A5001976685- Advanced Radiotherapy Techniques
- Radiation Therapy and Dosimetry
- Endometrial and Cervical Cancer Treatments
- Radiomics and Machine Learning in Medical Imaging
- Quantum Chromodynamics and Particle Interactions
- Medical Imaging Techniques and Applications
- Particle physics theoretical and experimental studies
- Effects of Radiation Exposure
- Mathematical Biology Tumor Growth
- Nuclear Physics and Applications
- Atomic and Subatomic Physics Research
- Quantum, superfluid, helium dynamics
- Radiation Dose and Imaging
- Radiation Effects and Dosimetry
- Heat shock proteins research
- Superconducting Materials and Applications
- Glioma Diagnosis and Treatment
- Ovarian cancer diagnosis and treatment
- Endoplasmic Reticulum Stress and Disease
- Magnetic confinement fusion research
- Head and Neck Cancer Studies
- Plant biochemistry and biosynthesis
- Cancer Research and Treatments
- Particle Detector Development and Performance
- MRI in cancer diagnosis
Qiannan Normal College For Nationalities
2025
The Ohio State University
2014-2024
The Ohio State University Comprehensive Cancer Center – Arthur G. James Cancer Hospital and Richard J. Solove Research Institute
2012-2024
The Ohio State University Wexner Medical Center
2013-2021
Chinese Academy of Medical Sciences & Peking Union Medical College
2018
Shenzhen Second People's Hospital
2013
University of Maryland, College Park
2000
Institute of High Energy Physics
1996-1999
Université Grenoble Alpes
1998
Academia Sinica
1992
Abstract Applications of mathematical modeling can improve outcome predictions cancer therapy. Here we present a kinetic model incorporating effects radiosensitivity, tumor repopulation, and dead-cell resolving on the analysis volume regression data 80 cervical patients (stages 1B2-IVA) who underwent radiation Regression rates derived parameters correlated significantly with clinical (P < 0.001; median follow-up: 6.2 years). The 6-year local control rate was 87% versus 54% using...
This article is an editorial, and it doesn't include abstract. Full text of this also available in HTML PDF . Cite as: Lu L. Dose calculation algorithms external beam photon radiation therapy. Int J Cancer Ther Oncol 2013; 1 (2):01025. DOI: http://dx.doi.org/10.14319/ijcto.0102.5
Multiple studies have reported favorable outcomes for stereotactic radiosurgery (SRS) in the treatment of limited brain metastases. An obstacle SRS management numerous metastases is longer time using traditional radiosurgery. Single-isocenter multitarget (SIMT) a novel technique that permits rapid therapy delivery to multiple There lack clinical evidence regarding its efficacy and safety. We report patients treated with this technique.We reviewed records intact or resected 1 5 fractions SIMT...
Abstract Over 50% of all patients with cancer are treated radiotherapy. However, radiotherapy is often insufficient as a monotherapy and requires nontoxic radiosensitizer. Squalene epoxidase (SQLE) controls cholesterol biosynthesis by converting squalene to 2,3-oxidosqualene. Given that SQLE frequently overexpressed in human cancer, this study investigated the importance breast non–small cell lung (NSCLC), two cancers SQLE-positive IHC staining was observed 68% 56% NSCLC specimens versus 15%...
Tumor-induced expansion of Tregs is a significant obstacle to cancer immunotherapy. However, traditional approaches deplete are often inefficient, provoking autoimmunity. We show here that administration IL-27-expressing recombinant adeno-associated virus (AAV-IL-27) significantly inhibits tumor growth and enhances T cell responses in tumors. Strikingly, we found AAV-IL-27 treatment causes rapid depletion peripheral blood, lymphoid organs, - most pronouncedly microenvironment....
Nuclear radiation and radioactive fallouts resulting from a nuclear weapon detonation or reactor accidents could result in injuries affecting multiple sensitive organs, defined as acute syndrome (ARS). Rapid early estimation of to organs using markers response is critical for identifying individuals who potentially exhibit ARS; however, there are currently no biodosimetry assays approved human use. We developed microRNA (miRNA)-based blood test dose reconstruction with ±0.5 Gy resolution at...
BackgroundCurrent standard of care treatment for patients with ≥15 brain metastases(BM) is whole radiation therapy(WBRT), despite poor neurocognitive outcomes. We analyzed our institutional experience treating these stereotactic radiosurgery(SRS), the aim evaluating safety, cognitive outcomes, and survival metrics.MethodsPatients who received SRS BMs in 1-5 fractions from 2014-2022 were included. Cognitive outcomes objectively evaluated using serial Patient-Reported Outcome Measurement...
