Madhav C. Menon
A5072561852- Renal Transplantation Outcomes and Treatments
- Renal Diseases and Glomerulopathies
- Organ Transplantation Techniques and Outcomes
- Chronic Kidney Disease and Diabetes
- Renal and Vascular Pathologies
- Organ Donation and Transplantation
- Renal and related cancers
- Transplantation: Methods and Outcomes
- Metabolism and Genetic Disorders
- Dialysis and Renal Disease Management
- Cytomegalovirus and herpesvirus research
- Genetic Syndromes and Imprinting
- COVID-19 Clinical Research Studies
- Liver Disease and Transplantation
- Electrolyte and hormonal disorders
- MRI in cancer diagnosis
- Colorectal Cancer Surgical Treatments
- Pregnancy and Medication Impact
- Advanced Glycation End Products research
- Colorectal Cancer Screening and Detection
- Acute Kidney Injury Research
- Long-Term Effects of COVID-19
- HIV/AIDS drug development and treatment
- Chronic Lymphocytic Leukemia Research
- Liver Disease Diagnosis and Treatment
Yale University
2021-2025
Pediatric Nephrology of Alabama
2014-2024
Icahn School of Medicine at Mount Sinai
2014-2023
Creative Commons
2023
Yale Cancer Center
2022
Stanford University
2022
Mount Sinai Hospital
2019-2021
RELX Group (United States)
2016-2020
Mount Sinai Hospital
2018-2019
Mount Sinai Hospital
2013-2019
Abstract Renal inflammation and fibrosis are the common pathways leading to progressive chronic kidney disease (CKD). We previously identified hematopoietic cell kinase (HCK) as upregulated in human allograft injury promoting fibrosis; however, cellular source molecular mechanisms unclear. Here, using immunostaining single sequencing data, we show that HCK expression is highly enriched pro-inflammatory macrophages diseased kidneys. HCK-knockout (KO) or HCK-inhibitor decreases macrophage...
The glomerular filtration barrier is a highly specialized blood interface that displays high conductance to small and midsized solutes in plasma but retains relative impermeability macromolecules. Its integrity maintained by physicochemical signalling interplay among its three core constituents-the endothelial cell, the basement membrane visceral epithelial cell (podocyte). Understanding pathomechanisms of inherited acquired human diseases as well experimental injury models this have helped...
Much of the higher risk for end-stage kidney disease (ESKD) in African American individuals relates to ancestry-specific variation apolipoprotein L1 gene (
ABSTRACT Importance Preliminary reports indicate that acute kidney injury (AKI) is common in coronavirus disease (COVID)-19 patients and associated with worse outcomes. AKI hospitalized COVID-19 the United States not well-described. Objective To provide information about frequency, outcomes recovery dialysis patients. Design Observational, retrospective study. Setting Admitted to hospital between February 27 April 15, 2020. Participants P atients aged ≥18 years laboratory confirmed Exposures...
Significance Statement Biomarkers for noninvasive diagnosis of subclinical acute rejection are needed to enable risk-stratification and tailoring immunosuppression kidney transplant recipients. Using RNA sequencing analyses whole blood collected from a cohort recipients at the time surveillance biopsy, authors identified transcriptional signature on basis set 17 genes that accurately detects ongoing rejection. After extensive validation, they developed sequencing-based targeted expression...
Fibrosis underlies the loss of renal function in patients with chronic kidney disease (CKD) and transplant recipients allograft nephropathy (CAN). Here, we studied effect an intronic SNP SHROOM3, which has previously been linked to CKD, on development CAN a prospective cohort recipients. The presence rs17319721 allele at SHROOM3 locus donor correlated increased expression allograft. In vitro, determined that sequence containing risk is transcription factor 7–like 2–dependent...
Whether kidney transplant recipients are capable of mounting an effective anti-severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) adaptive immune response despite chronic immunosuppression is unknown and has important implications for therapy. Herein, we analyzed peripheral blood cell surface intracellular cytokine phenotyping by flow cytometry along with serum antibody testing in 18 active disease 2019 (COVID-19) infection 36 matched, transplanted controls without COVID-19. We...
Interstitial fibrosis, tubular atrophy, and inflammation are major contributors to kidney allograft failure. Here we sought an objective, quantitative pathological assessment of these lesions improve predictive utility constructed a deep-learning-based pipeline recognizing normal vs. abnormal tissue compartments mononuclear leukocyte infiltrates. Periodic acid- Schiff stained slides transplant biopsies (60 training 33 testing) were used quantify specific for interstitium, tubules...
Dachshund homolog 1 (DACH1), a key cell-fate determinant, regulates transcription by DNA sequence–specific binding. We identified diminished Dach1 expression in large-scale screen for mutations that convert injury-resistant podocytes into injury-susceptible podocytes. In diabetic kidney disease (DKD) patients, podocyte DACH1 levels are diminished, condition strongly correlates with poor clinical outcomes. Global KO mice manifest renal hypoplasia and die perinatally. Podocyte-specific mice,...
The progression of proteinuric kidney diseases is associated with podocyte loss but the mechanisms underlying this process remain unclear. Podocytes re-enter cell cycle to repair double-stranded DNA (dsDNA) breaks. However, unsuccessful can result in podocytes crossing G1/S checkpoint and undergoing abortive cytokinesis. In study, we identified Pfn1 as indispensable maintaining glomerular integrity - its tissue-specific mouse results severe proteinuria failure. Our suggest that phenotype due...
An early posttransplant biomarker/surrogate marker for kidney allograft loss has the potential to guide targeted interventions. Previously published findings, including results from Clinical Trials in Organ Transplantation (CTOT)-01 study, showed that elevated urinary chemokine CXCL9 levels and frequencies of donor-reactive interferon gamma (IFNγ)-producing T cells by enzyme-linked immunosorbent spot (ELISPOT) assay associated with acute cellular rejection within first year lower 1-year...
The causes of diffuse abdominal pain following pelvic surgery are numerous. We present a rare case acute in woman the post-partum period.A 25-year-old Caucasian with neurofibromatosis type 1 presented to our hospital immediately after cesarean section. patient was acutely ill and toxic fever 38.8 degrees C, pulse 120 beats per minute distended abdomen absent bowel sounds. A computed tomography scan showed air wall stomach portal venous system. successfully treated intravenous antibiotics,...