Annie Huang
A5053563254- Glioma Diagnosis and Treatment
- Chromatin Remodeling and Cancer
- MicroRNA in disease regulation
- Neuroblastoma Research and Treatments
- Ferroptosis and cancer prognosis
- RNA modifications and cancer
- Epigenetics and DNA Methylation
- Cancer Mechanisms and Therapy
- Cancer Immunotherapy and Biomarkers
- Extracellular vesicles in disease
- Autophagy in Disease and Therapy
- Brain Metastases and Treatment
- Cancer Genomics and Diagnostics
- Cancer, Hypoxia, and Metabolism
- Angiogenesis and VEGF in Cancer
- Protein Degradation and Inhibitors
- Meningioma and schwannoma management
- Hedgehog Signaling Pathway Studies
- Gestational Trophoblastic Disease Studies
- Cancer Treatment and Pharmacology
- Microtubule and mitosis dynamics
- interferon and immune responses
- Renal and related cancers
- RNA Research and Splicing
- Cancer, Stress, Anesthesia, and Immune Response
Hospital for Sick Children
2016-2025
SickKids Foundation
2016-2025
University of Toronto
2015-2024
John Brown University
2021-2024
First Affiliated Hospital of University of South China
2024
University of South China
2024
University of California, Los Angeles
2024
University of California, Santa Barbara
2022
University of Canterbury
2022
Northwestern University
2022
Diffuse intrinsic pontine glioma (DIPG) is one of the most devastating pediatric malignancies and for which no effective therapy exists. A major contributor to failure therapeutic trials assumption that biologic properties brainstem tumors in children are identical cerebral high-grade gliomas adults. better understanding biology DIPG itself needed order develop agents targeted more specifically these children's disease. Herein, we address this lack knowledge by performing first...
Purpose BRAF V600E is a potentially highly targetable mutation detected in subset of pediatric low-grade gliomas (PLGGs). Its biologic and clinical effect within this diverse group tumors remains unknown. Patients Methods A combined genetic institutional study patients with PLGGs long-term follow-up was performed (N = 510). Clinical treatment data mutated PLGG (n 99) were compared large international independent cohort mutated-PLGG 180). Results 69 405 (17%) across broad spectrum histologies...
To uncover the genetic events leading to transformation of pediatric low-grade glioma (PLGG) secondary high-grade (sHGG).We retrospectively identified patients with sHGG from a population-based cohort 886 PLGG long clinical follow-up. Exome sequencing and array CGH were performed on available samples followed by detailed analysis entire cohort. Clinical outcome data genetically distinct subgroups obtained.sHGG was observed in 2.9% PLGGs (26 patients). Patients had high frequency nonsilent...
Three histological variants are known within the family of embryonal rosette-forming neuroepithelial brain tumors. These include tumor with abundant neuropil and true rosettes (ETANTR), ependymoblastoma (EBL), medulloepithelioma (MEPL). In this study, we performed a comprehensive clinical, pathological, molecular analysis 97 cases these rare neoplasms, including genome-wide DNA methylation copy number profiling 41 We identified uniform signatures in all tumors irrespective patterns,...
Purpose Vinblastine monotherapy has shown promising activity and a low-toxicity profile in patients with pediatric low-grade glioma (PLGG) who experienced treatment failure after initial chemotherapy and/or radiation. The aim of this study was to assess the vinblastine therapy-naïve children. Patients Methods < 18 years old unresectable progressive PLGG were eligible. administered once per week at dose 6 mg/m 2 intravenously over period 70 weeks. Vision, quality life, neurofibromatosis...
Chemoresistance to temozolomide (TMZ) is a major challenge in the treatment of glioblastoma (GBM). We previously found that miR-519a functions as tumor suppressor glioma by targeting signal transducer and activator transcription 3 (STAT3)-mediated autophagy oncogenic pathway. Here, we investigated effects on TMZ chemosensitivity GBM cells. Furthermore, underlying molecular mechanisms signaling pathways were explored.In present study, two stable TMZ-resistant cell lines successfully generated...
Atypical teratoid/rhabdoid tumor (AT/RT) is an aggressive, early-childhood brain without standard effective treatment. To our knowledge, we conducted the first AT/RT-specific cooperative group trial, ACNS0333, to examine efficacy and safety of intensive postoperative chemotherapy focal radiation treat AT/RT.Patients from birth 22 years age with AT/RT were eligible. After surgery, they received 2 courses multiagent chemotherapy, followed by 3 high-dose peripheral blood stem cell rescue...
The Wilms tumor locus on chromosome 11p13 has been mapped to a region defined by overlapping, tumor-specific deletions. Complementary DNA clones representing transcripts of 2.5 (WIT-1) and 3.5 kb (WIT-2) mapping this were isolated from kidney complementary library. Expression WIT-1 WIT-2 was restricted spleen. RNase protection revealed divergent transcription WIT-2, originating <600 bp. Both present at high concentrations in fetal much reduced amounts 5-year-old adult kidneys. Eleven 12...
Telomerase reverse transcriptase (TERT) promoter mutations were recently shown to drive telomerase activity in various cancer types, including medulloblastoma. However, the clinical and biological implications of TERT medulloblastoma have not been described. Hence, we sought describe these their impact a subgroup-specific manner. We analyzed by direct sequencing genotyping 466 medulloblastomas. The mutational distributions determined according subgroup affiliation, demographics, clinical,...