A5100610428- Ferroptosis and cancer prognosis
- MicroRNA in disease regulation
- Extracellular vesicles in disease
- RNA modifications and cancer
- Caveolin-1 and cellular processes
- Glioma Diagnosis and Treatment
- Cancer, Lipids, and Metabolism
- Renal Diseases and Glomerulopathies
- Phagocytosis and Immune Regulation
- Virus-based gene therapy research
- Immune Cell Function and Interaction
- Gout, Hyperuricemia, Uric Acid
- Hepatitis B Virus Studies
- Traumatic Brain Injury Research
- Proteoglycans and glycosaminoglycans research
- Adenosine and Purinergic Signaling
- Hepatocellular Carcinoma Treatment and Prognosis
- Occupational and environmental lung diseases
- Viral-associated cancers and disorders
- Biological Activity of Diterpenoids and Biflavonoids
- Eosinophilic Disorders and Syndromes
- Hemoglobin structure and function
- IL-33, ST2, and ILC Pathways
- Nanoplatforms for cancer theranostics
- Medicinal plant effects and applications
State Key Laboratory of Information Engineering in Surveying Mapping and Remote Sensing
2024
Southern Medical University
2017-2024
Nanfang Hospital
2017-2024
Hangzhou Hospital of Traditional Chinese Medicine
2024
Huazhong University of Science and Technology
2024
Union Hospital
2024
Ningxia Medical University
2024
Ningxia Medical University General Hospital
2024
First Affiliated Hospital of Xi'an Jiaotong University
2024
Second Xiangya Hospital of Central South University
2020
Chemoresistance to temozolomide (TMZ) is a major challenge in the treatment of glioblastoma (GBM). We previously found that miR-519a functions as tumor suppressor glioma by targeting signal transducer and activator transcription 3 (STAT3)-mediated autophagy oncogenic pathway. Here, we investigated effects on TMZ chemosensitivity GBM cells. Furthermore, underlying molecular mechanisms signaling pathways were explored.In present study, two stable TMZ-resistant cell lines successfully generated...
Temozolomide resistance remains a major obstacle in the treatment of glioblastoma (GBM). The combination temozolomide with another agent could offer an improved option if it overcome chemoresistance and prevent side effects. Here, we determined critical drug that cause ferroptosis GBM cells elucidated possible mechanism by which overcomes chemoresistance.Haloperidol/temozolomide synergism was assessed cell lines different dopamine D2 receptor (DRD2) expression vitro vivo. Inhibitors...
Abstract Radiofrequency ablation (RFA) is one of the most common minimally invasive techniques for treatment solid tumors, but residual malignant tissues or small satellite lesions after insufficient RFA (iRFA) are difficult to remove, often leading metastasis and recurrence. Here, Fe‐TPZ nanoparticles designed by metal ion (TPZ) ligand complexation synergistic enhancement tumor therapy. cleaved in acidic microenvironment generate Fe 2+ TPZ. TPZ, an anoxia‐dependent drug, activated tumors...
IgA nephropathy (IgAN) represents the main cause of renal failure, while precise pathogenetic mechanisms have not been fully determined. Herein, we conducted a cross-species single-cell survey on human IgAN and mouse rat models to explore pathogenic programs. Cross-species RNA sequencing (scRNA-Seq) revealed that mesangial cells (MCs) expressed high levels inflammatory signatures CXCL12, CCL2, CSF1, IL-34 specifically interacted with macrophages via CXCL12/CXCR4, CSF1/IL-34/CSF1 receptor,...
Dihydromyricetin, the most abundant natural flavonoid isolated from Ampelopsis grossedentata, exhibits broad anti-tumor effects. However, effects of dihydromyricetin on cholangiocarcinoma remain unclear. This study examined in two human cell lines HCCC9810 and TFK-1, underlying mechanism was also investigated. Our first to show that significantly inhibited proliferation, migration, invasion promoted apoptosis cells. By analyzing TCGA dataset, we found expression miR-21, an oncogene a...
