A5082744383- Meningioma and schwannoma management
- Vascular Malformations Diagnosis and Treatment
- Intracranial Aneurysms: Treatment and Complications
- Glioma Diagnosis and Treatment
- Neurofibromatosis and Schwannoma Cases
- Brain Metastases and Treatment
- Trigeminal Neuralgia and Treatments
- Pituitary Gland Disorders and Treatments
- Head and Neck Surgical Oncology
- Intracerebral and Subarachnoid Hemorrhage Research
- Facial Nerve Paralysis Treatment and Research
- Bone Tumor Diagnosis and Treatments
- Sarcoma Diagnosis and Treatment
- Adrenal and Paraganglionic Tumors
- Liver Disease Diagnosis and Treatment
- Lung Cancer Research Studies
- Oral and Maxillofacial Pathology
- Cerebrospinal fluid and hydrocephalus
- Neurosurgical Procedures and Complications
- Cerebral Venous Sinus Thrombosis
- Management of metastatic bone disease
- Vestibular and auditory disorders
- Hepatocellular Carcinoma Treatment and Prognosis
- Growth Hormone and Insulin-like Growth Factors
- Hepatitis C virus research
Dokkyo Medical University
2024
Neurological Surgery
2014-2024
University of Pittsburgh Medical Center
2011-2022
University of Pittsburgh
2012-2021
West Virginia University
2021
Oxford University Press (United Kingdom)
2018-2020
Pittsburg State University
2019
NYU Langone Health
2015-2018
Cleveland Clinic
2015-2018
Na Homolce Hospital
2018
Trigeminal neuralgia pain causes severe disability. Stereotactic radiosurgery is the least invasive surgical option for patients with trigeminal neuralgia. Since different medical and options have rates of relief morbidity, it important to evaluate longer-term outcomes.The authors retrospectively reviewed outcomes in 503 medically refractory who underwent Gamma Knife surgery (GKS). The median patient age was 72 years (range 26-95 years). Prior had failed 205 (43%). GKS typically performed...
Pituitary adenomas are fairly common intracranial neoplasms, and nonfunctioning ones constitute a large subgroup of these adenomas. Complete resection is often difficult may pose undue risk to neurological endocrine function. Stereotactic radiosurgery has come play an important role in the management patients with pituitary This study examines outcomes after large, multicenter patient population.Under auspices North American Gamma Knife Consortium, 9 surgery (GKS) centers retrospectively...
Object Many patients with acoustic neuromas (ANs) have hearing function at diagnosis and desire to maintain it. To date, radiosurgical techniques been focused on conformal irradiation of the tumor mass, less attention inner ear structures for which there was scant radiobiological information. The authors this study evaluated control preservation as they relate volume, imaging characteristics, nerve cochlear radiation dose following stereotactic radiosurgery (SRS) using Gamma Knife. Methods...
We define magnetic resonance imaging (MRI) and clinical criteria that differentiate radiation effect (RE) from tumor progression after stereotactic radiosurgery (SRS).We correlated postoperative histopathological data in 68 patients who underwent delayed resection of a brain metastasis SRS. Surgical was required these because evidence lesion 0.3 to 27.7 months At the time SRS, median target volume 7.1 mL (range, 0.5-26 mL), which increased 14 1.3-81 mL) at surgery. After initial routine...
OBJECTIVE In this multicenter study, the authors reviewed results following Gamma Knife radiosurgery (GKRS) of cerebral arteriovenous malformations (AVMs), determined predictors outcome, and assessed predictive value commonly used grading scales based upon large cohort with long-term follow-up. METHODS Data from a 2236 patients undergoing GKRS for AVMs were compiled International Research Foundation. Favorable outcome was defined as AVM obliteration no posttreatment hemorrhage or permanent...
The aim of this paper was to define the outcomes and risks stereotactic radiosurgery (SRS) for Spetzler-Martin Grade I II arteriovenous malformations (AVMs).Between 1987 2006, authors performed Gamma Knife surgery in 996 patients with brain AVMs, including 217 AVMs classified as or II. median maximum diameter target volumes were 1.9 cm (range 0.5-3.8 cm) 2.3 cm(3) 0.1-14.1 cm(3)), respectively. margin dose 22 Gy 15-27 Gy).Arteriovenous malformation obliteration confirmed by MR imaging 148...
Object Because of their critical location adjacent to brain, cranial nerve, and vascular structures, petroclival meningiomas remain a clinical challenge. The authors evaluated outcomes in 168 patients with who underwent Gamma Knife surgery (GKS) during 21-year interval. Methods was used as either primary or adjuvant treatment involving the region between petrous apex upper two-thirds clivus. most common presenting symptoms were trigeminal nerve dysfunction, balance problems, diplopia,...
OBJECTIVE To evaluate the role of stereotactic radiosurgery (SRS) in management recurrent or residual intracranial hemangioblastomas, we assessed tumor control, survival, and complications 32 consecutive patients. METHODS We retrospectively reviewed records hemangioblastoma patients (74 tumors) who underwent gamma knife SRS. The median patient age was 43.8 years (range, 21.3–79.4 yr). Thirty-one had undergone previous surgical resections. Nineteen sporadic lesions (22 tumors), 13 von...
In this paper the authors' goal was to define long-term benefits and risks of stereotactic radiosurgery (SRS) for patients with arteriovenous malformations (AVMs) who underwent prior embolization.Between 1987 2006, authors performed Gamma Knife surgery in 996 brain AVMs; 120 embolization followed by SRS. series, 64 (53%) had at least one hemorrhage. The median number embolizations varied from 1 5. target volume 6.6 cm(3) (range 0.2-26.3 cm(3)). margin dose 18 Gy 13.5-25 Gy).After...
