A5086410415- Intracranial Aneurysms: Treatment and Complications
- Traumatic Brain Injury and Neurovascular Disturbances
- Meningioma and schwannoma management
- Head and Neck Surgical Oncology
- Pituitary Gland Disorders and Treatments
- Cerebrospinal fluid and hydrocephalus
- Intracerebral and Subarachnoid Hemorrhage Research
- Neurosurgical Procedures and Complications
- Vascular Malformations Diagnosis and Treatment
- Neurofibromatosis and Schwannoma Cases
- Cerebrovascular and Carotid Artery Diseases
- Acute Ischemic Stroke Management
- Surgical Simulation and Training
- Glioma Diagnosis and Treatment
- Spinal Fractures and Fixation Techniques
- Anatomy and Medical Technology
- COVID-19 and healthcare impacts
- Bone Tumor Diagnosis and Treatments
- Adrenal and Paraganglionic Tumors
- Sinusitis and nasal conditions
- Trauma and Emergency Care Studies
- Ear and Head Tumors
- Augmented Reality Applications
- Brain Metastases and Treatment
- Stroke Rehabilitation and Recovery
Icahn School of Medicine at Mount Sinai
2016-2025
Mount Sinai Hospital
2017-2025
Mount Sinai Hospital
2017-2025
North American Skull Base Society
2024
Mount Sinai Health System
2014-2023
Mount Sinai Medical Center
1997-2023
Neurological Surgery
1992-2022
Mount Sinai Hospital
1999-2022
Autism Speaks
2022
Faculty of 1000 (United States)
2020-2022
We have examined the incidence and size of infarction after occlusion different portions rat middle cerebral artery (MCA) in order to define reliability predictability this model brain ischemia. developed a neurologic examination correlated changes status with location areas infarction. The MCA was surgically occluded at sites six groups normal rats. After 24 hr, rats were evaluated for extent deficits graded as having severe, moderate, or no deficit using new model. sacrificed determined...
We have evaluated the use of 2,3,5-triphenyltetrazolium chloride (TTC) as an histopathologic stain for identification infarcted rat brain tissue. The middle cerebral artery (MCA) 35 normal adult rats was occluded surgically. At various times after surgical occlusion, were sacrificed and slices obtained stained with TTC or hematoxolin eosin (H & E); size area tissue by each method quantified. In 24 hr occlusion MCA, infarction 21 +/- 2% coronal section TTC, H E (mean S.D., N = 13). areas...
Acute cerebral ischemia after subarachnoid hemorrhage (SAH) is a major cause of morbidity whose precise etiology unclear. The purpose this study was to examine the relationships between perfusion pressure (CPP) and cortical blood flow during SAH using new experimental model in rat.CPP (mean arterial minus intracranial pressure), laser-Doppler flowmetry (LDF), electroencephalogram were continuously recorded 16 ventilated rats. produced by advancing an intraluminal suture from external carotid...
HomeStrokeVol. 31, No. 11Recommendations for the Management of Patients With Unruptured Intracranial Aneurysms
We endeavored to develop an unruptured intracranial aneurysm (UIA) treatment score (UIATS) model that includes and quantifies key factors involved in clinical decision-making the management of UIAs assess agreement for this among specialists UIA research.
Background The Raymond–Roy Occlusion Classification (RROC) is the standard for evaluating coiled aneurysms (Class I: complete obliteration; Class II: residual neck; III: aneurysm), but not all III behave same over time. Methods This a retrospective review of 370 patients with 390 intracranial treated coil embolization. A Modified (MRRC), in which IIIa designates contrast within interstices and IIIb along aneurysm wall, was applied retrospectively. Results were more likely to improve I or II...
✓ Outcome after 252 posterior fossa explorations for the treatment of trigeminal neuralgia was determined by a retrospective review. Patients with distortion fifth nerve root caused extrinsic vascular compression underwent microvascular decompression, those no partial sensory rhizotomy, and contact but decompression rhizotomy. The mean follow-up period 5.1 years. An excellent (75%) or good (8%) clinical outcome achieved in 208 patients; 13 patients (5%) experienced little pain relief....
Decreased cerebral blood flow (CBF) and ischemia occurring immediately after subarachnoid hemorrhage (SAH) may be caused by acute microvascular constriction. However, CBF can also influenced changes in intracranial pressure (ICP) perfusion (CPP). The goal of these experiments was to assess the significance vasoconstriction SAH its relationship CBF, ICP, CPP, extracellular glutamate concentrations.Three were performed using endovascular filament technique produce SAH. In first experiment, CPP...
