A5077927938- Childhood Cancer Survivors' Quality of Life
- Glioma Diagnosis and Treatment
- Cancer-related cognitive impairment studies
- Neuroblastoma Research and Treatments
- Family and Disability Support Research
- Family Support in Illness
- Acute Lymphoblastic Leukemia research
- Meningioma and schwannoma management
- Infant Development and Preterm Care
- Spatial Neglect and Hemispheric Dysfunction
- Brain Metastases and Treatment
- Radiation Therapy and Dosimetry
- Testicular diseases and treatments
- Genetics and Neurodevelopmental Disorders
- Neural and Behavioral Psychology Studies
- Cancer therapeutics and mechanisms
- Ethics and Legal Issues in Pediatric Healthcare
- Anesthesia and Neurotoxicity Research
- Pituitary Gland Disorders and Treatments
- Patient-Provider Communication in Healthcare
- Palliative Care and End-of-Life Issues
- Botulinum Toxin and Related Neurological Disorders
- Hereditary Neurological Disorders
- Cancer survivorship and care
- Cancer Treatment and Pharmacology
Memorial Sloan Kettering Cancer Center
1998-2024
Kaiser Permanente
2024
Columbia University
2004-2016
Columbia University Irving Medical Center
2009-2016
Nationwide Children's Hospital
2015
The Ohio State University
2015
Porter Adventist Hospital
2014
Neurological Surgery
2014
Université de Montréal
2013
Presbyterian Hospital
2011
PURPOSE To evaluate a strategy that avoids radiotherapy in children less than 6 years of age with newly diagnosed malignant brain tumors, by administering myeloablative consolidation chemotherapy autologous bone marrow reconstitution (ABMR) after maximal surgical resection and conventional induction chemotherapy. PATIENTS AND METHODS Between March 1991 April 1995, 62 (median age, 30 months) tumors were enrolled onto this trial. Children received vincristine, cisplatin, cyclophosphamide,...
To determine the survival of infants and young children with non-metastatic medulloblastoma using intensive myeloablative chemotherapy autologous hematopoietic progenitor cell rescue (AuHCR).Twenty-one less than 3 years old at diagnosis were enrolled on two identical serial studies, "Head Start" I II. After surgery, patients received five cycles induction consisting vincristine, cisplatin, cyclophosphamide etoposide. Following induction, all underwent carboplatin, thiotepa etoposide AuHCR....
Convection-enhanced delivery of chemotherapeutics for the treatment malignant glioma is a technique that delivers drugs directly into tumor and surrounding interstitium through continuous, low-grade positive-pressure infusion. This allows high local concentrations drug while overcoming limitations imposed by toxicity blood-brain barrier in systemic therapies prevent use many potentially effective drugs.To examine safety profile conventional chemotherapeutic agent, topotecan, via...
"Head Start" III, was a prospective clinical trial using intensive induction followed by myeloablative chemotherapy and autologous hematopoietic cell rescue (AuHCR) to either avoid or reduce the dose/volume of irradiation in young children with medulloblastoma.
The authors set out to evaluate the quality of life (QOL), social-emotional functioning, and behavioral functioning children treated surgically for craniopharyngiomas.Twelve girls 17 boys with a mean age at diagnosis 8 +/- 3.8 years were between 1985 1998 New York University Medical Center. After follow-up period 6.8 3.5 years, these 29 patients administered either 36-item Short Form Health Survey version 2 or Child Questionnaire-Parent assess QOL, as well Achenbach Behavior Checklist Young...
Abstract Background Neurocognitive functioning is an important construct in childhood cancer survivorship, given the potential neurotoxicity of central nervous system (CNS) diseases and treatments relevance for functional outcomes adulthood. However, within pediatric oncology cooperative groups there have been significant barriers to neurocognitive data collection that historically resulted incomplete (<30% compliance), thereby limiting progress understanding survivors. This paper...
Background Due to the devastating late effects associated with cranial irradiation in young children central nervous system (CNS) tumors, treatment for these patients has evolved include use of intensive chemotherapy either avoid or postpone irradiation. While survival outcomes have improved, data survivors treated on such regimens are needed. Objective This multi-institutional study comprehensively describes Head Start I/II protocols. Methods Survivors CNS tumors protocols were enrolled....
