Olga Zheludkova
A5007905703- Glioma Diagnosis and Treatment
- Neuroblastoma Research and Treatments
- Cancer Genomics and Diagnostics
- Radiomics and Machine Learning in Medical Imaging
- Chromatin Remodeling and Cancer
- Brain Metastases and Treatment
- Hedgehog Signaling Pathway Studies
- Acute Lymphoblastic Leukemia research
- Childhood Cancer Survivors' Quality of Life
- Cancer Mechanisms and Therapy
- Ferroptosis and cancer prognosis
- Meningioma and schwannoma management
- MicroRNA in disease regulation
- Sarcoma Diagnosis and Treatment
- Pituitary Gland Disorders and Treatments
- Epigenetics and DNA Methylation
- Ocular Oncology and Treatments
- Adrenal and Paraganglionic Tumors
- Adrenal Hormones and Disorders
- Protein Degradation and Inhibitors
- Neurofibromatosis and Schwannoma Cases
- Radiopharmaceutical Chemistry and Applications
- Neuroendocrine Tumor Research Advances
- Effects of Radiation Exposure
- Gestational Trophoblastic Disease Studies
Scientific Center of Children's Health
2020-2024
Russian Children's Clinical Hospital
2021-2023
Krasnoyarsk State Medical University
2022
Research Center of Neurology
2015-2021
Burdenko Neurosurgery Institute
2021
Federal State Budgetary Institution Russian Scientific Center of Roentgenoradiology
2015-2020
Ministry of Health of the Russian Federation
2018-2019
Dmitry Rogachev National Research Center of Pediatric Hematology, Oncology and Immunology
2013-2015
Russian Cancer Research Center NN Blokhin
1995
Three histological variants are known within the family of embryonal rosette-forming neuroepithelial brain tumors. These include tumor with abundant neuropil and true rosettes (ETANTR), ependymoblastoma (EBL), medulloepithelioma (MEPL). In this study, we performed a comprehensive clinical, pathological, molecular analysis 97 cases these rare neoplasms, including genome-wide DNA methylation copy number profiling 41 We identified uniform signatures in all tumors irrespective patterns,...
The HIT-2000-BIS4 trial aimed to avoid highly detrimental craniospinal irradiation (CSI) in children < 4 years of age with nonmetastatic medulloblastoma by systemic chemotherapy, intraventricular methotrexate, and risk-adapted local radiotherapy.From 2001-2011, 87 patients received chemotherapy methotrexate. Until 2006, CSI was reserved for nonresponse or progression. After radiotherapy introduced nonresponders classic (CMB) large-cell/anaplastic (LCA). DNA methylation profiles infantile...
We sought to investigate clinical outcomes of relapsed medulloblastoma and compare molecular features between patient-matched diagnostic tumors.Children infants enrolled on either SJMB03 (NCT00085202) or SJYC07 (NCT00602667) trials who experienced relapse were analyzed for outcomes, including anatomic temporal patterns postrelapse survival. A largely independent, paired cohort was by DNA methylation array next-generation sequencing.A total 72 329 (22%) 52 79 (66%) patients with significant...
Diffuse intrinsic pontine glioma (DIPG) is a rare and deadly childhood malignancy. After 40 years of mostly single-center, often non-randomized trials with variable patient inclusions, there has been no improvement in survival. It therefore time for international collaboration DIPG research, to provide new hope children, parents medical professionals fighting DIPG. In first step towards collaboration, 2011, network biologists clinicians working the field was established within European...
Intraocular medulloepithelioma (IO MEPL) is an uncommon embryonal neuroepithelial neoplasm of the eye. These ocular neoplasms have been compared with intracranial medulloepitheliomas or other histologic variants CNS tumor multilayered rosettes (CNS ETMR) due to their morphological mimicry. We performed comprehensive molecular analysis explore histogenetic and biologic relationships between 22 IO MEPL 68 ETMR. Routinely prepared paraffin‐embedded samples were assessed for genome‐wide...
Wingless-activated medulloblastoma (WNT MB) represents a well-characterized molecular variant accounting for 10–15% of all MB and is associated with favorable clinical outcome. Patients localized WNT MBs could benefit from de-intensification combined treatment, which would require an accurate diagnosis these tumors. However, despite the presence features related signature (nuclear ß-catenin immunoexpression, CTNNB1 mutation, monosomy 6), prompt reliable diagnostic verification tumors not yet...
