A5075091836- Neurogenesis and neuroplasticity mechanisms
- Stress Responses and Cortisol
- Memory and Neural Mechanisms
- Neuroinflammation and Neurodegeneration Mechanisms
- Neuroscience and Neuropharmacology Research
- Traumatic Brain Injury Research
- Glioma Diagnosis and Treatment
- Behavioral Health and Interventions
- Traumatic Brain Injury and Neurovascular Disturbances
- Physical Activity and Health
- Neurotransmitter Receptor Influence on Behavior
- Tryptophan and brain disorders
- Neuroendocrine regulation and behavior
- Adipose Tissue and Metabolism
- Sarcoma Diagnosis and Treatment
- Neurobiology and Insect Physiology Research
- Nerve injury and regeneration
- Zebrafish Biomedical Research Applications
- Hormonal and reproductive studies
- Brain Metastases and Treatment
- Mindfulness and Compassion Interventions
- Spinal Cord Injury Research
- Cellular transport and secretion
- Transcranial Magnetic Stimulation Studies
- Pharmacology and Obesity Treatment
University of Houston
2016-2025
The Ohio State University Comprehensive Cancer Center – Arthur G. James Cancer Hospital and Richard J. Solove Research Institute
2012-2015
The Ohio State University
2012-2015
Drexel University
2011
University of Kentucky
2009
Salk Institute for Biological Studies
2000-2007
Christopher and Dana Reeve Foundation
2004
The University of Texas at Austin
2000-2003
Low-level developmental lead exposure is linked to cognitive and neurological disorders in children. However, the long-term effects of gestational (GLE) have received little attention.Our goals were establish a murine model human equivalent GLE determine dose-response on body weight, motor functions, dopamine neurochemistry year-old offspring.We exposed female C57BL/6 mice water containing 0, 27 (low), 55 (moderate), or 109 ppm (high) from 2 weeks prior mating, throughout gestation, until...
Social isolation negatively affects the behavior and health of laboratory rats. Recently, it has been found that social retards exercise-induced neurogenesis in hippocampal dentate gyrus (DG) male rats (Stranahan et al. (2006) Nat Neurosci 9:526-533). Since female react differently to housing changes exercise opportunities, we investigated whether would also suppress exercise-dependent increase proliferation progenitor cells females. Accordingly, were housed either alone (isolated) or groups...
Excessive alcohol intake produces structural and functional deficits in corticolimbic pathways that are thought to underlie cognitive the use disorders (AUDs). Animal models of binge administration support direct link high levels consumption neurotoxicity hippocampus surrounding cortex. In contrast, voluntary wheel running enhances hippocampal neurogenesis generally promotes health neurons.We investigated whether exercise prior exposure could protect against alcohol-induced cell loss. Female...
The hippocampus has two functionally distinct subregions-the dorsal portion, primarily associated with spatial navigation, and the ventral anxiety. In a prior study of chronic unpredictable stress (CUS) in rodents, we found that it selectively enhanced cellular plasticity hippocampal subregion while negatively impacting ventral. present study, determined whether this adaptive would confer CUS rats an advantage task-the radial arm water maze (RAWM). RAWM exposure is both stressful requires...
The objective of the present study was to determine whether chronic unpredictable stress (CUS) would induce hippocampal neuroplasticity in a region-specific manner. Recent evidence suggests that hippocampus has two functionally distinct subsections. dorsal (septal) portion appears be primarily associated with spatial navigation, while ventral (temporal) region been linked affect-related functions, such as anxiety. Chronic previously shown negatively affect by decreasing survival progenitor...
Binge drinking damages the brain, and although a significant amount of recovery occurs with abstinence, there is need for effective strategies to maximize neurorestoration. In contrast binge drinking, exercise promotes brain health, so present study assessed whether it could counteract ethanol-induced damage by augmenting natural self-repair processes following one or more exposures. Adult female rats were exposed 0 (control), 1 2 binges, using an established 4-day model binge-induced...
The female brain appears selectively vulnerable to the neurotoxic effects of alcohol, but reasons for this are unclear. One possibility is an exaggerated neuroimmune response in brain, such that alcohol increases microglia number and reactivity subsequent stimuli, as exercise. It important better characterize interactive neural exercise, exercise increasingly being used treatment use disorders. present study compared evidence their activation alcohol-vulnerable regions (medial prefrontal...
The mammalian neocortex is organized into unique areas that serve functions such as sensory perception and modality-specific behaviors. sizes of primary cortical vary across species, also within a raising the question whether area size dictates behavioral performance. We show adult mice genetically engineered to overexpress transcription factor EMX2 in embryonic progenitor cells, resulting reductions somatosensory motor areas, exhibit significant deficiencies at tactile Even increasing...
While cranial radiation therapy (CRT) is an effective treatment, healthy areas surrounding irradiation sites are negatively affected. Frontal lobe functions involving attention, processing speed, and inhibition control impaired. These deficits appear months to years after CRT impair quality of life. Exercise has been shown rejuvenate the brain aid in recovery post-injury through its effects on neurogenesis cognition. We developed a juvenile rodent model that reproduces neurocognitive...
The recognition of novel objects is a common cognitive test for rodents, but current paradigms have limitations, such as low sensitivity, possible odor confounds and stress due to being performed outside the homecage. We developed paradigm that takes place in homecage utilizes four stimuli per trial, increase sensitivity. Odor are eliminated because consist inexpensive, machined wooden beads purchased bulk, so each experimental animal has its own set stimuli. This consists three steps. In...