M. Pilar Zamora
A5076914104- Finance, Taxation, and Governance
- BRCA gene mutations in cancer
- Corporate Taxation and Avoidance
- Genetic Associations and Epidemiology
- Accounting and Financial Management
- Estrogen and related hormone effects
- Business, Education, Mathematics Research
- HER2/EGFR in Cancer Research
- Taxation and Legal Issues
- Cytokine Signaling Pathways and Interactions
- Genetic factors in colorectal cancer
- Genomic variations and chromosomal abnormalities
- Genomics and Chromatin Dynamics
- Gene expression and cancer classification
- Nutrition, Genetics, and Disease
- Comparative International Legal Studies
- RNA modifications and cancer
- Cancer Genomics and Diagnostics
- Administrative Law and Governance
- Cancer Risks and Factors
- Computational Drug Discovery Methods
- Financial Reporting and Valuation Research
- Bioinformatics and Genomic Networks
- DNA Repair Mechanisms
- Health Systems, Economic Evaluations, Quality of Life
Hospital Universitario La Paz
2010-2025
Universidad de Huelva
1998-2025
Cancer Research Center
2015-2021
University of Manchester
2021
St Mary's Hospital
2021
Edinburgh Cancer Research
2021
University Hospital Heidelberg
2015
University Medical Center Hamburg-Eppendorf
2015
University of Copenhagen
2015
Vanderbilt University
2015
Data for multiple common susceptibility alleles breast cancer may be combined to identify women at different levels of risk. Such stratification could guide preventive and screening strategies. However, empirical evidence genetic risk is lacking. We investigated the value using 77 cancer-associated single nucleotide polymorphisms (SNPs) stratification, in a study 33 673 cases 381 control European origin. tested all possible pair-wise multiplicative interactions constructed 77-SNP polygenic...
The rarity of mutations in PALB2, CHEK2 and ATM make it difficult to estimate precisely associated cancer risks. Population-based family studies have provided evidence that at least some these are with breast risk as high those rare BRCA2 mutations. We aimed the relative risks specific variants via a multicentre case-control study.
BackgroundA recent genome-wide association study identified single-nucleotide polymorphism (SNP) 2q35-rs13387042 as a marker of susceptibility to estrogen receptor (ER)–positive breast cancer. We attempted confirm this using the Breast Cancer Association Consortium.
Abstract Introduction Several common breast cancer genetic susceptibility variants have recently been identified. We aimed to determine how these combine with a subset of other known risk factors influence in white women European ancestry using case-control studies participating the Breast Cancer Association Consortium. Methods evaluated two-way interactions between each age at menarche, ever having had live birth, number births, first birth and body mass index (BMI) 12 single nucleotide...
Recent genome-wide association studies identified 11 single nucleotide polymorphisms (SNPs) associated with breast cancer (BC) risk. We investigated these and 62 other SNPs for their prognostic relevance. Confirmed BC risk rs17468277 (CASP8), rs1982073 (TGFB1), rs2981582 (FGFR2), rs13281615 (8q24), rs3817198 (LSP1), rs889312 (MAP3K1), rs3803662 (TOX3), rs13387042 (2q35), rs4973768 (SLC4A7), rs6504950 (COX11) rs10941679 (5p12) were genotyped 25 853 patients the available follow-up; SNPs,...
A genome-wide association study (GWAS) identified single-nucleotide polymorphisms (SNPs) at 1p11.2 and 14q24.1 (RAD51L1) as breast cancer susceptibility loci. The initial GWAS suggested stronger effects for both loci estrogen receptor (ER)-positive tumors. Using data from the Breast Cancer Association Consortium (BCAC), we sought to determine whether risks differ by ER, progesterone (PR), human epidermal growth factor 2 (HER2), grade, node status, tumor size, ductal or lobular morphology. We...
Genome-wide association studies (GWASs) have revealed SNP rs889312 on 5q11.2 to be associated with breast cancer risk in women of European ancestry. In an attempt identify the biologically relevant variants, we analyzed 909 genetic variants across 103,991 individuals and control from 52 Breast Cancer Association Consortium. Multiple logistic regression analyses identified three independent signals: strongest associations were 15 correlated (iCHAV1), where minor allele best candidate,...
Candidate variant association studies have been largely unsuccessful in identifying common breast cancer susceptibility variants, although most underpowered to detect associations of a realistic magnitude. We assessed 41 non-synonymous single-nucleotide polymorphisms (nsSNPs) for which evidence with risk had previously reported. Case-control data were combined from 38 white European women (46 450 cases and 42 600 controls) analyzed using unconditional logistic regression. Strong was observed...
Background/Objectives: The EndoPredict® assay has been widely used in recent years to estimate the risk of distant recurrence and absolute chemotherapy benefit for patients with estrogen (ER)-positive/human epidermal growth factor receptor 2 (HER2)-negative breast cancer. However, there are no well-defined criteria selecting who may from test. aim this study was develop a novel nomogram probability obtaining high-risk result clinical practice. Methods: cohort comprised 348 cases...