Ag85b and HspX of Mycobacterium tuberculosis (Mtb) (H37Rv) were expressed purified in this study. These two proteins combined with another fusion protein CFP-10:ESAT-6 (C/E) (Ag), then mixed the adjuvants CpG DNA aluminum hydroxide used to vaccinate mice guinea pigs challenged Mtb (H37Rv). The number spleen lymphocytes secreting Ag85b, C/E-specific interferon-γ significantly higher Ag+Al+CpG group than Ag groups. combination Ag, Al induced highest concentrations anti-Ag85b, anti-HspX...
Objective: To study roles of Clara cell protein 16 (CC16) and surfactant protein-D (SP-D) as serum biomarkers in the early diagnosis pathogenesis silicosis. Methods: Thirty healthy volunteers, 30 silica-exposed workers, workers with suspected silicosis phase I were included. Serum CC16 SP-D concentrations determined using enzyme-linked immunosorbent assay. Results: decreased when compared controls, but levels increased, this trend was obvious 0+ groups. Discriminant analysis showed that...
Intratumoral heterogeneity greatly hinders efficiency of target therapy in glioblastoma (GBM). To decipher the underlying mechanisms heterogeneity, patient-derived adult GBM cells were separately isolated from margins T1 gadolinium enhancing tumor lesions (PNCs) and core (ECs). Single clone culture was conducted ECs U87MG cell line to screen clones with distinct biological phenotypes. diverse phenotypes simultaneously separated U87 line. PNCs, GCs(H) U87(H) exhibited longer cellular...
The purpose of this study was to compare the chondroprotective effects chondroitin sulfate (CS)-hyaluronic acid (HA) (CS-HA) injection and HA in an experimental model osteoarthritis. After induction osteoarthritis rabbits, 28 rabbits were randomized into four groups: control group, 'HA' 'CS' 'CS-HA' group. 7 days, group respectively treated with normal saline, HA, CS, or CS-HA knees. All animals once weekly. continuously for 5 weeks. Histological biochemical evaluations performed. As shown...
Due to the size and location of tumor, incomplete radiofrequency ablation (iRFA) target tumor inhibits immunity. In this study, a murine herpes simplex virus (oHSV2-mGM) armed with granulocyte-macrophage colony-stimulating factor (GM-CSF) was constructed explore its effect on innate adaptive immunity during iRFA, inhibitory programmed cell death-1 (PD1) tumor.
The incidence and mortality rates of primary hepatocellular carcinoma (HCC) are high, the conventional treatment is radiofrequency ablation (RFA) with transcatheter arterial chemoembolization (TACE); however, 3-year survival rate still low. Further, there no visual methods to effectively predict their prognosis.
<p>Fig. S3. HP radiosensitive GBM cells.</p>
<p>Fig. S1. HP does not trigger apoptosis in GBM cells.</p>
<p>Fig. S4. Autophagy, endoplasmic reticulum stress and cAMP pathway are involved in TMZ+HP-induced ferroptosis GBM cells.</p>
<p>Fig. S2. TMZ+HP Hp induces ferroptosis in GBM cells.</p>
<p>Fig. S3. HP radiosensitive GBM cells.</p>
<p>Fig. S2. TMZ+HP Hp induces ferroptosis in GBM cells.</p>
<div>Abstract<p>Purpose:Temozolomide (TMZ) resistance remains a major obstacle in the treatment of glioblastoma (GBM). The combination TMZ with another agent could offer an improved option if it overcome chemoresistance and prevent side effects. Here, we determined critical drug that cause ferroptosis GBM cells elucidated possible mechanism by which overcomes chemoresistance. Experimental Design:Haloperidol/TMZ synergism was assessed cell lines different DRD2 expression...
<div>Abstract<p>Purpose:Temozolomide (TMZ) resistance remains a major obstacle in the treatment of glioblastoma (GBM). The combination TMZ with another agent could offer an improved option if it overcome chemoresistance and prevent side effects. Here, we determined critical drug that cause ferroptosis GBM cells elucidated possible mechanism by which overcomes chemoresistance. Experimental Design:Haloperidol/TMZ synergism was assessed cell lines different DRD2 expression...
<p>Fig. S2. TMZ+HP Hp induces ferroptosis in GBM cells.</p>
<p>Fig. S3. HP radiosensitive GBM cells.</p>
<p>Fig. S4. Autophagy, endoplasmic reticulum stress and cAMP pathway are involved in TMZ+HP-induced ferroptosis GBM cells.</p>