A5075393861- Head and Neck Cancer Studies
- Salivary Gland Tumors Diagnosis and Treatment
- Head and Neck Surgical Oncology
- Ear and Head Tumors
- Advanced Radiotherapy Techniques
- Breast Cancer Treatment Studies
- Cancer Diagnosis and Treatment
- Brain Metastases and Treatment
- Glioma Diagnosis and Treatment
- Lung Cancer Diagnosis and Treatment
- Breast Implant and Reconstruction
- Lung Cancer Research Studies
- Medical Imaging Techniques and Applications
- Radiomics and Machine Learning in Medical Imaging
- Tracheal and airway disorders
- Management of metastatic bone disease
- Oral health in cancer treatment
- Prostate Cancer Diagnosis and Treatment
- Lung Cancer Treatments and Mutations
- Prostate Cancer Treatment and Research
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Breast Lesions and Carcinomas
- Oral and Maxillofacial Pathology
- Tumors and Oncological Cases
- Colorectal and Anal Carcinomas
NYU Langone Health
2015-2024
NYU Langone’s Laura and Isaac Perlmutter Cancer Center
2018-2024
Memorial Sloan Kettering Cancer Center
2012-2023
New York University
2011-2023
American Academy of Otolaryngology — Head and Neck Surgery
2023
Temple University
2023
AID Atlanta
2023
Harvard University
2023
University of Pennsylvania
2023
Radiation Oncology Institute
2022
The anti-cytotoxic T-lymphocyte-associated antigen 4 (CTLA-4) monoclonal antibody ipilimumab has been shown to improve survival in patients with metastatic non-CNS melanoma. purpose of this study was investigate the efficacy CTLA-4 inhibitors treatment melanoma limited brain metastases treated stereotactic radiosurgery (SRS). Between January 2008 and June 2011, 58 from were SRS a median dose 20 Gy delivered 50% isodose line (range, 15–20 Gy). In 25 patients, administered intravenously at 3...
To the authors' knowledge, question of whether human papillomavirus (HPV) infection is associated with outcomes in patients sinonasal squamous cell carcinoma (SNSCC) not well studied at this time. In current study, authors investigated patterns HPV testing and its association survival SNSCC using National Cancer Data Base.The selected all cases diagnosed between 2010 2016. practices, clinicodemographic factors, treatments, were analyzed. Multivariable Cox regression propensity score-matched...
Objective To investigate differences in epidemiology of oropharyngeal squamous cell carcinoma (OPSCC) with regards to human papillomavirus (HPV), race, and socioeconomic status (SES) using the National Cancer Database (NCDB). Study Design Population‐based cohort study. Setting Racial disparities survival OPSCC have been previously acknowledged. However, distribution HPV‐related cancers its influence on conjunction race SES remain unclear. Subjects Methods All patients NCDB known HPV from...
To investigate the dose-volume factors in mastication muscles that are implicated as possible causes of trismus patients following treatment with intensity-modulated radiotherapy (IMRT) and concurrent chemotherapy for head neck cancers.All evaluable treated at our institution between January 2004 April 2009 IMRT squamous cell cancers oropharynx, nasopharynx, hypopharynx or larynx were included this analysis (N = 421). Trismus was assessed using CTCAE 4.0. Bi-lateral masseter, temporalis,...
To observe the effect of iodine in nonionic contrast media on thyroid function, we measured free thyroxine (FT4) and stimulating hormone (TSH) following radiography 73 patients (49 males; 24 females) aged 50 to 84 years, mean 65.7 years. FT4 was significantly (p < 0.01) raised above baseline at 8 weeks but not 4 injection (mean ± standard deviation, 17.1 5.9 14.3 4.0 vs 13.3 2.7 pmol/L baseline); however, TSH 0.03) depressed both (1.09 0.68 1.21 1.56 1.40 0.90 mlU/L). T3 did change...
Radiation therapy is known to impair wound healing. Higher dose per fraction believed increase this risk. This study sought quantify rates of complication in patients receiving preoperative conventionally fractionated radiotherapy (XRT) or high-dose hypofractionated image-guided radiation (IGRT) for spinal metastasis, and identify predictors complication.The records 165 consecutive who underwent spine surgery metastasis at Memorial Sloan-Kettering Cancer Center between 1999 2010, with a...
