Andreas Unterberg
A5014073957- Traumatic Brain Injury and Neurovascular Disturbances
- Glioma Diagnosis and Treatment
- Neurosurgical Procedures and Complications
- Meningioma and schwannoma management
- Traumatic Brain Injury Research
- Intracerebral and Subarachnoid Hemorrhage Research
- Intracranial Aneurysms: Treatment and Complications
- Cerebrospinal fluid and hydrocephalus
- Brain Metastases and Treatment
- Acute Ischemic Stroke Management
- Spinal Fractures and Fixation Techniques
- Cardiac Arrest and Resuscitation
- Immune cells in cancer
- Spine and Intervertebral Disc Pathology
- Cancer Genomics and Diagnostics
- Trauma and Emergency Care Studies
- Neurofibromatosis and Schwannoma Cases
- Radiomics and Machine Learning in Medical Imaging
- Vascular Malformations Diagnosis and Treatment
- Lung Cancer Treatments and Mutations
- S100 Proteins and Annexins
- Head and Neck Surgical Oncology
- Advanced MRI Techniques and Applications
- Spinal Dysraphism and Malformations
- Anesthesia and Neurotoxicity Research
Heidelberg University
2016-2025
University Hospital Heidelberg
2016-2025
University of Milano-Bicocca
2024
Neurological Surgery
2024
German Cancer Research Center
2009-2022
Addenbrooke's Hospital
2022
University of Groningen
2022
Deutschen Konsortium für Translationale Krebsforschung
2022
Antwerp University Hospital
2022
University of Antwerp
2022
The effect of decompressive craniectomy on clinical outcomes in patients with refractory traumatic intracranial hypertension remains unclear.
<b><i>Background:</i></b> Intracranial aneurysm with and without subarachnoid haemorrhage (SAH) is a relevant health problem: The overall incidence about 9 per 100,000 wide range, in some countries up to 20 100,000. Mortality rate conservative treatment within the first months 50–60%. About one third of patients left an untreated will die from recurrent bleeding 6 after recovering bleeding. prognosis further influenced by vasospasm, hydrocephalus, delayed ischaemic...
Medulloblastoma is the most common brain tumour in children; using whole-genome sequencing of samples authors show that clinically challenging Group 3 and 4 tumours can be tetraploid, reveal expression first medulloblastoma fusion genes identified. malignant children. Four papers published 2 August 2012 issue Nature use other techniques to produce a detailed picture genetics genomics this condition. Notable findings include identification recurrent mutations not previously implicated...
Background and Purpose— Decompressive surgery (hemicraniectomy) for life-threatening massive cerebral infarction represents a controversial issue in neurocritical care medicine. We report here the 30-day mortality 6- 12-month functional outcomes from DESTINY trial. Methods— (ISRCTN01258591) is prospective, multicenter, randomized, controlled, clinical trial based on sequential design that used after 30 days as first end point. When this point was reached, patient enrollment interrupted per...
Intracerebral hemorrhage (ICH) accounted for 9% to 27% of all strokes worldwide in the last decade, with high early case fatality and poor functional outcome. In view recent randomized controlled trials (RCTs) management ICH, European Stroke Organisation (ESO) has updated its evidence-based guidelines ICH.A multidisciplinary writing committee 24 researchers from 11 countries identified 20 questions relating ICH created recommendations based on evidence RCTs using Grading Recommendations...
The CD133 antigen has been identified as a putative stem cell marker in normal and malignant brain tissues. In gliomas, it is used to enrich subpopulation of highly tumorigenic cancer cells. According the hypothesis, CD133-positive cells determine long-term tumor growth and, therefore, are suspected influence clinical outcome. To date, correlation between expression primary tissues patients' prognosis not reported.To address this question, we analyzed series 95 gliomas various grade...
Early decompressive hemicraniectomy reduces mortality without increasing the risk of very severe disability among patients 60 years age or younger with complete subtotal space-occupying middle-cerebral-artery infarction. Its benefit in older is uncertain.
Recently, we described a machine learning approach for classification of central nervous system tumors based on the analysis genome-wide DNA methylation patterns [6]. Here, report methylation-based (CNS) tumor diagnostics conducted in our institution between years 2015 and 2018. In this period, more than 1000 from neurosurgical departments Heidelberg Mannheim referred external institutions were subjected to diagnostic purposes. We describe current integrated diagnosis CNS with focus...
This article represents the recommendations for management of spontaneous intracerebral haemorrhage European Stroke Initiative (EUSI). These are endorsed by 3 societies which represented in EUSI: Council, Neurological Society and Federation Societies.
Abstract Sarcomas are malignant soft tissue and bone tumours affecting adults, adolescents children. They represent a morphologically heterogeneous class of some entities lack defining histopathological features. Therefore, the diagnosis sarcomas is burdened with high inter-observer variability misclassification rate. Here, we demonstrate classification using machine learning classifier algorithm based on array-generated DNA methylation data. This sarcoma trained dataset 1077 profiles from...
In glioma-in contrast to various other cancers-the impact of T-lymphocytes on clinical outcome is not clear. We investigated the relevance and regulation T-cell infiltration in glioma.T-cell subpopulations from entire sections 93 WHO°II-IV gliomas were computationally identified using markers CD3, CD8, Foxp3; survival analysis was then done primary glioblastomas (pGBM). Endothelial cells expressing cellular adhesion molecules (CAM) similarly quantified same glioma tissues. Influence...
Stem-like tumor cells comprise a highly tumorigenic and therapy-resistant subpopulation, which is believed to substantially influence initiation therapy resistance in glioma. Currently, therapeutic, drug-induced differentiation considered as promising approach eradicate this tumor-driving cell population; retinoic acid well known potent modulator of proliferation normal stem cells. In glioma, knowledge about the efficacy acid-induced target stem-like pool could have therapeutic...