Manila Antonelli
A5066199348- Glioma Diagnosis and Treatment
- Particle physics theoretical and experimental studies
- Chromatin Remodeling and Cancer
- High-Energy Particle Collisions Research
- Brain Metastases and Treatment
- Neuroblastoma Research and Treatments
- Meningioma and schwannoma management
- Sarcoma Diagnosis and Treatment
- Quantum Chromodynamics and Particle Interactions
- Ocular Oncology and Treatments
- Cancer Genomics and Diagnostics
- Neurofibromatosis and Schwannoma Cases
- Cystic Fibrosis Research Advances
- Particle Detector Development and Performance
- MicroRNA in disease regulation
- Vascular Malformations Diagnosis and Treatment
- Cancer Mechanisms and Therapy
- Bone Tumor Diagnosis and Treatments
- Epigenetics and DNA Methylation
- Hedgehog Signaling Pathway Studies
- Advanced Electron Microscopy Techniques and Applications
- Pituitary Gland Disorders and Treatments
- Enzyme Catalysis and Immobilization
- Cancer-related molecular mechanisms research
- Radiopharmaceutical Chemistry and Applications
Sapienza University of Rome
2016-2025
Istituto Neurologico Mediterraneo
1995-2024
Policlinico Umberto I
1996-2024
Istituto Nazionale di Fisica Nucleare, Laboratori Nazionali di Frascati
2008-2023
Istituti di Ricovero e Cura a Carattere Scientifico
1992-2019
Vita-Salute San Raffaele University
2019
University of Bologna
2018
University of Colorado Denver
2018
Children's Hospital Colorado
2018
Princess Máxima Center
2018
Purpose Diffuse intrinsic pontine glioma (DIPG) is a brainstem malignancy with median survival of < 1 year. The International and European Society for Pediatric Oncology DIPG Registries collaborated to compare clinical, radiologic, histomolecular characteristics between short-term survivors (STSs) long-term (LTSs). Materials Methods Data abstracted from registry databases included patients North America, Australia, Germany, Austria, Switzerland, the Netherlands, Italy, France, United...
The jet energy scale (JES) and its systematic uncertainty are determined for jets measured with the ATLAS detector using proton–proton collision data a centre-of-mass of $$\sqrt{s}=7$$ TeV corresponding to an integrated luminosity $$4.7$$ $$\,\,\text{ fb }^{-1}$$ . Jets reconstructed from deposits forming topological clusters calorimeter cells anti- $$k_{t}$$ algorithm distance parameters $$R=0.4$$ or $$R=0.6$$ , calibrated MC simulations. A residual JES correction is applied account...
Dijet events produced in LHC proton-proton collisions at a center-of-mass energy s=8 TeV are studied with the ATLAS detector using full 2012 data set, an integrated luminosity of 20.3 fb−1. masses up to about 4.5 probed. No resonancelike features observed dijet mass spectrum. Limits on cross section times acceptance set 95% credibility level for various hypotheses new phenomena terms or scale, as appropriate. This analysis excludes excited quarks below 4.06 TeV, color-octet scalars 2.70...
Properties of the Higgs boson are measured in two-photon final state using 36.1 fb$^{-1}$ proton-proton collision data recorded at $\sqrt{s} = 13$ TeV by ATLAS experiment Large Hadron Collider. Cross-section measurements for production a through gluon-gluon fusion, vector-boson and association with vector bosonor top-quark pair reported. The signal strength, defined as ratio observed to expected yield, is each these processes well inclusively. global strength measurement $0.99 \pm 0.14$...
A search for the direct production of charginos and neutralinos in final states with three leptons missing transverse momentum is presented. The analysis based on 20.3 fb-1 sqrt(s) = 8 TeV proton--proton collision data delivered by Large Hadron Collider recorded ATLAS detector. Observations are consistent Standard Model expectations limits set R-parity-conserving phenomenological Minimal Supersymmetric Models simplified supersymmetric models, significantly extending previous results. For...
Three histological variants are known within the family of embryonal rosette-forming neuroepithelial brain tumors. These include tumor with abundant neuropil and true rosettes (ETANTR), ependymoblastoma (EBL), medulloepithelioma (MEPL). In this study, we performed a comprehensive clinical, pathological, molecular analysis 97 cases these rare neoplasms, including genome-wide DNA methylation copy number profiling 41 We identified uniform signatures in all tumors irrespective patterns,...
Dark matter particles, if sufficiently light, may be produced in decays of the Higgs boson. This Letter presents a statistical combination searches for $H\to\textrm{invisible}$ where $H$ is according to Standard Model via vector boson fusion, $Z(\ell\ell)H$, and $W\!/\!Z(\textrm{had})H$, all performed with ATLAS detector using 36.1 fb$^{-1}$ $pp$ collisions at center-of-mass energy $\sqrt s = 13$ TeV LHC. In results 7$ 8 TeV, an exclusion limit on branching ratio $0.26...