Abstract Primitive neuroectodermal tumors of the central nervous system (CNS-PNETs) are highly malignant neoplasms posing diagnostic challenge due to a lack defining molecular markers. CNS neuroblastoma with forkhead box R2 ( FOXR2 ) activation (CNS_NBL) emerged as distinct pediatric brain tumor entity from pool previously diagnosed primitive (CNS-PNETs). Current standard identifying CNS_NBL relies on analysis. We set out establish immunohistochemical markers allowing safely distinguishing...
Only few data are available on treatment-associated behavior of distinct rare CNS embryonal tumor entities previously treated as "CNS-primitive neuroectodermal tumors" (CNS-PNET). Respective specific entities, including neuroblastoma, FOXR2 activated (CNS NB-FOXR2), and tumors with multilayered rosettes (ETMR) needed for development differentiated treatment strategies. Within this retrospective, international study, samples clinically well-annotated patients the original diagnosis CNS-PNET...
Intraocular medulloepithelioma (IO-MEPL) is an uncommon embryonal neuroepithelial neoplasm of the eye. Little known about cytogenetics, molecular biology, and pathogenesis this tumor. In present study we investigated mutational landscape 19 IO-MEPL using targeted next-generation sequencing. Routinely prepared paraffin-embedded samples were assessed with high-coverage genome sequencing on Illumina NextSeq 500 platform a customized gene panel set covering coding region 130 genes. This revealed...
Abstract Purpose: International consensus and the 2021 WHO classification recognize eight molecular subgroups among non-WNT/non-SHH (Group 3/4) medulloblastoma, representing approximately 60% of tumors. However, very few clinical centers worldwide possess technical capabilities to determine DNA methylation profiles or other parameters high risk for group 3/4 As a result, biomarker-driven stratification therapy assignment constitutes major challenge in medulloblastoma research. Here, we...
Background. At present, there is no reliable statistical data (morbidity, mortality, one-year etc.) that characterize the state of medical care for children with cancers in Russian Federation seen due to lack an universal electronic database patients. Objective. Improve reliability data. Methods. In clinical practice two pilot facilities, pediatric cancer patients was introduced which allows: keep patient records a diagnosis, key dates, follow-up data; analyze treatment received earlier and...
Abstract Background Up to now, adult medulloblastoma (MB) patients are treated according the protocols elaborated for pediatric MB although these tumors different in terms of clinical outcomes and biology. Approximately 70% disclose a sonic hedgehog (SHH) molecular signature contrast about 30% cohorts. In addition, SHH-MB (aSHH-MB) clinically heterogeneous but there is consensus neither on their optimal treatment nor risk stratification. Thus, identification relevant subsets aSHH-MB...
A six-year-old patient with non-germinomatous germ cell tumor of the chiasmatic-sellar area developed polyuria and polydipsia as first symptoms disease. Then there were signs precocious puberty vision impairment. MRI examination revealed a shiasmatic sellar occlusive hydrocephalus. Tumor marker levels in blood serum elevated. The alpha-fetoprotein level was increased 5-fold; human chorionic gonadotropin 20-fold. These over time. received 2 cycles PEI multiagent chemotherapy (Ifosfamide 1.5...
High-dose multi-agent chemotherapy with autologous hematopoietic stem cell transplantation is applied in the treatment of children and young adults brain tumors different risk factors for poor prognosis. Thereby myeloablative administered high - patients ' group after initial surgery standard-dose chemotherapy. The success high-dose depends on histological type tumor, extent disease, surgical resection, response to prior This review presents results histologic types modern strategies...
Ependymoma is a brain tumor that develops from ependemic cells lining the inside of all ventricles brain. Ependymomas are twice as likely to appear in region posterior cranial fossa. Pseudoprogression change after surgical and/or chemoradiotherapy, caused by vascular changes leading transient increase permeability BBB. These coincide with early delayed reactions radiotherapy and considered subacute reaction On MRI, there occurrence foci accumulate contrast for several weeks 6 months or more...
Leukoses and tumours of the central nervous system (CNS) are leading malignant neoplasms encountered in childhood. The combined treatment these diseases including radiotherapy polychemotherapy may have negative consequences for functioning male reproductive system. objective present study was to estimate influence therapy acute lymphoblastic leukemia (ALL) posterior cranial fossa (PCF) childhood on endocrine systems adult men. included 17 patients who had undergone PCF 6 men after ALL. most...
the study objective was to improve quality of detection medulloblastoma metastases.Magnetic resonance imaging (MRI) spinal cord in a child with posterior cranial fossa, which performed on first day after surgery, detected contrast-positive thickenings meninges cervical, thoracic, and lumbar that might be erroneously diagnosed as metastasis. These lesions spontaneously regressed within 3 weeks, verified by control MRI.In case misinterpretation MRI picture meninges, patient is regarded having...