A5083076668- Platelet Disorders and Treatments
- Neonatal and fetal brain pathology
- Hematopoietic Stem Cell Transplantation
- Neonatal Respiratory Health Research
- Congenital Diaphragmatic Hernia Studies
- Immunotherapy and Immune Responses
- Neuroscience and Neuropharmacology Research
- Neutropenia and Cancer Infections
- Mitochondrial Function and Pathology
- Blood disorders and treatments
- Blood groups and transfusion
- Neonatal Health and Biochemistry
- Cancer Immunotherapy and Biomarkers
- Neuroscience of respiration and sleep
- Genital Health and Disease
- Neuroinflammation and Neurodegeneration Mechanisms
- Tryptophan and brain disorders
- Hemoglobinopathies and Related Disorders
- Traumatic Brain Injury and Neurovascular Disturbances
- Streptococcal Infections and Treatments
- Trauma and Emergency Care Studies
- Abdominal Trauma and Injuries
- Neuroblastoma Research and Treatments
- Immune Cell Function and Interaction
- Case Reports on Hematomas
University of Cape Town
2025
ProMedica Russell J. Ebeid Children's Hospital
2016-2022
Klinikum Brandenburg
2021
University of Toledo
2011-2014
ProMedica Toledo Hospital
2008
National Cancer Institute
1996-2000
National Institutes of Health
2000
Penn State Milton S. Hershey Medical Center
1988-1989
Pennsylvania State University
1988
An excessive accumulation of calcium in neuronal and other tissues has been postulated to represent a "final common pathway" for cell death arising from hypoxia-ischemia. To clarify the role altered flux into distribution within perinatal brain undergoing hypoxic-ischemic injury, 7-day postnatal rats underwent unilateral carotid artery ligation followed by 3 h hypoxia with 8% oxygen. This insult is known produce damage confined cerebral hemisphere ipsilateral arterial occlusion greater than...
Abstract Purpose To report the final analysis of survival outcomes for children with newly diagnosed high‐grade glioma (HGG) treated on “Head Start” (HS) II and III protocols chemotherapy intent to avoid irradiation in <6 years old. Patients Methods Between 1997 2009, 32 eligible were enrolled HS anaplastic astrocytoma (AA, n = 19), glioblastoma multiforme (GBM, 11), or other HGG (n 2). Central pathology review was completed 78% patients. predominantly brainstem tumors excluded. be single...
Abstract Children who are HIV-exposed and uninfected (HEU) at risk of neurodevelopmental delays, which may be partially due to maternal immune dysregulation during pregnancy. This study investigates associations between child profiles early neurometabolite in HEU HIV-unexposed (HU) children from a South African birth cohort. A subgroup 156 (66 HEU, 90 HU) the Drakenstein Child Health Study underwent magnetic resonance spectroscopy age 2–3 years, serum markers were measured multiple...
Desmopressin (DDAVP) 1-deamino-8-D-arginine vasopressin is used in patients with bleeding disorders, including mild factor VIII deficiency, types 1 and 2 von Willebrand disease, platelet function defects, undergoing surgeries to help control bleeding. We conducted a retrospective chart review of disorder inpatient surgery at Toledo Children's Hospital, OH, from 2005 2009. Our study population included 107 aged 19 years defects disease. aimed evaluate the extent hyponatremia caused by DDAVP...
We are reporting a rare case of primary squamous cell carcinoma lung with skeletal metastases in 7-year-old boy. The patient received chemotherapy initial improvement but eventually died the disease. A brief literature review is also presented.
<h3>Introduction</h3> Transudative pleural effusions is challenging to manage, with high morbidity and mortality rates.<sup>1</sup> They are usually secondary organ failure treatment targeted towards the underlying disease process rather than effusion itself. Lack of data has contributed difficulty in manging these patients.<sup>2</sup> <h3>Aim</h3> Evaluating our local centre experience managing transudative outcomes. <h3>Methods</h3> Retrospective review referrals clinic from January 2020...
Abstract Objective Tonsil/adenoidectomy (T/A) is a commonly performed procedure with an average post‐tonsillectomy bleed (PTB) rate between 3 and 5%. Patients bleeding disorders (BDs) are believed to have increased risk of PTB. We hypothesize that our medical management BD patients using combination DDAVP/antifibrinolytic agents has similar PTB control patients. This study suggests standardized protocol for BDs avoid Methods A retrospective cohort was completed who underwent tonsillectomy or...
Male circumcision is a common procedure, generally performed during the newborn period. Bleeding an uncommon but feared complication of circumcision. Few reports have evaluated bleeding rates in patients with disorders.To study male subjects who were diagnosed later life delta-storage pool deficiency (δ-SPD).We retrospectively reviewed medical records (≤18 years age) circumcised without hemostatic prophylaxis prior to δ-SPD diagnosis from 2000 2020. and severity main outcomes evaluated. We...
Whether a patient receives general or specialized outpatient palliative cancer care rarely follows clear criteria, leading to undertreatment overtreatment. Detailed scores exist predict prognosis, but not treatment requirements, leaving caregivers follow their intuition. As phenomenological indicator incorporating possibly important subjective information, intuition may in fact be helpful tool. In this prospective observational study, score estimate three global dimensions of patients'...