A5076723956- Neuroblastoma Research and Treatments
- Meningioma and schwannoma management
- Cancer, Hypoxia, and Metabolism
- Chromatin Remodeling and Cancer
- Cell death mechanisms and regulation
- Glioma Diagnosis and Treatment
- Cancer Genomics and Diagnostics
- Cellular transport and secretion
- Microtubule and mitosis dynamics
- Genomics and Rare Diseases
- Genetics and Neurodevelopmental Disorders
- Molecular Biology Techniques and Applications
- Protein Tyrosine Phosphatases
- Caveolin-1 and cellular processes
- Tumors and Oncological Cases
- Peroxisome Proliferator-Activated Receptors
- Colorectal and Anal Carcinomas
- Cardiac electrophysiology and arrhythmias
- Hippo pathway signaling and YAP/TAZ
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Head and Neck Surgical Oncology
- PARP inhibition in cancer therapy
- Cancer-related molecular mechanisms research
- Genomic variations and chromosomal abnormalities
- Circular RNAs in diseases
Dokuz Eylül University
2018-2024
Yale University
2014-2024
Yale Cancer Center
2017
Acıbadem University
2015
Memorial Sloan Kettering Cancer Center
2015
Selçuk University
2015
Abstract Meningiomas are mostly benign brain tumours, with a potential for becoming atypical or malignant. On the basis of comprehensive genomic, transcriptomic and epigenomic analyses, we compared meningiomas to ones. Here, show that majority primary ( de novo ) display loss NF2 , which co-occurs either genomic instability recurrent SMARCB1 mutations. These tumours harbour increased H3K27me3 signal hypermethylated phenotype, mainly occupying polycomb repressive complex 2 (PRC2) binding...
Malignant high-grade gliomas (HGGs), including the most aggressive form, glioblastoma multiforme, show significant clinical and genomic heterogeneity. Despite recent advances, overall survival of HGGs their response to treatment remain poor. In order gain further insight into disease pathophysiology by correlating landscape with behavior, thereby identifying distinct HGG molecular subgroups associated improved prognosis, we performed a comprehensive analysis. We analyzed compared 720...
While somatic variants of TRAF7 (Tumor necrosis factor receptor-associated 7) underlie anterior skull-base meningiomas, here we report the inherited mutations that cause congenital heart defects. We show mutants operate in a dominant manner, inhibiting protein function via heterodimerization with wild-type protein. Further, shared genetics two disparate pathologies can be traced to common origin forebrain meninges and cardiac outflow tract from TRAF7- expressing neural crest. Somatic disrupt...
Tangier disease (TD) is a rare, autosomal recessive inherited disorder caused by mutation in the adenosine triphosphate-binding cassette transporter 1 (ABCA1) gene, which results decrease plasma high-density lipoprotein (HDL) levels. Peripheral neuropathy can be seen approximately 50% of patients with TD, usually occurs after age 15 years, and characterized relapsing-remitting mono- or polyneuropathy syringomyelia-like neuropathy. Herein, we report 16-year-old female patient who was...
Tribbles Homolog 3 (TRIB3) is a member of the pseudokinase family tribbles and acts as an adaptor protein to regulate different cellular processes. Upregulation TRIB3 expression was shown either favorable or adverse prognostic factor in various adult malignancies. However, has not been examined pediatric cancers. Neuroblastoma most common malignant solid tumor childhood, which affects mostly children under 5 years old. Risk stratification patients defined by International Group used...
Structures from the Stone Age can provide unique insights into Late Glacial and Mesolithic cultures around Baltic Sea. Such structures, however, usually did not survive within densely populated Central European subcontinent. Here, we ...The Sea basins, some of which only submerged in mid-Holocene, preserve structures that on land. Yet, discovery these features is challenging requires cross-disciplinary approaches between archeology ...
