A5052564784- Salivary Gland Disorders and Functions
- Oral microbiology and periodontitis research
- Dental Health and Care Utilization
- Oral Health Pathology and Treatment
- Dental Erosion and Treatment
- Oral and gingival health research
- Oral health in cancer treatment
- Head and Neck Cancer Studies
- Salivary Gland Tumors Diagnosis and Treatment
- Head and Neck Surgical Oncology
- Laser Applications in Dentistry and Medicine
- Dental Radiography and Imaging
- Systemic Sclerosis and Related Diseases
- Growth Hormone and Insulin-like Growth Factors
- Reconstructive Facial Surgery Techniques
- Herpesvirus Infections and Treatments
- Geriatric Care and Nursing Homes
- Reconstructive Surgery and Microvascular Techniques
- Biosensors and Analytical Detection
- Dental Trauma and Treatments
- Metastasis and carcinoma case studies
- Dental Research and COVID-19
- SARS-CoV-2 detection and testing
- Advanced Drug Delivery Systems
- Dental Education, Practice, Research
Tufts University
2011-2025
Boston University
1999-2025
Tufts Medical Center
2009
Objectives: The purpose of this study was to determine the efficacy and safety a specially formulated remineralising toothpaste in controlling caries high‐risk population: head neck radiation patients. Design: compared performance with conventional fluoride dentifrice using double‐blind randomisation. Materials methods: Test products : contained equivalent quantities (1100 p.p.m.). dual‐phase toothpaste, Enamelon ® , also delivered soluble calcium phosphate ions, essential components teeth,...
ABSTRACT Purpose Osteoradionecrosis of the jaw (ORNJ) is a severe iatrogenic disease characterized by bone death after radiation therapy (RT) to head and neck. With over 9 published definitions at least 16 diagnostic/staging systems, true incidence severity ORNJ are obscured lack standard for definition assessment, leading inaccurate estimation incidence, reporting ambiguity, likely under-diagnosis worldwide. This study aimed achieve consensus on an explicit phenotype related precursor...
Results of efforts to diagnose infections with SARS-CoV-2 using a sampling method that was less invasive than the nasopharyngeal swab led rapid adoption anterior nasal swabs. Saliva also shown have potential as sample matrix and, like swabs, could be obtained non-invasively (e.g., passive drool). However, due its inherent complexity and heterogeneity across patient populations presence mucins RNases), saliva largely disregarded point-of-care diagnostics were being developed broadly...
A pivotal moment for the development of point care diagnostics COVID-19 was validation sample types that were alternatives to nasopharyngeal secretions. Specifically, anterior nasal fluid and saliva demonstrated a promising combination high viral loads minimal patient discomfort. However, only swabs widely adopted, in part due complexity saliva, its inherent variability between patients, lack standardized method collect quality sample. Herein, we aim standardize sampling by repurposing...
Background/Objectives: This double-blinded study aimed to evaluate the clinical performance of a giomer restorative material in comparison nanotechnology-based system for restoration non-carious cervical lesions over period 48 months. Methods: A 48-month randomized, controlled, split-mouth trial was conducted with 49 subjects at its baseline, which reduced 34 follow-up, yielding statistical power 69.55%. Cervical were restored using either BEAUTIFIL II LS (BL) or 3M/ESPE Filtek Supreme...
The Prevention of Adult Caries Study, an NIDCR-funded multicenter, double-blind, randomized clinical trial, enrolled 983 adults (aged 18-80 yrs) at high risk for developing caries (20 or more intact teeth and 2 lesions screening) to test the efficacy a chlorhexidine diacetate 10% weight per volume (w/v) dental coating (CHX). We excluded participants whom study treatment was contraindicated whose health might affect outcomes ability complete study. Participants were randomly assigned receive...
Objectives: This report describes the training of dental examiners participating in two caries clinical trials and reports inter- intra-examiner reliability scores from initial standardization sessions. Methods: Study were trained to use a modified International Caries Detection Assessment System II system detect visual signs non-cavitated cavitated adult subjects. Dental was classified as no (S), (D1), enamel (D2), dentine (D3). Three sessions involving 60 subjects 3,604 tooth surface calls...