OBJECTIVE Animal models and clinical studies suggest that intraventricular thrombolysis improves clot resolution outcomes among patients with hemorrhage. However, this intervention may increase the rates of rebleeding infection. To assess safety efficacy thrombolysis, we conducted a pilot, randomized, double-blind, controlled, multicenter study. METHODS Patients hemorrhage requiring ventriculostomy were randomized to receive injections normal saline solution or urokinase (25,000...
✓ A rat model was developed to determine the role of sinus thrombosis and elevated pressures in pathogenesis dural arteriovenous malformations (AVMs) Five protocols were tested compare various a sinus: 1) Control I, sham operation (five animals); 2) II, occlusion right common carotid artery, external jugular vein, vein draining left transverse sinus, as well sagittal (10 3) fistula (AVF) anastomosis artery causing retrograde flow through 4) AVF (as described I) (12 5) III, on animals). Mean...
Hyperresponsiveness to noxious stimulation (hyperalgesia) is observed with naloxone-precipitated morphine withdrawal in several experimental models, and may be due changes central nervous system neurons. Previous studies have demonstrated that certain neurons the rostral ventromedial medulla (on-cells) discharge just prior nocifensive reflexes are inhibited by morphine. Because tail flick latency (TFL) shorter when on-cells active, it has been proposed facilitate reflexes. The present study...
Seventy of 178 patients with acoustic tumors initially were treated conservatively and have been followed up for an average 26 +/- 2 months. The tumor size was determined by the mean maximum anteroposterior mediolateral diameters, using computed tomographic or magnetic resonance imaging scans obtained sequentially throughout follow-up period. growth 1.6 0.4 mm 1st year, 1.9 1.0 2nd year (range, -2 to 17 mm/y): 4 showed apparent regression, 28 (40%) had no detectable growth, 37 (53%)...
Purpose To compare different methods for generating features from radiology reports and to develop a method automatically identify findings in these reports. Materials Methods In this study, 96 303 head computed tomography (CT) were obtained. The linguistic complexity of was compared with that alternative corpora. Head CT preprocessed, machine-analyzable constructed by using bag-of-words (BOW), word embedding, Latent Dirichlet allocation-based approaches. Ultimately, 1004 manually labeled...
Endoscopic intracerebral hemorrhage (ICH) evacuation techniques have gained interest as a potential therapeutic option. However, the instrumentation and employed are still being refined to optimize hemostasis efficiency.We describe application of specific endoscopic technique in treatment ICH called Stereotactic Intracerebral Hemorrhage Underwater Blood Aspiration (SCUBA) technique. It differs from previously described minimally invasive interventions that it combines two separate...
Abstract Predictions of patient outcomes after a given therapy are fundamental to medical practice. We employ machine learning approach towards predicting the stereotactic radiosurgery for cerebral arteriovenous malformations (AVMs). Using three prospective databases, feature engineering and model optimization was implemented create most accurate predictor AVM outcomes. Existing prognostic systems were scored purposes comparison. The final secondarily validated on an independent site’s...
Embolization before stereotactic radiosurgery (SRS) for cerebral arteriovenous malformations (AVM) has been shown to negatively affect obliteration rates, but its impact on the risks of radiosurgery-induced complications and latency period hemorrhage is poorly defined.To determine, in a case-control study, effect prior embolization AVM SRS outcomes.We evaluated database patients who underwent SRS. Propensity score analysis was used match case (embolized nidi) control (nonembolized cohorts....
Background and Purpose —Intraventricular hemorrhage (IVH) remains associated with high morbidity mortality. Therapy external ventricular drainage alone has not modified outcome in these patients. Methods —Twelve pilot IVH patients who required were prospectively treated intraventricular urokinase followed by the randomized, double-blinded allocation of 8 to either treatment or placebo. Observed 30-day mortality was compared predicted obtained use a previously validated method. Results...
Object. The mechanisms underlying acute cerebral ischemia after subarachnoid hemorrhage (SAH) are not well established. Platelets aggregate within major vessels hours SAH, but this has been studied in the microvasculature. Platelet aggregates microvasculature could mechanically obstruct lumen and initiate events that injure vessel structure. In present study authors examined hypothesis platelets acutely SAH. Methods. Subarachnoid was induced rat by using endovascular perforation model....