This prospective study stratified patients by surgical resection (complete = NED vs incomplete ED) and centrally reviewed histology (World Health Organization [WHO] grade II III). WHO II/NED received focal radiotherapy (RT) up to 59.4 Gy with 1.8 Gy/day. Grade III/NED 4 courses of VEC (vincristine, etoposide, cyclophosphamide) after RT. ED 1–4 courses, second-look surgery, followed an 8-Gy boost in 2 fractions on still measurable residue. children aged 1–3 years tumors could receive 6 alone....
A likelihood-based discriminant for the identification of quark- and gluon-initiated jets is built validated using 4.7 fb $$^{-1}$$ proton–proton collision data at $$\sqrt{s}=7$$ $$\mathrm {\ TeV}$$ collected with ATLAS detector LHC. Data samples enriched quark or gluon content are used in construction validation templates jet properties that input to discriminant. The discriminating power tagger established both Monte Carlo within a systematic uncertainty $$\approx $$ 10–20 %. In data,...
Glioblastoma (GBM) and meningothelial meningioma (MM) are the most frequent malignant benign brain lesions, respectively. Mechanical cues play a major role in progression of both malignancies that is modulated by occurrence aberrant physical interactions between neoplastic cells extracellular matrix (ECM). Here we investigate nano-mechanical properties human GBM MM tissues atomic force microscopy. Our measures unveil mechanical fingerprint main hallmark features such as necrosis dural...
Ganglioglioma (GG) and pilocytic astrocytoma (PA) represent the most frequent low-grade gliomas (LGG) occurring in paediatric age. LGGs not amenable of complete resection (CR) a challenging subgroup where traditional treatments often fail. Activation MAP Kinase (MAPK) pathway caused by BRAFV600E mutation or KIAA1549-BRAF fusion has been reported pediatric GG PA, respectively. We report on case mutated cervicomedullary treated with standard chemotherapy surgery. After multiple relapse, BRAF...
A search is presented for the direct pair production of a chargino and neutralino $pp\to\tilde{\chi}^\pm_1\tilde{\chi}^0_2$, where decays to lightest $W$ boson, $\tilde{\chi}^\pm_1 \to \tilde{\chi}^0_1 (W^{\pm}\to\ell^{\pm}\nu)$, while 125 GeV Higgs $\tilde{\chi}^0_2 (h\to bb/\gamma\gamma/\ell^{\pm}\nu qq)$. The final states considered have large missing transverse momentum, an isolated electron or muon, one following: either two jets identified as originating from bottom quarks, photons,...
Measurements of the azimuthal anisotropy in lead-lead collisions at
Chordomas arise in the skull base and spine usually occur adults are rare pediatric population. Cases of chordoma age often poorly differentiated, showing cytologic atypia, increased cellularity, mitosis, their aggressive behavior is associated with a high incidence metastatic spread short patient survival. Recent studies have described loss SMARCB1/INI1 protein differentiated chordomas not point mutations but gene deletions instead. In this study, we considered immunohistochemistry...
A search for resonant and nonresonant pair production of Higgs bosons in the bb[over ¯]τ^{+}τ^{-} final state is presented. The uses 36.1 fb^{-1} pp collision data with sqrt[s]=13 TeV recorded by ATLAS experiment at LHC 2015 2016. Decays τ-lepton pairs least one τ lepton decaying to states hadrons a neutrino are considered. No significant excess above expected background observed data. cross-section times branching ratio boson constrained be less than 30.9 fb, 12.7 standard model...
The majority of glioblastomas develop rapidly with a short clinical history (primary glioblastoma IDH wild-type), whereas secondary progress from diffuse astrocytoma or anaplastic astrocytoma. mutations are the genetic hallmark glioblastomas. Gliosarcomas and giant cell rare histological variants, which usually rapidly. We determined patterns 36 gliosarcomas 19 IDH1 IDH2 were absent in all 18 analyzed, indicating that they variants primary glioblastoma. Furthermore, LOH 10q (88%) TERT...
The cross-section for the production of a single top quark in association with W boson proton-proton collisions at $$ \sqrt{s}=8\mathrm{T}\mathrm{e}\mathrm{V} is measured. dataset corresponds to an integrated luminosity 20.3 fb−1, collected by ATLAS detector 2012 Large Hadron Collider CERN. Events containing two leptons and one central b-jet are selected. t signal separated from backgrounds using boosted decision trees, each which combines number discriminating variables into classifier....
Atomic Force Microscopy (AFM) has the unique capability of probing nanoscale mechanical properties biological systems that affect and are affected by occurrence many pathologies, including cancer. This triggered growing interest in translational process AFM from physics laboratories to clinical practice. A factor still hindering current use diagnostics is related complexity data analysis, which time-consuming needs highly specialized personnel with a strong physical mathematical background....
Expression of the autoimmune regulator gene (AIRE) and presence CD25(+)/forkhead box p3 (FoxP3)(+) T regulatory (T(reg)) cells were investigated in histologically normal adult thymi thymomas using immunohistochemistry quantitative real-time polymerase chain reaction (PCR). In thymus staining for AIRE was detected nucleus some epithelial-like located medulla; AIRE-positive extremely rare could be only areas medullary differentiation two B1 type, organoid thymomas. RNA extracted from 36 cases...