stig E. Bojesen Bernardo Bonanni Anne‐Lise Børresen‐Dale Anikó Bozsik Angela R. Bradbury Judith S. Brand Hiltrud Brauch Hermann Brenner Brigitte Bressac–de Paillerets Carole Brewer Louise A. Brinton Per Broberg Angela Brooks‐Wilson Joan Brunet Thomas Brüning Barbara Burwinkel Saundra S. Buys Jinyoung Byun Qiuyin Cai Trinidad Caldés Maria A. Caligo Ian Campbell Federico Canzian Olivier Caron Ángel Carracedo Brian D. Carter Jose E. Castelao Laurent Castéra Virginie Caux‐Moncoutier Salina Chan Jenny Chang‐Claude Stephen J. Chanock Xiaohong Chen Ting‐Yuan David Cheng Jocelyne Chiquette Hans Christiansen Kathleen Claes Christine L. Clarke Thomas Conner Don Conroy Jackie Cook

10.1038/ng.3785 article EN Nature Genetics 2017-10-23
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