Stig E. Bojesen
- BRCA gene mutations in cancer
- Genetic Associations and Epidemiology
- Nutrition, Genetics, and Disease
- Cancer Genomics and Diagnostics
- Epigenetics and DNA Methylation
- Nutritional Studies and Diet
- Genetic factors in colorectal cancer
- Pancreatic and Hepatic Oncology Research
- RNA modifications and cancer
- Inflammatory Biomarkers in Disease Prognosis
- Cancer Risks and Factors
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Bioinformatics and Genomic Networks
- Genomics and Chromatin Dynamics
- Telomeres, Telomerase, and Senescence
- Radiomics and Machine Learning in Medical Imaging
- Estrogen and related hormone effects
- Cancer-related molecular mechanisms research
- Genomic variations and chromosomal abnormalities
- Global Cancer Incidence and Screening
- Breast Cancer Treatment Studies
- Studies on Chitinases and Chitosanases
- Gene expression and cancer classification
- Adipokines, Inflammation, and Metabolic Diseases
- Molecular Biology Techniques and Applications
University of Copenhagen
2016-2025
Gentofte Hospital
2016-2025
Weatherford College
2025
Copenhagen University Hospital
2015-2024
Frederiksberg Hospital
2014-2024
Rigshospitalet
2001-2024
Capital Region of Denmark
2009-2024
Bispebjerg Hospital
2005-2023
Herlev Hospital
2013-2022
Cancer Research Center
2010-2021
Stratification of women according to their risk breast cancer based on polygenic scores (PRSs) could improve screening and prevention strategies. Our aim was develop PRSs, optimized for prediction estrogen receptor (ER)-specific disease, from the largest available genome-wide association dataset empirically validate PRSs in prospective studies. The development comprised 94,075 case subjects 75,017 control European ancestry 69 studies, divided into training validation sets. Samples were...
Genetic testing for breast cancer susceptibility is widely used, but many genes, evidence of an association with weak, underlying risk estimates are imprecise, and reliable subtype-specific lacking.
Common variation on 14q24.1, close to RAD51B, has been associated with breast cancer: rs999737 and rs2588809 the risk of female cancer rs1314913 male cancer. The aim this study was investigate role RAD51B variants in predisposition, particularly context familial Finland. We sequenced coding region 168 Finnish patients from Helsinki for identification possible recurrent founder mutations. In addition, we studied known rs999737, rs2588809, SNPs haplotypes 44,791 cases 43,583 controls 40...
Background Assessing the relationship between lung cancer and metabolic conditions is challenging because of confounding effect tobacco. Mendelian randomization (MR), or use genetic instrumental variables to assess causality, may help identify drivers cancer. Methods findings We identified instruments for potential risk factors evaluated these in relation using 29,266 cases (including 11,273 adenocarcinomas, 7,426 squamous cell 2,664 small cases) 56,450 controls. The MR analysis suggested a...
Genetic variations, such as single nucleotide polymorphisms (SNPs) in microRNAs (miRNA) or the miRNA binding sites may affect dependent gene expression regulation, which has been implicated various cancers, including breast cancer, and alter individual susceptibility to cancer. We investigated associations between related SNPs cancer risk. First we evaluated 2,196 a case-control study combining nine genome wide association studies (GWAS). Second, further 42 with suggestive evidence for using...
Data for multiple common susceptibility alleles breast cancer may be combined to identify women at different levels of risk. Such stratification could guide preventive and screening strategies. However, empirical evidence genetic risk is lacking. We investigated the value using 77 cancer-associated single nucleotide polymorphisms (SNPs) stratification, in a study 33 673 cases 381 control European origin. tested all possible pair-wise multiplicative interactions constructed 77-SNP polygenic...
Rationale: Patients with chronic obstructive pulmonary disease (COPD) have an ongoing systemic inflammation, which can be assessed by measuring serum C-reactive protein (CRP).Objective: To determine whether increased CRP in individuals airway obstruction predicts future hospitalization and death from COPD.Methods: We performed a cohort study median of 8-yr follow-up 1,302 selected the Copenhagen City Heart Study.Measurements Main Results: measured at baseline, recorded COPD admissions deaths...
Biomarkers for the early diagnosis of patients with pancreatic cancer are needed to improve prognosis.To describe differences in microRNA expression whole blood between cancer, chronic pancreatitis, and healthy participants identify panels microRNAs use compared antigen 19-9 (CA19-9).A case-control study that included 409 25 pancreatitis who had been prospectively Danish BIOPAC (Biomarkers Patients Pancreatic Cancer) (July 2008-October 2012) plus 312 donors as participants. The expressions...
We tested the hypothesis that baseline plasma levels of C-reactive protein (CRP) are associated with risk incident cancer in general population and early death patients cancer.A total 10,408 individuals from Danish who had CRP measured at were observed for up to 16 years; 1,624 developed cancer, these, 998 died during follow-up. Follow-up was 100% complete. excluded a diagnosis baseline.Baseline more than 3 versus less 1 mg/L multifactorially adjusted hazard ratios 1.3 (95% CI, 1.0 1.6) any...
A three-stage genome-wide association study recently identified single nucleotide polymorphisms (SNPs) in five loci (fibroblast growth receptor 2 (FGFR2), trinucleotide repeat containing 9 (TNRC9), mitogen-activated protein kinase 3 K1 (MAP3K1), 8q24, and lymphocyte-specific 1 (LSP1)) associated with breast cancer risk. We investigated whether the associations between these SNPs risk varied by clinically important tumor characteristics up to 23,039 invasive cases 26,273 controls from 20...