A5102800237- Advanced Radiotherapy Techniques
- Radiation Therapy and Dosimetry
- Boron Compounds in Chemistry
- Radiation Dose and Imaging
- Nuclear Physics and Applications
- Medical Imaging Techniques and Applications
- Radiomics and Machine Learning in Medical Imaging
- Radiopharmaceutical Chemistry and Applications
- Endometrial and Cervical Cancer Treatments
- Glioma Diagnosis and Treatment
- Breast Cancer Treatment Studies
- Brain Metastases and Treatment
- Advanced X-ray and CT Imaging
- Lung Cancer Diagnosis and Treatment
- Cancer Treatment and Pharmacology
- Effects of Radiation Exposure
- Boron and Carbon Nanomaterials Research
- Radiation Effects and Dosimetry
- Prostate Cancer Diagnosis and Treatment
- Mathematical Biology Tumor Growth
- Advances in Oncology and Radiotherapy
- Digital Radiography and Breast Imaging
- Ovarian cancer diagnosis and treatment
- MRI in cancer diagnosis
- Advanced Breast Cancer Therapies
The Ohio State University
2014-2024
The Ohio State University Comprehensive Cancer Center – Arthur G. James Cancer Hospital and Richard J. Solove Research Institute
2004-2024
The Ohio State University Wexner Medical Center
2008-2023
U-M Rogel Cancer Center
2023
NRG Oncology
2015-2019
Avera Health
2019
University of North Carolina at Chapel Hill
2019
Center for Innovation
2017
RTOG Foundation
2014-2015
Memorial Medical Center
2015
Abstract Background: The benefit of adjuvant regional nodal irradiation including the chest wall after mastectomy (CWI+RNI) and with whole breast (WBI+RNI) conserving surgery (BCS) is well established in pts pathologically positive axillary nodes (pN+). Pts who present node involvement (cN+), receive neoadjuvant chemotherapy (NC), are found to be node-negative at (ypN0), have lower loco-regional recurrence (LRR) rates compared those remain node-positive (ypN+). This phase III, randomized...
Abstract Applications of mathematical modeling can improve outcome predictions cancer therapy. Here we present a kinetic model incorporating effects radiosensitivity, tumor repopulation, and dead-cell resolving on the analysis volume regression data 80 cervical patients (stages 1B2-IVA) who underwent radiation Regression rates derived parameters correlated significantly with clinical (P < 0.001; median follow-up: 6.2 years). The 6-year local control rate was 87% versus 54% using...
TPS600 Background: This phase III post-NC trial evaluates if CWRNRT post-Mx or whole breast irradiation (WBI) with RNRT after BCS significantly reduces the IBCR-FI rate in pts PPAx nodes that are pathologically negative NC. Secondary aims OS, LRR-FI, DR-FI, DFS-DCIS, second primary cancer, and comparison of RT effect on cosmesis reconstructed Mx pts. Correlative science examines by tumor subtype, molecular outcome predictors for residual disease, degree reduction loco-regional recurrence....
Virtual three-dimensional clinical target volume definition requires the identification of areas suspected containing microscopic disease (frequently related to nodal stations) on a set computed tomographic (CT) images, rather than traditional approach based anatomic landmarks. This atlas displays clinically relevant stations and their correlation with normal lymphatic pathways CT images.
We present commissioning and comprehensive evaluation for ArcCHECK as a QA equipment volumetric-modulated arc therapy (VMAT), using the 6 MV photon beam with without flattening filter, SNC patient software (version 6.2). In addition to involving absolute dose calibration, array PMMA density verification, was evaluated its response dependency on linac rate, instantaneous radiation field size, angle, couch insertion. Scatter characterization, consistency symmetry of response, dosimetry...
TPS1141 Background: This phase III randomized post-NC trial will evaluate if CWRNRT after mastectomy (Mx) or whole breast irradiation (WBI) with RNRT breast-conserving surgery (BCS) significantly reduces the rate of IBCR-FI in pts who present histologically positive Ax nodes but become negative →NC. Secondary aims are OS, LRR-FI, DRFI, DFS-DCIS, and second primary cancer. Correlative science examine effect RT by tumor subtype, molecular predictors outcome for residual disease, development...
Abstract A novel procedure for in vivo imaging of the oxygen partial pressure (pO 2 ) implanted tumors is reported. The uses electron paramagnetic resonance (EPRI) oxygen‐sensing nanoprobes embedded tumor cells. Unlike existing methods pO quantification, wherein probes are physically inserted at time measurement, new approach cells that preinternalized (labeled) with probes, which become permanently developed tumor. Radiation‐induced fibrosarcoma (RIF‐1) cells, internalized lithium octa‐ n...
Purpose: To examine the outcomes of patients with a single brain metastasis from radioresistant histologies (renal cell carcinoma and melanoma) treated stereotactic radiosurgery (SRS) or without whole radiotherapy (WBRT). Methods Materials: We reviewed medical records 27 at our institution between 2000 2007 metastasis. Patients were Gamma Knife based SRS. Tumor included renal melanoma. Results: to median marginal dose was 20 Gy (range, 15–22 Gy). At follow-up intervals ranging 1.8 23.2...
ABSTRACT OBJECTIVE The purpose of this study was to obtain tumor and normal brain tissue biodistribution data pharmacokinetic profiles for sodium borocaptate (Na2B12H11SH) (BSH), a drug that has been used clinically in Europe Japan boron neutron capture therapy tumors. performed with group 25 patients who had preoperative diagnoses either glioblastoma multiforme (GBM) or anaplastic astrocytoma (AA) were candidates debulking surgery. Nineteen these subsequently shown have histopathologically...
In this study we determined if treatment combining radiation therapy (RT) with intracerebral (i.c.) administration of carboplatin to F98 glioma bearing rats could improve survival over that previously reported by us a 15 Gy dose (5 × 3) 6 MV photons. First, in order reduce tumor interstitial pressure, biodistribution was carried out determine pretreatment dexamethasone alone or combination mannitol and furosemide (DMF) would increase uptake following convection enhanced delivery (CED). Next,...
Brachytherapy using permanent seed implants has been an effective treatment for prostate cancer. However, seeds will migrate after implant, thus making the evaluation of post-implant dosimetry difficult. In this study, we developed a computer program to simulate migration and analyzed dosimetric changes due at various amounts. The study was based on 14 patients treated with Pd-103 James Cancer Hospital. Modeling migration, including direction, distance as well day clinical observations....
Abstract Purpose To identify high‐priority risks in a clinical trial investigating the use of radiation to alleviate COVID‐19 pneumonia using multi‐phase failure modes and effects analysis (FMEA). Methods A comprehensive FMEA survey 133 possible causes was developed for workflow (Phase I). The occurrence, severity, detection risk each cause scored by three medical physicists. High‐risk potential were identified priority number (RPN) severity scores, which re‐scored 13 participants oncology...