Abstract Objectives Neuroblastoma is the most common extracranial solid tumor in childhood. YAP (Yes‐associated protein) a highly expressed protein NB. Nestin an important marker of neuronal differentiation Orthodenticle homeobox (OTX) transcription factor and overexpressed blastoma‐derived tumors. The aim this study was to examine potential roles YAP‐1, Nestin, OTX‐2 proteins prognosis risk stratification neuroblastoma Methods Tumor sections 56 patients with different NB groups were...
Nöroblastom, gelişmekte olan sinir sisteminden köken alan ve çocukluk çağının en sık görülen solid tümörüdür. Klinik seyri lokalize veya spontane gerileme gösterebilen hastalıktan, yoğun multimodal tedavi rejimlerine dirençli metastatik hastalığa değişen heterojen bir davranış göstermektedir. Ras Homolog Ailesi Üyesi B (RhoB), Rho GTPaz ailesinin üyesidir sitoiskeletet organizasyonunda, reseptör sinyal proteinlerinin iletiminde, DNA hasar tamirinde apoptozda rol oynar. RhoB ekspresyonu...
Neuroblastoma (NB) is the most frequent extracranial solid tumor of childhood, remarkable for its broad spectrum clinical behavior. This diversity in behavior correlates closely with defined and biological features combinations prognostic variables are used risk-group assignment. S-100 proteins have roles differentiation were shown to be frequently dysregulated NB. MATH-1 protein plays role neuronal cell through development. However, up date, there no studies evaluating relationship between...
Ewing sarcoma is a bone and soft tissue tumor either neuroectodermal or mesenchymal originated affecting children adolescents. In the present study, we aimed to find out prognostic predictive biomarkers for sarcoma. Hence, examined copy number alterations (and related possible genes) among ten patient samples associations with clinical outcome. DNA extraction from formalin fixed paraffin embedded archive tissues was performed. Whole genome Comparative Genomic Hybridization (CGH) performed by...
Neuroblastoma (NB) is the most common extracranial solid tumor in children with incidence rate 10.2 per 1 million under 15 years old. NB has great diversity clinical behavior while some tumors are easily curable and spontaneously regressed, others resistant to chemotherapies exhibiting high relapse rates. Despite intensive usage of chemotherapies, still 5-year survival about 40% for advanced stage bad prognostic patient group. Hence, there need more effective therapeutics novel biomarkers...
Abstract Background: SMAC mimetics (SM) are compounds that developed on secondary mitochondria-derived activators of caspase (SMAC) protein structure and sensitize cancer cells to cell death, either alone or in the presence death ligands chemotherapies. However, their efficacy as a single agent combination with chemotherapy is highly variable limited. In this study, we aimed identify transcriptomic changes SH-SY5Y upon induction SM using RNA sequencing (RNA-seq). Hence, total gene expression...
Objective: Tribbles protein (TRIB) family was first identified in Drosophila, plays role coordinating cell division and morphogenesis. TRIB3 is one of the members this family, its expression levels patient prognosis has been examined various studies. While correlated with poor hepatocellular cancer patients, were associated increased disease-free survival a better response to therapy luminal breast patients. Neuroblastoma (NB) most common solid tumor children accounts for ~15% childhood...
Introduction: Neuroblastoma (NB) is the most common solid tumors in childhood. MYCN main prognostic factor for risk classification and staging NB patients. YAP (Yes Associated Protein) plays a critical role many types of cancer. In NB, expression levels may be correlate with advanced tumor staging. Nestin an important neuronal differentiation cancer stem cell marker NB. The aim this study to examine potential roles YAP-1 expressions terms prognosis classifications neuroblastoma. Materials...
Objective: S-100 is an acidic-calcium-binding protein and was first described in cells of neuroendocrine origin. It plays important role various cellular processes such as cell differentiation proliferation. to be a negative prognostic marker for the advanced stages melanoma evaluated biomarker different cancers. Neuroblastoma(NB) remarkable its broad spectrum clinical behavior, varying from spontaneous regression progressive disease accounts ~15% childhood cancer‐related mortality. This...