A5100363961- Head and Neck Cancer Studies
- Radiomics and Machine Learning in Medical Imaging
- Advanced Radiotherapy Techniques
- Medical Imaging Techniques and Applications
- MRI in cancer diagnosis
- Oral health in cancer treatment
- Lung Cancer Diagnosis and Treatment
- Advanced MRI Techniques and Applications
- Dysphagia Assessment and Management
- Head and Neck Surgical Oncology
- Radiation Dose and Imaging
- Bone and Joint Diseases
- Cancer Diagnosis and Treatment
- Advanced Neuroimaging Techniques and Applications
- Meta-analysis and systematic reviews
- Brain Metastases and Treatment
- Salivary Gland Tumors Diagnosis and Treatment
- Nutrition and Health in Aging
- Glioma Diagnosis and Treatment
- Advanced X-ray and CT Imaging
- Radiation Therapy and Dosimetry
- Voice and Speech Disorders
- AI in cancer detection
- Medical Imaging and Analysis
- Oral Health Pathology and Treatment
The University of Texas MD Anderson Cancer Center
2016-2025
Baylor College of Medicine
2023-2025
Mid Essex Hospital Services NHS Trust
2024
Cambridge University Hospitals NHS Foundation Trust
2024
Addenbrooke's Hospital
2024
Broomfield Hospital
2024
London North West Healthcare NHS Trust
2024
The University of Texas Health Science Center at Houston
2017-2023
Hôpital Beaujon
2023
Surrey and Borders Partnership NHS Foundation Trust
2023
Major weight loss is common in patients with head and neck squamous cell carcinoma (HNSCC) who undergo radiotherapy (RT). How baseline posttreatment body composition affects outcome unknown.
Owing to its physical properties, intensity-modulated proton therapy (IMPT) used for patients with oropharyngeal carcinoma has the ability reduce dose organs at risk compared radiotherapy (IMRT) while maintaining adequate tumor coverage. Our aim was compare clinical outcomes of these two treatment modalities.
BACKGROUND The current study was conducted to evaluate long‐term disease control, survival, and functional outcomes after surgical nonsurgical initial treatment for patients with T4 larynx cancer. METHODS Demographics, stage, characteristics were reviewed 221 sequential treated laryngeal squamous cell cancer at a single institution between 1983 2011. Survival control calculated. RESULTS median follow‐up time 47 months (71 still alive the of analysis). overall 5‐year 10‐year survival rates...
Abstract: In the context of clinical oncology, a fundamental goal radiomics is extraction large amounts quantitative features whose subsequent analysis can be used for decision support towards personalized and actionable cancer care. Head neck cancers present unique set diagnostic therapeutic challenges by nature its complex anatomy heterogeneity. Radiomics holds potential to address these barriers, but only if as collective field we direct future effort investigating specific oncologic...
Target volumes and organs-at-risk (OARs) for radiotherapy (RT) planning are manually defined, which is a tedious inaccurate process. We sought to assess the feasibility, time reduction, acceptability of an atlas-based autosegmentation (AS) compared manual segmentation (MS) OARs.A commercial platform generated 16 OARs. Resident physicians were randomly assigned modify AS OAR (AS+R) or draw MS followed by attending physician correction. Dice similarity coefficient (DSC) was used measure...
Radiomics is one such "big data" approach that applies advanced image refining/data characterization algorithms to generate imaging features can quantitatively classify tumor phenotypes in a non-invasive manner. We hypothesize certain textural of oropharyngeal cancer (OPC) primary tumors will have statistically significant correlations patient outcomes as local control. Patients from an IRB-approved database dispositioned (chemo)radiotherapy for locally OPC were included this retrospective...
First-order radiomic features, such as metabolic tumor volume (MTV) and total lesion glycolysis (TLG), are associated with disease progression in early-stage classical Hodgkin lymphoma (HL). We hypothesized that a model incorporating first- second-order features would more accurately predict outcome than MTV or TLG alone. assessed whether extracted from baseline PET scans predicted relapsed refractory status cohort of 251 patients stage I-II HL who were managed at tertiary cancer center....
The outcomes of patients with unresected anaplastic thyroid carcinoma (ATC) from the National Cancer Data Base (NCDB) were assessed, and potential correlations explored between radiation therapy (RT) dose overall survival (OS).The study cohort was comprised who underwent either no surgery or grossly incomplete resection. Correlates OS using univariate analysis multivariable (MVA).In total, 1288 analyzed. mean patient age 70.2 years, 59.7% women, 47.6% received neck RT. median 2.27 months,...
Abstract Imaging metabolic dysfunction, a hallmark of solid tumors, usually requires radioactive tracers. Chemical exchange saturation transfer (CEST) imaging can potentially detect and visualize glucose uptake metabolism, without the need for radioisotopes. Here, we tested feasibility using CEST (glucoCEST) to image unlabeled in head neck cancer by clinical 3T magnetic resonance (MRI) scanner. The average contrast between tumors normal tissue 17 patients was 7.58% ( P = 0.006) 3–4 ppm...
Abstract Cross sectional imaging is essential for the patient-specific planning and delivery of radiotherapy, a primary determinant head neck cancer outcomes. Due to challenges ensuring data quality patient de-identification, publicly available datasets including diagnostic radiation treatment are scarce. In this descriptor, we detail collection processing computed tomography based in 215 patients with squamous cell carcinoma that were treated radiotherapy. Using cross imaging, calculated...
Cancers arising from the oropharynx have become increasingly more studied in past few years, as they are now epidemic domestically. These tumors treated with definitive (chemo)radiotherapy, and local recurrence a primary mode of clinical failure. Recent data suggest that 'radiomics', or extraction image texture analysis to generate mineable quantitative medical images, can reflect phenotypes for various cancers. Several groups shown developed radiomic signatures, head neck cancers, be...
PurposeThis prospective study is, to our knowledge, the first report of daily adaptive radiation therapy (ART) for head and neck cancer (HNC) using a 1.5T magnetic resonance imaging-linear accelerator (MR-linac) with particular focus on safety feasibility dosimetric results an online rigid registration-based adapt position (ATP) workflow.Methods MaterialsTen patients HNC received ART 1.5T/7MV MR-linac, 6 ATP only 4 1 offline adapt-to-shape replan. Setup variability custom immobilization...