Laura M. Yerges-Armstrong
A5010137415- Genetic Associations and Epidemiology
- Nutrition, Genetics, and Disease
- Genetic and phenotypic traits in livestock
- Growth Hormone and Insulin-like Growth Factors
- Genetic Mapping and Diversity in Plants and Animals
- Adipose Tissue and Metabolism
- Bone health and osteoporosis research
- Genomics and Rare Diseases
- Renal Diseases and Glomerulopathies
- Chronic Kidney Disease and Diabetes
- Osteoarthritis Treatment and Mechanisms
- Diet and metabolism studies
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Sex and Gender in Healthcare
- Epigenetics and DNA Methylation
- Wnt/β-catenin signaling in development and cancer
- Health, Environment, Cognitive Aging
- Bone Metabolism and Diseases
- Genetics, Aging, and Longevity in Model Organisms
- Renal and related cancers
- Genetic Syndromes and Imprinting
- Lipid metabolism and disorders
- Cancer-related molecular mechanisms research
- BRCA gene mutations in cancer
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
GlaxoSmithKline (United States)
2017-2024
Target (United States)
2017-2024
University of Maryland, Baltimore
2012-2019
GlaxoSmithKline (United Kingdom)
2019
GlaxoSmithKline (Netherlands)
2018-2019
Center for Genomic Science
2018
University of Maryland, College Park
2016
University of Pittsburgh
2010-2016
British Heart Foundation
2015
Institute of Cancer Research
2015
The UK Biobank is a prospective study of 502,543 individuals, combining extensive phenotypic and genotypic data with streamlined access for researchers around the world
SUMMARY The UK Biobank is a prospective study of 502,543 individuals, combining extensive phenotypic and genotypic data with streamlined access for researchers around the world. Here we describe first tranche large-scale exome sequence 49,960 participants, revealing approximately 4 million coding variants (of which ~98.4% have frequency < 1%). includes 231,631 predicted loss function variants, >10-fold increase compared to imputed same participants. Nearly all genes (>97%) had ≥1...
Gout is the most common cause of inflammatory arthritis worldwide, particularly in Pacific regions. We aimed to establish prevalence gout and hyperuricaemia French Polynesia, their associations with dietary habits, comorbidities, HLA-B*58:01 allele, current management disease.
Abstract Isolated populations can empower the identification of rare variation associated with complex traits through next generation association studies, but generalizability such findings remains unknown. Here we genotype 1,267 individuals from a Greek population isolate on Illumina HumanExome Beadchip, in search functional coding variants lipids traits. We find genome-wide significant evidence for between R19X, variant APOC3 , increased high-density lipoprotein and decreased triglycerides...
Abstract To characterize the extent and impact of ancestry-related biases in precision genomic medicine, we use 642 whole-genome sequences from Consortium on Asthma among African-ancestry Populations Americas (CAAPA) project to evaluate typical filters databases. We find significant correlations between estimated African ancestry proportions number variants per individual all variant classification sets but one. The source these is highlighted more detail by looking at interaction filtering...
Abstract More than 100 loci have been identified for age at menarche by genome-wide association studies; however, collectively these explain only ∼3% of the trait variance. Here we test two overlooked sources variation in 192,974 European ancestry women: low-frequency protein-coding variants and X-chromosome variants. Five missense/nonsense (in ALMS1 / LAMB2 TNRC6A/TACR3/PRKAG1 ) are associated with (minor allele frequencies 0.08–4.6%; effect sizes 0.08–1.25 years per allele; P <5 × 10 −8...
Abstract Rosacea is a common, chronic skin disease of variable severity with limited treatment options. The cause rosacea unknown, but it believed to be due combination hereditary and environmental factors. Little known about the genetics disease. We performed genome-wide association study (GWAS) symptom data from 73 265 research participants European ancestry 23andMe customer base. Seven loci had variants associated at significance level (P < 5 × 10−8). Further analyses highlighted...
Background: The aim of this study was to investigate overall vitamin D status in the Faroese population and assess correlation between levels various sociodemographic anthropometric factors, including sex, age, exercise, alcohol tobacco consumption, BMI, body fat percentage, seasonal variations. To best our knowledge, is first across all adult age groups within population. Methods: P25-hydroxyvitamin concentrations, measurements questionnaires from 1748 individuals enrolled FarGen 2 cohort...
Homozygosity for the SERPINA1 Z allele causes α 1 -antitrypsin deficiency, a rare condition that can cause lung and liver disease. However, effects of heterozygosity on nonrespiratory phenotypes, function in general population, remain unclear. We conducted large, population-based study to determine >2400 phenotypes UK Biobank (N=303 353). was strongly associated with increased height (β=1.02 cm, p=3.91×10 −68 ), other including risk gall bladder disease, reduced heart disease lower blood...
Abstract Although low body weight is a risk factor for osteoporosis-related fractures, conflicting data exist the association between adiposity and bone mineral density (BMD). Studies examining these relationships have measured fat BMD with dual-energy X-ray absorptiometry (DXA), which cannot distinguish subcutaneous adipose tissue area (SAT) from total or trabecular cortical bone. To investigate relationship further, we analyzed composition distribution by quantitative computed tomography...
Objective. The etiology of knee osteoarthritis (OA), the most common form arthritis, is complex and may differ by race or ethnicity. In recent years, genetic studies have identified many variants associated with OA, but nearly all were conducted in European whites Asian Americans. Few focused on genetics OA African Methods. We performed a genome-wide association study radiographic 1217 Americans from 2 North American cohort studies: 590 subjects Johnston County Osteoarthritis Project 627...