A pesar del riesgo en los ámbitos contable y fiscal que supone el mantenimiento largo plazo de la cuenta efectivo con socios, se trata una práctica habitual empresa española. Este artículo centra las diferentes soluciones pueden ser utilizadas para eliminar saldo deudor 551 y, por tanto, minimización consecuencias contables fiscales podrían producir sociedad sus socios. Para ello, lleva a cabo un doble análisis desde enfoque. Concretamente, estudian está continúa funcionamiento, así como...
The 6q25.1 locus was first identified via a genome-wide association study (GWAS) in Chinese women and marked by single nucleotide polymorphism (SNP) rs2046210, approximately 180 Kb upstream of ESR1. There have been conflicting reports about the this with breast cancer Europeans, GWAS Europeans different SNP, tagged here rs12662670. We examined associations both SNPs up to 61,689 cases 58,822 controls from forty-four studies collaborating Breast Cancer Association Consortium, which four were...
Abstract Introduction We have previously shown that a tag single nucleotide polymorphism (rs10235235), which maps to the CYP3A locus (7q22.1), was associated with reduction in premenopausal urinary estrone glucuronide levels and modest risk of breast cancer women age ≤50 years. Methods further investigated association rs10235235 large case control study 47,346 cases 47,570 controls from 52 studies participating Breast Cancer Association Consortium. Genotyping conducted using custom Illumina...
Previous studies have suggested that polymorphisms in CASP8 on chromosome 2 are associated with breast cancer risk. To clarify the role of susceptibility, we carried out dense genotyping this region Breast Cancer Association Consortium (BCAC). Single-nucleotide (SNPs) spanning a 1 Mb around were genotyped 46 450 cases and 42 600 controls European origin from 41 participating BCAC as part custom array experiment (iCOGS). Missing genotypes SNPs imputed and, after quality exclusions, 501 typed...
We recently identified a novel susceptibility variant, rs865686, for estrogen-receptor positive breast cancer at 9q31.2. Here, we report fine-mapping analysis of the 9q31.2 locus using 43 160 cases and 42 600 controls European ancestry ascertained from 52 studies further 5795 6624 Asian nine studies. Single nucleotide polymorphism (SNP) rs676256 was most strongly associated with risk in Europeans (odds ratios [OR] = 0.90 [0.88–0.92]; P-value 1.58 × 10−25). This SNP is one cluster highly...
A recent two-stage genome-wide association study (GWAS) identified five novel breast cancer susceptibility loci on chromosomes 9, 10, and 11. To provide more reliable estimates of the relative risk associated with these investigate possible heterogeneity by subtype cancer, we genotyped variants rs2380205, rs1011970, rs704010, rs614367, rs10995190 in 39 studies from Breast Cancer Association Consortium (BCAC), involving 49,608 cases 48,772 controls predominantly European ancestry. Four showed...
Abstract Part of the substantial unexplained familial aggregation breast cancer may be due to interactions between common variants, but few studies have had adequate statistical power detect realistic magnitude. We aimed assess all two-way in susceptibility 70 917 single nucleotide polymorphisms (SNPs) selected primarily based on prior evidence a marginal effect. Thirty-eight international contributed data for 46 450 cases and 42 461 controls European origin as part multi-consortium project...
Abstract Background: The single-nucleotide polymorphism (SNP) 5p12-rs10941679 has been found to be associated with risk of breast cancer, particularly estrogen receptor (ER)-positive disease. We aimed further explore this association overall, and by tumor histopathology, in the Breast Cancer Association Consortium. Methods: Data were combined from 37 studies, including 40,972 invasive cases, 1,398 cases ductal carcinoma situ (DCIS), 46,334 controls, all white European ancestry, as well 3,007...
The chromosomal passenger complex (CPC) plays a pivotal role in the regulation of cell division. Therefore, inherited CPC variability could influence tumor development. present candidate gene approach investigates relationship between single nucleotide polymorphisms (SNPs) genes encoding key components and breast cancer risk. Fifteen SNPs four (INCENP, AURKB, BIRC5 CDCA8) were genotyped 88 911 European women from 39 case-control studies Breast Cancer Association Consortium. Possible...
Our recent genome-wide association study identified a novel breast cancer susceptibility locus at 9q31.2 (rs865686).To further investigate the rs865686-breast association, we conducted replication within Breast Cancer Association Consortium, which comprises 37 case-control studies (48,394 cases, 50,836 controls).This provides additional strong evidence of an inverse between rs865686 and risk [study-adjusted per G-allele OR, 0.90; 95% confidence interval (CI), 0.88; 0.91, P = 2.01 × 10(-29)]...