A5069828946- Genetic and phenotypic traits in livestock
- Genetic Mapping and Diversity in Plants and Animals
- Milk Quality and Mastitis in Dairy Cows
- Meat and Animal Product Quality
- Cancer-related molecular mechanisms research
- Occupational and environmental lung diseases
- Air Quality and Health Impacts
- Sperm and Testicular Function
- Reproductive Physiology in Livestock
- Mycobacterium research and diagnosis
- Animal Genetics and Reproduction
- Genetic Associations and Epidemiology
- Animal Nutrition and Physiology
- Probiotics and Fermented Foods
- Agriculture and Rural Development Research
- Nutrition, Genetics, and Disease
- Occupational exposure and asthma
- BRCA gene mutations in cancer
- Carcinogens and Genotoxicity Assessment
- Prostate Cancer Diagnosis and Treatment
- Gut microbiota and health
- Aquaculture Nutrition and Growth
- Wheat and Barley Genetics and Pathology
- Head and Neck Cancer Studies
- Ruminant Nutrition and Digestive Physiology
Génétique Animale et Biologie Intégrative
2015-2024
AgroParisTech
2014-2024
Institut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement
2020-2024
Université Paris-Saclay
2016-2024
Hôpital Bichat-Claude-Bernard
2023
Centre de recherche en Epidémiologie et Santé des Populations
2013-2019
Inserm
2013-2019
Université Paris-Sud
2013-2019
Université de Versailles Saint-Quentin-en-Yvelines
2016-2019
Hôpital l'Archet
2017
The rarity of mutations in PALB2, CHEK2 and ATM make it difficult to estimate precisely associated cancer risks. Population-based family studies have provided evidence that at least some these are with breast risk as high those rare BRCA2 mutations. We aimed the relative risks specific variants via a multicentre case-control study.
Background There is extensive epidemiological evidence that menopausal hormone therapy (MHT) increases breast cancer risk, particularly combinations of estrogen and progestagen (EP). We investigated the effects specific formulations types therapies used by French women. Progestagen constituents, regimen (continuous or sequential treatment progestagen), time interval between onset menopause start MHT were examined. Methods conducted a population-based case-control study in France 1555 women...
Genome-wide association studies (GWAS) were performed at the sequence level to identify candidate mutations that affect expression of six major milk proteins in Montbéliarde (MON), Normande (NOR), and Holstein (HOL) dairy cattle. Whey protein (α-lactalbumin β-lactoglobulin) casein (αs1, αs2, β, κ) contents estimated by mid-infrared (MIR) spectrometry, with medium high accuracy (0.59 ≤ R2 0.92), for 848,068 test-day samples from 156,660 cows first three lactations. Milk composition was...
Abstract The Chernobyl accident, which occurred April 26, 1986, resulted in a large release of radionuclides, were deposited over very wide area, particularly Europe. Although an increased risk thyroid cancer exposed children has been clearly demonstrated the most contaminated regions, impact accident on other cancers as well elsewhere Europe is less clear. objective present study was to evaluate human burden whole from radioactive fallout accident. Average country‐ and region‐specific...
Genome-wide association studies (GWASs) have revealed SNP rs889312 on 5q11.2 to be associated with breast cancer risk in women of European ancestry. In an attempt identify the biologically relevant variants, we analyzed 909 genetic variants across 103,991 individuals and control from 52 Breast Cancer Association Consortium. Multiple logistic regression analyses identified three independent signals: strongest associations were 15 correlated (iCHAV1), where minor allele best candidate,...
Night shift work has been associated with an increased risk of breast cancer pointing to a role circadian disruption. We investigated the clock gene polymorphisms and their interaction nightwork in population-based case–control study France including 1126 cases 1174 controls. estimated each 577 single nucleotide (SNPs) 23 genes. also used gene- pathway-based approach investigate overall effect on variants that might not be detected analyses based individual SNPs. Interactions were tested at...
Numerous quantitative trait loci (QTL) have been detected in pigs over the past 20 years using microsatellite markers. However, due to low density of these markers, accuracy QTL location has generally poor. Since 2009, dense genome coverage provided by Illumina PorcineSNP60 BeadChip made it possible more accurately map genome-wide association studies (GWAS). Our objective was perform high-density GWAS order identify genomic regions and corresponding haplotypes associated with production...
Conflicting results regarding alterations to sperm DNA methylation in cases of spermatogenesis defects, male infertility and poor developmental outcomes have been reported humans. Bulls used for artificial insemination represent a relevant model this field, as the broad dissemination bull semen considerably alleviates confounding factors enables precise assessment fertility. This study was therefore designed assess potential predict fertility.A unique collection 100 samples constituted by...
Intramuscular fat content is generally associated with improved sensory quality and better acceptability of fresh pork. However, conclusive evidence still lacking for the biological mechanisms underlying i.m. variability in pigs. The current study aimed to determine whether variations longissimus muscle are related adipocyte cellularity, lipid metabolism, or contractile properties whole muscle. To this end, crossbred (Large White x Duroc) pigs exhibiting either a high (2.82 +/- 0.38%, HF)...
Abstract Chronic inflammation may play a role in prostate cancer carcinogenesis. In that context, our objective was to investigate the of nonsteroidal anti‐inflammatory drugs ( NSAID s) risk based on EPICAP data. is population‐based case–control study carried out 2012–2013 département Hérault, France) enrolled 819 men aged less than 75 years old newly diagnosed for and 879 controls frequency matched cases age. Face face interviews gathered information several potential factors including s...
Milk quality in dairy cattle is routinely assessed via analysis of mid-infrared (MIR) spectra; this approach can also be used to predict the milk's cheese-making properties (CMP) and composition. When method high-throughput phenotyping combined with efficient imputations whole-genome sequence data from cows' genotyping data, it provides a unique powerful framework which carry out genomic analyses. The goal study was use identify genes gene networks associated milk CMP composition...
Abstract Background Over the last years, genome-wide association studies (GWAS) based on imputed whole-genome sequences (WGS) have been used to detect quantitative trait loci (QTL) and highlight candidate genes for important traits. However, in general this approach does not allow validate effects of mutations or determine if they are truly causative trait(s) question. To address these questions, we applied a two-step, within-breed GWAS 15 traits (5 linked with milk production, 2 udder...
Abstract Background Improving pork quality can be done by increasing intramuscular fat (IMF) content. This trait is influenced quantitative loci (QTL) sought out in different pig populations. Considering the high IMF content observed Duroc pig, it was appealing to determine whether favourable alleles at a major gene or QTL could found. The detection performed an experimental F2 × Large White population first segregation analysis, then mapping using additional molecular information. Results...
Abstract Background Bovine paratuberculosis is a contagious disease, caused by Mycobacterium avium subsp. (MAP), with adverse effects on animal welfare and serious economic consequences. Published results host genetic resistance to MAP are inconsistent, mainly because of difficulties in characterizing the infection status cows. The objectives this study were identify quantitative trait loci (QTL) for Holstein Normande cows an accurately defined MAP. Results From MAP-infected herds, without...