A5074363126- Meningioma and schwannoma management
- Brain Metastases and Treatment
- Advanced Radiotherapy Techniques
- Radiation Therapy and Dosimetry
- Glioma Diagnosis and Treatment
- Boron Compounds in Chemistry
- Medical Imaging Techniques and Applications
- Nuclear Physics and Applications
- Radiomics and Machine Learning in Medical Imaging
- Intracranial Aneurysms: Treatment and Complications
- Brain Tumor Detection and Classification
- Vascular Malformations Diagnosis and Treatment
- Nuclear reactor physics and engineering
- Radiation Dose and Imaging
- Vestibular and auditory disorders
- Non-Destructive Testing Techniques
- Graphite, nuclear technology, radiation studies
- Nuclear Materials and Properties
- Lung Cancer Treatments and Mutations
- Nuclear Engineering Thermal-Hydraulics
- Cerebral Venous Sinus Thrombosis
- Neurofibromatosis and Schwannoma Cases
- Bone Tumor Diagnosis and Treatments
- Radiation Effects and Dosimetry
- Lung Cancer Diagnosis and Treatment
NYU Langone Health
2019-2023
Hinge Health
2023
New York University
2022-2023
Neurological Surgery
2022
The Ohio State University
1990-1993
Abstract Background Long-term follow-up using volumetric measurement could significantly assist in the management of vestibular schwannomas (VS). Manual segmentation VS from MRI for treatment planning and assessment is labor-intensive time-consuming. This study aims to develop a deep learning technique fully automatically segment MRI. Methods retrospectively analyzed data 737 patients who received gamma knife radiosurgery VS. Treatment T1-weighted isotropic MR manually contoured gross tumor...
The detection and tracking of metastatic cancer over the lifetime a patient remains major challenge in clinical trials real-world care. Advances deep learning combined with massive datasets may enable development tools that can address this challenge. We present NYUMets-Brain, world's largest, longitudinal, dataset consisting imaging, follow-up, medical management 1,429 patients. Using we developed Segmentation-Through-Time, neural network which explicitly utilizes longitudinal structure...
Abstract Purpose Stereotactic radiosurgery (SRS) has become an important modality in the treatment of brain metastases. The purpose this study is to investigate potential radiomic features from planning magnetic resonance (MR) images and dose maps predict local failure after SRS for Materials/Methods Twenty‐eight patients who received Gamma Knife (GK) metastases were retrospectively reviewed IRB‐approved study. 179 irradiated tumors included 42 that locally failed within one‐year follow‐up....
<title>Abstract</title> The detection and tracking of metastatic cancer over the lifetime a patient remains major challenge in clinical trials real-world care. <sup>1–3</sup> Recent advances deep learning combined with massive, datasets may enable development tools that can address this challenge. We present our work NYUMets Project to develop NYUMets-Brain novel longitudinal neural network (DNN), segmentation-through-time (STT). is world's largest, longitudinal, dataset consisting imaging,...
BACKGROUND AND OBJECTIVES: Dose selection for brain metastases stereotactic radiosurgery (SRS) classically has been based on tumor diameter with a reduction of dose in the settings prior irradiation, larger volumes, and critical location. However, retrospective series have shown local control rates to be suboptimal reduced doses. We hypothesized that lower doses could effective specific biologies concomitant systemic therapies. This study aims report (LC) toxicity when using low-dose SRS era...
Purpose: The isocenter of a medical linac system is frequently used concept in clinical practice. However, so far not all the isocenters are rigorously defined. This work intended as an attempt deriving consistent and operable definitions. Methods: definition based on fundamental concept, axis rotation rigid body. determined using trajectory any point plane that intersects A found through minimal bounding sphere when body makes full rotation. essential mathematical tool three-dimensional...
Abstract Purpose The purpose of this study is to quantify dosimetric changes throughout the delivery oropharyngeal cancer treatment and investigate application statistical process control (SPC) for management significant deviations during course radiotherapy. Methods Thirteen patients with daily cone beam computed tomography (CBCT) were retrospectively reviewed. Cone images every other fraction imported Velocity software registered planning CT using 6 DOF (degrees freedom) couch shifts...
