A5028761825- Asthma and respiratory diseases
- Allergic Rhinitis and Sensitization
- Sinusitis and nasal conditions
- Occupational exposure and asthma
- Contact Dermatitis and Allergies
- Food Allergy and Anaphylaxis Research
- Drug-Induced Adverse Reactions
- Respiratory and Cough-Related Research
- Indoor Air Quality and Microbial Exposure
- Dermatology and Skin Diseases
- Urticaria and Related Conditions
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Inhalation and Respiratory Drug Delivery
- Immunodeficiency and Autoimmune Disorders
- IL-33, ST2, and ILC Pathways
- Otitis Media and Relapsing Polychondritis
- Mast cells and histamine
- Nasal Surgery and Airway Studies
- Occupational and environmental lung diseases
- Eosinophilic Esophagitis
- Pediatric health and respiratory diseases
- Cystic Fibrosis Research Advances
- Monoclonal and Polyclonal Antibodies Research
- Head and Neck Surgical Oncology
- Olfactory and Sensory Function Studies
Northwestern University
2016-2025
ENT and Allergy
2003-2019
Johns Hopkins Hospital
2019
Midwestern University
2016
Uppsala University
2013
British School at Rome
2013
AO Foundation
2013
Menlo School
2013
Northwestern University
2013
Northwestern Memorial Hospital
1984-2012
During neuronal-induced inflammation, mast cells may respond to stimuli such as neuropeptides in an FcepsilonRI-independent manner. In this study, we characterized human cell responses substance P (SP), nerve growth factor (NGF), calcitonin gene-related peptide (CGRP) and vasoactive intestinal polypeptide (VIP) compared these immunoglobulin E (IgE)/anti-IgE compound 48/80. Primary cultured cells, generated from CD34(+) progenitors the presence of stem interleukin-6 (IL-6), (LAD2) were...
The mechanisms that underlie the pathogenesis of chronic rhinosinusitis without nasal polyps (CRSsNP), with (CRSwNP), and aspirin-exacerbated respiratory disease (AERD) are not clear.To first evaluate inflammatory profiles CRSsNP CRSwNP tissues then to investigate whether clinical differences observed between AERD in part secondary mediator expression within polyp (NP) tissues.Expression levels numerous mediators were determined by quantitative real-time polymerase chain reaction, ELISA,...
Background The effect of comorbid conditions such as asthma and atopy on the severity chronic rhinosinusitis (CRS) presence nasal polyps (NPs) remains an area investigation. We sought to elucidate relationship among these entities. Methods study population included 106 consecutive patients who were referred a multidisciplinary, university-based allergy sinus clinic that underwent computed tomography (CT) scan, skin-prick testing, had CRS. Data analyzed determine Lund-MacKay score (LMS), NPs,...
Background There is a clinical association between asthma and chronic rhinosinusitis (CRS). This study was designed to determine whether severity of coexistent affects the presentation CRS. Methods Cross-sectional analysis performed prospectively collected data in 187 patients with CRS who were evaluated large, tertiary academic nasal sinus center. Patients stratified into three groups based on status using National Institutes Health criteria: (1) nonasthmatic, (2) intermittent/mild asthma,...
Leukocytes of only one 11 nonatopic donors could be passively sensitized for histamine release elicited by ragweed extract. A short incubation in an unbuffered isotonic saline at pH 3.9 or 0.01 M lactic acid/lactate-buffered dissociated from 4 X 10(5) to less than 3 10(4) IgE molecules per basophil washed leukocytes several a series six atopic and donors. After such treatment, the not release. Basophils four ragweed-sensitive lost their sensitivity after but all resensitized; three these...
Abstract The African Diaspora in the Western Hemisphere represents one of largest forced migrations history and had a profound impact on genetic diversity modern populations. To date, fine-scale population structure descendants remains largely uncharacterized. Here we present variation from deeply sequenced genomes 642 individuals North South American, Caribbean West populations, substantially increasing lexicon human genomic suggesting much to be discovered African-admixed populations...
Nasal polyps (NPs) are characterized by intense edema or formation of pseudocysts filled with plasma proteins, mainly albumin. However, the mechanisms underlying NP retention proteins in their submucosa remain unclear.We hypothesized that a fibrin mesh retains NPs. We assessed deposition and expression components fibrinolytic system patients chronic rhinosinusitis (CRS).We nasal tissue from CRS control subjects means immunofluorescence. Fibrinolytic components, d-dimer, plasminogen...