A5005263466- Meningioma and schwannoma management
- Glioma Diagnosis and Treatment
- Neurofibromatosis and Schwannoma Cases
- Pituitary Gland Disorders and Treatments
- Head and Neck Surgical Oncology
- Bone Tumor Diagnosis and Treatments
- Radiomics and Machine Learning in Medical Imaging
- Brain Metastases and Treatment
- Cancer Genomics and Diagnostics
- Chromatin Remodeling and Cancer
- Vascular Malformations Diagnosis and Treatment
- Cerebral Venous Sinus Thrombosis
- Adrenal and Paraganglionic Tumors
- Medical Imaging Techniques and Applications
- Trigeminal Neuralgia and Treatments
- Epigenetics and DNA Methylation
- Management of metastatic bone disease
- Cancer, Hypoxia, and Metabolism
- Single-cell and spatial transcriptomics
- Cancer Treatment and Pharmacology
- Traumatic Brain Injury and Neurovascular Disturbances
- PARP inhibition in cancer therapy
- Sexual function and dysfunction studies
- Myasthenia Gravis and Thymoma
- Hedgehog Signaling Pathway Studies
Yale New Haven Hospital
2010-2025
Yale University
2015-2024
Smilow Cancer Hospital
2019-2024
Yale Cancer Center
2017-2024
University of New Haven
2011-2022
Stony Brook University
2021
Neurological Surgery
2010-2021
Kanazawa University
2021
Cleveland Clinic Lerner College of Medicine
2018
Center for Innovation
2018
Abstract Meningiomas are mostly benign brain tumours, with a potential for becoming atypical or malignant. On the basis of comprehensive genomic, transcriptomic and epigenomic analyses, we compared meningiomas to ones. Here, show that majority primary ( de novo ) display loss NF2 , which co-occurs either genomic instability recurrent SMARCB1 mutations. These tumours harbour increased H3K27me3 signal hypermethylated phenotype, mainly occupying polycomb repressive complex 2 (PRC2) binding...
OBJECTIVE Recent large-cohort sequencing studies have investigated the genomic landscape of meningiomas, identifying somatic coding alterations in NF2 , SMARCB1 SMARCE1 TRAF7, KLF4, POLR2A BAP1 and members PI3K Hedgehog signaling pathways. Initial associations between clinical features subgroups been described, including location, grade, histology. However, further investigation using an expanded collection samples is needed to confirm previous findings, as well elucidate relationships not...
We and others have identified mutually exclusive molecular subgroups of meningiomas; however, the implications this classification for clinical prognostication remain unclear. Integrated genomic epigenomic analyses implicate unique oncogenic processes associated with each subgroup, suggesting potential divergent courses. The aim study was to understand outcomes as could optimize treatment patients.We analyzed outcome data 469 meningiomas known including extent resection, postoperative...
Abstract High-grade meningiomas are associated with neuro-cognitive morbidity and have limited treatments. harbor an immunosuppressive tumor microenvironment (TME) programmed death-ligand 1 (PD-L1) expression may contribute to their aggressive phenotype. Here, we present the results of a single-arm, open-label phase 2 trial (NCT03279692) evaluating efficacy pembrolizumab, PD-1 inhibitor, in cohort 25 evaluable patients recurrent progressive grade 3 meningiomas. The primary endpoint is...
While most meningiomas are benign, 1%-3% display anaplastic features, with little current understanding regarding the molecular mechanisms underlying their formation. In a large single-center cohort, authors tested hypothesis that two distinct subtypes of meningiomas, those arise de novo and progress from lower grade tumors, exist exhibit different clinical behavior.Pathology reports data 37 patients treated between 1999 2012 for meningioma at Memorial Sloan-Kettering Cancer Center (MSKCC)...
The authors set out to evaluate the quality of life (QOL), social-emotional functioning, and behavioral functioning children treated surgically for craniopharyngiomas.Twelve girls 17 boys with a mean age at diagnosis 8 +/- 3.8 years were between 1985 1998 New York University Medical Center. After follow-up period 6.8 3.5 years, these 29 patients administered either 36-item Short Form Health Survey version 2 or Child Questionnaire-Parent assess QOL, as well Achenbach Behavior Checklist Young...
Object The use of minimally invasive surgical techniques, including microscope-assisted tubular lumbar microdiscectomy (tLMD), has gained increasing popularity in treating disc herniations (LDHs). This particular procedure been shown to be both cost-efficient and effective, resulting outcomes comparable those open procedures. Lumbar herniation recurrence necessitating reoperation, however, remains an issue following spinal surgery, with overall reported incidence approximately 3–13%....
Trigeminal neuralgia (TN) is a common, debilitating neuropathic face pain syndrome often resistant to therapy. The familial clustering of TN cases suggests that genetic factors play role in disease pathogenesis. However, no unbiased, large-scale genomic study has been performed date. Analysis 290 whole exome-sequenced probands, including 20 multiplex kindreds and 70 parent-offspring trios, revealed enrichment rare, damaging variants GABA receptor-binding genes cases. Mice engineered with...
Object Gamma Knife surgery (GKS) improves overall survival in patients with malignant melanoma metastatic to the brain. In this study authors investigated which patient- or treatment-specific factors influence of brain metastases; they pay particular interest pre- and post-GKS hemorrhage. Methods Demographic, treatment, data on 59 a total 208 intracranial metastases who underwent GKS between 1998 2007 were abstracted from treatment records Connecticut Tumor Registry. Multivariate analysis...
Despite being promising, the clinical application of magnetic hyperthermia for brain cancer treatment is limited by requirement highly invasive intracranial injections. To overcome this limitation, here we report development gallic acid-coated nanoclovers (GA-MNCs), which allow not only noninvasive delivery but also targeted systemic chemotherapy to tumors. GA-MNCs are composed clover-shaped MNCs in core, can induce heat high efficiency, and polymerized GA on shell, enables tumor...
While somatic variants of TRAF7 (Tumor necrosis factor receptor-associated 7) underlie anterior skull-base meningiomas, here we report the inherited mutations that cause congenital heart defects. We show mutants operate in a dominant manner, inhibiting protein function via heterodimerization with wild-type protein. Further, shared genetics two disparate pathologies can be traced to common origin forebrain meninges and cardiac outflow tract from TRAF7- expressing neural crest. Somatic disrupt...
Abstract Hedgehog signaling mediates embryologic development of the central nervous system and other tissues is frequently hijacked by neoplasia to facilitate uncontrolled cellular proliferation. Meningiomas, most common primary brain tumor, exhibit activation in 6.5% cases, triggered recurrent mutations pathway mediators such as SMO . In this study, we find 35.6% meningiomas that lack previously known drivers acquired various types somatic structural variations affecting chromosomes 2q35...
OBJECTIVE The association of seizures with meningiomas is poorly understood. Moreover, any relationship between and the underlying meningioma genomic subgroup has not been studied. Herein, authors report on their experience identifying clinical factors associated preoperative postoperative seizure presentation in patients. METHODS Clinical sequencing data 394 patients surgically treated for at Yale New Haven Hospital were reviewed. Correlations clinical, histological, or variables occurrence...