The purpose of this study is to determine the efficacy and safety a specially formulated remineralizing toothpaste in controlling caries group high risk, head neck radiation patients.The compares performance with leading conventional fluoride dentifrice using double-blind randomization. TEST PRODUCTS: products compared both contain equivalent quantities (1150 ppm). also delivers soluble calcium phosphate ions, essential components teeth.On completion, 50 subjects who received > Gy...
Background: The primary objective of this study was to compare the efficacy a stannous fluoride (SnF2) dentifrice relative positive control triclosan for prevention clinical attachment loss (CAL) in xerostomic patients. A secondary dentifrices root caries remineralization. Methods: This 2‐year, randomized, double‐masked, parallel‐group study. 0.454% SnF2/sodium hexametaphosphate tested versus (sodium fluoride/0.30% triclosan/copolymer) 440 medication‐induced adults identified 1‐year, run‐in...
The purpose of this study was to determine if using a Sonicare* toothbrush beneficial treatment xerostomia. Sixty-one subjects with medication-induced xerostomia were randomly assigned Sonicare CSC) or manual (MTB). Subjects followed for four visits (one month apart); after two months, the MTB group crossed over SC. At each visit, saliva flow measured by expectorating five minutes at collection periods. For first sample asked spit while brushing three and brushing. Five-minute collections...
The aim of this study was to evaluate the efficacy and tolerability an experimental moisturizing mouthwash versus water only in participants experiencing dry mouth symptoms, including those with Sjögren syndrome (n = 28).Participants were randomized group 53) or water-only 47). For 8 days, used 1 2 doses/day at home; both groups could sip water, as needed. Supervised treatment occurred on days 1, 3, 8, during treatment, before after administration, completed Product Performance Attributes...
ABSTRACT The purpose of this study was to evaluate whether the use a Sonicare*** toothbrush could be beneficiai in reducing coronal and/or root caries among patients with medication‐induced xerostomia. Eighty subjects drug‐induced xerostomia using either Sonicare (SC) or manual (MTB) were included study. Control MTB frequency‐matched 40 SC, based on age, gender, number teeth at baseline, and salivary flow rates. Subjects individually matched according type xerostomic medication they taking....
A randomized, double-blind, placebo-controlled clinical trial was conducted to evaluate the effectiveness and safety of peroxide-containing strip-based tooth whitening among subjects with medication-induced hyposalivation.Eligibility for this study limited dentate adults taking xerogenic medications an unstimulated salivary flow < or = 0.2 ml/min. After giving informed consent, 42 were randomized using a 2:1 ratio 10% hydrogen peroxide strips (Crest Whitestrips Premium) placebo without...
The purpose of the current study was to determine if saliva contains biomarkers that can be used as diagnostic tools for Sjögren's syndrome (SjS). Twenty seven SjS patients and 27 age-matched healthy controls were recruited these studies. Unstimulated glandular collected from Wharton's duct using a suction device. Two μl salvia processed mass spectrometry analyses on prOTOF 2000 matrix-assisted laser desorption/ionization orthogonal time flight (MALDI O-TOF) spectrometer. Raw data analyzed...
Sjögren's disease (SjD) is the second most prevalent autoimmune disorder that involves chronic inflammation of exocrine glands. Correct diagnosis primary SjD (pSjD) can span over many years since symptoms manifest only in advanced stages salivary and lachrymal glandular destruction, consensus diagnostic methods have critical sensitivity selectivity limitations. Using nuclear magnetic resonance (NMR) spectroscopy, we determined composition metabolites unstimulated saliva samples from 30 pSjD...
This secondary analysis of data from the Prevention Adult Caries Study (PACS) assesses risk factors for progression coronal caries.Participants (n = 983) were adults at increased caries with least one cavitated and noncavitated lesions who enrolled in a randomized clinical trial to test effect 10% w/v chlorhexidine varnish coating on progression. Calibrated examiners scored tooth surfaces using modified International Detection Assessment System (ICDAS) classification baseline 7 13 months...