Annegien Broeks
- Cancer Immunotherapy and Biomarkers
- BRCA gene mutations in cancer
- Cancer Genomics and Diagnostics
- Breast Cancer Treatment Studies
- Genetic Associations and Epidemiology
- Genetic factors in colorectal cancer
- Cancer Risks and Factors
- Bladder and Urothelial Cancer Treatments
- Estrogen and related hormone effects
- Pancreatic and Hepatic Oncology Research
- Genomics and Chromatin Dynamics
- Nutrition, Genetics, and Disease
- DNA Repair Mechanisms
- Immunotherapy and Immune Responses
- Genomic variations and chromosomal abnormalities
- RNA modifications and cancer
- Gene expression and cancer classification
- Cancer-related Molecular Pathways
- Lung Cancer Research Studies
- HER2/EGFR in Cancer Research
- CAR-T cell therapy research
- Cancer Cells and Metastasis
- Urinary and Genital Oncology Studies
- Epigenetics and DNA Methylation
- Bioinformatics and Genomic Networks
The Netherlands Cancer Institute
2015-2024
Oncode Institute
2015-2024
Dutch Cancer Society
2017-2023
The University of Texas MD Anderson Cancer Center
2019
Utrecht University
2017-2019
Leiden University Medical Center
2006-2017
Catharina Ziekenhuis
2015-2017
Radboud University Nijmegen
2006-2017
Erasmus MC Cancer Institute
2009-2017
King's College London
2012-2017
Previous studies have suggested that breast cancer risk factors are associated with estrogen receptor (ER) and progesterone (PR) expression status of the tumors.
Genetic variations, such as single nucleotide polymorphisms (SNPs) in microRNAs (miRNA) or the miRNA binding sites may affect dependent gene expression regulation, which has been implicated various cancers, including breast cancer, and alter individual susceptibility to cancer. We investigated associations between related SNPs cancer risk. First we evaluated 2,196 a case-control study combining nine genome wide association studies (GWAS). Second, further 42 with suggestive evidence for using...
Data for multiple common susceptibility alleles breast cancer may be combined to identify women at different levels of risk. Such stratification could guide preventive and screening strategies. However, empirical evidence genetic risk is lacking. We investigated the value using 77 cancer-associated single nucleotide polymorphisms (SNPs) stratification, in a study 33 673 cases 381 control European origin. tested all possible pair-wise multiplicative interactions constructed 77-SNP polygenic...
Female survivors of Hodgkin's disease (HD) have a strongly elevated risk breast cancer, but factors responsible for the increased are not well known.We investigated effects radiation dose, chemotherapy (CT), and reproductive on cancer in nested case-control study The Netherlands cohort 770 female patients who had been diagnosed with HD before age 41. Detailed treatment information data were collected 48 case developed 5 or more years after diagnosis 175 matched control subjects. dose was...
Purpose We assessed the long-term risk of breast cancer (BC) after treatment for Hodgkin's lymphoma (HL). focused on volume tissue exposed to radiation and influence gonadotoxic chemotherapy (CT). Patients Methods performed a cohort study among 1,122 female 5-year survivors treated HL before age 51 years between 1965 1995. compared incidence BC with that in general population. To assess according hormone factors, we multivariate Cox regression analyses. Results After median follow-up 17.8...