A5058373918- Brain Metastases and Treatment
- Glioma Diagnosis and Treatment
- Lung Cancer Research Studies
- Meningioma and schwannoma management
- Lung Cancer Treatments and Mutations
- Cancer Immunotherapy and Biomarkers
- Advanced Radiotherapy Techniques
- Medical Imaging Techniques and Applications
- Vascular Malformations Diagnosis and Treatment
- Radiopharmaceutical Chemistry and Applications
- Radiomics and Machine Learning in Medical Imaging
- Melanoma and MAPK Pathways
- Intracranial Aneurysms: Treatment and Complications
- CAR-T cell therapy research
- Lung Cancer Diagnosis and Treatment
- Traumatic Brain Injury and Neurovascular Disturbances
- Management of metastatic bone disease
- Nanoplatforms for cancer theranostics
- Cutaneous Melanoma Detection and Management
- Neurofibromatosis and Schwannoma Cases
- Neurosurgical Procedures and Complications
- Immunotherapy and Immune Responses
- Head and Neck Surgical Oncology
- Renal cell carcinoma treatment
- Trigeminal Neuralgia and Treatments
Yale University
2016-2025
Yale Cancer Center
2013-2023
Yale New Haven Hospital
2013-2022
Creative Commons
2021
West Virginia University
2021
Neurological Surgery
2018-2020
British Heart Foundation
2020
University of Glasgow
2020
The Barbara Ann Karmanos Cancer Institute
2020
Emory University
2020
Our group has previously published the Graded Prognostic Assessment (GPA), a prognostic index for patients with brain metastases. Updates have been refinements to create diagnosis-specific indices. The purpose of this report is present updated GPA indices in single, unified, user-friendly allow ease access and use by treating physicians.A multi-institutional retrospective (1985 2007) database 3,940 newly diagnosed metastases underwent univariate multivariate analyses factors associated...
Lung cancer is the leading cause of cancer-related mortality in United States and worldwide. As systemic therapies improve, patients with lung live longer thus are at increased risk for brain metastases. Understanding how prognosis varies across this heterogeneous patient population essential to individualize care design future clinical trials.To update current Diagnosis-Specific Graded Prognostic Assessment (DS-GPA) non-small-cell (NSCLC) The DS-GPA based on data from diagnosed between 1985...
Purpose Stereotactic radiosurgery (SRS), whole-brain radiotherapy (WBRT), and epidermal growth factor receptor (EGFR)-tyrosine kinase inhibitors (TKIs) are treatment options for brain metastases in patients with EGFR-mutant non-small-cell lung cancer (NSCLC). This multi-institutional analysis sought to determine the optimal management of NSCLC who develop have not received EGFR-TKI. Materials Methods A total 351 from six institutions developed met inclusion criteria study. Exclusion included...
Conventional wisdom has rendered patients with brain metastases ineligible for clinical trials fear that poor survival could mask the benefit of otherwise promising treatments. Our group previously published diagnosis-specific Graded Prognostic Assessment (GPA). Updates larger contemporary cohorts using molecular markers and newly identified prognostic factors have been published. The purposes this work are to present all updated indices in a single report guide treatment choice, stratify...
Object A prospectively collected cohort of 77 patients who underwent definitive radiosurgery between 2002 and 2010 for melanoma brain metastases was retrospectively reviewed to assess the impact ipilimumab use other clinical variables on survival. Methods The authors conducted an institutional review board–approved chart patient age at time metastasis diagnosis, sex, primary disease location, initial date, number treated, performance status, systemic therapy history, whole-brain radiation...
We performed a multi-institutional study to identify prognostic factors and determine outcomes for patients with ALK-rearranged non-small-cell lung cancer (NSCLC) brain metastasis.A total of 90 metastases from NSCLC were identified six institutions; 84 received radiotherapy the (stereotactic radiosurgery [SRS] or whole-brain [WBRT]), 86 tyrosine kinase inhibitor (TKI) therapy. Estimates overall (OS) intracranial progression-free survival determined clinical by Cox proportional hazards...
Pembrolizumab is active in melanoma, but activity patients with untreated brain metastasis less established. We present long-term follow-up of pembrolizumab-treated new or progressing metastases treated on a phase II clinical trial ( ClinicalTrials.gov identifier: NCT02085070).We enrolled 23 melanoma one more asymptomatic, 5- to 20-mm not requiring corticosteroids; 70% had prior systemic therapy. was administered for up 24 months. Brain response, the primary end point, assessed by modified...
OBJECT Radiation necrosis (RN), or its imaging equivalent, treatment-related changes (TRIC), is an inflammatory reaction to high-dose radiation in the brain. The authors sought investigate hypothesis that immunotherapy increases risk of developing RN/TRIC after stereotactic Gamma Knife (GK) radiosurgery for brain metastases. METHODS A total 180 patients who underwent GK surgery metastases between 2006 and 2012 were studied. systemic therapy they received was classified as cytotoxic...
Pituitary adenomas are fairly common intracranial neoplasms, and nonfunctioning ones constitute a large subgroup of these adenomas. Complete resection is often difficult may pose undue risk to neurological endocrine function. Stereotactic radiosurgery has come play an important role in the management patients with pituitary This study examines outcomes after large, multicenter patient population.Under auspices North American Gamma Knife Consortium, 9 surgery (GKS) centers retrospectively...
Growing evidence suggests that immunotherapy and radiation therapy can be synergistic in the treatment of cancer. This study was performed to determine effect relative timing type immune checkpoint on response melanoma brain metastases (BrMets) with stereotactic radiosurgery (SRS).Seventy-five patients 566 BrMets were treated both SRS between 2007 2015 at a single institution. Immunotherapy any lesion considered concurrent if administered within 4 weeks immunotherapy. The impact lesional...
Abstract Purpose: Programmed death ligand-1 (PD-L1) tumor expression represents a mechanism of immune escape for melanoma cells. Drugs blocking PD-L1 or its receptor have shown unprecedented activity in melanoma, and our purpose was to characterize associated T-cell infiltration metastatic melanomas. Experimental Design: We used tissue microarray (TMA) consisting two cores from 95 melanomas characterized clinical stage, outcome, anatomic site disease. assessed tumor-infiltrating lymphocyte...
Laser Ablation After Stereotactic Radiosurgery (LAASR) is a multicenter prospective study of laser interstitial thermal (LITT) ablation in patients with radiographic progression after stereotactic radiosurgery for brain metastases.
<h3>Importance</h3> Although stereotactic radiosurgery (SRS) is preferred for limited brain metastases from most histologies, whole-brain radiotherapy (WBRT) has remained the standard of care patients with small cell lung cancer. Data on SRS are limited. <h3>Objective</h3> To characterize and compare first-line outcomes (without prior WBRT or prophylactic cranial irradiation) those WBRT. <h3>Design, Setting, Participants</h3> FIRE-SCLC (First-line Radiosurgery Small-Cell Lung Cancer) was a...
The routine use of intraoperative angiography as an aid in the surgical treatment aneurysms is uncommon. advantages ability to visualize residual aneurysm or unintended occlusion parent vessels intraoperatively must be weighed against complications associated with repeated and prolonged vascular access. authors reviewed results their determine its safety efficacy.Prospectively gathered data from all cases treated surgically between January 1996 June 2000 were reviewed. A total 303 operations...