BACKGROUND AND OBJECTIVES: Stereotactic radiosurgery (SRS) of larger arteriovenous malformations (AVM) is associated with an elevated incidence adverse radiation effects (ARE). To date, volume–response and dose–response models have been used to predict such effects. understand radiological outcomes their hemodynamic on the regional brain. METHODS: A retrospective analysis was conducted at our institution using a prospective registry patients managed between 2014 2020. We included AVM nidus...
BACKGROUND AND OBJECTIVES: Trigeminal neuralgia affects approximately 2% of patients with multiple sclerosis (MS) and often shows higher rates pain recurrence after treatment. Previous studies on the effectiveness stereotactic radiosurgery (SRS) for trigeminal did not consider different MS subtypes, including remitting relapsing (RRMS), primary progressive (PPMS), secondary (SPMS). Our objective was to investigate how subtypes are related control (PC) SRS. METHODS: We conducted a...
Morphological and angioarchitectural features of cerebral arteriovenous malformations (AVMs) have been widely described associated with outcomes; however, few studies conducted a quantitative analysis AVM flow. The authors examined brain flow transit time on angiograms using direct visual computer-based method correlated these factors the obliteration response after Gamma Knife radiosurgery.
Detector arrays and profile-scans have widely replaced film-measurements for quality assurance (QA) on linear accelerators. Film is still used relative output factor (ROF) measurements, positioning, dose-profile verification annual Leksell Gamma Knife (LGK) QA. This study shows that small-field active detector measurements can be performed in the easily accessed clinical mode they are an effective replacement to time-consuming exacting film measurements.Beam profiles positioning scans 4-mm,...
The effect of head phantom size on the 10 B and 1 H[ n ,γ] 2 H dose distributions for a broad epithermal neutron radiation field generated by an accelerator‐based source boron capture therapy (BNCT) have been studied. Also two techniques calculating absorbed gamma from measured gamma‐ray distribution are compared: Monte Carlo technique, which is well accepted in BNCT community, Point Kernel technique. count‐rate central plane three rectangular parallelopiped water phantoms irradiated with...
INTRODUCTION: Clinicians are not able to predict the growth-rate of a vestibular schwannoma (VS) by reviewing standard MRI. Recently, field radiomics has enabled high-dimensional, quantitative datasets be created from imaging obtained during routine clinical care. This study investigates whether supervised machine learning techniques can yield accurate predictions volumetric based on radiomic data MRIs treatment-naïve VSs. METHODS: A total 212 patients diagnosed with unilateral VS between...
BACKGROUND AND OBJECTIVES: To study the clinical, imaging, and survival outcomes in patients with motor cortex brain metastases treated stereotactic radiosurgery (SRS). METHODS: Imaging clinical data were obtained from our prospective patient registry. Tumor volumes serial imaging data. RESULTS: The of 208 involving who underwent SRS between 2012 2021 analyzed. A total 279 (0.01 cm 3 -12.18 , mean 0.74 ) irradiated. margin dose varied 10 to 20 Gy (mean 16.9 Gy). overall tumor control rate...
Previously, a neutronic study of an accelerator-based epithermal neutron irradiation facility (AENIF) for boron capture therapy (BNCT) was performed using three-dimensional Monte Carlo transport calculations. The major components the AENIF are radio-frequency quadrupole proton accelerator, 7Li target, and moderator assembly. Neutrons generated by bombarding target with 2.5-MeV protons. neutrons emerging from too energetic to be used BNCT moderated as they traverse assembly patient.The design...
<h3>Objective:</h3> To study the neurological presentation and outcomes of patients with motor cortex brain metastases treated stereotactic radiosurgery (SRS). <h3>Background:</h3> Literature on neuro-oncological impact in eloquent regions regards to safety, efficacy, survival is limited. <h3>Design/Methods:</h3> We used our prospective patient registry obtain data imaging clinical outcomes. Additional volumetric measurements were made from data. <h3>Results:</h3> 279 volumes 0.01 cm3 12.18...
Click to increase image sizeClick decrease size Additional informationNotes on contributorsChristoph Homann[Dr. rer. nat., Hannover University, Federal Republic of Germany (FRG), 1977] has previously worked in the field plasma physics. Since 1978 he been involved numerical simulation thermohydraulic behavior partially blocked liquid-metal fast breeder reactor (LMFBR) subassemblies at Kernforschungszentrum Karlsruhe (KfK).Maurizio Bottoni(Dr. Eng., Bologna Italy, 1965) working KfK since 1974....