Hans‐Peter Sinn
A5002219591- Breast Cancer Treatment Studies
- HER2/EGFR in Cancer Research
- Cancer Genomics and Diagnostics
- Breast Lesions and Carcinomas
- Cancer Immunotherapy and Biomarkers
- Advanced Breast Cancer Therapies
- Estrogen and related hormone effects
- Cancer Cells and Metastasis
- Cancer Treatment and Pharmacology
- BRCA gene mutations in cancer
- Gene expression and cancer classification
- Ovarian cancer diagnosis and treatment
- Breast Implant and Reconstruction
- Cancer-related Molecular Pathways
- Genomic variations and chromosomal abnormalities
- Cancer and Skin Lesions
- Computational Drug Discovery Methods
- Immunotherapy and Immune Responses
- Inflammatory mediators and NSAID effects
- Cancer, Stress, Anesthesia, and Immune Response
- Monoclonal and Polyclonal Antibodies Research
- Radiopharmaceutical Chemistry and Applications
- Medical Imaging Techniques and Applications
- Genetic factors in colorectal cancer
- Cancer Diagnosis and Treatment
Heidelberg University
2015-2024
University Hospital Heidelberg
2015-2024
Universitätsklinikum Aachen
2023
Universitätsklinikum des Saarlandes
2023
Klinik für Frauenheilkunde
2010-2023
University Hospital Frankfurt
2023
Goethe University Frankfurt
2003-2023
Martin Luther University Halle-Wittenberg
2007-2023
German Cancer Research Center
1995-2021
Deutschen Konsortium für Translationale Krebsforschung
2016-2021
Purpose Modulation of immunologic interactions in cancer tissue is a promising therapeutic strategy. To investigate the immunogenicity human epidermal growth factor receptor 2 (HER2) –positive and triple-negative (TN) breast cancers (BCs), we evaluated tumor-infiltrating lymphocytes (TILs) immunologically relevant genes neoadjuvant GeparSixto trial. Patients Methods investigated effect adding carboplatin (Cb) to an anthracycline-plus-taxane combination (PM) on pathologic complete response...
Previous studies have suggested that breast cancer risk factors are associated with estrogen receptor (ER) and progesterone (PR) expression status of the tumors.
While the diagnostic benefits of gadolinium (Gd)-chelate contrast agents are firmly established in magnetic resonance imaging (MRI) tumors, pathophysiologic basis enhancement observed and its histopathologic correlate remained vague. Tumor angiogenesis is fundamental for growth metastasis also interest new therapeutic concepts. By correlative analysis a) histology; b) vascular density (CD31); c) permeability (vascular factor/vascular endothelial factor [VPF/VEGF]), we found significantly (P...
Cytotoxic CD8+ tumor-infiltrating lymphocytes (TILs) participate in immune control of epithelial ovarian cancer; however, little is known about prognostic patterns TILs by histotype and relation to other clinical factors.
Phosphatidylinositol 3-kinase (PI3K)/AKT pathway aberrations are common in breast cancer, with mutations PIK3CA being the most common. This study investigated association between genotype and pathologic complete response (pCR) rates human epidermal growth factor receptor 2 (HER2)-positive cancer treated either dual or single anti-HER2 treatment addition to neoadjuvant chemotherapy.PIK3CA 504 tumor samples from participants GeparQuattro, GeparQuinto, GeparSixto studies were evaluated. All...
In Germany, most breast cancer patients are treated in specialized units (BCU), which certified, and routinely monitored. Herein, we evaluate up-to-date oncological outcome of (BC) molecular subtypes routine clinical care a BCU.The study was prospectively single-center cohort 4102 female cases with primary, unilateral, non-metastatic between 01 January 2003 31 December 2012. The five used (Luminal A-like, Luminal B/HER2 negative-like, positive-like, HER2-type, Triple negative) were analyzed....
Abstract Metastatic colonization relies on interactions between disseminated cancer cells and the microenvironment in secondary organs. Here, we show that breast evoke phenotypic changes lung fibroblasts, forming a supportive metastatic niche. Colonization of lungs confers an inflammatory phenotype metastasis-associated fibroblasts. Specifically, IL-1α IL-1β secreted by induce CXCL9 CXCL10 production fibroblasts via NF-κB signaling, fueling growth metastases. Notably, find chemokine receptor...
Abstract Disseminated cancer cells frequently lodge near vasculature in secondary organs. However, our understanding of the cellular crosstalk invoked at perivascular sites is still rudimentary. Here, we identify intercellular machinery governing formation a pro-metastatic vascular niche during breast colonization lung. We show that specific secreted factors, induced metastasis-associated endothelial (ECs), promote metastasis mice by enhancing stem cell properties and viability cells....
Breast cancers demonstrate substantial biological, clinical and etiological heterogeneity. We investigated breast cancer risk associations of eight susceptibility loci identified in GWAS two putative candidate genes relation to specific tumor subtypes. Subtypes were defined by five markers (ER, PR, HER2, CK5/6, EGFR) other pathological features. Analyses included up 30 040 invasive cases 53 692 controls from 31 studies within the Cancer Association Consortium. confirmed previous reports...
Purpose Primary systemic therapy (PST) with gemcitabine (G), epirubicin (E), and docetaxel (Doc) has resulted in a pathologic complete response (pCR) 26% of primary breast cancer patients. This study was aimed at the identification gene expression signature diagnostic core biopsy tissue samples that predicts pCR. Patients Methods Core from patients operable cancer, T2-4N0-2M0, enrolled onto two phase I II trials evaluating GEDoc (n = 48) GE sequentially followed by Doc (GEsDoc; n 52) as PST...
Abstract Loss of H4 lysine 16 (H4K16) acetylation was shown to be a common feature in human cancer. However, it remained unclear which enzyme is responsible for the loss this modification. Having recently identified histone acetyltransferase MOF (hMOF) required bulk H4K16 acetylation, here we examined involvement hMOF expression and breast cancer medulloblastoma. Analysis recent mRNA profiling study ( n = 100 cases) an array‐CGH screen medulloblastomas 102 cases), revealed downregulation 40%...
Over the last few years, circulating microRNAs (miRNAs) have emerged as promising novel and minimally invasive markers for various diseases, including cancer. We already showed that certain miRNAs are deregulated in plasma of breast cancer patients when compared to healthy women. Herein we further explored their potential serve early detection blood plasma. Circulating miR-127-3p, miR-376a miR-652, selected candidates from a miRNA array-based screening, were found be associated with first...
Abstract Triple-negative breast cancers are an aggressive subtype of cancer with poor survival, but there remains little known about the etiologic factors that promote its initiation and development. Commonly inherited risk identified through genome-wide association studies display heterogeneity effect among subtypes as defined by status estrogen progesterone receptors. In Triple Negative Breast Cancer Consortium (TNBCC), 22 common susceptibility variants were investigated in 2,980 Caucasian...