Background Delays in postoperative head and neck (HN) radiotherapy have been associated with decreased overall survival; however, the impact of delays HN chemoradiotherapy remains undefined. Methods All patients nonmetastatic cancer (oral cavity, oropharynx, larynx, hypopharynx) who underwent curative intent surgery received adjuvant were identified from National Cancer Database (2005–2012). Overall treatment time (OTT) was defined as to end radiation therapy. Statistical methods included...
Abstract Background. The results of RTOG-MRC randomized trial photon (n=15) versus neutron (n=17) therapy in the 1980’s reported an improved local control (LC) with radiotherapy for unresectable salivary gland tumors. Due to increased severe toxicity and paucity neutron-therapy centers, we analyzed our institution’s Patients methods. From 1990 2009, 27 patients cancer underwent definitive at institution. Nodal involvement on presentation was found 9 patients. Median dose 70 Gy. Chemotherapy...
To assess whether sparing neck-level IB in target delineation of node-positive (N+) oropharyngeal carcinoma (OPC) can improve xerostomia outcomes without compromising locoregional control (LRC).A total 125 N+ OPC patients with a median age 57 years underwent chemoradiation between May 2010 and December 2011. A 74% had T1-T2 disease, 26% T3-T4, 16% N1, 8% N2A, 48% N2B, 28% N2C; 53% base tongue, 41% tonsil, 6% other. Patients were divided into those who bilateral level (the spared cohort)...
Objectives To describe patterns of primary surgical treatments in patients with T4b oral cavity squamous cell carcinoma (OCSCC). Study Design Historical cohort study. Setting National Cancer Database. Methods Review the Database between 2004 and 2017 for all OCSCCs. Only curative treatment methods were included survival analysis. Surgical nonsurgical outcomes compared by multivariable propensity score matching Results A total 1515 cases OCSCC identified. minority (n = 363, 24.0%) underwent...
Whole brain radiation therapy (WBRT) reduces local recurrence in patients after surgical resection of metastases without improving overall survival. Involved field (IFRT) has been used at our center to avoid delayed neurotoxicity associated with WBRT well-selected surgically resected single metastases. The purpose this study was evaluate the long-term outcomes these patients.Thirty-three consecutive from a known primary tumor were treated gross total followed by IFRT between 2006 and 2011....
Abstract Background The present study characterizes national trends in the utilization of adjuvant chemotherapy to treat salivary gland malignancies. Methods National Cancer Database was queried for malignancies treated by surgery with radiation 2004–2019. Proportions patients receiving over period were analyzed linear regression. impact on overall survival assessed using Kaplan–Meier and Cox proportional hazards analyses. Results Among 15 965 meeting inclusion criteria, 2355 (14.8%)...
We expanded upon our previous experience using involved-field fractionated radiotherapy (IFRT) as an alternative to whole brain or stereotactic radiosurgery for patients with surgically resected metastases (BM).All single BM who underwent surgical resection followed by IFRT at institution from 2006 2013 were evaluated. Local recurrence (LR)-free survival, distant failure (DF)-free and overall survival (OS) determined. Analyses performed associating clinical variables LR DF. Salvage...
Abstract Purpose The purpose of this study is to quantify dosimetric changes throughout the delivery oropharyngeal cancer treatment and investigate application statistical process control (SPC) for management significant deviations during course radiotherapy. Methods Thirteen patients with daily cone beam computed tomography (CBCT) were retrospectively reviewed. Cone images every other fraction imported Velocity software registered planning CT using 6 DOF (degrees freedom) couch shifts...
Non-squamous cell carcinoma (SCC) malignancies are rare, but well described laryngeal pathologies. However, the epidemiology and clinical behavior of these tumors is not studied.Retrospective cohort study.Patients diagnosed with non-squamous larynx cancer from 2004 to 2017 in National Cancer Database were selected. Demographic, clinicopathologic factors, treatments, survival analyzed. Univariable multivariable cox regression performed. Survival was compared a propensity score-matched (PSM)...