A5000128482- Reproductive System and Pregnancy
- Pharmacogenetics and Drug Metabolism
- Retinal Diseases and Treatments
- Neuroinflammation and Neurodegeneration Mechanisms
- Reproductive Physiology in Livestock
- Antibiotics Pharmacokinetics and Efficacy
- Ocular Diseases and Behçet’s Syndrome
- Berberine and alkaloids research
- Immune Response and Inflammation
- Pharmaceutical studies and practices
- Pharmacological Effects of Natural Compounds
- Endometriosis Research and Treatment
- Natural product bioactivities and synthesis
- Inflammatory mediators and NSAID effects
- Natural Compounds in Disease Treatment
- Microbial Community Ecology and Physiology
- Drug Transport and Resistance Mechanisms
- Retinal and Optic Conditions
- Cancer-related molecular mechanisms research
- Retinal Imaging and Analysis
- TGF-β signaling in diseases
- Neurological Disease Mechanisms and Treatments
- Medicinal plant effects and applications
- Genomics and Phylogenetic Studies
- Nuclear Receptors and Signaling
Chinese Academy of Medical Sciences & Peking Union Medical College
2022-2024
China Pharmaceutical University
2021-2024
Nanjing Medical University
2023-2024
Guangxi Medical University
2024
First Affiliated Hospital of GuangXi Medical University
2024
Third Hospital of Changsha
2018-2024
Central South University
2013-2024
Qingdao Agricultural University
2023
Qingdao Academy of Agricultural Sciences
2023
The Affiliated Yongchuan Hospital of Chongqing Medical University
2023
Significance Vogt–Koyanagi–Harada (VKH) disease is one of the most common and severe vision-threatening autoimmune uveitis in Asians. However, functional heterogeneity among subsets human blood monocytes VKH disease-relevant populations remains elusive. This study encoded landscape monocytes, clustered six with distinct functions, revealed two populations, using single-cell RNA sequencing. Surprisingly, we discovered a disease-specific subset, proinflammatory implicating immune activation...
Objective: Emerging evidence suggests that brain angiotensin-(1– 7) (Ang-(1– 7)) deficiency contributes to the pathogenesis of Alzheimer's disease (AD). Meanwhile, our previous studies revealed restoration Ang-(1– levels provided neuroprotection by inhibition inflammatory responses during AD progress. However, potential molecular mechanisms which modulates neuroinflammation remain unclear. Materials and Methods: APP/PS1 mice were injected intraperitoneally with AVE0991 (a nonpeptide analogue...
Harmful algal blooms (HABs) in natural waters are of escalating global concern due to their detrimental impact on environmental health. Emerging evidence indicates that algae-bacteria symbionts can affect HAB features, though much about this interplay remains largely unexplored. The current study isolated a new species Mucilaginibacter (type strain JXJ CY 39 T ) from culture biomass the bloom-causing Microcystis aeruginosa FACHB-905 (Maf) Lake Dianchi, China. Strain was an aerobic,...
Triptolide (TP), the main bioactive component of Tripterygium wilfordii Hook F, can cause severe hepatotoxicity. Isoliquitigenin (ISL) has been reported to protect against TP-induced liver injury, but mechanisms are not fully elucidated. This study aims explore role nuclear transcription factor E2-related 2 (Nrf2) and hepatic transporters in hepatotoxicity reversal effect ISL on it. TP treatment caused both cytotoxicity L02 hepatocytes acute injury mice. Particularly, led a disorder bile...
Abstract Natural products were extracted from traditional Chinese herbal emerging as potential therapeutic drugs for treating cardiovascular diseases. This study examines the role and underlying mechanism of dihydromyricetin (DMY), a natural compound Ampelopsis grossedentata , in atherosclerosis. DMY treatment significantly inhibits atherosclerotic lesion formation, proinflammatory gene expression influx lesional macrophages CD4‐positive T cells vessel wall hepatic inflammation, whereas...
Abstract An alpha-proteobacterial strain JXJ CY 53 T was isolated from the cyanosphere of Microcystis sp. FACHB-905 (MF-905) collected Lake Dianchi, China. observed to be an aerobic, Gram-stain-negative, oval shaped, and mucus-secreting bacterium. It had C 18:1 ω7c 16:0 as major cellular fatty acids, Q-10 predominant ubiquinone, sphingoglycolipid, diphosphatidylglycerol, phosphatidylcholine, phosphatidylmethylethanolamine polar lipids. The G + content DNA 65.85%. bacterium 16S rRNA gene...
Objective The aim of this study was to investigate the characteristics and related functional pathways gut microbiota in patients with IgA nephropathy (IgAN) through metagenomic sequencing technology.
The development and application of solid-state electrolytes in lithium-ion batteries (LIBs) have become mainstream the industry LIBs. Compared with liquid electrolytes, offer higher safety energy...