Allogeneic transplantation of hematopoietic stem cells (HSC) in combination with T has a curative potential for malignancies through graft-versus-leukemia (GVL) effects, but is often compromised by the notorious side effect graft-versus-host disease (GVHD) resulting from alloreactivity donor cells. Here, we tested if temporary immunoisolation achieved conformally encapsulating within biocompatible and biodegradable porous film (∼450 nm thickness) chitosan alginate could attenuate GVHD...
To explore the value of contrast-enhanced CT radiomics in predicting occult lymph node metastasis (OLNM) patients with clinical N0 (cN0) stage non-small cell lung cancer (NSCLC) prior to surgery. Descriptive study. Place and Duration Study: Department Radiology, Guangzhou First People's Hospital, Guangzhou, Guangdong, China, from January 2023 November 2024. A total 290 NSCLC two hospitals were divided into training validation sets. Radiomics features extracted tumour volume interest, optimal...
ABSTRACT Cutaneous wounds caused by an exposure to high doses of ionizing radiation remain a therapeutic challenge. While new experimental strategies for treatment are being developed, there currently no off‐the‐shelf therapies the cutaneous injury that have been proven promote repair damaged tissues. Plasma‐based biomaterials biologically active made from platelet enriched plasma, which can be into both solid and semi‐solid forms, inexpensive, available as off‐the‐shelf, nonrefrigerated...
Abstract Background The Pediatric Preclinical Testing Program (PPTP) has been successfully used to determine the efficacy of novel agents against solid tumors by testing them within a mouse‐flank in vivo model. To date, radiation therapy not applied this system. We report on feasibility and biologic outcomes pilot study using alveolar embryonal rhabdomyosarcoma xenograft lines. Procedures developed high‐throughput irradiation device that allows safe delivery radiotherapy clinically relevant...
To use NanoDot dosimeters to study the RS 2000 X-ray Biological Irradiator dosimetry characteristics and perform in vivo for cell or small animal experiments.We first calibrated Landauer NanoDot(™) Reader by irradiating some with a set of known doses at specific positions defined irradiator. A group five were placed where dose rates provided Each was irradiated times respectively. By correlating readings given doses, we established dose-reading relationship irradiator under running...
To determine the magnitude of MRI image distortion based on 6 consecutive years annual quality assurances/measurements 14 scanners used for radiation therapy and to provide evidence inclusion additional margin treatment planning.We commercial phantoms quantitatively study over period up 1.5 3 T that could potentially be images planning. With phantom collected from 2016 2022, we investigated distortion, dependence distance imaging isocenter, possible causes large discovered.MRI increases with...
Purpose: To introduce a practical method of using an Electron Density Phantom (EDP) to evaluate different dose calculation algorithms for photon beams in treatment planning system (TPS) and commission the Anisotropic Analytical Algorithm (AAA) with inhomogeneity correction Varian Eclipse TPS. Methods Materials: The same EDP various tissue-equivalent plugs (water, lung exhale, inhale, liver, breast, muscle, adipose, dense bone, trabecular bone) used calibrate computed tomography (CT)...
Undesirable exposure of diaphragm to radiation during thoracic therapy has not been fully considered over the past decades. Our study aims examine potential biological effects on induced by radiation. One-time ionizing irradiation 10 Gy was applied either diaphragmatic region mice or cultured C2C12 myocytes. Each sample then assayed for muscle function, oxidative stress, cell viability days 1, 3, 5, and 7 after irradiation. mouse model shows that significantly reduced function 5th 7th...
Background and Purpose: To perform a retrospective in vivo dosimetry study of 129 total body irradiation (TBI) on leukemia bone marrow transplant patients treated our clinic from 2008 to 2011 find out if there is any indication the necessity developing new efficient TBI approach. Materials Methods: The data with between were retrieved database analyzed. These mostly regime single fraction or 6 fractions some exceptions 8-fraction 2-fraction treatments depending protocols that applied. For...
We developed a novel technology capable of detecting early-stage pancreatic cancers using high-resolution three-dimensional endoscopic optical coherence tomography (Endo-OCT), and treating them high dose rate brachytherapy (HDR) under the Endo-OCT image guidance. This integrates our custom-built ultra-high resolution OCT diagnostic imaging device with commercial system (HDR), resulting in compact, portable, easy-to-operate, low-cost image-guided (OCT-IGHDR) system. The has dual functions...