Providing care to one's child during and after a hematopoietic stem cell transplant (HSCT) is universally stressful experience, but few psychological interventions have been developed reduce caregiver distress. The goal of this study was test the efficacy brief cognitive-behavioral intervention delivered primary caregivers.Two hundred eighteen caregivers were assigned either best-practice psychosocial (BPC) or parent social-cognitive program (P-SCIP). 5 session P-SCIP HSCT hospitalization....
Cognitive ERPs and EEG spectral differences were compared in three groups of children: nonreferred controls, those with a dominant hyperactivity/impulsivity factor (ADHD-Im), inattentive (ADHD-Ia). The results from the ERP analyses indicated that P250, P350, P500 components differed between groups. most marked seen respect to amplitude components. In addition, topographic foci for CON ADHD-Im symmetrical, but ADHD-Ia group featured P250 P350 biased away right hemisphere. Nevertheless, was...
Abstract Background To evaluate the neuropsychological late effects amongst survivors treated on Head Start II protocol between 1997 and 2003. Procedures Forty‐nine patients (mean age 2.9 years) diagnosed with a malignant brain tumor underwent baseline assessment prior to autologous hematopoietic cell transplantation (AuHCT). Twenty‐six were retested after 3 years of follow‐up as 20 did not survive. Patients evaluated for intelligence, academic achievement, receptive language, visual‐motor...
Object Controversy persists concerning the optimal treatment of craniopharyngiomas in children, and no standard outcome metric exists for comparison across modalities, nor is there one that adequately reflects multisystem dysfunction may arise. Methods The authors retrospectively analyzed records 86 consecutive children who underwent a uniform paradigm attempted radical resection performed by single surgeon. Excluding 3 perioperative deaths patients with inadequate follow-up, 80 (34 girls 46...
Although corticosteroids remain a mainstay of treatment for acute lymphoblastic leukemia (ALL), they can cause troublesome neurobehavioral changes during active treatment, especially in young children. We evaluated side effects corticosteroid therapy preschool versus school-age children by obtaining structured reports weekly 1 month.Parents 62 (2-17 years) treated on Dana-Farber Cancer Institute (DFCI) ALL Consortium Protocol 00-01 participated the continuation phase treatment. Patients...
Abstract Purpose To report the final analysis of survival outcomes for children with newly diagnosed high‐grade glioma (HGG) treated on “Head Start” (HS) II and III protocols chemotherapy intent to avoid irradiation in <6 years old. Patients Methods Between 1997 2009, 32 eligible were enrolled HS anaplastic astrocytoma (AA, n = 19), glioblastoma multiforme (GBM, 11), or other HGG (n 2). Central pathology review was completed 78% patients. predominantly brainstem tumors excluded. be single...
Abstract Background Neuropsychological comparison of medulloblastoma (MB) and cerebellar low‐grade astrocytoma (LGA) survivors to controls can clarify treatment‐related neurocognitive late effects. While both brain tumor groups undergo surgery the posterior fossa, children with MB additionally receive craniospinal irradiation boost chemotherapy. This study provides an updated neuropsychological functioning in these two examines effects demographic risk factors upon outcomes. Procedure...
Abstract Purpose To evaluate the accuracy, comprehensiveness, empathetic tone, and patient preference for AI urologist responses to messages concerning common BPH questions across phases of care. Methods Cross-sectional study evaluating 20 BPH-related generated by 2 chatbots 4 urologists in a simulated clinical messaging environment without direct interaction. Accuracy, completeness, tone assessed experts using Likert scales, preferences perceptions authorship (chatbot vs. human) rated...
Abstract Background The trajectory of Heath‐Related Quality Life (HRQoL) in pediatric recipients who have undergone hematopoietic stem cell transplantation (HSCT), as well the demographic and medical factors that predict HRQoL, has lagged behind adult research. Methods A prospective longitudinal study HRQoL HSCT was conducted with 95 patients at Columbia University Medical Center between 2002 2009. Both children parents completed PedsQL 4.0 prior to days 100, 180, 365‐post‐HSCT. Results...
Background Dexamethasone is more efficacious than prednisone in the treatment of acute lymphoblastic leukemia (ALL), but has also been associated with greater toxicity. We compared neuropsychological outcomes for patients treated on DFCI ALL Consortium Protocol 00-01, which included a randomized comparison two steroid preparations during post-induction therapy children and adolescents ALL. Procedure Between 2000 2005, 408 standard-risk or high-risk Dana-Farber Cancer Institute 00-01 were...