Anita Hüttner
A5007901652- Glioma Diagnosis and Treatment
- Meningioma and schwannoma management
- Neurofibromatosis and Schwannoma Cases
- CNS Lymphoma Diagnosis and Treatment
- Radiomics and Machine Learning in Medical Imaging
- Brain Metastases and Treatment
- Vascular Malformations Diagnosis and Treatment
- Neuroinflammation and Neurodegeneration Mechanisms
- Cancer Genomics and Diagnostics
- Epilepsy research and treatment
- Lymphoma Diagnosis and Treatment
- Sarcoma Diagnosis and Treatment
- Alzheimer's disease research and treatments
- Single-cell and spatial transcriptomics
- Cardiac tumors and thrombi
- Brain Tumor Detection and Classification
- Pituitary Gland Disorders and Treatments
- Head and Neck Surgical Oncology
- Nanoparticle-Based Drug Delivery
- RNA Interference and Gene Delivery
- Cerebrospinal fluid and hydrocephalus
- Hedgehog Signaling Pathway Studies
- RNA regulation and disease
- Genomics and Rare Diseases
- Infectious Diseases and Tuberculosis
Yale University
2016-2025
Sorbonne Université
2024
Centre National de la Recherche Scientifique
2024
Assistance Publique – Hôpitaux de Paris
2024
Institut du Cerveau
2024
Inserm
2024
Smilow Cancer Hospital
2020-2023
Yale Cancer Center
2019-2023
University of New Haven
2022
Yale New Haven Hospital
2015-2022
Although COVID-19 is considered to be primarily a respiratory disease, SARS-CoV-2 affects multiple organ systems including the central nervous system (CNS). Yet, there no consensus on consequences of CNS infections. Here, we used three independent approaches probe capacity infect brain. First, using human brain organoids, observed clear evidence infection with accompanying metabolic changes in infected and neighboring neurons. However, for type I interferon responses was detected. We...
INTRODUCTION The brain is responsible for cognition, behavior, and much of what makes us uniquely human. development the a highly complex process, this process reliant on precise regulation molecular cellular events grounded in spatiotemporal transcriptome. Disruption can lead to neuropsychiatric disorders. RATIONALE regulatory, epigenomic, transcriptomic features human have not been comprehensively compiled across time, regions, or cell types. Understanding etiology disorders requires...
In multiple sclerosis patients, B cells mature in the draining cervical lymph nodes before trafficking across blood-brain barrier.
Current therapy for glioblastoma multiforme is insufficient, with nearly universal recurrence. Available drug therapies are unsuccessful because they fail to penetrate through the region of brain containing tumor cells and kill most responsible development resistance, cancer stem (BCSCs). To address these challenges, we combined two major advances in technology: ( i ) brain-penetrating polymeric nanoparticles that can be loaded drugs optimized intracranial convection-enhanced delivery ii...
The hippocampal-entorhinal system supports cognitive functions, has lifelong neurogenic capabilities in many species, and is selectively vulnerable to Alzheimer's disease. To investigate potential cellular diversity, we profiled single-nucleus transcriptomes five subregions humans, macaques, pigs. Integrated cross-species analysis revealed robust transcriptomic histologic signatures of neurogenesis the adult mouse, pig, macaque but not humans. Doublecortin (DCX), a widely accepted marker...
Summary Although COVID-19 is considered to be primarily a respiratory disease, SARS-CoV-2 affects multiple organ systems including the central nervous system (CNS). Yet, there no consensus whether virus can infect brain, or what consequences of CNS infection are. Here, we used three independent approaches probe capacity brain. First, using human brain organoids, observed clear evidence with accompanying metabolic changes in infected and neighboring neurons. However, for type I interferon...
Abstract The eye, an anatomical extension of the central nervous system (CNS), exhibits many molecular and cellular parallels to brain. Emerging research demonstrates that changes in brain are often reflected particularly retina 1 . Still, possibility immunological nexus between posterior eye rest CNS tissues remains unexplored. Here, studying immune responses herpes simplex virus brain, we observed intravitreal immunization protects mice against intracranial viral challenge. This protection...
Macrophages are a source of both proinflammatory and restorative functions in damaged tissue through complex dynamic phenotypic changes. Here, we sought to determine whether monocyte-derived macrophages (MDMs) contribute recovery after acute sterile brain injury. By profiling the transcriptional dynamics MDMs murine experimental intracerebral hemorrhage (ICH), found robust changes infiltrating over time demonstrated that essential for optimal hematoma clearance neurological recovery. Next,...
OBJECTIVE Recent large-cohort sequencing studies have investigated the genomic landscape of meningiomas, identifying somatic coding alterations in NF2 , SMARCB1 SMARCE1 TRAF7, KLF4, POLR2A BAP1 and members PI3K Hedgehog signaling pathways. Initial associations between clinical features subgroups been described, including location, grade, histology. However, further investigation using an expanded collection samples is needed to confirm previous findings, as well elucidate relationships not...
We and others have identified mutually exclusive molecular subgroups of meningiomas; however, the implications this classification for clinical prognostication remain unclear. Integrated genomic epigenomic analyses implicate unique oncogenic processes associated with each subgroup, suggesting potential divergent courses. The aim study was to understand outcomes as could optimize treatment patients.We analyzed outcome data 469 meningiomas known including extent resection, postoperative...
Abstract Introduction An animal model of late‐onset Alzheimer's disease is needed to research what causes degeneration in the absence dominant genetic insults and why association cortex particularly vulnerable degeneration. Methods We studied progression tau amyloid cortical pathology aging rhesus macaque using immunoelectron microscopy biochemical assays. Results Aging macaques exhibited same qualitative pattern sequence as humans, reaching Braak stage III/IV. Pathology began young‐adult...
Malignant high-grade gliomas (HGGs), including the most aggressive form, glioblastoma multiforme, show significant clinical and genomic heterogeneity. Despite recent advances, overall survival of HGGs their response to treatment remain poor. In order gain further insight into disease pathophysiology by correlating landscape with behavior, thereby identifying distinct HGG molecular subgroups associated improved prognosis, we performed a comprehensive analysis. We analyzed compared 720...
Abstract Nanoparticles are of long-standing interest for the treatment neurological diseases such as glioblastoma. Most past work focused on methods to introduce nanoparticles into brain, suggesting that reaching brain interstitium will be sufficient ensure therapeutic efficacy. However, optimized nanoparticle design drug delivery central nervous system is limited by our understanding their cellular deposition in brain. Here, we investigated fate poly(lactic acid) presenting different...