A5039495379- Reproductive System and Pregnancy
- Pregnancy and preeclampsia studies
- Uterine Myomas and Treatments
- Endometriosis Research and Treatment
- Birth, Development, and Health
- Endometrial and Cervical Cancer Treatments
- Pregnancy and Medication Impact
- Ovarian cancer diagnosis and treatment
- Advanced Optical Sensing Technologies
- Advanced Measurement and Detection Methods
- Breast Implant and Reconstruction
- Sarcoma Diagnosis and Treatment
- Maternal and fetal healthcare
- Medical and Health Sciences Research
- Gestational Diabetes Research and Management
- Gynecological conditions and treatments
- Growth Hormone and Insulin-like Growth Factors
- Pregnancy-related medical research
- Reproductive Physiology in Livestock
- Health and Medical Studies
- Infrared Target Detection Methodologies
- Preterm Birth and Chorioamnionitis
- Angiogenesis and VEGF in Cancer
- Blood Coagulation and Thrombosis Mechanisms
- Cancer and Skin Lesions
Universitätsmedizin Greifswald
2016-2025
Klinik für Frauenheilkunde
2009-2025
Universität Greifswald
2015-2024
Military University of Technology in Warsaw
2013-2024
Klinik und Poliklinik für Frauenheilkunde und Geburtshilfe
2007-2021
Olgahospital
2013-2020
British Heart Foundation
2015
Institute of Cancer Research
2015
Cancer Council Victoria
2015
Medical Research Council
2015
Angiogenesis and vascular remodeling are crucial processes in tumor invasion metastasis as well embryo implantation normal development of the placenta. We have previously shown that hCG expressed trophoblast various malignant tumors promotes cellular motility uterine endothelium expresses hCG/LH receptor vivo. In this study was proposed to promote angiogenesis. A three-dimensional vitro angiogenesis system consisting microvascular endothelial cells seeded on microcarriers entrapped a fibrin...
Gestational diabetes mellitus (GDM) is the most frequent complication during pregnancy. Untreated GDM a severe threat to maternal and neonatal health. Based on recent evidence, up 15% of all pregnancies may be affected by GDM. We hypothesized that in rural birth cohort, higher BMI adverse socioeconomic conditions would promote GDM, which turn lead effects pregnancy outcomes.
Objective. Low total testosterone levels (TT) have been associated with increased morbidity and mortality. However, the prevalence incidence of deficiency (TD) in association its risk has not assessed systematically to date.Methods. Data from prospective population-based Study Health Pomerania were used. From 2117 men aged 20–79 years at baseline, 1490 complete TT data analysed. Crude age-specific rates TD estimated by below 10th percentile. Analysis covariance Poisson regression models used...
Pregnancy hides an immunological riddle combining two antagonistic characteristics of immunology: the existence a tolerance that allows gestation semiallogeneic fetus and proper protection against pathogens threatening health immunocompromised mother. Despite fundamental role B cells play in orchestrating immune response, their behavior context pregnancy has been barely investigated. Here we demonstrate numbers pre/pro immature were progressively diminished bone marrow (BM) pregnant mice,...
BACKGROUNDTransmural uterine compression suturing methods are a fertility-preserving alternative in patients with atonic primary postpartum hemorrhage (PPPH), which does not respond to manual or drugs. This study evaluated the effectiveness of modified U-suturing technique effecting PPPH after Cesarean section.
We have previously shown that both HCG and insulin-like growth factor-II (IGF-II) stimulate trophoblastic invasion. Furthermore, the invasion-promoting function of IGF-II resulted from mannose 6-phosphate receptor (IGF-II/M6PR) activation. Since did not an additive effect on cell migration extravillous trophoblast (EVT) line, HTR-8 SVneo, we hypothesized actions are mediated via alterations in expression and/or axis. treatment (50-50,000 mU/ml) HTR-8/SVneo cells alter either factor-I or mRNA...
Individualized Medicine aims at providing optimal treatment for an individual patient a given time based on his specific genetic and molecular characteristics. This requires excellent clinical stratification of patients as well the availability genomic data biomarkers prerequisites development novel diagnostic tools therapeutic strategies. The University Greifswald, Germany, has launched "Greifswald Approach to Medicine" (GANI_MED) project address major challenges Medicine. Herein, we...
The success of eutherian mammal evolution was certainly supported by the ability already existing immune system to adapt presence semi-allogeneic fetus without losing capability defend mother against infections. This required acquisition highly regulated and coordinated immunological mechanisms. Failures in development these strategies not only lead interruption pregnancy but also compromise maternal health. Alongside changes on cytokine profile - expansion tolerogenic dendritic regulatory T...
Abstract More than 100 loci have been identified for age at menarche by genome-wide association studies; however, collectively these explain only ∼3% of the trait variance. Here we test two overlooked sources variation in 192,974 European ancestry women: low-frequency protein-coding variants and X-chromosome variants. Five missense/nonsense (in ALMS1 / LAMB2 TNRC6A/TACR3/PRKAG1 ) are associated with (minor allele frequencies 0.08–4.6%; effect sizes 0.08–1.25 years per allele; P <5 × 10 −8...
Summary A significant number of hematopoietic stem/progenitor cells (HSPC) in human umbilical cord blood could serve as a reservoir for the placental vasculature, yet, their morphological and functional features are not completely understood. Here, we describe characterization purified CD133+ progenitor from blood, subset CD34+ progenitors that were grown proliferation medium containing Flt3-ligand, thrombopoietin stem cell factor. Following isolation enrichment by immunomagnetic sorting,...
Adaptation of the maternal uterine vasculature is essential for normal fetal and placental development in which angiogenesis considered one most critical adaptive changes during pregnancy. Highly expressed cytotrophoblasts endothelial cells pregnancy, IGF-II promotes cell migration regulates growth. We hypothesized that Both isolated microvascular high levels IGF-II/mannose-6 phosphate receptor mRNA as shown by situ hybridization. Physiological concentrations significantly increased vessel...
Several types of peripheral blood cells express ABC transporters. ABCC4 (MRP4) and ABCC5 (MRP5) localize to different cellular sites fulfill lineage-specific functions such as mediator storage in platelets' dense granules. All mature originate from the same precursor specific functionalities arise during differentiation. To characterize this process, expression, localization function MRP4 MRP5 were assessed differentiating human CD34+ progenitors leukemia cell lines using real time...
The subtle interaction between the implanting embryo and maternal endometrium plays a pivotal role during process of implantation. Human endometrial stromal cells (ESCs) express Fas trophoblast secrete ligand (FASLG, FasL), suggesting possible for Fas-mediated signaling early Here we show that ESCs are primarily resistant to apoptosis independently their state hormonal differentiation. Pre-treatment with interferon (IFN)-γ tumor necrosis factor (TNF)-α sensitizes them become apoptotic upon...
Various cytokines derived from placental cells are essential for normal placenta development and successful pregnancy. Interleukin-6 (IL-6) is a multifunctional cytokine produced by extravillous cytotrophoblasts regulating the functions of these cells, e.g. migration, invasion, trophoblast differentiation proliferation. In macrophages, newly synthesized IL-6 accumulates in Golgi complex exits tubulovesicular carriers fused with recycling endosomes secreted as soluble protein....