Triptolide (TP), an active ingredient of Tripterygium wilfordii Hook f., possesses a wide range biological activities. Oxidative stress likely plays role in TP‐induced hepatotoxicity. Isoliquiritigenin (ISL) and glycyrrhetinic acid (GA) are potent hepatoprotection agents. The aim the present study was to investigate whether Nrf2 pathway is associated with protective effects ISL GA against oxidative or not. HepG2 cells were treated TP (50 nM) for 24 h after pretreatment (5, 10, 20 μ M) 12 h,...
Currently, polymyxin B has been widely used in the treatment of multidrug-resistant Gram-negative pathogen infections. Due to limited pharmacokinetic/pharmacodynamic data, optimal dosage regimen for recently proposed therapeutic target area under concentration-time curve over 24 h steady state divided by minimum inhibitory concentration 50–100 mg⋅h/L not yet established. Moreover, most studies have focused on critically ill patients, there no field renal transplantation. To optimize strategy...
Oxidative stress and inflammation damage play pivotal roles in vascular dementia (VaD). Trimethylamine N-oxide (TMAO), an intestinal microbiota-stemming metabolite, was reported to promote oxidative stress, involved the etiology of several diseases. Still, these effects have not been investigated VaD. Here, we tested whether pre-existing, circulating, high levels TMAO could affect VaD-induced cognitive decline. (120 mg/kg) given rats for a total 8 weeks, underwent sham operation or bilateral...
Alzheimer's disease (AD) is the most common type of neurodegenerative disorder. There are few effective medications for halting progression AD. Telmisartan (TEL) a widely used anti-hypertensive drug approved by FDA. Aside from treating hypertension, TEL has been revealed to provide protection against However, underlying mechanisms remain unclear.To investigate beneficial effects AD.Eight-month-old APP/PS1 mice were administered with 5 mg/kg once per day 4 successive months. Nesting test,...
Vascular dementia (VaD) is the second most common in world. An increasing number of studies have demonstrated important role long non-coding RNAs (lncRNAs) VaD. Our previous investigation that Trimethylamine-N-oxide (TMAO) exacerbates cognitive impairment and neuropathological alterations VaD rats. Thus, we hypothesized TMAO could play an injury by regulating lncRNAs.
Dihydromyricetin, the most abundant natural flavonoid isolated from Ampelopsis grossedentata, exhibits broad anti-tumor effects. However, effects of dihydromyricetin on cholangiocarcinoma remain unclear. This study examined in two human cell lines HCCC9810 and TFK-1, underlying mechanism was also investigated. Our first to show that significantly inhibited proliferation, migration, invasion promoted apoptosis cells. By analyzing TCGA dataset, we found expression miR-21, an oncogene a...
Purpose: Our previous study has shown that AVE 0991, a nonpeptide analogue of Ang-(1-7), ameliorates cognitive decline and inhibits NLRP3 inflammasome astrocytes in Alzheimer's disease model mice. Additionally, several studies have suggested activation autophagy appears to effectively inhibit the progression neuroinflammation. However, it is unclear whether 0991 can modulate astrocyte suppress neuroinflammation disease. Materials Methods: APP/PS1 mice Aβ-treated primary were used as research...
Mycobacterium species exhibit high bioremediation potential for the degradation of polycyclic aromatic hydrocarbons (PAHs) that are significant environmental pollutants. In this study, three Gram-positive, rapidly growing strains (YC-RL4T, MB418T, and HX176T) were isolated from petroleum-contaminated soils classified as within family Mycobacteriaceae. Genomic average nucleotide identity (ANI; < 95%) digital DNA-DNA hybridization (dDDH; 70%) values relative to other spp. indicated represented...
Isoliquiritigenin, a flavonoid found in licorice, has been considered as an antioxidive and hepato-protective agent. Recent studies have shown that possible mechanism for triptolide-induced hepatotoxicity is related to oxidative damage induced by reactive oxygen species. This study was done investigate the protection effect of isoliquiritigenin against involved. An acute liver injury model established intraperitoneal injection triptolide (1.0 mg · kg-1) mice. Different doses (12.5, 25 50...
AIM: To investigate microvascular changes in eyes with central retinal vein occlusion (CRVO) complicated by macular edema before and after intravitreal conbercept injection evaluate correlations between these best-corrected visual acuity (BCVA) thickness. METHODS: Twenty-eight of 28 patients caused CRVO were included this retrospective study. All received a single to treat edema. BCVA the results optical coherence tomography angiography (OCTA) automatic measurements vessel density...
While vitamin D 3 is recognized as a neuroactive steroid affecting both brain development and function, efficient analytical method in determining metabolites the tissue still lacking, relationship of status between serum remains elusive. Therefore, we developed novel analysis by using high performance liquid chromatography-tandem mass spectrometry (HPLC-MS/MS) to simultaneously quantify concentrations 25-hydroxyvitamin (25(OH)D ) 24,25-dihydroxyvitamin (24,25(OH) 2 rats fed with different...