A5103026478- Glioma Diagnosis and Treatment
- Neuroblastoma Research and Treatments
- Chromatin Remodeling and Cancer
- Hedgehog Signaling Pathway Studies
- Meningioma and schwannoma management
- Brain Metastases and Treatment
- Epigenetics and DNA Methylation
- Ocular Oncology and Treatments
- Cancer Genomics and Diagnostics
- Hematopoietic Stem Cell Transplantation
- RNA modifications and cancer
- Acute Myeloid Leukemia Research
- Sarcoma Diagnosis and Treatment
- Histone Deacetylase Inhibitors Research
- MicroRNA in disease regulation
- Radiomics and Machine Learning in Medical Imaging
- Cancer Cells and Metastasis
- Neutropenia and Cancer Infections
- Cancer Treatment and Pharmacology
- PARP inhibition in cancer therapy
- Neurofibromatosis and Schwannoma Cases
- Blood disorders and treatments
- Cancer-related molecular mechanisms research
- Immunotherapy and Immune Responses
- Renal and related cancers
University of Bonn
2014-2025
University Hospital Bonn
2008-2025
Life & Brain (Germany)
2017-2024
German Center for Neurodegenerative Diseases
2018
Universität Hamburg
2010-2016
University Medical Center Hamburg-Eppendorf
2010-2016
Medizinische Hochschule Hannover
1990-2016
German Cancer Research Center
2016
University Hospital Heidelberg
2012-2016
University of Zurich
2016
Major discoveries in the biology of nervous system tumors have raised question how non-histological data such as molecular information can be incorporated into next World Health Organization (WHO) classification central tumors. To address this question, a meeting neuropathologists with expertise diagnosis was held Haarlem, Netherlands, under sponsorship International Society Neuropathology (ISN). Prior to meeting, participants solicited input from clinical colleagues diverse...
Abstract Gastrointestinal stromal tumors (GIST) are characterized by a strong KIT receptor activation most often resulting from mutations. In smaller subgroup of without mutations, analogous activating mutations found in the platelet-derived growth factor α (PDGFRα) gene. Both PDGFRα and receptors targets tyrosine kinase inhibitor imatinib (Glivec) which has improved treatment advanced GISTs significantly. However, show secondary progress under therapy with after initial response. One...
To compare event-free survival (EFS), overall (OS), pattern of relapse, and hearing loss in children with standard-risk medulloblastoma treated by postoperative hyperfractionated or conventionally fractionated radiotherapy followed maintenance chemotherapy.In all, 340 age 4 to 21 years from 122 European centers were postoperatively staged randomly assigned treatment (HFRT) standard (conventional) (STRT) a common chemotherapy regimen consisting eight cycles cisplatin, lomustine,...
Histopathological grading of ependymoma has been controversial with respect to its reproducibility and clinical significance. In a 3-phase study, we reviewed the pathology 229 intracranial ependymomas from European trial cohorts infants (2 trials - SFOP/CNS9204) older children AIEOP/CNS9904) assess both diagnostic concordance among five neuropathologists prognostic utility histopathological variables, particularly tumor grading.In phase 1, using WHO criteria without first discussing any...
The Hirntumorstudien (HIT)-LGG-1996 protocol offered a comprehensive treatment strategy for pediatric patients with low-grade glioma (LGG), ie, observation, surgery, adjuvant radiotherapy, and chemotherapy to defer the start of irradiation in young children. In this current study, we sought determine clinical factors progression survival. Between October 1, 1996 March 31, 2004, 1031 were prospectively recruited into an observation arm (n = 668) nonsurgical stratifying 12 months...
Three histological variants are known within the family of embryonal rosette-forming neuroepithelial brain tumors. These include tumor with abundant neuropil and true rosettes (ETANTR), ependymoblastoma (EBL), medulloepithelioma (MEPL). In this study, we performed a comprehensive clinical, pathological, molecular analysis 97 cases these rare neoplasms, including genome-wide DNA methylation copy number profiling 41 We identified uniform signatures in all tumors irrespective patterns,...
Optimal treatment and precise classification for anaplastic glioma are needed. The objective long-term follow-up of NOA-04 is to optimize the sequence patients with gliomas. Patients were randomized 2:1:1 receive standard radiotherapy (RT) (arm A), procarbazine, lomustine vincristine (PCV) B1), or temozolomide (TMZ) B2). Primary endpoint was time-to-treatment-failure (TTF), defined as progression after 2 lines therapy any time before if no further administered. Exploratory analyses examined...
In patients with newly diagnosed glioblastoma that harbors a nonmethylated O(6)-methylguanine-DNA methyltransferase promotor, standard temozolomide (TMZ) has, at best, limited efficacy. The GLARIUS trial thus explored bevacizumab plus irinotecan (BEV+IRI) as an alternative to TMZ.In this phase II, unblinded 182 in 22 centers were randomly assigned 2:1 BEV (10 mg/kg every 2 weeks) during radiotherapy (RT) followed by maintenance IRI(125 mg/m(2) or daily TMZ (75 mg/m(2)) RT six courses of...
This study was designed to confirm the previously observed favorable survival rates and prognostic factors in young children with nonmetastatic medulloblastoma (MB) treated postoperative chemotherapy alone. Patients who received a diagnosis during period January 2001 through December 2005 were aged <4 years 3 cycles of systemic multiagent intraventricular methotrexate. In cases complete remission, treatment terminated after 2 additional chemotherapy. Otherwise, secondary surgery,...
Background: Intracranial choroid plexus tumors (CPT) are rare and primarily affect young children. Leptomeningeal dissemination (LMD) has been reported not only in high-grade carcinoma (CPC) but also lower histological grades; however, a systematic evaluation of CPT-specific imaging characteristics remains lacking. Methods: We analyzed the LMD single-center pediatric cohort 22 CPT patients (thirteen papilloma (CPP), six atypical (aCPP), three CPC), comparing features with those primary...
Background: Low grade gliomas arise in all CNS-locations and age groups, chiasmatic-hypothalamic tumors occur especially young children. Early radiotherapy (RT) shall be deferred by chemotherapy (CT) within the concept of HIT-LGG 1996 study, offering a comprehensive treatment strategy for groups. Patients: 198 905 protocol patients (21.9 %) had chiasmatic (34), (144) or hypothalamic (20) primary tumor, median at diagnosis 3.6 years (0.2-16.3 y.), 54 neurofibromatosis (27.3 %), 108 female...
Abstract Background Although Temozolomide is effective against glioblastoma, the prognosis remains dismal and new regimens with synergistic activity are sought for. Methods In this phase-I/II trial, pegylated liposomal doxorubicin (Caelyx™, PEG-Dox) prolonged administration of in addition to radiotherapy was investigated 63 patients newly diagnosed glioblastoma. phase-I, PEG-Dox administered a 3-by-3 dose-escalation regimen. phase-II, 20 mg/m 2 given once prior on days 1 15 each 28-day cycle...
We aimed to test the hypothesis that medulloblastoma (MB) variants show a different age distribution and clinical behavior reflecting their specific biology, MB occurring at very young is associated with cancer predisposition syndromes such as Gorlin syndrome (GS).We investigated frequency, distribution, location, response treatment, outcome, association familial in series of 82 cases patients ages <14 years diagnosed Giannina Gaslini Children's Hospital, Genoa, between 1987...