The object of this study was to define the long-term outcomes and risks arteriovenous malformation (AVM) management using 2 or more stages stereotactic radiosurgery (SRS) for symptomatic large-volume lesions unsuitable surgery.In 1992, authors prospectively began stage treatment anatomical components deliver higher single doses AVMs with a volume than 10 cm(3). Forty-seven patients such underwent volume-staged SRS. In series, 18 (38%) had prior hemorrhage 21 (45%) embolization. median...
Object Estimating survival time in cancer patients is crucial for clinicians, patients, families, and payers. To provide appropriate cost-effective care, various data sources are used to rational, reliable, reproducible estimates. The accuracy of such estimates unknown. Methods authors prospectively estimated 150 consecutive (median age 62 years) with brain metastases undergoing radiosurgery. They recorded type, number metastases, neurological presentation, extracranial disease status,...
Although considered slow-growing, low-grade malignancies, chordomas are locally aggressive and destructive tumors with high recurrence rates.To assess patient survival, tumor control, complications, selected variables that predict outcome in patients who underwent Gamma Knife stereotactic radiosurgery (SRS) as primary, adjuvant, or salvage management for of the skull base.Six participating centers North American Consortium identified 71 SRS chordoma. The median age was 45 years (range, 7-80...
To better establish the role of stereotactic radiosurgery (SRS) in treating patients with 10 or more intracranial metastases, authors assessed clinical outcomes and identified prognostic factors associated survival tumor control who underwent using Leksell Gamma Knife Perfexion (LGK PFX) unit.The retrospectively reviewed data all had undergone LGK PFX surgery to treat brain metastases a single session at University Pittsburgh. Posttreatment imaging studies were used assess response, patient...
Object The authors conducted a study to define the long-term outcomes and risks of stereotactic radiosurgery (SRS) for pediatric arteriovenous malformations (AVMs). Methods Between 1987 2006, performed Gamma Knife surgery in 996 patients with brain AVMs; 135 were younger than 18 years age. median maximum diameter target volumes 2.0 cm (range 0.6–5.2 cm) 2.5 3 0.1–17.5 ), respectively. margin dose was 20 Gy 15–25 Gy). Results actuarial rates total obliteration documented by angiography or MR...
Nonfunctional pituitary adenomas (NFPAs) represent approximately 50% of all tumors.To evaluate the long-term outcomes stereotactic radiosurgery for NFPAs.We evaluated management Gamma Knife in 125 patients with NFPAs over an interval 22 years. The median patient age was 54 years (range, 16-88 years). One hundred ten (88%) had residual or recurrent tumors after ≥ 1 surgical procedures, and 17 (14%) undergone prior fractionated radiation therapy. target volume 3.5 cm3 0.4-28.1 cm3), tumor...
The object of this study was to evaluate the outcomes and risks repeat stereotactic radiosurgery (SRS) for incompletely obliterated cerebral arteriovenous malformations (AVMs).Between 1987 2006, Gamma Knife surgery performed in 996 patients with AVMs. During period, SRS 105 who had AVMs at a median 40.9 months after initial (range 27.5-139 months). AVM target volume 6.4 cm(3) 0.2-26.3 cm(3)) but reduced 2.3 0.1-18.2 time second procedure. margin dose both 18 Gy.The actuarial rate total...
The benefit of intervention for patients with unruptured cerebral arteriovenous malformations (AVMs) was challenged by results demonstrating superior clinical outcomes conservative management from A Randomized Trial Unruptured Brain AVMs (ARUBA). aim this multicenter, retrospective cohort study is to analyze the stereotactic radiosurgery ARUBA-eligible patients.We combined AVM outcome data 7 institutions participating in International Gamma Knife Research Foundation. Patients ≥12 months...
Abstract Predictions of patient outcomes after a given therapy are fundamental to medical practice. We employ machine learning approach towards predicting the stereotactic radiosurgery for cerebral arteriovenous malformations (AVMs). Using three prospective databases, feature engineering and model optimization was implemented create most accurate predictor AVM outcomes. Existing prognostic systems were scored purposes comparison. The final secondarily validated on an independent site’s...
Parasellar and sellar meningiomas are challenging tumors owing in part to their proximity important neurovascular endocrine structures. Complete resection can be associated with significant morbidity, incomplete resections common. In this study, the authors evaluated outcomes of parasellar managed Gamma Knife radiosurgery (GKRS) both as an adjunct microsurgical removal or conventional radiation therapy a primary treatment modality.A multicenter study patients benign was conducted through...
OBJECTIVE Brain arteriovenous malformations (AVMs) are the most common cause of spontaneous intracranial hemorrhage in pediatric patients (age < 18 years). Since cumulative lifetime risk AVM is considerable children, an improved understanding factors influencing hemorrhagic presentation may aid management AVMs. The aims this first a 2-part multicenter, retrospective cohort study to evaluate incidence and determine predictors patients. METHODS authors analyzed pooled radiosurgery data from 7...
Cushing disease (CD) due to adrenocorticotropic hormone–secreting pituitary tumors can be a management challenge. To better understand the outcomes of stereotactic radiosurgery (SRS) for CD and define its role in management. International, multicenter, retrospective cohort analysis. Ten medical centers participating International Gamma Knife Research Foundation. Patients with >6 months endocrine follow-up. SRS using radiosurgery. The primary outcome was control hypercortisolism (defined as...