Jens Schittenhelm
A5040991417- Glioma Diagnosis and Treatment
- Meningioma and schwannoma management
- Neurofibromatosis and Schwannoma Cases
- Brain Metastases and Treatment
- Cancer, Hypoxia, and Metabolism
- Neuroblastoma Research and Treatments
- Chromatin Remodeling and Cancer
- Pituitary Gland Disorders and Treatments
- Epigenetics and DNA Methylation
- MRI in cancer diagnosis
- Head and Neck Surgical Oncology
- Radiomics and Machine Learning in Medical Imaging
- Sarcoma Diagnosis and Treatment
- Advanced MRI Techniques and Applications
- Cancer Cells and Metastasis
- Vascular Malformations Diagnosis and Treatment
- Hedgehog Signaling Pathway Studies
- Cancer Research and Treatments
- Advanced Neuroimaging Techniques and Applications
- Cell Adhesion Molecules Research
- Ocular Oncology and Treatments
- MicroRNA in disease regulation
- Angiogenesis and VEGF in Cancer
- Immune cells in cancer
- Renal and related cancers
University of Tübingen
2016-2025
German Cancer Research Center
2015-2025
Deutschen Konsortium für Translationale Krebsforschung
2016-2025
University Children's Hospital Tübingen
2014-2024
Bernstein Center for Computational Neuroscience Tübingen
2016-2024
Center for Neuro-Oncology
2024
Universitätsklinikum Tübingen
2014-2021
Heidelberg University
2020
Università Cattolica del Sacro Cuore
2019
West China Hospital of Sichuan University
2017
Abstract Sarcomas are malignant soft tissue and bone tumours affecting adults, adolescents children. They represent a morphologically heterogeneous class of some entities lack defining histopathological features. Therefore, the diagnosis sarcomas is burdened with high inter-observer variability misclassification rate. Here, we demonstrate classification using machine learning classifier algorithm based on array-generated DNA methylation data. This sarcoma trained dataset 1077 profiles from...
The World Health Organization (WHO) classification and grading system attempts to predict the clinical course of meningiomas based on morphological parameters. However, because high interobserver variation some criteria, more reliable prognostic markers are required. Here, we assessed TERT promoter for mutations in hotspot regions C228T C250T meningioma samples from 252 patients. Mutations were detected 16 (6.4% across cohort, 1.7%, 5.7%, 20.0% WHO grade I, II, III cases, respectively). Data...
Brain metastases are generally considered to be well demarcated from the surrounding brain parenchyma, although infiltrative growth patterns have been observed. We systemically investigated infiltration and expression of adhesion molecules in a large well-defined series autopsy cases metastases. Ninety-seven specimens 57 metastasis patients (primary tumor: 27 lung cancer, 6 breast 8 melanoma, 2 colorectal 1 kidney 13 other) were evaluated for invasion into parenchyma. Expression integrins...
Abstract Background Variability in standard-of-care classifications precludes accurate predictions of early tumor recurrence for individual patients with meningioma, limiting the appropriate selection who would benefit from adjuvant radiotherapy to delay recurrence. We aimed develop an individualized prediction model risk combining clinical and molecular factors meningioma. Methods DNA methylation profiles clinically annotated samples across multiple institutions were used a methylome 5-year...
Infant high-grade gliomas appear clinically distinct from their counterparts in older children, indicating that histopathologic grading may not accurately reflect the biology of these tumors. We have collected 241 cases under 4 years age, and carried out histologic review, methylation profiling, custom panel, genome, or exome sequencing. After excluding tumors representing other established entities subgroups, we identified 130 to be part an "intrinsic" spectrum disease specific infant...
Meningiomas are the most frequent primary intracranial tumors. Patient outcome varies widely from benign to highly aggressive, ultimately fatal courses. Reliable identification of risk progression for individual patients is pivotal importance. However, only biomarkers aggressive tumors established (CDKN2A/B and TERT), whereas no molecularly based stratification exists broad spectrum with low- intermediate-risk meningioma.DNA methylation data copy-number information were generated 3,031...
Research Article14 December 2015Open Access Source Data Endothelial cell-derived angiopoietin-2 is a therapeutic target in treatment-naive and bevacizumab-resistant glioblastoma Alexander Scholz Institute of Neurology (Edinger Institute), Goethe University Medical School, Frankfurt, Germany Search for more papers by this author Patrick N Harter German Cancer Consortium (DKTK), Partner Site Frankfurt/Mainz, Sebastian Cremer Burak H Yalcin Stefanie Gurnik Maiko Yamaji Mariangela Di Tacchio...
We analyzed the histologic features of peripheral nerve sheath tumors occurring in 14 patients with schwannomatosis. Among a total 31 tumors, 19 (61%) showed schwannoma-like nodules within neurofibroma-like tumor, corresponding to hybrid neurofibroma/schwannoma. At least 1 tumor occurred 10 (71%) schwannomatosis patients. then retrieved cases without documented relation from our database and identified 41 arising 23 More than half these (14/23) were reported suffer multiple favoring...
Abstract Intestinal ischemia/reperfusion injury (IR) is characterized by intermittent loss of perfusion to the gut, resulting in dramatic increases morbidity and mortality. Based on previous studies indicating an anti-inflammatory role for hypoxia-inducible factor (HIF)-1–elicited enhancement extracellular adenosine production via ecto-5′-nucleotidase (CD73) signaling through A2B receptor (A2BAR), we targeted HIF-1 during IR using pharmacological or genetic approaches. Initial with HIF...