D. Gelblum
A5013919564- Lung Cancer Diagnosis and Treatment
- Head and Neck Cancer Studies
- Lung Cancer Treatments and Mutations
- Advanced Radiotherapy Techniques
- Radiomics and Machine Learning in Medical Imaging
- Cancer Diagnosis and Treatment
- Lung Cancer Research Studies
- Head and Neck Surgical Oncology
- Effects of Radiation Exposure
- Medical Imaging Techniques and Applications
- Brain Metastases and Treatment
- Cancer Immunotherapy and Biomarkers
- Salivary Gland Tumors Diagnosis and Treatment
- Medical Imaging and Pathology Studies
- Breast Cancer Treatment Studies
- Oral health in cancer treatment
- Cancer Genomics and Diagnostics
- Radiation Dose and Imaging
- Management of metastatic bone disease
- Ear and Head Tumors
- Reconstructive Surgery and Microvascular Techniques
- Advanced MRI Techniques and Applications
- COVID-19 and healthcare impacts
- Neuroendocrine Tumor Research Advances
- Breast Implant and Reconstruction
Memorial Sloan Kettering Cancer Center
2016-2025
Radiation Oncology Associates
2024
Cornell University
2022
Rensselaer Polytechnic Institute
2015
Harrison Medical Center
2015
Mercy Medical Center
2000
Mercy Medical Center
1999
Neurological Surgery
1998
Weatherford College
1991
Tufts Medical Center
1991
PURPOSE Standard curative-intent chemoradiotherapy for human papillomavirus (HPV)–related oropharyngeal carcinoma results in significant toxicity. Since hypoxic tumors are radioresistant, we posited that the aerobic state of a tumor could identify patients eligible de-escalation while maintaining treatment efficacy. METHODS We enrolled with HPV-related to receive de-escalated definitive phase II study (ClinicalTrials.gov identifier: NCT03323463 ). Patients first underwent surgical removal...
ASCO Guidelines provide recommendations with comprehensive review and analyses of the relevant literature for each recommendation, following guideline development process as outlined in Methodology Manual . follow Conflict Interest Policy Clinical Practice other guidance (“Guidance”) provided by is not a or definitive guide to treatment options. It intended voluntary use providers should be used conjunction independent professional judgment. Guidance may applicable all patients,...
A recent randomized radiation dose-escalation trial in unresectable stage III non-small-cell lung cancer (NSCLC) (Radiation Therapy Oncology Group [RTOG] 0617) showed a lower survival rate the high-dose therapy (RT) arm (74 Gy) than low-dose (60 with concurrent chemotherapy.The primary QOL hypothesis predicted clinically meaningful decline quality of life (QOL) via Functional Assessment Cancer (FACT)-Lung Subscale (LCS) RT at 3 months.The RTOG 0617 was phase study (conducted from November...
<h3>Importance</h3> Several de-escalation strategies for human papillomavirus (HPV)–associated oropharyngeal carcinoma (OPC) have focused on deintensifying gross disease treatment. Reduction of radiotherapy dose and target volume to subclinical regions may achieve good clinical outcomes with favorable patient quality life (QOL). <h3>Objective</h3> To determine from a systematic approach reducing the elective treatment in patients HPV-associated OPC undergoing concurrent chemoradiotherapy...
Importance Use of proton therapy reirradiation (PT-ReRT) for head and neck cancer is increasing; however, reports are heterogenous outcomes can be difficult to interpret. Objective To evaluate toxic effects following PT-ReRT in a uniform consecutive cohort patients with squamous cell carcinoma. Design, Setting, Participants This retrospective study included recurrent primary carcinoma who were treated from January 1, 2013, December 31, 2020, at single institution. Patient, clinical,...
PURPOSE NRG-RTOG0617 demonstrated a detrimental effect of uniform high-dose radiation in stage III non–small cell lung cancer. NRG-RTOG1106/ECOG-ACRIN6697 (ClinicalTrials.gov identifier: NCT01507428 ), randomized phase II trial, studied whether midtreatment 18 F-fluorodeoxyglucose positron emission tomography/computed tomography (FDG-PET/CT) can guide individualized/adaptive dose-intensified radiotherapy (RT) to improve and predict outcomes patients with this disease. MATERIALS AND METHODS...
Abstract BACKGROUND: The clinical benefit of routine placement prophylactic percutaneous endoscopic gastrostomy (pPEG) tubes was assessed in patients with oropharyngeal cancer (OPC) who are undergoing intensity‐modulated radiotherapy (IMRT) concurrent chemotherapy. METHODS: From 1998 through 2009, 400 consecutive OPC underwent chemoradiation were included. Of these, 325 had a pPEG and 75 did not (nPEG). Weight albumin change from baseline to mid‐IMRT, end IMRT, 1 month post‐IMRT, 3 months...
Background: Stereotactic body radiotherapy (SBRT) has been adopted as the standard of care for inoperable early-stage non-small cell lung cancer (NSCLC), with local control rates consistently >90%. However, data directly comparing outcomes SBRT those conventionally fractionated (CONV) is lacking.Material and methods: Between 1990 2013, 497 patients (525 lesions) NSCLC (T1-T2N0M0) were treated CONV (n = 127) or 398). In this retrospective analysis, five endpoints compared, without adjusting...
Abstract Introduction Durvalumab after concurrent chemoradiation (cCRT) is now standard of care for unresected stage III non–small cell lung cancer (NSCLC). However, there limited data on radiation pneumonitis (RP) with this regimen. Therefore, we assessed RP and evaluated previously validated toxicity models in predicting patients treated cCRT durvalumab. Methods Patients ≥ 1 dose durvalumab were to identify cases grade 2 RP. The validity published was cohort as well a reference alone....
<h3>Importance</h3> Patients with nonmetastatic nasopharyngeal carcinoma (NPC) are primarily treated by radiotherapy curative intent or without chemotherapy and often experience substantial treatment-related toxic effects even modern radiation techniques, such as intensity-modulated therapy (IMRT). Intensity-modulated proton (IMPT) may improve the toxicity profile; however, there is a paucity of data given limited availability IMPT in regions endemic NPC. <h3>Objective</h3> To compare...
Importance Patients with oropharyngeal carcinoma (OPC) treated radiotherapy often experience substantial toxic effects, even modern techniques such as intensity-modulated radiation therapy (IMRT). Intensity-modulated proton (IMPT) has a potential advantage over IMRT due to reduced dose the surrounding organs at risk; however, data are scarce given limited availability and use of IMPT. Objective To compare effects oncologic outcomes among patients newly diagnosed nonmetastatic OPC IMPT vs or...
ABSTRACT Purpose Osteoradionecrosis of the jaw (ORNJ) is a severe iatrogenic disease characterized by bone death after radiation therapy (RT) to head and neck. With over 9 published definitions at least 16 diagnostic/staging systems, true incidence severity ORNJ are obscured lack standard for definition assessment, leading inaccurate estimation incidence, reporting ambiguity, likely under-diagnosis worldwide. This study aimed achieve consensus on an explicit phenotype related precursor...